KEGG   Homo sapiens (human): 125965
Entry
125965            CDS       T01001                                 

Gene name
COX6B2, COXVIB2, CT59
Definition
(RefSeq) cytochrome c oxidase subunit 6B2
  KO
K02267  cytochrome c oxidase subunit 6b
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04260  Cardiac muscle contraction
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease (NAFLD)
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05016  Huntington disease
Module
hsa_M00154  Cytochrome c oxidase
Network
nt06418  Oxidative phosphorylation
nt06460  Alzheimer disease
  Element
N00998  Electron transfer in Complex IV
N00999  Mutation-caused aberrant Abeta to electron transfer in Complex IV
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    125965 (COX6B2)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    125965 (COX6B2)
  09159 Environmental adaptation
   04714 Thermogenesis
    125965 (COX6B2)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    125965 (COX6B2)
   05012 Parkinson disease
    125965 (COX6B2)
   05016 Huntington disease
    125965 (COX6B2)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease (NAFLD)
    125965 (COX6B2)
SSDB
Motif
Pfam: COX6B CX9C
Other DBs
NCBI-GeneID: 125965
NCBI-ProteinID: NP_653214
OMIM: 618127
HGNC: 24380
Ensembl: ENSG00000160471
Vega: OTTHUMG00000180774
Pharos: Q6YFQ2(Tdark)
UniProt: Q6YFQ2
Position
19q13.42
AA seq 88 aa
MLDVEAQEPPKGKWSTPPFDPRFPSQNQIRNCYQNFLDYHRCLKTRTRRGKSTQPCEYYF
RVYHSLCPISWVESWNEQIKNGIFAGKI
NT seq 267 nt   +upstreamnt  +downstreamnt
atgttggatgtggaagcccaggagccccccaaggggaaatggtcgacgccgcccttcgac
ccgcgcttccccagccagaaccagatccgtaactgctaccagaacttcctggactaccac
cgctgcctcaagaccaggacccgccgcgggaagagcacgcagccctgcgagtactatttc
cgcgtgtaccactcgctgtgccccatcagctgggtggagagctggaacgagcagatcaag
aacgggattttcgccggcaaaatctga

KEGG   Homo sapiens (human): 1327
Entry
1327              CDS       T01001                                 

Gene name
COX4I1, COX_IV-1, COX4, COX4-1, COXIV, COXIV-1
Definition
(RefSeq) cytochrome c oxidase subunit 4I1
  KO
K02263  cytochrome c oxidase subunit 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04260  Cardiac muscle contraction
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease (NAFLD)
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05016  Huntington disease
Module
hsa_M00154  Cytochrome c oxidase
Network
nt06418  Oxidative phosphorylation
nt06460  Alzheimer disease
  Element
N00998  Electron transfer in Complex IV
N00999  Mutation-caused aberrant Abeta to electron transfer in Complex IV
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    1327 (COX4I1)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    1327 (COX4I1)
  09159 Environmental adaptation
   04714 Thermogenesis
    1327 (COX4I1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    1327 (COX4I1)
   05012 Parkinson disease
    1327 (COX4I1)
   05016 Huntington disease
    1327 (COX4I1)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease (NAFLD)
    1327 (COX4I1)
SSDB
Motif
Pfam: COX4 GAPT
Other DBs
NCBI-GeneID: 1327
NCBI-ProteinID: NP_001305715
OMIM: 123864
HGNC: 2265
Ensembl: ENSG00000131143
Vega: OTTHUMG00000137649
Pharos: P13073(Tbio)
UniProt: P13073 Q86WV2
Structure
PDB: 
5Z62

Position
16q24.1
AA seq 169 aa
MLATRVFSLVGKRAISTSVCVRAHESVVKSEDFSLPAYMDRRDHPLPEVAHVKHLSASQK
ALKEKEKASWSSLSMDEKVELYRIKFKESFAEMNRGSNEWKTVVGGAMFFIGFTALVIMW
QKHYVYGPLPQSFDKEWVAKQTKRMLDMKVNPIQGLASKWDYEKNEWKK
NT seq 510 nt   +upstreamnt  +downstreamnt
atgttggctaccagggtatttagcctagttggcaagcgagcaatttccacctctgtgtgt
gtacgagctcatgaaagtgttgtgaagagcgaagacttttcgctcccagcttatatggat
cggcgtgaccaccccttgccggaggtggcccatgtcaagcacctgtctgccagccagaag
gcattgaaggagaaggagaaggcctcctggagcagcctctccatggatgagaaagtcgag
ttgtatcgcattaagttcaaggagagctttgctgagatgaacaggggctcgaacgagtgg
aagacggttgtgggcggtgccatgttcttcatcggtttcaccgcgctcgttatcatgtgg
cagaagcactatgtgtacggccccctcccgcaaagctttgacaaagagtgggtggccaag
cagaccaagaggatgctggacatgaaggtgaaccccatccagggcttagcctccaagtgg
gactacgaaaagaacgagtggaagaagtga

