KEGG T01001: 1131

Homo sapiens (human): 1131

Entry

1131              CDS       T01001

Symbol

CHRM3, EGBRS, HM3, PBS

Name

(RefSeq) cholinergic receptor muscarinic 3

K04131

muscarinic acetylcholine receptor M3

Organism

hsa Homo sapiens (human)

Pathway

hsa04020

Calcium signaling pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04725

Cholinergic synapse

hsa04742

Taste transduction

hsa04810

Regulation of actin cytoskeleton

hsa04911

Insulin secretion

hsa04970

Salivary secretion

hsa04971

Gastric acid secretion

hsa04972

Pancreatic secretion

hsa05010

Alzheimer disease

hsa05022

Pathways of neurodegeneration - multiple diseases

Network

nt06410 Calcium signaling
nt06460 Alzheimer disease

Element

N01000

mAChR-Ca2+ -apoptotic pathway

N01001

Mutation-caused aberrant Abeta to mAchR-Ca2+ -apoptotic pathway

Disease

H02129

Prune belly syndrome

Drug target

Acetylcholine (DG01133):

D00999<JP/US>

Aclatonium (DG01291):

D01955

Aclidinium bromide:

D08837<JP/US>

Alvameline maleate:

D02876

Anisotropine methylbromide:

D00232

Atropine (DG00052):

D00113<US> D02069<JP/US>

Atropine oxide (DG01243):

D03011 D07477

Batefenterol (DG01627):

D10545 D10546

Benapryzine hydrochloride:

D03076

Benzatropine (DG00859):

D00778<US> D07511

Benzetimide (DG01301):

D03087 D07513

Benzilone:

D03088

Bethanechol (DG00991):

D01000<JP/US>

Bevonium:

D01532

Biperiden (DG00852):

D00779 D02246<JP> D02247<JP>

Blarcamesine (DG03048):

D11383 D11549

Bornaprine:

D07302

Butropium bromide:

D01491<JP>

Butylscopolamine:

D01451<JP>

Carbachol:

D00524<US>

Carpronium (DG01289):

D01175<JP> D09752<JP>

Cevimeline (DG00993):

D00661<JP/US> D07667

Chlorpromazine (DG00867):

D00270 D00789<JP/US> D03274 D04034<JP> D09819

Choline alfoscerate:

D07349

Cimetropium bromide:

D07099

Clidinium bromide:

D00716

Cyclopentolate (DG01141):

D01002<JP/US> D07759

Darifenacin (DG00482):

D01699<US> D03654

Darotropium bromide:

D09402

Desfesoterodine:

D10853

Dexetimide (DG00856):

D03711 D07804

Dexpanthenol:

D00193<JP>

Dicycloverine (DG00032):

D00717<US> D07820

Diethazine (DG01921):

D02603 D07823

Difemerine:

D07079

Dihexyverine (DG00033):

D03824 D07821

Diphemanil:

D06878

Diphenidol (DG02880):

D01318<JP> D03858 D03859

Diphenylpiperidinomethyldioxolan iodide:

Diponium bromide:

Elantrine:

Elucaine:

Esoxybutynin chloride:

D04057

Etomidoline:

D01359

Etybenzatropine:

D04087

Eucatropine hydrochloride:

D04116

Fenpiverinium:

D07070

Fentonium:

D07951

Fesoterodine (DG00483):

D07226 D08923<JP/US>

Flutropium bromide:

D02417

Glycopyrronium:

D00540<JP/US>

Glycopyrronium (DG02467):

D10938 D10939<JP/US>

Heteronium bromide:

D04434

Hexocyclium (DG00039):

D01003

Homatropine (DG01142):

D01004

Homatropine methylbromide:

D02070

Hyoscyamine (DG00053):

D00147 D00719 D01648 D04479

Imidafenacin:

D06273<JP>

Ipratropium bromide:

D02212<JP/US>

Isopropamide (DG00038):

D01005

Mazaticol (DG00857):

D03264<JP> D08157

Mebeverine (DG00030):

D04868 D08160

Mepenzolate (DG00040):

D00720<JP>

Methacholine:

D04970<JP/US>

Methantheline (DG00036):

D00721

Methscopolamine bromide:

D00715<US>

Methylatropine (DG01242):

D01077 D03814

Methylbenactyzium bromide:

D01315

Methylscopolamine:

D01976<JP>

Metixene (DG00853):

D01871 D08209

Metoquizine:

D05012

Milameline hydrochloride:

D05035

Navafenterol (DG03123):

Otilonium bromide:

Oxapium iodide:

Oxitropium bromide:

Oxybutynin (DG00478):

D00465<US> D00722<JP/US>

Oxyphencyclimine (DG00029):

D01006 D08325

Parapenzolate bromide:

D05360

Pentapiperium methylsulfate:

Penthienate:

Phencarbamide:

Phenglutarimide:

Pilocarpine (DG00992):

D00525 D02200<JP/US> D05478 D08376

Pipenzolate:

D07084

Piperidolate (DG00034):

D01165<JP> D08382

Pipethanate (DG01255):

D01521 D08384

Pipethanate ethobromide:

D01987

Pirenzepine (DG00026):

D01297 D05276<JP> D08389

Piroheptine (DG01272):

D01231<JP> D08395

Poldine:

D05535

Pridinol (DG00774):

D02064<JP> D08418 D08419

Prifinium bromide:

D01377

Procyclidine (DG00854):

D00782 D08425

Profenamine (DG00855):

D01118 D03276 D08426

Propantheline (DG00035):

