KEGG   Homo sapiens (human): 114Help
Entry
114               CDS       T01001                                 

Gene name
ADCY8, AC8, ADCY3, HBAC1
Definition
(RefSeq) adenylate cyclase 8
  KO
K08048  adenylate cyclase 8 [EC:4.6.1.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00230  Purine metabolism
hsa01522  Endocrine resistance
hsa04015  Rap1 signaling pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04062  Chemokine signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04114  Oocyte meiosis
hsa04211  Longevity regulating pathway
hsa04213  Longevity regulating pathway - multiple species
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04371  Apelin signaling pathway
hsa04540  Gap junction
hsa04611  Platelet activation
hsa04713  Circadian entrainment
hsa04714  Thermogenesis
hsa04720  Long-term potentiation
hsa04723  Retrograde endocannabinoid signaling
hsa04724  Glutamatergic synapse
hsa04725  Cholinergic synapse
hsa04727  GABAergic synapse
hsa04742  Taste transduction
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04911  Insulin secretion
hsa04912  GnRH signaling pathway
hsa04913  Ovarian steroidogenesis
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
hsa04916  Melanogenesis
hsa04918  Thyroid hormone synthesis
hsa04921  Oxytocin signaling pathway
hsa04923  Regulation of lipolysis in adipocytes
hsa04925  Aldosterone synthesis and secretion
hsa04926  Relaxin signaling pathway
hsa04927  Cortisol synthesis and secretion
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04934  Cushing's syndrome
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion
hsa04972  Pancreatic secretion
hsa04976  Bile secretion
hsa05032  Morphine addiction
hsa05166  HTLV-I infection
hsa05200  Pathways in cancer
hsa05414  Dilated cardiomyopathy (DCM)
Module
hsa_M00695  cAMP signaling
Network
N00288  PTH-PTH1R-PKA signaling pathway
N00289  Mutation-inactivated GNAS to PTH-PTH1R-PKA signaling pathway
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00321  Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00324  CRHR-PKA-ACTH signaling pathway
N00325  Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway
N00326  Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway
N00327  Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
Drug target
Colforsin daropate hydrochloride: D01697
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Metabolism
  Nucleotide metabolism
   00230 Purine metabolism
    114 (ADCY8)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    114 (ADCY8)
   04371 Apelin signaling pathway
    114 (ADCY8)
   04020 Calcium signaling pathway
    114 (ADCY8)
   04072 Phospholipase D signaling pathway
    114 (ADCY8)
   04024 cAMP signaling pathway
    114 (ADCY8)
   04022 cGMP - PKG signaling pathway
    114 (ADCY8)
 Cellular Processes
  Cell growth and death
   04114 Oocyte meiosis
    114 (ADCY8)
  Cellular community - eukaryotes
   04540 Gap junction
    114 (ADCY8)
 Organismal Systems
  Immune system
   04611 Platelet activation
    114 (ADCY8)
   04062 Chemokine signaling pathway
    114 (ADCY8)
  Endocrine system
   04911 Insulin secretion
    114 (ADCY8)
   04923 Regulation of lipolysis in adipocyte
    114 (ADCY8)
   04912 GnRH signaling pathway
    114 (ADCY8)
   04913 Ovarian Steroidogenesis
    114 (ADCY8)
   04915 Estrogen signaling pathway
    114 (ADCY8)
   04914 Progesterone-mediated oocyte maturation
    114 (ADCY8)
   04921 Oxytocin signaling pathway
    114 (ADCY8)
   04926 Relaxin signaling pathway
    114 (ADCY8)
   04918 Thyroid hormone synthesis
    114 (ADCY8)