KEGG   Homo sapiens (human): 1329
Entry
1329              CDS       T01001                                 

Gene name
COX5B, COXVB
Definition
(RefSeq) cytochrome c oxidase subunit 5B
  KO
K02265  cytochrome c oxidase subunit 5b
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04260  Cardiac muscle contraction
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease (NAFLD)
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05016  Huntington disease
Module
hsa_M00154  Cytochrome c oxidase
Network
nt06418  Oxidative phosphorylation
nt06460  Alzheimer disease
  Element
N00998  Electron transfer in Complex IV
N00999  Mutation-caused aberrant Abeta to electron transfer in Complex IV
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    1329 (COX5B)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    1329 (COX5B)
  09159 Environmental adaptation
   04714 Thermogenesis
    1329 (COX5B)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    1329 (COX5B)
   05012 Parkinson disease
    1329 (COX5B)
   05016 Huntington disease
    1329 (COX5B)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease (NAFLD)
    1329 (COX5B)
SSDB
Motif
Pfam: COX5B zf-CHCC
Other DBs
NCBI-GeneID: 1329
NCBI-ProteinID: NP_001853
OMIM: 123866
HGNC: 2269
Ensembl: ENSG00000135940
Vega: OTTHUMG00000130548
Pharos: P10606(Tbio)
UniProt: P10606 A0A384NL93
Structure
PDB: 
5Z62

Position
2q11.2
AA seq 129 aa
MASRLLRGAGTLAAQALRARGPSGAAAMRSMASGGGVPTDEEQATGLEREIMLAAKKGLD
PYNVLAPKGASGTREDPNLVPSISNKRIVGCICEEDNTSVVWFWLHKGEAQRCPRCGAHY
KLVPQQLAH
NT seq 390 nt   +upstreamnt  +downstreamnt
atggcttcaaggttacttcgcggagctggaacgctggccgcgcaggccctgagggctcgc
ggccccagtggcgcggccgcgatgcgctccatggcatctggaggtggtgttcccactgat
gaagagcaggcgactgggttggagagggagatcatgctggctgcaaagaagggactggac
ccatacaatgtactggccccaaagggagcttcaggcaccagggaagaccctaatttagtc
ccctccatctccaacaagagaatagtaggctgcatctgtgaagaggacaataccagcgtc
gtctggttttggctgcacaaaggcgaggcccagcgatgcccccgctgtggagcccattac
aagctggtgccccagcagctggcacactga

KEGG   Homo sapiens (human): 1337
Entry
1337              CDS       T01001                                 

Gene name
COX6A1, CMTRID, COX6A, COX6AL
Definition
(RefSeq) cytochrome c oxidase subunit 6A1
  KO
K02266  cytochrome c oxidase subunit 6a
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04260  Cardiac muscle contraction
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease (NAFLD)
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05016  Huntington disease
Module
hsa_M00154  Cytochrome c oxidase
Network
nt06418  Oxidative phosphorylation
nt06460  Alzheimer disease
  Element
N00998  Electron transfer in Complex IV
N00999  Mutation-caused aberrant Abeta to electron transfer in Complex IV
Disease
H00264  Charcot-Marie-Tooth disease
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    1337 (COX6A1)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    1337 (COX6A1)
  09159 Environmental adaptation
   04714 Thermogenesis
    1337 (COX6A1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    1337 (COX6A1)
   05012 Parkinson disease
    1337 (COX6A1)
   05016 Huntington disease
    1337 (COX6A1)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease (NAFLD)
    1337 (COX6A1)
SSDB
Motif
Pfam: COX6A
Other DBs
NCBI-GeneID: 1337
NCBI-ProteinID: NP_004364
OMIM: 602072
HGNC: 2277
Ensembl: ENSG00000111775
Vega: OTTHUMG00000047791
Pharos: P12074(Tbio)
UniProt: P12074 H6SG15
Structure
PDB: 
5Z62

