KEGG   Homo sapiens (human): 121278
Entry
121278            CDS       T01001                                 

Gene name
TPH2, ADHD7, NTPH
Definition
(RefSeq) tryptophan hydroxylase 2
  KO
K00502  tryptophan 5-monooxygenase [EC:1.14.16.4]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00380  Tryptophan metabolism
hsa00790  Folate biosynthesis
hsa01100  Metabolic pathways
hsa04726  Serotonergic synapse
Module
hsa_M00037  Melatonin biosynthesis, animals, tryptophan => serotonin => melatonin
Disease
H01646  Major depressive disorder
H01895  Attention deficit hyperactivity disorder (ADHD)
Drug target
Telotristat (DG02809): D09973 D09974<US> D09975
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    121278 (TPH2)
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    121278 (TPH2)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    121278 (TPH2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.16  With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.16.4  tryptophan 5-monooxygenase
     121278 (TPH2)
SSDB
Motif
Pfam: Biopterin_H ACT
Other DBs
NCBI-GeneID: 121278
NCBI-ProteinID: NP_775489
OMIM: 607478
HGNC: 20692
Ensembl: ENSG00000139287
Vega: OTTHUMG00000169677
Pharos: Q8IWU9(Tchem)
UniProt: Q8IWU9
Structure
PDB: 
4V06

Position
12q21.1
AA seq 490 aa
MQPAMMMFSSKYWARRGFSLDSAVPEEHQLLGSSTLNKPNSGKNDDKGNKGSSKREAATE
SGKTAVVFSLKNEVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFN
ELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHP
GFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYL
KNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQ
YIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFF
TIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYF
VSESFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDA
LNKMNQYLGI
NT seq 1473 nt   +upstreamnt  +downstreamnt
atgcagccagcaatgatgatgttttccagtaaatactgggcacggagagggttttccctg
gattcagcagtgcccgaagagcatcagctacttggcagctcaacactaaataaacctaac
tctggcaaaaatgacgacaaaggcaacaagggaagcagcaaacgtgaagctgctaccgaa
agtggcaagacagcagttgttttctccttgaagaatgaagttggtggattggtaaaagca
ctgaggctctttcaggaaaaacgtgtcaacatggttcatattgaatccaggaaatctcgg
cgaagaagttctgaggttgaaatctttgtggactgtgagtgtgggaaaacagaattcaat
gagctcattcagttgctgaaatttcaaaccactattgtgacgctgaatcctccagagaac
atttggacagaggaagaagagctagaggatgtgccctggttccctcggaagatctctgag
ttagacaaatgctctcacagagttctcatgtatggttctgagcttgatgctgaccaccca
ggatttaaggacaatgtctatcgacagagaagaaagtattttgtggatgtggccatgggt
tataaatatggtcagcccattcccagggtggagtatactgaagaagaaactaaaacttgg
ggtgttgtattccgggagctctccaaactctatcccactcatgcttgccgagagtatttg
aaaaacttccctctgctgactaaatactgtggctacagagaggacaatgtgcctcaactc
gaagatgtctccatgtttctgaaagaaaggtctggcttcacggtgaggccggtggctgga
tacctgagcccacgagactttctggcaggactggcctacagagtgttccactgtacccag
tacatccggcatggctcagatcccctctacaccccagaaccagacacatgccatgaactc
ttgggacatgttccactacttgcggatcctaagtttgctcagttttcacaagaaataggt
ctggcgtctctgggagcatcagatgaagatgttcagaaactagccacgtgctatttcttc
acaatcgagtttggcctttgcaagcaagaagggcaactgcgggcatatggagcaggactc
ctttcctccattggagaattaaagcacgccctttctgacaaggcatgtgtgaaagccttt
gacccaaagacaacttgcttacaggaatgccttatcaccaccttccaggaagcctacttt
gtttcagaaagttttgaagaagccaaagaaaagatgagggactttgcaaagtcaattacc
cgtcccttctcagtatacttcaatccctacacacagagtattgaaattctgaaagacacc
agaagtattgaaaatgtggtgcaggaccttcgcagcgacttgaatacagtgtgtgatgct
ttaaacaaaatgaaccaatatctggggatttga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Drug (3)   
   KEGG DRUG (3)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (9)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (10)   
   RefSeq(nuc) (2)   
   GenBank (4)   
   EMBL (4)   
Protein domain (2)   
   Pfam (2)   
All databases (50)   