D00481<JP/US>

Propenzolate hydrochloride:

D05628

Propiverine (DG00479):

D01007<JP> D08441

Rapacuronium bromide:

D05703

Revefenacin:

D10978<US>

Rociverine:

D07078

Rocuronium bromide:

D00765<JP/US>

Scopolamine (DG00065):

D00138<US> D02071<JP>

Sofpironium bromide:

D10989<JP>

Solifenacin (DG00481):

D01269<JP/US> D08522

Tazomeline citrate:

D06015

Tematropium methylsulfate:

D06061

Tiemonium (DG01254):

D08595

Tiemonium iodide:

D01201

Timepidium bromide (DG00041):

D02535<JP>

Tiotropium bromide:

D01929<JP/US>

Tiquizium bromide:

D01875<JP>

Tofenacin hydrochloride:

D06175

Tolterodine (DG00480):

D00646 D01148<JP/US>

Toquizine:

D06192

Triampyzine sulfate:

D06217

Tridihexethyl (DG00037):

D00723

Trihexyphenidyl (DG00851):

D00787<JP/US> D08638

Tropatepine (DG00858):

D07303 D08653

Tropicamide:

D00397<JP/US>

Trospium:

D01103<US>

Umeclidinium (DG01253):

D10180

Umeclidinium bromide:

D10181<JP/US>

Valethamate:

D01538

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    1131 (CHRM3)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1131 (CHRM3)
09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    1131 (CHRM3)
09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    1131 (CHRM3)
  09154 Digestive system
   04970 Salivary secretion
    1131 (CHRM3)
   04971 Gastric acid secretion
    1131 (CHRM3)
   04972 Pancreatic secretion
    1131 (CHRM3)
  09156 Nervous system
   04725 Cholinergic synapse
    1131 (CHRM3)
  09157 Sensory system
   04742 Taste transduction
    1131 (CHRM3)
09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    1131 (CHRM3)
   05022 Pathways of neurodegeneration - multiple diseases
    1131 (CHRM3)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    1131 (CHRM3)
G protein-coupled receptors [BR:hsa04030]
Rhodopsin family
  Biogenic amine
   Acetylcholine (muscarinic)
    1131 (CHRM3)

SSDB

Motif

Pfam:

7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srbc

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Pharos:

P20309(Tclin)

UniProt:

P20309 A0A024R3W1

Structure

Position

1:239386568..239915450

AA seq 590 aa
MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPL
GGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVI
SMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR
TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF
YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSM
KRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE
TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSF
PKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKR
MSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVN
PVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL

NT seq 1773 nt +upstreamnt +downstreamnt
atgaccttgcacaataacagtacaacctcgcctttgtttccaaacatcagctcctcctgg
atacacagcccctccgatgcagggctgcccccgggaaccgtcactcatttcggcagctac
aatgtttctcgagcagctggcaatttctcctctccagacggtaccaccgatgaccctctg
ggaggtcataccgtctggcaagtggtcttcatcgctttcttaacgggcatcctggccttg
gtgaccatcatcggcaacatcctggtaattgtgtcatttaaggtcaacaagcagctgaag
acggtcaacaactacttcctcttaagcctggcctgtgccgatctgattatcggggtcatt
tcaatgaatctgtttacgacctacatcatcatgaatcgatgggccttagggaacttggcc
tgtgacctctggcttgccattgactacgtagccagcaatgcctctgttatgaatcttctg
gtcatcagctttgacagatacttttccatcacgaggccgctcacgtaccgagccaaacga
acaacaaagagagccggtgtgatgatcggtctggcttgggtcatctcctttgtcctttgg
gctcctgccatcttgttctggcaatactttgttggaaagagaactgtgcctccgggagag
tgcttcattcagttcctcagtgagcccaccattacttttggcacagccatcgctgctttt
tatatgcctgtcaccattatgactattttatactggaggatctataaggaaactgaaaag
cgtaccaaagagcttgctggcctgcaagcctctgggacagaggcagagacagaaaacttt
gtccaccccacgggcagttctcgaagctgcagcagttacgaacttcaacagcaaagcatg
aaacgctccaacaggaggaagtatggccgctgccacttctggttcacaaccaagagctgg
aaacccagctccgagcagatggaccaagaccacagcagcagtgacagttggaacaacaat
gatgctgctgcctccctggagaactccgcctcctccgacgaggaggacattggctccgag
acgagagccatctactccatcgtgctcaagcttccgggtcacagcaccatcctcaactcc
accaagttaccctcatcggacaacctgcaggtgcctgaggaggagctggggatggtggac
ttggagaggaaagccgacaagctgcaggcccagaagagcgtggacgatggaggcagtttt
ccaaaaagcttctccaagcttcccatccagctagagtcagccgtggacacagctaagact
tctgacgtcaactcctcagtgggtaagagcacggccactctacctctgtccttcaaggaa
gccactctggccaagaggtttgctctgaagaccagaagtcagatcactaagcggaaaagg
atgtccctggtcaaggagaagaaagcggcccagaccctcagtgcgatcttgcttgccttc
atcatcacttggaccccatacaacatcatggttctggtgaacaccttttgtgacagctgc
atacccaaaaccttttggaatctgggctactggctgtgctacatcaacagcaccgtgaac
cccgtgtgctatgctctgtgcaacaaaacattcagaaccactttcaagatgctgctgctg
tgccagtgtgacaaaaaaaagaggcgcaagcagcagtaccagcagagacagtcggtcatt
tttcacaagcgcgcacccgagcaggccttgtag

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