Position
12q24.31; 12q24.2
AA seq 109 aa
MAVVGVSSVSRLLGRSRPQLGRPMSSGAHGEEGSARMWKTLTFFVALPGVAVSMLNVYLK
SHHGEHERPEFIAYPHLRIRTKPFPWGDGNHTLFHNPHVNPLPTGYEDE
NT seq 330 nt   +upstreamnt  +downstreamnt
atggcggtagttggtgtgtcctcggtttctcggctgctgggtcggtcccgcccacagctg
gggcggcctatgtcgagtggcgcccatggcgaagagggctcagctcgcatgtggaagact
ctcaccttcttcgtcgcgctccccggggtggcagtcagcatgctgaatgtgtacctgaag
tcgcaccacggagagcacgagagacccgagttcatcgcctacccccatctccgcatcagg
accaagccgtttccctggggagatggtaaccatactctattccataaccctcatgtgaat
ccacttccaactggctacgaagatgaataa

KEGG   Homo sapiens (human): 1339
Entry
1339              CDS       T01001                                 

Gene name
COX6A2, COX6AH, COXVIAH
Definition
(RefSeq) cytochrome c oxidase subunit 6A2
  KO
K02266  cytochrome c oxidase subunit 6a
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04260  Cardiac muscle contraction
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease (NAFLD)
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05016  Huntington disease
Module
hsa_M00154  Cytochrome c oxidase
Network
nt06418  Oxidative phosphorylation
nt06460  Alzheimer disease
  Element
N00998  Electron transfer in Complex IV
N00999  Mutation-caused aberrant Abeta to electron transfer in Complex IV
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    1339 (COX6A2)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    1339 (COX6A2)
  09159 Environmental adaptation
   04714 Thermogenesis
    1339 (COX6A2)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    1339 (COX6A2)
   05012 Parkinson disease
    1339 (COX6A2)
   05016 Huntington disease
    1339 (COX6A2)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease (NAFLD)
    1339 (COX6A2)
SSDB
Motif
Pfam: COX6A
Other DBs
NCBI-GeneID: 1339
NCBI-ProteinID: NP_005196
OMIM: 602009
HGNC: 2279
Ensembl: ENSG00000156885
Vega: OTTHUMG00000132463
Pharos: Q02221(Tbio)
UniProt: Q02221
Position
16p11.2
AA seq 97 aa
MALPLRPLTRGLASAAKGGHGGAGARTWRLLTFVLALPSVALCTFNSYLHSGHRPRPEFR
PYQHLRIRTKPYPWGDGNHTLFHNSHVNPLPTGYEHP
NT seq 294 nt   +upstreamnt  +downstreamnt
atggctttgcctctgaggcccctgacccggggcttggccagcgctgccaaaggaggccac
ggaggagcaggagctcgtacctggcgtctgctgaccttcgtgctggcgctgcccagcgtg
gccctctgcaccttcaactcctatctccactcgggccaccgcccgcgccccgagttccgt
ccctaccaacacctccgcatccgcaccaagccctacccctggggggacggcaaccacact
ctgttccacaatagccacgtgaaccctctgcccacgggctacgaacacccctga

KEGG   Homo sapiens (human): 1340
Entry
1340              CDS       T01001                                 

Gene name
COX6B1, COX6B, COXG, COXVIb1
Definition
(RefSeq) cytochrome c oxidase subunit 6B1
  KO
K02267  cytochrome c oxidase subunit 6b
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04260  Cardiac muscle contraction
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease (NAFLD)
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05016  Huntington disease
Module
hsa_M00154  Cytochrome c oxidase
Network
nt06418  Oxidative phosphorylation
nt06460  Alzheimer disease
  Element
N00998  Electron transfer in Complex IV
N00999  Mutation-caused aberrant Abeta to electron transfer in Complex IV
Disease
H01368  Cytochrome c oxidase (COX) deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    1340 (COX6B1)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    1340 (COX6B1)
  09159 Environmental adaptation
   04714 Thermogenesis
    1340 (COX6B1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    1340 (COX6B1)
   05012 Parkinson disease
    1340 (COX6B1)
   05016 Huntington disease
    1340 (COX6B1)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease (NAFLD)
    1340 (COX6B1)
SSDB
Motif
Pfam: COX6B
Other DBs
NCBI-GeneID: 1340
NCBI-ProteinID: NP_001854
OMIM: 124089
HGNC: 2280
Ensembl: ENSG00000126267
Vega: OTTHUMG00000048112
Pharos: P14854(Tbio)
UniProt: P14854
Structure
PDB: 
5Z62

