KEGG   Homo sapiens (human): 11280Help
Entry
11280             CDS       T01001                                 

Gene name
SCN11A, FEPS3, HSAN7, NAV1.9, NaN, PN5, SCN12A, SNS-2
Definition
(RefSeq) sodium voltage-gated channel alpha subunit 11
  KO
K04843  voltage-gated sodium channel type XI alpha
Organism
hsa  Homo sapiens (human)
Disease
H00265  Hereditary sensory and autonomic neuropathy
H01391  Familial episodic pain syndrome
Drug target
Actisomide: D02762
Ajmaline: D00199
Aminobenzoic acid (DG00379): D02456 D02906 D02907
Amiodarone (DG00204): D00636 D02910
Aprindine (DG00199): D01326 D02969
Articaine (DG00805): D02991 D07468
Benzocaine: D00552
Bupivacaine (DG00801): D01450 D07552
Carbamazepine: D00252
Chloroprocaine (DG00800): D00732 D07678
Cibenzoline (DG00209): D01455 D03492
Cinchocaine (DG00297): D00733 D02220
Cocaine (DG00808): D00110 D02182
Disopyramide (DG00194): D00303 D00637
Eleclazine: D11155
Encainide (DG00203): D03991 D07894
Eslicarbazepine (DG00848): D09215 D09612
Ethyl piperidinoacetylaminobenzoate: D01519
Flecainide (DG00201): D00638 D07962
Fosphenytoin (DG00847): D02096 D07595 D07993
Indecainide hydrochloride: D04521
Lamotrigine: D00354
Levobupivacaine (DG00807): D01287 D08116
Levosemotiadil fumarate: D09833
Lidocaine (DG00196): D00358 D02086 D08127
Lorajmine: D04774
Mephenytoin: D00375
Mepivacaine (DG00802): D00738 D08181
Mexiletine (DG00197): D00639 D08215
Oxcarbazepine: D00533
Oxetacaine (DG00299): D01152 D08311
Oxybuprocaine (DG00392): D01768 D08319
Phenytoin (DG00846): D00512 D02103
Pilsicainide (DG01257): D01554 D08377
Pirmenol (DG01381): D01785 D06517 D08394
Pramocaine (DG00300): D00739 D08407
Prilocaine (DG00803): D00553 D01243
Procainamide (DG00193): D00477 D08421
Procaine (DG00298): D00740 D08422
Propafenone (DG00200): D00640 D08435
Proxymetacaine (DG01145): D02098 D08448
Quinidine (DG00192): D00642 D00643 D02272 D08458 D08459
Recainam (DG01421): D05708 D05709
Ropivacaine (DG00806): D04048 D08490
Rufinamide: D05775
Sparteine (DG00195): D01041 D02239
Tetracaine (DG00296): D00551 D00741
Tocainide (DG00198): D02088 D06172
Topiramate: D00537
Transcainide: D06203
Zonisamide: D00538
p-Butylaminobenzoyldiethylaminoethyl hydrochloride: D01967
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    11280 (SCN11A)
Ion channels [BR:hsa04040]
 Voltage-gated cation channels
  Sodium channel, voltage-gated (Nav)
   11280 (SCN11A)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Ion_trans Na_trans_assoc PKD_channel GPHH
Motif
Other DBs
NCBI-GeneID: 11280
NCBI-ProteinID: NP_054858
OMIM: 604385
HGNC: 10583
Ensembl: ENSG00000168356
Vega: OTTHUMG00000048246
Pharos: Q9UI33(Tclin)
UniProt: Q9UI33
Position
3p22.2
AA seq 1791 aa AA seqDB search
MDDRCYPVIFPDERNFRPFTSDSLAAIEKRIAIQKEKKKSKDQTGEVPQPRPQLDLKASR
KLPKLYGDIPRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRS
LAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILA
RGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLK
VIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHC
FEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDS
WEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKM
FQEAQQLLKEEKEALVAMGIDRSSLTSLETSYFTPKKRKLFGNKKRKSFFLRESGKDQPP
GSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVSILTITMKEQEKSQ
EPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHK
MEASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCV
LQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGM
QLFGRSFNSQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGEWIENMWECMQEA
NASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQLALDRFR
RAFCFVRHTLEHFCHKWCRKQNLPQQKEVAGGCAAQSKDIIPLVMEMKRGSETQEELGIL
TSVPKTLGVRHDWTWLAPLAEEEDDVEFSGEDNAQRITQPEPEQQAYELHQENKKPTSQR
VQSVEIDMFSEDEPHLTIQDPRKKSDVTSILSECSTIDLQDGFGWLPEMVPKKQPERCLP
KGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHL
ENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLINL
MELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFF
SGKFGKCINGTDSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWM
DIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGG
QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNM
ISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALRQYYFTNGWNLFDCVVVLLS
IVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNI
GLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPM
LRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGE
DDFDIFYEVWEKFDPEATQFIKYSALSDFADALPEPLRVAKPNKYQFLVMDLPMVSEDRL
HCMDILFAFTARVLGGSDGLDSMKAMMEEKFMEANPLKKLYEPIVTTTKRKEEERGAAII
QKAFRKYMMKVTKGDQGDQNDLENGPHSPLQTLCNGDLSSFGVAKGKVHCD
NT seq 5376 nt NT seq  +upstreamnt  +downstreamnt
atggatgacagatgctacccagtaatctttccagatgagcggaatttccgccccttcact
tccgactctctggctgcaattgagaagcggattgccatccaaaaggagaaaaagaagtct
aaagaccagacaggagaagtaccccagcctcggcctcagcttgacctaaaggcctccagg
aagttgcccaagctctatggcgacattcctcgtgagctcataggaaagcctctggaagac
ttggacccattctaccgaaatcataagacatttatggtgttaaacagaaagaggacaatc
taccgcttcagtgccaagcatgccttgttcatttttgggcctttcaattcaatcagaagt
ttagccattagagtctcagtccattcattgttcagcatgttcattatcggcaccgttatc
atcaactgcgtgttcatggctacagggcctgctaaaaacagcaacagtaacaatactgac
attgcagagtgtgtcttcactgggatttatatttttgaagctttgattaaaatattggca
agaggtttcattctggatgagttttctttccttcgagatccatggaactggctggactcc
attgtcattggaatagcgattgtgtcatatattccaggaatcaccatcaaactattgccc
ctgcgtaccttccgtgtgttcagagctttgaaagcaatttcagtagtttcacgtctgaag
gtcatcgtgggggccttgctacgctctgtgaagaagctggtcaacgtgattatcctcacc
ttcttttgcctcagcatctttgccctggtaggtcagcagctcttcatgggaagtctgaac
ctgaaatgcatctcgagggactgtaaaaatatcagtaacccggaagcttatgaccattgc
tttgaaaagaaagaaaattcacctgaattcaaaatgtgtggcatctggatgggtaacagt
gcctgttccatacaatatgaatgtaagcacaccaaaattaatcctgactataattatacg
aattttgacaactttggctggtcttttcttgccatgttccggctgatgacccaagattcc
tgggagaagctttatcaacagaccctgcgtactactgggctctactcagtcttcttcttc
attgtggtcattttcctgggctccttctacctgattaacttaaccctggctgttgttacc
atggcatatgaggagcagaacaagaatgtagctgcagagatagaggccaaggaaaagatg
tttcaggaagcccagcagctgttaaaggaggaaaaggaggctctggttgccatgggaatt
gacagaagttcacttacttcccttgaaacatcatattttaccccaaaaaagagaaagctc
tttggtaataagaaaaggaagtccttctttttgagagagtctgggaaagaccagcctcct
gggtcagattctgatgaagattgccaaaaaaagccacagctcctagagcaaaccaaacga
ctgtcccagaatctatcactggaccactttgatgagcatggagatcctctccaaaggcag
agagcactgagtgctgtcagcatcctcaccatcaccatgaaggaacaagaaaaatcacaa
gagccttgtctcccttgtggagaaaacctggcatccaagtacctcgtgtggaactgttgc
ccccagtggctgtgcgttaagaaggtcctgagaactgtgatgactgacccgtttactgag
ctggccatcaccatctgcatcatcatcaacactgtcttcttggccatggagcatcacaag
atggaggccagttttgagaagatgttgaatatagggaatttggttttcactagcattttt
atagcagaaatgtgcctaaaaatcattgcgctcgatccctaccactactttcgccgaggc
tggaacatttttgacagcattgttgctcttctgagttttgcagatgtaatgaactgtgta
cttcaaaagagaagctggccattcttgcgttccttcagagtgctcagggtcttcaagtta
gccaaatcctggccaactttgaacacactaattaagataatcggcaactctgtcggagcc
cttggaagcctgactgtggtcctggtcattgtgatctttattttctcagtagttggcatg
cagctttttggccgtagcttcaattcccaaaagagtccaaaactctgtaacccgacaggc
ccgacagtctcatgtttacggcactggcacatgggggatttctggcactccttcctagtg
gtattccgcatcctctgcggggaatggatcgaaaatatgtgggaatgtatgcaagaagcg
aatgcatcatcatcattgtgtgttattgtcttcatattgatcacggtgataggaaaactt
