KEGG   Homo sapiens (human): 1142
Entry
1142              CDS       T01001                                 
Symbol
CHRNB3
Name
(RefSeq) cholinergic receptor nicotinic beta 3 subunit
  KO
K04814  nicotinic acetylcholine receptor beta-3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
Drug target
Acetylcholine (DG01133): D00999<JP/US>
Atracurium (DG00771): D00758<US>
Cisatracurium: D00759<US>
Cytisinicline: D07770
Dimethyltubocurarine: D07272
Doxacurium chloride: D00760
Fazadinium bromide: D07273
Hexamethonium bromide: D02204
Lobeline (DG01287): D02202 D02364 D08138
Mecamylamine (DG00252): D00611<US>
Mivacurium chloride: D00763
Nicotine (DG00994): D03365<JP/US> D05156 D05157
Pancuronium (DG00769): D00492
Pipecuronium bromide: D00764
Rocuronium bromide: D00765<JP/US>
Tubocurarine (DG00767): D02207 D08655
Vecuronium (DG00770): D00767<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1142 (CHRNB3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    1142 (CHRNB3)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Acetylcholine (nicotinic)
   1142 (CHRNB3)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb PepSY_TM
Other DBs
NCBI-GeneID: 1142
NCBI-ProteinID: NP_000740
OMIM: 118508
HGNC: 1963
Ensembl: ENSG00000147432
UniProt: Q05901
Structure
Position
8:42697366..42737407
AA seq 458 aa
MLPDFMLVLIVLGIPSSATTGFNSIAENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFGL
KISQLVDVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFEN
ADGRFEGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTM
VDLILINENVDRKDFFDNGEWEILNAKGMKGNRRDGVYSYPFITYSFVLRRLPLFYTLFL
IIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYL
LFIMIFVTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSPE
KEESQPVVKGKVLEKKKQKQLSDGEKVLVAFLEKAADSIRYISRHVKKEHFISQVVQDWK
FVAQVLDRIFLWLFLIVSVTGSVLIFTPALKMWLHSYH
NT seq 1377 nt   +upstreamnt  +downstreamnt
atgctcccagattttatgctggttctcatcgtccttggcatcccttcctcagccaccaca
ggtttcaactcaatcgccgaaaatgaagatgccctcctcagacatttgttccaaggttat
cagaaatgggtccgccctgtattacattctaatgacaccataaaagtatattttggattg
aaaatatcccagcttgtagatgtggatgaaaagaatcagctgatgacaaccaatgtgtgg
ctcaaacaggaatggacagaccacaagttacgctggaatcctgatgattatggtgggatc
cattccattaaagttccatcagaatctctgtggcttcctgacatagttctctttgaaaat
gctgacggccgcttcgaaggctccctgatgaccaaggtcatcgtgaaatcaaacggaact
gttgtctggacccctcccgccagctacaaaagctcctgcaccatggacgtcacgtttttc
ccgttcgaccgacagaactgctccatgaagtttggatcctggacttatgatggcaccatg
gttgacctcattttgatcaatgaaaatgtcgacagaaaagacttcttcgataacggagaa
tgggaaatactgaacgcaaaggggatgaaggggaacagaagggacggcgtgtactcctat
ccctttatcacgtattccttcgtcctgagacgcctgcctttattctataccctctttctc
atcatcccctgcctggggctgtctttcctaacagttcttgtgttctatttaccttcggat
gaaggagaaaaactttcattatccacatcggtcttggtttctctgacagttttcctttta
gtgattgaagaaatcatcccatcgtcttccaaagtcattcctctcattggagagtacctg
ctgttcatcatgatttttgtgaccctgtccatcattgttaccgtgtttgtcattaacgtt
caccacagatcttcttccacgtaccaccccatggccccctgggttaagaggctctttctg
cagaaacttccaaaattactttgcatgaaagatcatgtggatcgctactcatccccagag
aaagaggagagtcaaccagtagtgaaaggcaaagtcctcgaaaaaaagaaacagaaacag
cttagtgatggagaaaaagttctagttgcttttttggaaaaagctgctgattccattaga
tacatttcgagacatgtgaagaaagaacattttatcagccaggtagtacaagactggaaa
tttgtagctcaagttcttgaccgaatcttcctgtggctctttctgatagtgtcagtaaca
ggctcggttctgatttttacccctgctttgaagatgtggctacatagttaccattag

  All links  
Disease (1)   
   OMIM (1)   
Gene (6)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (18)   
   RefSeq(nuc) (4)   
   GenBank (7)   
   EMBL (7)   
3D Structure (1)   
   PDB (1)   
Protein domain (3)   
   Pfam (3)   
All databases (35)   

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