Position
19q13.12
AA seq 86 aa
MAEDMETKIKNYKTAPFDSRFPNQNQTRNCWQNYLDFHRCQKAMTAKGGDISVCEWYQRV
YQSLCPTSWVTDWDEQRAEGTFPGKI
NT seq 261 nt   +upstreamnt  +downstreamnt
atggcggaagacatggagaccaaaatcaagaactacaagaccgccccttttgacagccgc
ttccccaaccagaaccagactagaaactgctggcagaactacctggacttccaccgctgt
cagaaggcaatgaccgctaaaggaggcgatatctctgtgtgcgaatggtaccagcgtgtg
taccagtccctctgccccacatcctgggtcacagactgggatgagcaacgggctgaaggc
acgtttcccgggaagatctga

KEGG   Homo sapiens (human): 1345
Entry
1345              CDS       T01001                                 

Gene name
COX6C
Definition
(RefSeq) cytochrome c oxidase subunit 6C
  KO
K02268  cytochrome c oxidase subunit 6c
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04260  Cardiac muscle contraction
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease (NAFLD)
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05016  Huntington disease
Module
hsa_M00154  Cytochrome c oxidase
Network
nt06418  Oxidative phosphorylation
nt06460  Alzheimer disease
  Element
N00998  Electron transfer in Complex IV
N00999  Mutation-caused aberrant Abeta to electron transfer in Complex IV
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    1345 (COX6C)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    1345 (COX6C)
  09159 Environmental adaptation
   04714 Thermogenesis
    1345 (COX6C)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    1345 (COX6C)
   05012 Parkinson disease
    1345 (COX6C)
   05016 Huntington disease
    1345 (COX6C)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease (NAFLD)
    1345 (COX6C)
SSDB
Motif
Pfam: COX6C
Other DBs
NCBI-GeneID: 1345
NCBI-ProteinID: NP_004365
OMIM: 124090
HGNC: 2285
Ensembl: ENSG00000164919
Vega: OTTHUMG00000164703
Pharos: P09669(Tbio)
UniProt: P09669 A0A024R9B7
Structure
PDB: 
5Z62

Position
8q22.2
AA seq 75 aa
MAPEVLPKPRMRGLLARRLRNHMAVAFVLSLGVAALYKFRVADQRKKAYADFYRNYDVMK
DFEEMRKAGIFQSVK
NT seq 228 nt   +upstreamnt  +downstreamnt
atggctcccgaagttttgccaaaacctcggatgcgtggccttctggccaggcgtctgcga
aatcatatggctgtagcattcgtgctatccctgggggttgcagctttgtataagtttcgt
gtggctgatcaaagaaagaaggcatacgcagatttctacagaaactacgatgtcatgaaa
gattttgaggagatgaggaaggctggtatctttcagagtgtaaagtaa

KEGG   Homo sapiens (human): 1346
Entry
1346              CDS       T01001                                 

Gene name
COX7A1, COX7A, COX7AH, COX7AM
Definition
(RefSeq) cytochrome c oxidase subunit 7A1
  KO
K02270  cytochrome c oxidase subunit 7a
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04260  Cardiac muscle contraction
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease (NAFLD)
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05016  Huntington disease
Module
hsa_M00154  Cytochrome c oxidase
Network
nt06418  Oxidative phosphorylation
nt06460  Alzheimer disease
  Element
N00998  Electron transfer in Complex IV
N00999  Mutation-caused aberrant Abeta to electron transfer in Complex IV
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    1346 (COX7A1)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    1346 (COX7A1)
  09159 Environmental adaptation
   04714 Thermogenesis
    1346 (COX7A1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    1346 (COX7A1)
   05012 Parkinson disease
    1346 (COX7A1)
   05016 Huntington disease
    1346 (COX7A1)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease (NAFLD)
    1346 (COX7A1)
SSDB
Motif
Pfam: COX7a COX14
Other DBs
NCBI-GeneID: 1346
NCBI-ProteinID: NP_001855
OMIM: 123995
HGNC: 2287
Ensembl: ENSG00000161281
Vega: OTTHUMG00000048144
Pharos: P24310(Tbio)
UniProt: P24310 Q6FGI7
Position
19q13.12
AA seq 79 aa
MQALRVSQALIRSFSSTARNRFQNRVREKQKLFQEDNDIPLYLKGGIVDNILYRVTMTLC
LGGTVYSLYSLGWASFPRN
NT seq 240 nt   +upstreamnt  +downstreamnt
atgcaggcccttcgggtgtcccaggcgctgatccgctccttcagctccaccgcccggaac
cgctttcagaaccgagtgcgcgagaaacagaagctcttccaggaggacaatgacatcccg
ttgtacctgaagggcggcatcgttgacaacatcctgtaccgagtgacaatgacgctgtgt
ctgggcggcactgtctacagcttgtactcccttggctgggcctccttccccaggaattaa

