Entry |
|
Symbol |
CHUK, BPS2, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16
|
Name |
(RefSeq) component of inhibitor of nuclear factor kappa B kinase complex
|
KO |
K04467 | inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10] |
|
Organism |
|
Pathway |
hsa04620 | Toll-like receptor signaling pathway |
hsa04621 | NOD-like receptor signaling pathway |
hsa04622 | RIG-I-like receptor signaling pathway |
hsa04625 | C-type lectin receptor signaling pathway |
hsa04658 | Th1 and Th2 cell differentiation |
hsa04660 | T cell receptor signaling pathway |
hsa04662 | B cell receptor signaling pathway |
hsa04920 | Adipocytokine signaling pathway |
hsa05120 | Epithelial cell signaling in Helicobacter pylori infection |
hsa05130 | Pathogenic Escherichia coli infection |
hsa05163 | Human cytomegalovirus infection |
hsa05166 | Human T-cell leukemia virus 1 infection |
hsa05167 | Kaposi sarcoma-associated herpesvirus infection |
hsa05168 | Herpes simplex virus 1 infection |
hsa05170 | Human immunodeficiency virus 1 infection |
hsa05208 | Chemical carcinogenesis - reactive oxygen species |
hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
hsa05418 | Fluid shear stress and atherosclerosis |
|
Network |
nt06114 PI3K signaling (viruses) nt06121 TLR signaling (viruses and bacteria) nt06123 TNF signaling (viruses and bacteria) nt06124 Chemokine signaling (viruses) nt06133 RLR signaling (viruses) nt06139 NLR signaling (viruses and bacteria) nt06150 Cytokine-cytokine receptor interaction (viruses) nt06160 Human T-cell leukemia virus 1 (HTLV-1) nt06161 Human immunodeficiency virus type 1 (HIV-1) nt06162 Hepatitis B virus (HBV) nt06163 Hepatitis C virus (HCV) nt06164 Kaposi sarcoma-associated herpesvirus (KSHV) nt06165 Epstein-Barr virus (EBV) nt06167 Human cytomegalovirus (HCMV) nt06168 Herpes simplex virus 1 (HSV-1) nt06169 Measles virus (MV) nt06170 Influenza A virus (IAV) nt06214 PI3K signaling nt06223 TNF signaling nt06263 Hepatocellular carcinoma |
Element |
N00151 | TNF-NFKB signaling pathway |
N00171 | KSHV vFLIP to NFKB signaling pathway |
N00173 | KSHV K15 to TNF-NFKB signaling pathway |
N00174 | KSHV vFLIP to TNF-NFKB signaling pathway |
N00179 | KSHV K1 to PI3K-NFKB signaling pathway |
N00182 | IGF-IGFR-PI3K-NFKB signaling pathway |
N00265 | EBV LMP1 to NFKB signaling pathway |
N00390 | EGF-EGFR-PI3K-NFKB signaling pathway |
N00391 | HCMV gB to EGFR-PI3K-NFKB signaling pathway |
N00397 | HCMV UL26 to NFKB signaling pathway |
N00399 | CCR2-GNB/G-PI3K-NFKB signaling pathway |
N00400 | HCMV US28 to GNB/G-PI3K-NFKB signaling pathway |
N00435 | TLR2/4-NFKB signaling pathway |
N00441 | HIV gp120 to TNF-NFKB signaling pathway |
N00442 | HIV Nef to TNF-NFKB signaling pathway |
N00467 | EBV BPLF1 to TLR2/4-NFKB signaling pathway |
N00501 | HTLV-1 Tax to EGFR-PI3K-NFKB signaling pathway |
N00504 | HTLV-1 Tax to NFKB signaling pathway |
N00505 | CD40-NFKB signaling pathway |
N00506 | HTLV-1 Tax to CD40-NFKB signaling pathway |
N00559 | LIGHT-HVEM-NFKB signaling pathway |
N00560 | HSV gD to HVEM-NFKB signaling pathway |
N00563 | TLR3-NFKB signaling pathway |
N00688 | RIG-I-NFKB signaling pathway |
N00940 | NOD-NFKB signaling pathway |
