KEGG   Homo sapiens (human): 115004
Entry
115004            CDS       T01001                                 
Symbol
CGAS, C6orf150, D4, MB21D1, h-cGAS
Name
(RefSeq) cyclic GMP-AMP synthase
  KO
K17834  cyclic GMP-AMP synthase [EC:2.7.7.86]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04623  Cytosolic DNA-sensing pathway
hsa05131  Shigellosis
hsa05163  Human cytomegalovirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05171  Coronavirus disease - COVID-19
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06182  Shigella
nt06520  CGAS-STING signaling
  Element
N00395  cGAS-STING signaling pathway
N00569  HSV UL41 to cGAS-STING signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04623 Cytosolic DNA-sensing pathway
    115004 (CGAS)
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    115004 (CGAS)
   05171 Coronavirus disease - COVID-19
    115004 (CGAS)
   05168 Herpes simplex virus 1 infection
    115004 (CGAS)
   05163 Human cytomegalovirus infection
    115004 (CGAS)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    115004 (CGAS)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.86  cyclic GMP-AMP synthase
     115004 (CGAS)
SSDB
Motif
Pfam: Mab-21 Mab-21_C Sld3_STD
Other DBs
NCBI-GeneID: 115004
NCBI-ProteinID: NP_612450
OMIM: 613973
HGNC: 21367
Ensembl: ENSG00000164430
UniProt: Q8N884
Structure
Position
6:complement(73423711..73452297)
AA seq 522 aa
MQPWHGKAMQRASEAGATAPKASARNARGAPMDPTESPAAPEAALPKAGKFGPARKSGSR
QKKSAPDTQERPPVRATGARAKKAPQRAQDTQPSDATSAPGAEGLEPPAAREPALSRAGS
CRQRGARCSTKPRPPPGPWDVPSPGLPVSAPILVRRDAAPGASKLRAVLEKLKLSRDDIS
TAAGMVKGVVDHLLLRLKCDSAFRGVGLLNTGSYYEHVKISAPNEFDVMFKLEVPRIQLE
EYSNTRAYYFVKFKRNPKENPLSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKR
KRGGSPAVTLLISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLV
PKHAKEGNGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQL
KERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKL
ENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDEF
NT seq 1569 nt   +upstreamnt  +downstreamnt
atgcagccttggcacggaaaggccatgcagagagcttccgaggccggagccactgccccc
aaggcttccgcacggaatgccaggggcgccccgatggatcccaccgagtctccggctgcc
cccgaggccgccctgcctaaggcgggaaagttcggccccgccaggaagtcgggatcccgg
cagaaaaagagcgccccggacacccaggagaggccgcccgtccgcgcaactggggcccgc
gccaaaaaggcccctcagcgcgcccaggacacgcagccgtctgacgccaccagcgcccct
ggggcagaggggctggagcctcctgcggctcgggagccggctctttccagggctggttct
tgccgccagaggggcgcgcgctgctccacgaagccaagacctccgcccgggccctgggac
gtgcccagccccggcctgccggtctcggcccccattctcgtacggagggatgcggcgcct
ggggcctcgaagctccgggcggttttggagaagttgaagctcagccgcgatgatatctcc
acggcggcggggatggtgaaaggggttgtggaccacctgctgctcagactgaagtgcgac
tccgcgttcagaggcgtcgggctgctgaacaccgggagctactatgagcacgtgaagatt
tctgcacctaatgaatttgatgtcatgtttaaactggaagtccccagaattcaactagaa
gaatattccaacactcgtgcatattactttgtgaaatttaaaagaaatccgaaagaaaat
cctctgagtcagtttttagaaggtgaaatattatcagcttctaagatgctgtcaaagttt
aggaaaatcattaaggaagaaattaacgacattaaagatacagatgtcatcatgaagagg
aaaagaggagggagccctgctgtaacacttcttattagtgaaaaaatatctgtggatata
accctggctttggaatcaaaaagtagctggcctgctagcacccaagaaggcctgcgcatt
caaaactggctttcagcaaaagttaggaagcaactacgactaaagccattttaccttgta
cccaagcatgcaaaggaaggaaatggtttccaagaagaaacatggcggctatccttctct
cacatcgaaaaggaaattttgaacaatcatggaaaatctaaaacgtgctgtgaaaacaaa
gaagagaaatgttgcaggaaagattgtttaaaactaatgaaataccttttagaacagctg
aaagaaaggtttaaagacaaaaaacatctggataaattctcttcttatcatgtgaaaact
gccttctttcacgtatgtacccagaaccctcaagacagtcagtgggaccgcaaagacctg
ggcctctgctttgataactgcgtgacatactttcttcagtgcctcaggacagaaaaactt
gagaattattttattcctgaattcaatctattctctagcaacttaattgacaaaagaagt
aaggaatttctgacaaagcaaattgaatatgaaagaaacaatgagtttccagtttttgat
gaattttga

  All links  
Disease (1)   
   OMIM (1)   
Gene (26)   
   RefGene (20)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (18)   
   RefSeq(nuc) (2)   
   GenBank (8)   
   EMBL (8)   
3D Structure (101)   
   PDB (101)   
Protein domain (3)   
   Pfam (3)   
All databases (153)   

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