KEGG   Homo sapiens (human): 1347
Entry
1347              CDS       T01001                                 

Gene name
COX7A2, COX7AL, COX7AL1, COXVIIAL, COXVIIa-L, VIIAL
Definition
(RefSeq) cytochrome c oxidase subunit 7A2
  KO
K02270  cytochrome c oxidase subunit 7a
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04260  Cardiac muscle contraction
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease (NAFLD)
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05016  Huntington disease
Module
hsa_M00154  Cytochrome c oxidase
Network
nt06418  Oxidative phosphorylation
nt06460  Alzheimer disease
  Element
N00998  Electron transfer in Complex IV
N00999  Mutation-caused aberrant Abeta to electron transfer in Complex IV
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    1347 (COX7A2)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    1347 (COX7A2)
  09159 Environmental adaptation
   04714 Thermogenesis
    1347 (COX7A2)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    1347 (COX7A2)
   05012 Parkinson disease
    1347 (COX7A2)
   05016 Huntington disease
    1347 (COX7A2)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease (NAFLD)
    1347 (COX7A2)
SSDB
Motif
Pfam: COX7a
Other DBs
NCBI-GeneID: 1347
NCBI-ProteinID: NP_001856
OMIM: 123996
HGNC: 2288
Ensembl: ENSG00000112695
Vega: OTTHUMG00000015049
Pharos: P14406(Tdark)
UniProt: P14406 H0UI06
Structure
PDB: 
5Z62

Position
6q14.1
AA seq 115 aa
MHTQDSEVVPVPAWPFSLVVFSCGGCWSVTAKMLRNLLALRQIGQRTISTASRRHFKNKV
PEKQKLFQEDDEIPLYLKGGVADALLYRATMILTVGGTAYAIYELAVASFPKKQE
NT seq 348 nt   +upstreamnt  +downstreamnt
atgcatacgcaagactcggaggtagttccggttccggcgtggccattttcgttggtggtg
ttcagttgtggcggttgctggtcagtaacagccaagatgctgcggaatctgctggctctt
cgtcagattgggcagaggacgataagcactgcttcccgcaggcattttaaaaataaagtt
ccggagaagcaaaaactgttccaggaggatgatgaaattccactgtatctaaagggtggg
gtagctgatgccctcctgtatagagccaccatgattcttacagttggtggaacagcatat
gccatatatgagctggctgtggcttcatttcccaagaagcaggagtga

KEGG   Homo sapiens (human): 1349
Entry
1349              CDS       T01001                                 

Gene name
COX7B, APLCC, LSDMCA2
Definition
(RefSeq) cytochrome c oxidase subunit 7B
  KO
K02271  cytochrome c oxidase subunit 7b
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04260  Cardiac muscle contraction
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease (NAFLD)
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05016  Huntington disease
Module
hsa_M00154  Cytochrome c oxidase
Network
nt06418  Oxidative phosphorylation
nt06460  Alzheimer disease
  Element
N00998  Electron transfer in Complex IV
N00999  Mutation-caused aberrant Abeta to electron transfer in Complex IV
Disease
H01904  Microphthalmia with linear skin defects syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    1349 (COX7B)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    1349 (COX7B)
  09159 Environmental adaptation
   04714 Thermogenesis
    1349 (COX7B)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    1349 (COX7B)
   05012 Parkinson disease
    1349 (COX7B)
   05016 Huntington disease
    1349 (COX7B)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease (NAFLD)
    1349 (COX7B)
SSDB
Motif
Pfam: COX7B Deltameth_res
Other DBs
NCBI-GeneID: 1349
NCBI-ProteinID: NP_001857
OMIM: 300885
HGNC: 2291
Ensembl: ENSG00000131174
Vega: OTTHUMG00000022718
Pharos: P24311(Tbio)
UniProt: P24311
Structure
PDB: 
5Z62

Position
Xq21.1
AA seq 80 aa
MFPLVKSALNRLQVRSIQQTMARQSHQKRTPDFHDKYGNAVLASGATFCIVTWTYVATQV
GIEWNLSPVGRVTPKEWRNQ
NT seq 243 nt   +upstreamnt  +downstreamnt
atgtttcccttggtcaaaagcgcactaaatcgtctccaagttcgaagcattcagcaaaca
atggcaaggcagagccaccagaaacgtacacctgattttcatgacaaatacggtaatgct
gtattagctagtggagccactttctgtattgttacatggacatatgtagcaacacaagtc
ggaatagaatggaacctgtcccctgttggcagagttaccccaaaggaatggaggaatcag
taa