N01112 | Salmonella SopE/E2 to NOD-NFKB signaling pathway |
N01410 | Metals to NFKB signaling pathway |
N01411 | Metals to NFKB signaling pathway |
|
Disease |
|
Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
1147 (CHUK)
04014 Ras signaling pathway
1147 (CHUK)
04064 NF-kappa B signaling pathway
1147 (CHUK)
04668 TNF signaling pathway
1147 (CHUK)
04068 FoxO signaling pathway
1147 (CHUK)
04151 PI3K-Akt signaling pathway
1147 (CHUK)
04150 mTOR signaling pathway
1147 (CHUK)
09140 Cellular Processes
09143 Cell growth and death
04210 Apoptosis
1147 (CHUK)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
1147 (CHUK)
04621 NOD-like receptor signaling pathway
1147 (CHUK)
04622 RIG-I-like receptor signaling pathway
1147 (CHUK)
04623 Cytosolic DNA-sensing pathway
1147 (CHUK)
04625 C-type lectin receptor signaling pathway
1147 (CHUK)
04660 T cell receptor signaling pathway
1147 (CHUK)
04658 Th1 and Th2 cell differentiation
1147 (CHUK)
04659 Th17 cell differentiation
1147 (CHUK)
04657 IL-17 signaling pathway
1147 (CHUK)
04662 B cell receptor signaling pathway
1147 (CHUK)
04062 Chemokine signaling pathway
1147 (CHUK)
09152 Endocrine system
04920 Adipocytokine signaling pathway
1147 (CHUK)
09158 Development and regeneration
04380 Osteoclast differentiation
1147 (CHUK)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
1147 (CHUK)
05208 Chemical carcinogenesis - reactive oxygen species
1147 (CHUK)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
1147 (CHUK)
09162 Cancer: specific types
05212 Pancreatic cancer
1147 (CHUK)
05221 Acute myeloid leukemia
1147 (CHUK)
05220 Chronic myeloid leukemia
1147 (CHUK)
05215 Prostate cancer
1147 (CHUK)
05222 Small cell lung cancer
1147 (CHUK)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
1147 (CHUK)
05170 Human immunodeficiency virus 1 infection
1147 (CHUK)
05161 Hepatitis B
1147 (CHUK)
05160 Hepatitis C
1147 (CHUK)
05171 Coronavirus disease - COVID-19
1147 (CHUK)
05164 Influenza A
1147 (CHUK)
05162 Measles
1147 (CHUK)
05168 Herpes simplex virus 1 infection
1147 (CHUK)
05163 Human cytomegalovirus infection
1147 (CHUK)
05167 Kaposi sarcoma-associated herpesvirus infection
1147 (CHUK)
05169 Epstein-Barr virus infection
1147 (CHUK)
05165 Human papillomavirus infection
1147 (CHUK)
09171 Infectious disease: bacterial
05120 Epithelial cell signaling in Helicobacter pylori infection
1147 (CHUK)
05130 Pathogenic Escherichia coli infection
1147 (CHUK)
05132 Salmonella infection
1147 (CHUK)
05131 Shigellosis
1147 (CHUK)
05135 Yersinia infection
1147 (CHUK)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
1147 (CHUK)
05142 Chagas disease
1147 (CHUK)
09164 Neurodegenerative disease
05010 Alzheimer disease
1147 (CHUK)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
1147 (CHUK)
05418 Fluid shear stress and atherosclerosis
1147 (CHUK)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
1147 (CHUK)
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
1147 (CHUK)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:hsa01001]
1147 (CHUK)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.10 IkappaB kinase
1147 (CHUK)
Protein kinases [BR:hsa01001]
Serine/threonine kinases: Other
IKK family [OT]
1147 (CHUK)
|
SSDB |
|
Motif |
|
