| Entry |
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| Gene name |
CGAS, C6orf150, MB21D1, h-cGAS
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| Definition |
(RefSeq) cyclic GMP-AMP synthase
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| KO |
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| Organism |
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| Pathway |
| hsa05163 | Human cytomegalovirus infection |
| hsa05168 | Herpes simplex virus 1 infection |
| hsa05170 | Human immunodeficiency virus 1 infection |
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| Network |
nt06134 CGAS-STING signaling (viruses and bacteria) nt06161 Human immunodeficiency virus type 1 (HIV-1) nt06167 Human cytomegalovirus (HCMV) nt06168 Herpes simplex virus 1 (HSV-1) |
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| Element |
| N00395 | cGAS-STING signaling pathway |
| N00569 | HSV UL41 to cGAS-STING signaling pathway |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09150 Organismal Systems
09151 Immune system
04623 Cytosolic DNA-sensing pathway
115004 (CGAS)
09160 Human Diseases
09171 Infectious disease: bacterial
05131 Shigellosis
115004 (CGAS)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
115004 (CGAS)
05168 Herpes simplex virus 1 infection
115004 (CGAS)
05163 Human cytomegalovirus infection
115004 (CGAS)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.7 Nucleotidyltransferases
2.7.7.86 cyclic GMP-AMP synthase
115004 (CGAS)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
PDB: |
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| Position |
6q13
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| AA seq |
522 aa
MQPWHGKAMQRASEAGATAPKASARNARGAPMDPTESPAAPEAALPKAGKFGPARKSGSR
QKKSAPDTQERPPVRATGARAKKAPQRAQDTQPSDATSAPGAEGLEPPAAREPALSRAGS
CRQRGARCSTKPRPPPGPWDVPSPGLPVSAPILVRRDAAPGASKLRAVLEKLKLSRDDIS
TAAGMVKGVVDHLLLRLKCDSAFRGVGLLNTGSYYEHVKISAPNEFDVMFKLEVPRIQLE
EYSNTRAYYFVKFKRNPKENPLSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKR
KRGGSPAVTLLISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLV
PKHAKEGNGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQL
KERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKL
ENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDEF |
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| NT seq |
1569 nt +upstreamnt +downstreamnt
atgcagccttggcacggaaaggccatgcagagagcttccgaggccggagccactgccccc
aaggcttccgcacggaatgccaggggcgccccgatggatcccaccgagtctccggctgcc
cccgaggccgccctgcctaaggcgggaaagttcggccccgccaggaagtcgggatcccgg
cagaaaaagagcgccccggacacccaggagaggccgcccgtccgcgcaactggggcccgc
gccaaaaaggcccctcagcgcgcccaggacacgcagccgtctgacgccaccagcgcccct
ggggcagaggggctggagcctcctgcggctcgggagccggctctttccagggctggttct
tgccgccagaggggcgcgcgctgctccacgaagccaagacctccgcccgggccctgggac
gtgcccagccccggcctgccggtctcggcccccattctcgtacggagggatgcggcgcct
ggggcctcgaagctccgggcggttttggagaagttgaagctcagccgcgatgatatctcc
acggcggcggggatggtgaaaggggttgtggaccacctgctgctcagactgaagtgcgac
tccgcgttcagaggcgtcgggctgctgaacaccgggagctactatgagcacgtgaagatt
tctgcacctaatgaatttgatgtcatgtttaaactggaagtccccagaattcaactagaa
gaatattccaacactcgtgcatattactttgtgaaatttaaaagaaatccgaaagaaaat
cctctgagtcagtttttagaaggtgaaatattatcagcttctaagatgctgtcaaagttt
aggaaaatcattaaggaagaaattaacgacattaaagatacagatgtcatcatgaagagg
aaaagaggagggagccctgctgtaacacttcttattagtgaaaaaatatctgtggatata
accctggctttggaatcaaaaagtagctggcctgctagcacccaagaaggcctgcgcatt
caaaactggctttcagcaaaagttaggaagcaactacgactaaagccattttaccttgta
cccaagcatgcaaaggaaggaaatggtttccaagaagaaacatggcggctatccttctct
cacatcgaaaaggaaattttgaacaatcatggaaaatctaaaacgtgctgtgaaaacaaa
gaagagaaatgttgcaggaaagattgtttaaaactaatgaaataccttttagaacagctg
aaagaaaggtttaaagacaaaaaacatctggataaattctcttcttatcatgtgaaaact
gccttctttcacgtatgtacccagaaccctcaagacagtcagtgggaccgcaaagacctg
ggcctctgctttgataactgcgtgacatactttcttcagtgcctcaggacagaaaaactt
gagaattattttattcctgaattcaatctattctctagcaacttaattgacaaaagaagt
aaggaatttctgacaaagcaaattgaatatgaaagaaacaatgagtttccagtttttgat
gaattttga |
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