KEGG   Homo sapiens (human): 1350
Entry
1350              CDS       T01001                                 

Gene name
COX7C
Definition
(RefSeq) cytochrome c oxidase subunit 7C
  KO
K02272  cytochrome c oxidase subunit 7c
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04260  Cardiac muscle contraction
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease (NAFLD)
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05016  Huntington disease
Module
hsa_M00154  Cytochrome c oxidase
Network
nt06418  Oxidative phosphorylation
nt06460  Alzheimer disease
  Element
N00998  Electron transfer in Complex IV
N00999  Mutation-caused aberrant Abeta to electron transfer in Complex IV
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    1350 (COX7C)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    1350 (COX7C)
  09159 Environmental adaptation
   04714 Thermogenesis
    1350 (COX7C)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    1350 (COX7C)
   05012 Parkinson disease
    1350 (COX7C)
   05016 Huntington disease
    1350 (COX7C)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease (NAFLD)
    1350 (COX7C)
SSDB
Motif
Pfam: COX7C
Other DBs
NCBI-GeneID: 1350
NCBI-ProteinID: NP_001858
OMIM: 603774
HGNC: 2292
Ensembl: ENSG00000127184
Vega: OTTHUMG00000119049
Pharos: P15954(Tdark)
UniProt: P15954
Structure
PDB: 
5Z62

Position
5q14.3
AA seq 63 aa
MLGQSIRRFTTSVVRRSHYEEGPGKNLPFSVENKWSLLAKMCLYFGSAFATPFLVVRHQL
LKT
NT seq 192 nt   +upstreamnt  +downstreamnt
atgttgggccagagcatccggaggttcacaacctctgtggtccgtaggagccactatgag
gagggccctgggaagaatttgccattttcagtggaaaacaagtggtcgttactagctaag
atgtgtttgtactttggatctgcatttgctacacccttccttgtagtaagacaccaactg
cttaaaacataa

KEGG   Homo sapiens (human): 1351
Entry
1351              CDS       T01001                                 

Gene name
COX8A, COX, COX8, COX8-2, COX8L, VIII, VIII-L
Definition
(RefSeq) cytochrome c oxidase subunit 8A
  KO
K02273  cytochrome c oxidase subunit 8
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04260  Cardiac muscle contraction
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease (NAFLD)
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05016  Huntington disease
Module
hsa_M00154  Cytochrome c oxidase
Network
nt06418  Oxidative phosphorylation
nt06460  Alzheimer disease
  Element
N00998  Electron transfer in Complex IV
N00999  Mutation-caused aberrant Abeta to electron transfer in Complex IV
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    1351 (COX8A)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    1351 (COX8A)
  09159 Environmental adaptation
   04714 Thermogenesis
    1351 (COX8A)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    1351 (COX8A)
   05012 Parkinson disease
    1351 (COX8A)
   05016 Huntington disease
    1351 (COX8A)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease (NAFLD)
    1351 (COX8A)
SSDB
Motif
Pfam: COX8
Other DBs
NCBI-GeneID: 1351
NCBI-ProteinID: NP_004065
OMIM: 123870
HGNC: 2294
Ensembl: ENSG00000176340
Vega: OTTHUMG00000167785
Pharos: P10176(Tbio)
UniProt: P10176 Q53XN1
Structure
PDB: 
5Z62

Position
11q13.1
AA seq 69 aa
MSVLTPLLLRGLTGSARRLPVPRAKIHSLPPEGKLGIMELAVGLTSCFVTFLLPAGWILS
HLETYRRPE
NT seq 210 nt   +upstreamnt  +downstreamnt
atgtccgtcctgacgccgctgctgctgcggggcttgacaggctcggcccggcggctccca
gtgccgcgcgccaagatccattcgttgccgccggaggggaagcttgggatcatggaattg
gccgttgggcttacctcctgcttcgtgaccttcctcctgccagcgggctggatcctgtca
cacctggagacctacaggaggccagagtga