   04928 Parathyroid hormone synthesis, secretion and action
    114 (ADCY8)
   04916 Melanogenesis
    114 (ADCY8)
   04925 Aldosterone synthesis and secretion
    114 (ADCY8)
   04927 Cortisol synthesis and secretion
    114 (ADCY8)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    114 (ADCY8)
   04270 Vascular smooth muscle contraction
    114 (ADCY8)
  Digestive system
   04970 Salivary secretion
    114 (ADCY8)
   04971 Gastric acid secretion
    114 (ADCY8)
   04972 Pancreatic secretion
    114 (ADCY8)
   04976 Bile secretion
    114 (ADCY8)
  Nervous system
   04724 Glutamatergic synapse
    114 (ADCY8)
   04727 GABAergic synapse
    114 (ADCY8)
   04725 Cholinergic synapse
    114 (ADCY8)
   04720 Long-term potentiation
    114 (ADCY8)
   04723 Retrograde endocannabinoid signaling
    114 (ADCY8)
  Sensory system
   04742 Taste transduction
    114 (ADCY8)
   04750 Inflammatory mediator regulation of TRP channels
    114 (ADCY8)
  Aging
   04211 Longevity regulating pathway - mammal
    114 (ADCY8)
   04213 Longevity regulating pathway - multiple species
    114 (ADCY8)
  Environmental adaptation
   04713 Circadian entrainment
    114 (ADCY8)
   04714 Thermogenesis
    114 (ADCY8)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    114 (ADCY8)
  Substance dependence
   05032 Morphine addiction
    114 (ADCY8)
  Cardiovascular diseases
   05414 Dilated cardiomyopathy (DCM)
    114 (ADCY8)
  Endocrine and metabolic diseases
   04934 Cushing's syndrome
    114 (ADCY8)
  Infectious diseases
   05166 HTLV-I infection
    114 (ADCY8)
  Drug resistance
   01522 Endocrine resistance
    114 (ADCY8)
Enzymes [BR:hsa01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     114 (ADCY8)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Guanylate_cyc AC_N DUF1053
Motif
Other DBs
NCBI-GeneID: 114
NCBI-ProteinID: NP_001106
OMIM: 103070
HGNC: 239
Ensembl: ENSG00000155897
Vega: OTTHUMG00000164756
Pharos: P40145(Tbio)
UniProt: P40145 A0A0K0K1K3 Q4F7X0
Position
8q24.22
AA seq 1251 aa AA seqDB search
MELSDVRCLTGSEELYTIHPTPPAGDGRSASRPQRLLWQTAVRHITEQRFIHGHRGGSGS
GSGGSGKASDPAGGGPNHHAPQLSGDSALPLYSLGPGERAHSTCGTKVFPERSGSGSASG
SGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRK
SEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHT
YLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTS
LLQVILQVVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEAR
LRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADV
KGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAH
CCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKL
ESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPED
IVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHV
QSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAF
IVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINE
TYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTG
VLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKEV
SLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVA
RHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDE
LLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKH
SFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLIL
KDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLV
QSLNRQRQKQLLNENNNTGIIKGHYNRRTLLSPSGTEPGAQAEGTDKSDLP
NT seq 3756 nt NT seq  +upstreamnt  +downstreamnt
atggagctctccgatgtgcgctgccttacaggcagcgaggaactctacaccatccacccg
acgcccccggccggcgacggcaggagcgcctcccggccgcagcggctgctgtggcagacg
gcggtgcgacacatcacggagcagcgcttcattcacgggcaccggggaggcagcggcagc
gggagtggaggctcgggcaaagcctcggaccctgcgggcggcggccccaaccaccacgcg
ccgcagctgtcaggcgactcggcgctgcccctctactcgctgggcccgggagagcgagcg
