KEGG   Homo sapiens (human): 1131
Entry
1131              CDS       T01001                                 
Symbol
CHRM3, EGBRS, HM3, PBS, m3AChR
Name
(RefSeq) cholinergic receptor muscarinic 3
  KO
K04131  muscarinic acetylcholine receptor M3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04082  Neuroactive ligand signaling
hsa04725  Cholinergic synapse
hsa04742  Taste transduction
hsa04810  Regulation of actin cytoskeleton
hsa04911  Insulin secretion
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion
hsa04972  Pancreatic secretion
hsa05010  Alzheimer disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06460  Alzheimer disease
nt06466  Pathways of neurodegeneration
nt06528  Calcium signaling
nt06544  Neuroactive ligand signaling
  Element
N01000  mAChR-Ca2+ -apoptotic pathway
N01001  Mutation-caused aberrant Abeta to mAchR-Ca2+ -apoptotic pathway
N01640  GPCR-PLCB-ITPR signaling pathway
N01894  Acetylcholine-CHRM-GNAQ/11 signaling pathway
Disease
H02129  Prune belly syndrome
Drug target
Acetylcholine (DG01133): D00999<JP/US>
Aclatonium (DG01291): D01955
Aclidinium bromide: D08837<JP/US>
Alvameline maleate: D02876
Anisotropine methylbromide: D00232
Atropine (DG00052): D00113<US> D02069<JP/US>
Atropine oxide (DG01243): D03011 D07477
Batefenterol (DG01627): D10545 D10546
Benapryzine hydrochloride: D03076
Benzatropine (DG00859): D00778<US> D07511
Benzetimide (DG01301): D03087 D07513
Benzilone: D03088
Bethanechol (DG00991): D01000<JP/US>
Bevonium: D01532
Biperiden (DG00852): D00779 D02246<JP> D02247<JP>
Blarcamesine (DG03048): D11383 D11549
Bornaprine: D07302
Butropium bromide: D01491
Butylscopolamine: D01451<JP>
Carbachol: D00524<US>
Carpronium (DG01289): D01175<JP> D09752<JP>
Cevimeline (DG00993): D00661<JP/US> D07667
Chlorpromazine (DG00867): D00270 D00789<JP/US> D03274 D04034<JP> D09819
Choline alfoscerate: D07349
Cimetropium bromide: D07099
Clidinium bromide: D00716
Cyclopentolate (DG01141): D01002<JP/US> D07759
Darifenacin (DG00482): D01699<US> D03654
Darotropium bromide: D09402
Desfesoterodine: D10853
Dexetimide (DG00856): D03711 D07804
Dexpanthenol: D00193<JP>
Dicycloverine (DG00032): D00717<US> D07820
Diethazine (DG01921): D02603 D07823
Difemerine: D07079
Dihexyverine (DG00033): D03824 D07821
Diphemanil: D06878
Diphenidol (DG02880): D01318<JP> D03858 D03859
Diphenylpiperidinomethyldioxolan iodide: D01600
Diponium bromide: D01463
Elantrine: D03970
Elucaine: D03979
Esoxybutynin chloride: D04057
Etomidoline: D01359
Etybenzatropine: D04087
Eucatropine hydrochloride: D04116
Fenpiverinium: D07070
Fentonium: D07951
Fesoterodine (DG00483): D07226 D08923<JP/US>
Flutropium bromide: D02417
Glycopyrronium (DG02467): D10938 D10939<JP/US>
Glycopyrronium bromide: D00540<JP/US>
Heteronium bromide: D04434
Hexocyclium (DG00039): D01003
Homatropine (DG01142): D01004
Homatropine methylbromide: D02070
Hyoscyamine (DG00053): D00147 D00719 D01648 D04479
Imidafenacin: D06273<JP>
Ipratropium bromide: D02212<JP/US>
Isopropamide (DG00038): D01005
Mazaticol (DG00857): D03264 D08157
Mebeverine (DG00030): D04868 D08160
Mepenzolate (DG00040): D00720<JP>
Methacholine: D04970<JP/US>
Methantheline (DG00036): D00721
Methscopolamine bromide: D00715<US>
Methylatropine (DG01242): D01077 D03814
Methylbenactyzium bromide: D01315
Methylscopolamine: D01976
Metixene (DG00853): D01871 D08209
Metoquizine: D05012
Milameline hydrochloride: D05035
Navafenterol (DG03123): D11900 D11901
Otilonium bromide: D07083
Oxapium iodide: D01815
Oxitropium bromide: D01946
Oxybutynin (DG00478): D00465<US> D00722<JP/US>
Oxyphencyclimine (DG00029): D01006 D08325
Parapenzolate bromide: D05360
Pentapiperium methylsulfate: D05418
Penthienate: D07081
Phencarbamide: D05452
Phenglutarimide: D07301
Pilocarpine (DG00992): D00525 D02200<JP/US> D05478 D08376
Pipenzolate: D07084
Piperidolate (DG00034): D01165<JP> D08382
Pipethanate (DG01255): D01521 D08384
Pipethanate ethobromide: D01987
Pirenzepine (DG00026): D01297 D05276<JP> D08389
Piroheptine (DG01272): D01231<JP> D08395
Poldine: D05535
Pridinol (DG00774): D02064<JP> D08418 D08419
Prifinium bromide: D01377
Procyclidine (DG00854): D00782 D08425
Profenamine (DG00855): D01118 D03276 D08426
Propantheline (DG00035): D00481<JP>
Propenzolate hydrochloride: D05628
Propiverine (DG00479): D01007<JP> D08441
Rapacuronium bromide: D05703
Revefenacin: D10978<US>
Rociverine: D07078
Rocuronium bromide: D00765<JP/US>
Scopolamine (DG00065): D00138<US> D02071
Sofpironium bromide: D10989<JP/US>
Solifenacin (DG00481): D01269<JP/US> D08522
Tazomeline citrate: D06015