KEGG   Homo sapiens (human): 170712
Entry
170712            CDS       T01001                                 

Gene name
COX7B2
Definition
(RefSeq) cytochrome c oxidase subunit 7B2
  KO
K02271  cytochrome c oxidase subunit 7b
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04260  Cardiac muscle contraction
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease (NAFLD)
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05016  Huntington disease
Module
hsa_M00154  Cytochrome c oxidase
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    170712 (COX7B2)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    170712 (COX7B2)
  09159 Environmental adaptation
   04714 Thermogenesis
    170712 (COX7B2)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    170712 (COX7B2)
   05012 Parkinson disease
    170712 (COX7B2)
   05016 Huntington disease
    170712 (COX7B2)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease (NAFLD)
    170712 (COX7B2)
SSDB
Motif
Pfam: COX7B Deltameth_res
Other DBs
NCBI-GeneID: 170712
NCBI-ProteinID: NP_570972
OMIM: 609811
HGNC: 24381
Ensembl: ENSG00000170516
Vega: OTTHUMG00000099423
Pharos: Q8TF08(Tdark)
UniProt: Q8TF08
Position
4p12
AA seq 81 aa
MMFPLARNALSSLKIQSILQSMARHSHVKHSPDFHDKYGNAVLASGTAFCVATWVFTATQ
IGIEWNLSPVGRVTPKEWKHQ
NT seq 246 nt   +upstreamnt  +downstreamnt
atgatgtttcccttggccagaaatgcactaagcagtctcaagattcaaagcattctgcaa
agcatggcaagacatagccatgtaaaacactcaccagattttcatgataaatatggtaat
gctgtgctagccagtggaactgctttctgtgttgctacatgggtgtttacagccactcag
attggaatagaatggaacctatcccctgttggcagagttaccccaaaagagtggaaacat
cagtaa

KEGG   Homo sapiens (human): 341947
Entry
341947            CDS       T01001                                 

Gene name
COX8C, COX8-3
Definition
(RefSeq) cytochrome c oxidase subunit 8C
  KO
K02273  cytochrome c oxidase subunit 8
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04260  Cardiac muscle contraction
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease (NAFLD)
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05016  Huntington disease
Module
hsa_M00154  Cytochrome c oxidase
Network
nt06418  Oxidative phosphorylation
nt06460  Alzheimer disease
  Element
N00998  Electron transfer in Complex IV
N00999  Mutation-caused aberrant Abeta to electron transfer in Complex IV
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    341947 (COX8C)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    341947 (COX8C)
  09159 Environmental adaptation
   04714 Thermogenesis
    341947 (COX8C)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    341947 (COX8C)
   05012 Parkinson disease
    341947 (COX8C)
   05016 Huntington disease
    341947 (COX8C)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease (NAFLD)
    341947 (COX8C)
SSDB
Motif
Pfam: COX8
Other DBs
NCBI-GeneID: 341947
NCBI-ProteinID: NP_892016
OMIM: 616855
HGNC: 24382
Ensembl: ENSG00000187581
Vega: OTTHUMG00000171279
Pharos: Q7Z4L0(Tdark)
UniProt: Q7Z4L0
Position
14q32.12
AA seq 72 aa
MPLLRGRCPARRHYRRLALLGLQPAPRFAHSGPPRQRPLSAAEMAVGLVVFFTTFLTPAA
YVLGNLKQFRRN
NT seq 219 nt   +upstreamnt  +downstreamnt
atgcctctcctgcgtgggcgctgtcctgcccgccgccactaccgccgcttggccctgctc
ggcctgcagcccgctccccgcttcgcccactcggggcccccgcgccagcggcccctgtct
gccgcggaaatggctgttggacttgtggtgttttttacgaccttcttaacaccagctgca
tatgtgctaggcaacctgaagcagttcagaaggaattag