cacagcacctgcggcaccaaagtcttcccggaacgcagcgggagcggcagtgccagcggc
agcggaggcgggggcgacctgggcttcctgcaccttgactgtgcccctagcaactcggat
ttctttcttaatgggggctatagctaccgaggggtcattttccccaccctgcgcaactcc
ttcaaatctcgggatttggaacgcctctaccagcgctatttcttgggccaaaggcgcaaa
tcggaagtggtgatgaacgtgctggacgtgctgaccaaactcactctcttggtcctacac
ttgagcctggcctcggcccccatggacccgctcaagggcatcctgctgggcttcttcacc
ggcattgaggtagtgatctgcgccctggtggtggtcaggaaggacaccacctcccacacg
tacctgcagtacagcggcgtggtcacctgggtggccatgaccacccagatcctggcagca
ggcctcggctacgggctcctgggcgacggcataggctacgtgctcttcacgctcttcgcc
acctacagtatgctgccgctgccgctcacctgggccatcctggccggcctgggcacctcg
ctgctgcaggtcatcctccaagtggtcataccccggctggcggtcatttccatcaaccag
gttgtggcccaggcagtgctattcatgtgtatgaacacagctggaatcttcatcagttac
ctgtcagaccgggcccagcgccaagctttcctggagactcggaggtgtgtggaggccagg
ctgcgcctggagacagagaaccaaagacaggagcggctcgtgctttctgtgctcccccgg
tttgttgtcctggaaatgatcaacgacatgaccaatgtggaagatgagcacctgcagcac
cagttccatcggatctacatccatcgctatgagaacgtcagtattctttttgcagatgtt
aaaggatttaccaacctctccacgaccttgtctgctcaggagctggtcaggatgctcaac
gagctctttgccagatttgatcgactggcccatgagcatcactgccttcgtattaaaatc
ctgggggactgctactactgcgtgtctggacttcctgagccccgccaggaccatgcccac
tgctgtgttgaaatgggtctcagcatgatcaaaaccatcaggtatgtgcggtcaaggaca
aaacacgatgttgacatgaggattggaatccactccggctcggtgctgtgcggtgttttg
ggactaaggaagtggcagtttgatgtctggtcttgggatgtggatattgcaaacaaactc
gaatctggaggaatccctgggaggattcacatttccaaagccacgctggactgtctcaac
ggtgactataacgtggaagagggccatggtaaagagaggaatgaattcctgaggaagcat
aatatcgaaacttacttaattaagcagcctgaggacagtctgctgtccttgcctgaagat
atcgtcaaggagtcagtgagctcctcagaccggagaaacagtggggccacattcactgaa
ggatcctggagccctgaactgccctttgataatatcgtggggaaacagaatactctggct
gccctaacaagaaattcaataaatctgcttccaaaccatcttgcacaagctttgcatgtc
cagtctgggcctgaggaaattaacaagagaatagaacataccatcgacttgcggagtggc
gataaattgagaagagagcatatcaagccattctcactgatgtttaaagactccagcctg
gagcacaagtattctcaaatgagggatgaagtgttcaagtcaaacttggtctgtgcattt
atcgttcttctatttatcacggcaatacaaagtttgcttccttcttcaagagtgatgcca
atgaccatccagttctccattctgattatgctgcactcggctctggtcctcatcaccaca
gcagaggattataaatgtttgcccctcatcctccggaaaacttgctgttggattaatgag
acctatttggcccggaacgtcatcatctttgcatccattttgattaatttcctgggtgcc
atcttaaatatcctgtggtgtgattttgacaagtcgatacccttgaagaacctgactttc
aattcctcagctgtgtttacagatatctgctcctacccagagtactttgtcttcacgggg
gtgttggccatggtgacctgtgcagttttcctccggctgaactccgtcctgaagctggca
gtgctgctgatcatgattgccatctatgccctgctcactgagaccgtctacgcaggcctc
tttctgcgttatgacaacctcaaccacagtggagaagatttcctggggaccaaggaggta
tcactgctactgatggccatgttcctcctggctgtgttctaccatggacagcagctggag
tacacagcccgcctggacttcctttggcgagtacaggccaaagaggagatcaatgagatg
aaggagctgagggaacacaatgagaacatgctccggaatatcttacccagccatgtggcc
cgccatttcctagagaaggaccgagacaatgaggagctgtattctcaatcctatgatgct
gttggggtgatgtttgcctccatcccaggatttgcggacttttactctcagactgaaatg
aataaccagggagtggaatgcctgcgcttgctcaatgagatcattgctgacttcgatgag
ttgcttggtgaagaccgatttcaagacattgaaaagattaagaccattggcagcacctac
atggccgtgtcaggcctgtcacctgaaaaacagcaatgtgaagacaagtggggacatttg
tgtgctctggctgacttctcactcgccctgacagaaagcatacaggagatcaacaagcat
tcattcaacaattttgaactccggattggcatcagccacggctcagtggtagctggcgtt
atcggcgctaagaaaccacagtatgacatttggggcaaaactgtgaacctggcaagccga
atggacagcacgggggttagtggccggatccaagtcccagaggagacctatctcatcctg
aaggaccagggctttgcctttgattaccgaggggagatctatgtgaagggtatcagtgaa
caggaaggaaaaatcaaaacgtactttcttctgggaagagtccaacccaacccattcatc
ttgcccccaagaagactgcctgggcagtactccctggccgcggttgtcctgggacttgtc
cagtccctcaataggcaaaggcagaagcagctactcaatgagaacaacaacacaggaatc
atcaagggtcattacaaccggcggactttgttgtcacccagcggcacagagcctggagcc
caggctgaaggcaccgacaaatctgatttgccataa

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