gtggtgctcaacctcttcattgccttactgctcaattcctttagcaatgaggaaagaaat
ggaaacttagaaggagaggccaggaaaactaaagtccagttagcactggatcgattccgc
cgggctttttgttttgtgagacacactcttgagcatttctgtcacaagtggtgcaggaag
caaaacttaccacagcaaaaagaggtggcaggaggctgtgctgcacaaagcaaagacatc
attcccctggtcatggagatgaaaaggggctcagagacccaggaggagcttggtatacta
acctctgtaccaaagaccctgggcgtcaggcatgattggacttggttggcaccacttgcg
gaggaggaagatgacgttgaattttctggtgaagataatgcacagcgcatcacacaacct
gagcctgaacaacaggcctatgagctccatcaggagaacaagaagcccacgagccagaga
gttcaaagtgtggaaattgacatgttctctgaagatgagcctcatctgaccatacaggat
ccccgaaagaagtctgatgttaccagtatactatcagaatgtagcaccattgatcttcag
gatggctttggatggttacctgagatggttcccaaaaagcaaccagagagatgtttgccc
aaaggctttggttgctgctttccatgctgtagcgtggacaagagaaagcctccctgggtc
atttggtggaacctgcggaaaacctgctaccaaatagtgaaacacagctggtttgagagc
tttattatctttgtgattctgctgagcagtggggcactgatatttgaagatgttcacctt
gagaaccaacccaaaatccaagaattactaaattgtactgacattatttttacacatatt
tttatcctggagatggtactaaaatgggtagccttcggatttggaaagtatttcaccagt
gcctggtgctgccttgatttcatcattgtgattgtctctgtgaccaccctcattaactta
atggaattgaagtccttccggactctacgagcactgaggcctcttcgtgcgctgtcccag
tttgaaggaatgaaggtggtggtcaatgctctcataggtgccatacctgccattctgaat
gttttgcttgtctgcctcattttctggctcgtattttgtattctgggagtatacttcttt
tctggaaaatttgggaaatgcattaatggaacagactcagttataaattataccatcatt
acaaataaaagtcaatgtgaaagtggcaatttctcttggatcaaccagaaagtcaacttt
gacaatgtgggaaatgcttacctcgctctgctgcaagtggcaacatttaagggctggatg
gatattatatatgcagctgttgattccacagagaaagaacaacagccagagtttgagagc
aattcactcggttacatttacttcgtagtctttatcatctttggctcattcttcactctg
aatctcttcattggcgttatcattgacaacttcaaccaacagcagaaaaagttaggtggc
caagacatttttatgacagaagaacagaagaaatactataatgcaatgaaaaaattagga
tccaaaaaacctcaaaaacccattccacggcctctgaacaaatgtcaaggtctcgtgttc
gacatagtcacaagccagatctttgacatcatcatcataagtctcattatcctaaacatg
attagcatgatggctgaatcatacaaccaacccaaagccatgaaatccatccttgaccat
ctcaactgggtctttgtggtcatctttacgttagaatgtctcatcaaaatctttgctttg
aggcaatactacttcaccaatggctggaatttatttgactgtgtggtcgtgcttctttcc
attgttagtacaatgatttctaccttggaaaatcaggagcacattcctttccctccgacg
ctcttcagaattgtccgcttggctcggattggccgaatcctgaggcttgtccgggctgca
cgaggaatcaggactctcctctttgctctgatgatgtcgcttccttctctgttcaacatt
ggtcttctactctttctgattatgtttatctatgccattctgggtatgaactggttttcc
aaagtgaatccagagtctggaatcgatgacatattcaacttcaagacttttgccagcagc
atgctctgtctcttccagataagcacatcagcaggttgggattccctgctcagccccatg
ctgcgatcaaaagaatcatgtaactcttcctcagaaaactgccacctccctggcatagcc
acatcctactttgtcagttacattatcatctcctttctcattgttgtcaacatgtacatt
gctgtgattttagagaacttcaatacagccactgaagaaagtgaggaccctttgggtgaa
gatgactttgacatattttatgaagtgtgggaaaagtttgacccagaagcaacacaattt
atcaaatattctgccctttctgactttgctgatgccttgcctgagcctttgcgtgtcgca
aagccaaataaatatcaatttctagtaatggacttgcccatggtgagtgaagatcgcctc
cactgcatggatattcttttcgccttcaccgctagggtactcggtggctctgatggccta
gatagtatgaaagcaatgatggaagagaagttcatggaagccaatcctctcaagaagttg
tatgaacccatagtcaccaccaccaagagaaaggaagaggaaagaggtgctgctattatt
caaaaggcctttcgaaagtacatgatgaaggtgaccaagggtgaccaaggtgaccaaaat
gacttggaaaacgggcctcattcaccactccagactctttgcaatggagacttgtctagc
tttggggtggccaagggcaaggtccactgtgactga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Drug (94)   
   KEGG DRUG (94)   
Genome (1)   
   KEGG GENOME (1)   
Gene (58)   
   KEGG ORTHOLOGY (1)   
   RefGene (50)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (11)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (9)   
DNA sequence (21)   
   RefSeq(nuc) (11)   
   GenBank (5)   
   EMBL (5)   
Protein domain (4)   
   Pfam (4)   
All databases (196)   

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