Tematropium methylsulfate: D06061
Tiemonium (DG01254): D08595
Tiemonium iodide: D01201
Timepidium bromide (DG00041): D02535<JP>
Tiotropium bromide: D01929<JP/US>
Tiquizium bromide: D01875<JP>
Tofenacin hydrochloride: D06175
Tolterodine (DG00480): D00646 D01148<US>
Toquizine: D06192
Triampyzine sulfate: D06217
Tridihexethyl (DG00037): D00723
Trihexyphenidyl (DG00851): D00787<JP/US> D08638
Tropatepine (DG00858): D07303 D08653
Tropicamide: D00397<JP/US>
Trospium: D01103<US>
Umeclidinium (DG01253): D10180
Umeclidinium bromide: D10181<JP/US>
Valethamate: D01538
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    1131 (CHRM3)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1131 (CHRM3)
   04082 Neuroactive ligand signaling
    1131 (CHRM3)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    1131 (CHRM3)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    1131 (CHRM3)
  09154 Digestive system
   04970 Salivary secretion
    1131 (CHRM3)
   04971 Gastric acid secretion
    1131 (CHRM3)
   04972 Pancreatic secretion
    1131 (CHRM3)
  09156 Nervous system
   04725 Cholinergic synapse
    1131 (CHRM3)
  09157 Sensory system
   04742 Taste transduction
    1131 (CHRM3)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    1131 (CHRM3)
   05022 Pathways of neurodegeneration - multiple diseases
    1131 (CHRM3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    1131 (CHRM3)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Acetylcholine (muscarinic)
    1131 (CHRM3)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srbc
Other DBs
NCBI-GeneID: 1131
NCBI-ProteinID: NP_000731
OMIM: 118494
HGNC: 1952
Ensembl: ENSG00000133019
UniProt: P20309
Structure
Position
1:239386568..239915450
AA seq 590 aa
MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPL
GGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVI
SMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR
TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF
YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSM
KRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE
TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSF
PKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKR
MSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVN
PVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
NT seq 1773 nt   +upstreamnt  +downstreamnt
atgaccttgcacaataacagtacaacctcgcctttgtttccaaacatcagctcctcctgg
atacacagcccctccgatgcagggctgcccccgggaaccgtcactcatttcggcagctac
aatgtttctcgagcagctggcaatttctcctctccagacggtaccaccgatgaccctctg
ggaggtcataccgtctggcaagtggtcttcatcgctttcttaacgggcatcctggccttg
gtgaccatcatcggcaacatcctggtaattgtgtcatttaaggtcaacaagcagctgaag
acggtcaacaactacttcctcttaagcctggcctgtgccgatctgattatcggggtcatt
tcaatgaatctgtttacgacctacatcatcatgaatcgatgggccttagggaacttggcc
tgtgacctctggcttgccattgactacgtagccagcaatgcctctgttatgaatcttctg
gtcatcagctttgacagatacttttccatcacgaggccgctcacgtaccgagccaaacga
acaacaaagagagccggtgtgatgatcggtctggcttgggtcatctcctttgtcctttgg
gctcctgccatcttgttctggcaatactttgttggaaagagaactgtgcctccgggagag
tgcttcattcagttcctcagtgagcccaccattacttttggcacagccatcgctgctttt
tatatgcctgtcaccattatgactattttatactggaggatctataaggaaactgaaaag
cgtaccaaagagcttgctggcctgcaagcctctgggacagaggcagagacagaaaacttt
gtccaccccacgggcagttctcgaagctgcagcagttacgaacttcaacagcaaagcatg
aaacgctccaacaggaggaagtatggccgctgccacttctggttcacaaccaagagctgg
aaacccagctccgagcagatggaccaagaccacagcagcagtgacagttggaacaacaat
gatgctgctgcctccctggagaactccgcctcctccgacgaggaggacattggctccgag
acgagagccatctactccatcgtgctcaagcttccgggtcacagcaccatcctcaactcc
accaagttaccctcatcggacaacctgcaggtgcctgaggaggagctggggatggtggac
ttggagaggaaagccgacaagctgcaggcccagaagagcgtggacgatggaggcagtttt
ccaaaaagcttctccaagcttcccatccagctagagtcagccgtggacacagctaagact
tctgacgtcaactcctcagtgggtaagagcacggccactctacctctgtccttcaaggaa
gccactctggccaagaggtttgctctgaagaccagaagtcagatcactaagcggaaaagg
atgtccctggtcaaggagaagaaagcggcccagaccctcagtgcgatcttgcttgccttc
atcatcacttggaccccatacaacatcatggttctggtgaacaccttttgtgacagctgc
atacccaaaaccttttggaatctgggctactggctgtgctacatcaacagcaccgtgaac
cccgtgtgctatgctctgtgcaacaaaacattcagaaccactttcaagatgctgctgctg
tgccagtgtgacaaaaaaaagaggcgcaagcagcagtaccagcagagacagtcggtcatt
tttcacaagcgcgcacccgagcaggccttgtag

  All links  
Disease (2)   
   OMIM (2)   
Gene (11)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (55)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (53)   
DNA sequence (76)   
   RefSeq(nuc) (54)   
   GenBank (11)   
   EMBL (11)   
3D Structure (5)   
   PDB (5)   
Protein domain (4)   
   Pfam (4)   
All databases (153)   

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