KEGG   Homo sapiens (human): 1161
Entry
1161              CDS       T01001                                 
Symbol
ERCC8, CKN1, CSA, UVSS2
Name
(RefSeq) ERCC excision repair 8, CSA ubiquitin ligase complex subunit
  KO
K10570  DNA excision repair protein ERCC-8
Organism
hsa  Homo sapiens (human)
Pathway
hsa03420  Nucleotide excision repair
hsa04120  Ubiquitin mediated proteolysis
Network
nt06502  Nucleotide excision repair
  Element
N01430  Transcription-coupled NER
Disease
H00076  Cockayne syndrome
H00403  Disorders of nucleotide excision repair
H02131  UV-sensitive syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    1161 (ERCC8)
  09124 Replication and repair
   03420 Nucleotide excision repair
    1161 (ERCC8)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    1161 (ERCC8)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    1161 (ERCC8)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  Multi subunit type E3
   Cul4 complex
    Target recognizing subunit (DCAF)
     1161 (ERCC8)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   NER (nucleotide excision repair)
    TCR (transcription coupled repair) factors
     Cul4-CSA complex
      1161 (ERCC8)
SSDB
Motif
Pfam: WD40 WD40_Prp19 WD40_CDC20-Fz WD40_WDHD1_1st Beta-prop_EML_2 EIF3I Beta-prop_TEP1_2nd Beta-prop_WDR75_1st WD40_MABP1-WDR62_2nd Beta-prop_CAF1B_HIR1 Beta-prop_EIPR1 Beta-prop_RIG_2nd Beta-prop_WDR90_POC16_2nd WDR55 Beta-prop_EML WD_LRWD1 ANAPC4_WD40 Beta-prop_TEP1_C WD40_RFWD3 WDR90_beta-prop_4th WD40_MABP1-WDR62_1st Beta-prop_IFT122_1st Beta-prop_WDR19_1st Beta-prop_IFT140_1st NBCH_WD40 Beta-prop_RIG_1st Beta-prop_Nup120_160 Beta-prop_WDR35_TULP_N Beta-prop_WDR11_1st Beta-prop_HPS5 Beta-prop_NUP159_NUP214
Other DBs
NCBI-GeneID: 1161
NCBI-ProteinID: NP_000073
OMIM: 609412
HGNC: 3439
Ensembl: ENSG00000049167
UniProt: Q13216
Structure
Position
5:complement(60866454..60945070)
AA seq 396 aa
MLGFLSARQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYML
SGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSF
DKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSH
ILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESA
NTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVS
CGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILA
WVPSLYEPVPDDDETTTKSQLNPAFEDAWSSSDEEG
NT seq 1191 nt   +upstreamnt  +downstreamnt
atgctggggtttttgtccgcacgccaaacgggtttggaggaccctcttcgccttcggaga
gcagagtcaacacggagagttttgggactggaattaaataaagacagagatgttgaaaga
atccacggcggtggaattaacacccttgacattgaacctgttgaagggagatacatgtta
tcaggtggttcagatggtgtgattgtactttatgaccttgagaactccagcagacaatct
tattacacatgtaaagcagtgtgttccattggcagagatcatcctgatgttcacagatac
agtgtggagactgtacagtggtatcctcatgacactggcatgttcacatcaagctcattt
gataaaactctgaaagtatgggatacaaatacattacaaactgcagatgtatttaatttt
gaggaaacagtttatagtcatcatatgtctccagtctccaccaagcactgtttggtagca
gttggtactagaggacccaaagtacaactttgtgacttgaagtctggatcctgttctcac
attctacagggtcacagacaagaaatattagcagtttcctggtctccacgttatgactat
atcttggcaacagcaagtgctgacagtagagtaaaattatgggatgtgagaagagcatca
ggatgtttgattactcttgatcaacataatgggaaaaagtcacaagctgttgaatcagca
aacactgctcataatgggaaagttaatggcttatgttttacaagtgatggacttcacctc
ctcactgttggtacagataatcgaatgaggctctggaatagttccaatggagaaaacaca
cttgtgaactatggaaaagtttgtaataacagtaaaaaaggattgaaattcactgtctcc
tgtggctgcagttcagaatttgtttttgtaccatatggtagcaccattgctgtttataca
gtttactcaggagaacagataactatgcttaagggacattataaaactgttgactgctgt
gtatttcagtcaaatttccaggaactttatagtggtagcagagactgcaacattctggct
tgggttccatccttatatgaaccagttcctgatgatgatgagactacaacaaaatcacaa
ttaaatccggcctttgaagatgcctggagcagcagtgatgaagaaggatga

  All links  
Disease (3)   
   OMIM (3)   
Gene (16)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (7)   
   OC (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (38)   
   RefSeq(nuc) (4)   
   GenBank (17)   
   EMBL (17)   
3D Structure (15)   
   PDB (15)   
Protein domain (31)   
   Pfam (31)   
All databases (109)   

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