Other DBs |
|
Structure |
|
Position |
10:complement(100186319..100229596)
|
AA seq |
745 aa
MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCH
EIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ
ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTS
FVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPK
CIFACEEMSGEVRFSSHLPQPNSLCSLVVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRC
FVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTGSQELLSETGI
SLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPI
IQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKL
EFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLEDQIMSLHAE
IMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPSDHSYSDSTEMVKIIVHTVQSQDRV
LKELFGHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQ
SSARSLVGSSLEGAVTPQTSAWLPPTSAEHDHSLSCVVTPQDGETSAQMIEENLNCLGHL
STIIHEANEEQGNSMMNLDWSWLTE |
NT seq |
2238 nt +upstreamnt +downstreamnt
atggagcggcccccggggctgcggccgggcgcgggcgggccctgggagatgcgggagcgg
ctgggcaccggcggcttcgggaacgtctgtctgtaccagcatcgggaacttgatctcaaa
atagcaattaagtcttgtcgcctagagctaagtaccaaaaacagagaacgatggtgccat
gaaatccagattatgaagaagttgaaccatgccaatgttgtaaaggcctgtgatgttcct
gaagaattgaatattttgattcatgatgtgcctcttctagcaatggaatactgttctgga
ggagatctccgaaagctgctcaacaaaccagaaaattgttgtggacttaaagaaagccag
atactttctttactaagtgatatagggtctgggattcgatatttgcatgaaaacaaaatt
atacatcgagatctaaaacctgaaaacatagttcttcaggatgttggtggaaagataata
cataaaataattgatctgggatatgccaaagatgttgatcaaggaagtctgtgtacatct
tttgtgggaacactgcagtatctggccccagagctctttgagaataagccttacacagcc
actgttgattattggagctttgggaccatggtatttgaatgtattgctggatataggcct
tttttgcatcatctgcagccatttacctggcatgagaagattaagaagaaggatccaaag
tgtatatttgcatgtgaagagatgtcaggagaagttcggtttagtagccatttacctcaa
ccaaatagcctttgtagtttagtagtagaacccatggaaaactggctacagttgatgttg
aattgggaccctcagcagagaggaggacctgttgaccttactttgaagcagccaagatgt
tttgtattaatggatcacattttgaatttgaagatagtacacatcctaaatatgacttct
gcaaagataatttcttttctgttaccacctgatgaaagtcttcattcactacagtctcgt
attgagcgtgaaactggaataaatactggttctcaagaacttctttcagagacaggaatt
tctctggatcctcggaaaccagcctctcaatgtgttctagatggagttagaggctgtgat
agctatatggtttatttgtttgataaaagtaaaactgtatatgaagggccatttgcttcc
agaagtttatctgattgtgtaaattatattgtacaggacagcaaaatacagcttccaatt
atacagctgcgtaaagtgtgggctgaagcagtgcactatgtgtctggactaaaagaagac
tatagcaggctctttcagggacaaagggcagcaatgttaagtcttcttagatataatgct
aacttaacaaaaatgaagaacactttgatctcagcatcacaacaactgaaagctaaattg
gagttttttcacaaaagcattcagcttgacttggagagatacagcgagcagatgacgtat
gggatatcttcagaaaaaatgctaaaagcatggaaagaaatggaagaaaaggccatccac
tatgctgaggttggtgtcattggatacctggaggatcagattatgtctttgcatgctgaa
atcatggagctacagaagagcccctatggaagacgtcagggagacttgatggaatctctg
gaacagcgtgccattgatctatataagcagttaaaacacagaccttcagatcactcctac
agtgacagcacagagatggtgaaaatcattgtgcacactgtgcagagtcaggaccgtgtg
ctcaaggagctgtttggtcatttgagcaagttgttgggctgtaagcagaagattattgat
ctactccctaaggtggaagtggccctcagtaatatcaaagaagctgacaatactgtcatg
ttcatgcagggaaaaaggcagaaagaaatatggcatctccttaaaattgcctgtacacag
agttctgcccggtcccttgtaggatccagtctagaaggtgcagtaacccctcagacatca
gcatggctgcccccgacttcagcagaacatgatcattctctgtcatgtgtggtaactcct
caagatggggagacttcagcacaaatgatagaagaaaatttgaactgccttggccattta
agcactattattcatgaggcaaatgaggaacagggcaatagtatgatgaatcttgattgg
agttggttaacagaatga |