KEGG   Homo sapiens (human): 114548
Entry
114548            CDS       T01001                                 
Symbol
NLRP3, AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, DFNA34, FCAS, FCAS1, FCU, KEFH, MWS, NALP3, PYPAF1
Name
(RefSeq) NLR family pyrin domain containing 3
  KO
K12800  NACHT, LRR and PYD domains-containing protein 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04217  Necroptosis
hsa04621  NOD-like receptor signaling pathway
hsa04623  Cytosolic DNA-sensing pathway
hsa04625  C-type lectin receptor signaling pathway
hsa05130  Pathogenic Escherichia coli infection
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05133  Pertussis
hsa05135  Yersinia infection
hsa05164  Influenza A
hsa05171  Coronavirus disease - COVID-19
hsa05417  Lipid and atherosclerosis
Network
nt06170  Influenza A virus (IAV)
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06182  Shigella
nt06183  Yersinia
nt06521  NLR signaling
  Element
N00742  NLRP3 inflammasome signaling pathway
N00743  IAV NS1 to NLRP3 inflammasome signaling pathway
N00864  Yersinia YopK to NLRP3 Inflammasome signaling pathway
N00933  Escherichia NleA to NLRP3 inflammasome signaling pathway
N00934  Non-canonical inflammasome signaling pathway
N00948  Shigella IpaH7.8 to NLRP3 Inflammasome signaling pathway
N01568  Regulation of NLRP3 inflammasome signaling pathway, NLRP3 inhibition
Disease
H00282  Cryopyrin associated periodic syndrome
H00604  Deafness, autosomal dominant
H02159  Familial cold autoinflammatory syndrome
H02555  Muckle-Wells syndrome
H02556  CINCA syndrome
Drug target
Nibrozetone: D12720
Selnoflast (DG03239): D12422 D12423
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    114548 (NLRP3)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    114548 (NLRP3)
   04623 Cytosolic DNA-sensing pathway
    114548 (NLRP3)
   04625 C-type lectin receptor signaling pathway
    114548 (NLRP3)
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    114548 (NLRP3)
   05164 Influenza A
    114548 (NLRP3)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    114548 (NLRP3)
   05132 Salmonella infection
    114548 (NLRP3)
   05131 Shigellosis
    114548 (NLRP3)
   05135 Yersinia infection
    114548 (NLRP3)
   05133 Pertussis
    114548 (NLRP3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    114548 (NLRP3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    114548 (NLRP3)
  09183 Protein families: signaling and cellular processes
   04054 Pattern recognition receptors [BR:hsa04054]
    114548 (NLRP3)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Other autophagy associated proteins
   TRIM-directed selective autophagy
    114548 (NLRP3)
Pattern recognition receptors [BR:hsa04054]
 Cytoplasmic pattern recognition receptors
  NOD-like receptors
   114548 (NLRP3)
SSDB
Motif
Pfam: NACHT NLRC4_HD2 PYRIN LRR_6 FISNA NOD2_WH LRR_4 nSTAND3
Other DBs
NCBI-GeneID: 114548
NCBI-ProteinID: NP_004886
OMIM: 606416
HGNC: 16400
Ensembl: ENSG00000162711
UniProt: Q96P20
Structure
Position
1:247416077..247448817
AA seq 1036 aa
MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID
FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL
LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ
QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM
LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL
MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH
LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT
GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ
KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK
EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI
SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR
MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL
VNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRC
GLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLT
SACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVC
CSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWD
LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALET
LQEEKPELTVVFEPSW
NT seq 3111 nt   +upstreamnt  +downstreamnt
atgaagatggcaagcacccgctgcaagctggccaggtacctggaggacctggaggatgtg
gacttgaagaaatttaagatgcacttagaggactatcctccccagaagggctgcatcccc
ctcccgaggggtcagacagagaaggcagaccatgtggatctagccacgctaatgatcgac
ttcaatggggaggagaaggcgtgggccatggccgtgtggatcttcgctgcgatcaacagg
agagacctttatgagaaagcaaaaagagatgagccgaagtggggttcagataatgcacgt
gtttcgaatcccactgtgatatgccaggaagacagcattgaagaggagtggatgggttta
ctggagtacctttcgagaatctctatttgtaaaatgaagaaagattaccgtaagaagtac
agaaagtacgtgagaagcagattccagtgcattgaagacaggaatgcccgtctgggtgag
agtgtgagcctcaacaaacgctacacacgactgcgtctcatcaaggagcaccggagccag
caggagagggagcaggagcttctggccatcggcaagaccaagacgtgtgagagccccgtg
agtcccattaagatggagttgctgtttgaccccgatgatgagcattctgagcctgtgcac
accgtggtgttccagggggcggcagggattgggaaaacaatcctggccaggaagatgatg
ttggactgggcgtcggggacactctaccaagacaggtttgactatctgttctatatccac
tgtcgagaggtgagccttgtgacacagaggagcctgggggacctgatcatgagctgctgc
cccgacccaaacccacccatccacaagatcgtgagaaaaccctccagaatcctcttcctc
atggacggcttcgatgagctgcaaggtgcctttgacgagcacataggaccgctctgcact
gactggcagaaggccgagcggggagacattctcctgagcagcctcatcagaaagaagctg
cttcccgaggcctctctgctcatcaccacgagacctgtggccctggagaaactgcagcac
ttgctggaccatcctcggcatgtggagatcctgggtttctccgaggccaaaaggaaagag
tacttcttcaagtacttctctgatgaggcccaagccagggcagccttcagtctgattcag
gagaacgaggtcctcttcaccatgtgcttcatccccctggtctgctggatcgtgtgcact
ggactgaaacagcagatggagagtggcaagagccttgcccagacatccaagaccaccacc
gcggtgtacgtcttcttcctttccagtttgctgcagccccggggagggagccaggagcac
ggcctctgcgcccacctctgggggctctgctctttggctgcagatggaatctggaaccag
aaaatcctgtttgaggagtccgacctcaggaatcatggactgcagaaggcggatgtgtct
gctttcctgaggatgaacctgttccaaaaggaagtggactgcgagaagttctacagcttc
atccacatgactttccaggagttctttgccgccatgtactacctgctggaagaggaaaag
gaaggaaggacgaacgttccagggagtcgtttgaagcttcccagccgagacgtgacagtc
cttctggaaaactatggcaaattcgaaaaggggtatttgatttttgttgtacgtttcctc
tttggcctggtaaaccaggagaggacctcctacttggagaagaaattaagttgcaagatc
tctcagcaaatcaggctggagctgctgaaatggattgaagtgaaagccaaagctaaaaag
ctgcagatccagcccagccagctggaattgttctactgtttgtacgagatgcaggaggag
gacttcgtgcaaagggccatggactatttccccaagattgagatcaatctctccaccaga
atggaccacatggtttcttccttttgcattgagaactgtcatcgggtggagtcactgtcc
ctggggtttctccataacatgcccaaggaggaagaggaggaggaaaaggaaggccgacac
cttgatatggtgcagtgtgtcctcccaagctcctctcatgctgcctgttctcatggattg
gtgaacagccacctcacttccagtttttgccggggcctcttttcagttctgagcaccagc
cagagtctaactgaattggacctcagtgacaattctctgggggacccagggatgagagtg
ttgtgtgaaacgctccagcatcctggctgtaacattcggagattgtggttggggcgctgt
ggcctctcgcatgagtgctgcttcgacatctccttggtcctcagcagcaaccagaagctg
gtggagctggacctgagtgacaacgccctcggtgacttcggaatcagacttctgtgtgtg
ggactgaagcacctgttgtgcaatctgaagaagctctggttggtcagctgctgcctcaca
tcagcatgttgtcaggatcttgcatcagtattgagcaccagccattccctgaccagactc
tatgtgggggagaatgccttgggagactcaggagtcgcaattttatgtgaaaaagccaag
aatccacagtgtaacctgcagaaactggggttggtgaattctggccttacgtcagtctgt
tgttcagctttgtcctcggtactcagcactaatcagaatctcacgcacctttacctgcga
ggcaacactctcggagacaaggggatcaaactactctgtgagggactcttgcaccccgac
tgcaagcttcaggtgttggaattagacaactgcaacctcacgtcacactgctgctgggat
ctttccacacttctgacctccagccagagcctgcgaaagctgagcctgggcaacaatgac
ctgggcgacctgggggtcatgatgttctgtgaagtgctgaaacagcagagctgcctcctg
cagaacctggggttgtctgaaatgtatttcaattatgagacaaaaagtgcgttagaaaca
cttcaagaagaaaagcctgagctgaccgtcgtctttgagccttcttggtag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (12)   
   KEGG PATHWAY (12)   
Network (13)   
   KEGG NETWORK (13)   
Disease (11)   
   KEGG DISEASE (5)   
   OMIM (6)   
Drug (3)   
   KEGG DRUG (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (30)   
   KEGG ORTHOLOGY (1)   
   RefGene (22)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (35)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (33)   
DNA sequence (67)   
   RefSeq(nuc) (33)   
   GenBank (17)   
   EMBL (17)   
3D Structure (12)   
   PDB (12)   
Protein domain (8)   
   Pfam (8)   
All databases (195)   

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