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KEGG   Homo sapiens (human): 7166
Entry
7166              CDS       T01001                                 

Gene name
TPH1, TPRH, TRPH, TPH
Definition
(RefSeq) tryptophan hydroxylase 1
  KO
K00502  tryptophan 5-monooxygenase [EC:1.14.16.4]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00380  Tryptophan metabolism
hsa00790  Folate biosynthesis
hsa01100  Metabolic pathways
hsa04726  Serotonergic synapse
Module
hsa_M00037  Melatonin biosynthesis, animals, tryptophan => serotonin => melatonin
Drug target
Rodatristat (DG02986): D11317 D11318
Telotristat (DG02809): D09973 D09974<US> D09975
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    7166 (TPH1)
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    7166 (TPH1)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    7166 (TPH1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.16  With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.16.4  tryptophan 5-monooxygenase
     7166 (TPH1)
SSDB
Motif
Pfam: Biopterin_H ACT ACT_4
Other DBs
NCBI-GeneID: 7166
NCBI-ProteinID: NP_004170
OMIM: 191060
HGNC: 12008
Ensembl: ENSG00000129167
Vega: OTTHUMG00000166421
Pharos: P17752(Tchem)
UniProt: P17752
Structure
PDB: 

Position
11p15.1
AA seq 444 aa
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEF
EIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCAN
RVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQE
LNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRD
FLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA
SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITC
KQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSA
MNELQHDLDVVSDALAKVSRKPSI
NT seq 1335 nt   +upstreamnt  +downstreamnt
atgattgaagacaataaggagaacaaagaccattccttagaaaggggaagagcaagtctc
attttttccttaaagaatgaagttggaggacttataaaagccctgaaaatctttcaggag
aagcatgtgaatctgttacatatcgagtcccgaaaatcaaaaagaagaaactcagaattt
gagatttttgttgactgtgacatcaacagagaacaattgaatgatatttttcatctgctg
aagtctcataccaatgttctctctgtgaatctaccagataattttactttgaaggaagat
ggtatggaaactgttccttggtttccaaagaagatttctgacctggaccattgtgccaac
agagttctgatgtatggatctgaactagatgcagaccatcctggcttcaaagacaatgtc
taccgtaaacgtcgaaagtattttgcggacttggctatgaactataaacatggagacccc
attccaaaggttgaattcactgaagaggagattaagacctggggaaccgtattccaagag
ctcaacaaactctacccaacccatgcttgcagagagtatctcaaaaacttacctttgctt
tctaaatattgtggatatcgggaggataatatcccacaattggaagatgtctccaacttt
ttaaaagagcgtacaggtttttccatccgtcctgtggctggttacttatcaccaagagat
ttcttatcaggtttagcctttcgagtttttcactgcactcaatatgtgagacacagttca
gatcccttctataccccagagccagatacctgccatgaactcttaggtcatgtcccgctt
ttggctgaacctagttttgcccaattctcccaagaaattggcttggcttctcttggcgct
tcagaggaggctgttcaaaaactggcaacgtgctactttttcactgtggagtttggtcta
tgtaaacaagatggacagctaagagtctttggtgctggcttactttcttctatcagtgaa
ctcaaacatgcactttctggacatgccaaagtaaagccctttgatcccaagattacctgc
aaacaggaatgtcttatcacaacttttcaagatgtctactttgtatctgaaagttttgaa
gatgcaaaggagaagatgagagaatttaccaaaacaattaagcgtccatttggagtgaag
tataatccatatacacggagtattcagatcctgaaagacaccaagagcataaccagtgcc
atgaatgagctgcagcatgatctcgatgttgtcagtgatgcccttgctaaggtcagcagg
aagccgagtatctaa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Disease (1)   
   OMIM (1)   
Drug (5)   
   KEGG DRUG (5)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (15)   
   RefSeq(nuc) (1)   
   GenBank (7)   
   EMBL (7)   
Protein domain (3)   
   Pfam (3)   
All databases (56)   

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