KEGG   Homo sapiens (human): 4512
Entry
4512              CDS       T01001                                 

Gene name
COX1, COI, MTCO1, MT-CO1
Definition
(RefSeq) cytochrome c oxidase subunit I
  KO
K02256  cytochrome c oxidase subunit 1 [EC:7.1.1.9]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04260  Cardiac muscle contraction
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease (NAFLD)
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05016  Huntington disease
Module
hsa_M00154  Cytochrome c oxidase
Network
nt06418  Oxidative phosphorylation
nt06460  Alzheimer disease
  Element
N00998  Electron transfer in Complex IV
N00999  Mutation-caused aberrant Abeta to electron transfer in Complex IV
Disease
H00068  Leber hereditary optic atrophy
H01368  Cytochrome c oxidase (COX) deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    4512 (COX1)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    4512 (COX1)
  09159 Environmental adaptation
   04714 Thermogenesis
    4512 (COX1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    4512 (COX1)
   05012 Parkinson disease
    4512 (COX1)
   05016 Huntington disease
    4512 (COX1)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease (NAFLD)
    4512 (COX1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis [BR:hsa03029]
    4512 (COX1)
Enzymes [BR:hsa01000]
 7. Translocases
  7.1  Catalysing the translocation of hydrons
   7.1.1  Linked to oxidoreductase reactions
    7.1.1.9  cytochrome-c oxidase
     4512 (COX1)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial DNA-encoded proteins
   Cytochrome c oxidase
    4512 (COX1)
SSDB
Motif
Pfam: COX1
Other DBs
NCBI-GeneID: 4512
NCBI-ProteinID: YP_003024028
OMIM: 516030
HGNC: 7419
Pharos: P00395(Tchem)
UniProt: P00395 U5YWV7 A0A1X7RBG2 B2XLA7 Q9B1J9
Structure
PDB: 
5Z62

Position
MT
AA seq 513 aa
MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTA
HAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEA
GAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQ
TPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGH
PEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVD
TRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGGLTGIVLAN
SSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFTIMFIG
VNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKR
KVLMVEEPSMNLEWLYGCPPPYHTFEEPVYMKS
NT seq 1542 nt   +upstreamnt  +downstreamnt
atgttcgccgaccgttgactattctctacaaaccacaaagacattggaacactataccta
ttattcggcgcatgagctggagtcctaggcacagctctaagcctccttattcgagccgag
ctgggccagccaggcaaccttctaggtaacgaccacatctacaacgttatcgtcacagcc
catgcatttgtaataatcttcttcatagtaatacccatcataatcggaggctttggcaac
tgactagttcccctaataatcggtgcccccgatatggcgtttccccgcataaacaacata
agcttctgactcttacctccctctctcctactcctgctcgcatctgctatagtggaggcc
ggagcaggaacaggttgaacagtctaccctcccttagcagggaactactcccaccctgga
gcctccgtagacctaaccatcttctccttacacctagcaggtgtctcctctatcttaggg
gccatcaatttcatcacaacaattatcaatataaaaccccctgccataacccaataccaa
acgcccctcttcgtctgatccgtcctaatcacagcagtcctacttctcctatctctccca
gtcctagctgctggcatcactatactactaacagaccgcaacctcaacaccaccttcttc
gaccccgccggaggaggagaccccattctataccaacacctattctgatttttcggtcac
cctgaagtttatattcttatcctaccaggcttcggaataatctcccatattgtaacttac
tactccggaaaaaaagaaccatttggatacataggtatggtctgagctatgatatcaatt
ggcttcctagggtttatcgtgtgagcacaccatatatttacagtaggaatagacgtagac
acacgagcatatttcacctccgctaccataatcatcgctatccccaccggcgtcaaagta
tttagctgactcgccacactccacggaagcaatatgaaatgatctgctgcagtgctctga
gccctaggattcatctttcttttcaccgtaggtggcctgactggcattgtattagcaaac
tcatcactagacatcgtactacacgacacgtactacgttgtagcccacttccactatgtc
ctatcaataggagctgtatttgccatcataggaggcttcattcactgatttcccctattc
tcaggctacaccctagaccaaacctacgccaaaatccatttcactatcatattcatcggc
gtaaatctaactttcttcccacaacactttctcggcctatccggaatgccccgacgttac
tcggactaccccgatgcatacaccacatgaaacatcctatcatctgtaggctcattcatt
tctctaacagcagtaatattaataattttcatgatttgagaagccttcgcttcgaagcga
aaagtcctaatagtagaagaaccctccataaacctggagtgactatatggatgcccccca
ccctaccacacattcgaagaacccgtatacataaaatctaga

KEGG   Homo sapiens (human): 4513
Entry
4513              CDS       T01001                                 

Gene name
COX2, COII, MTCO2, MT-CO2
Definition
(RefSeq) cytochrome c oxidase subunit II
  KO
K02261  cytochrome c oxidase subunit 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04260  Cardiac muscle contraction
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease (NAFLD)
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05016  Huntington disease
Module
hsa_M00154  Cytochrome c oxidase
Network
nt06418  Oxidative phosphorylation
nt06460  Alzheimer disease
  Element
N00998  Electron transfer in Complex IV
N00999  Mutation-caused aberrant Abeta to electron transfer in Complex IV
Disease
H01368  Cytochrome c oxidase (COX) deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    4513 (COX2)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    4513 (COX2)
  09159 Environmental adaptation
   04714 Thermogenesis
    4513 (COX2)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    4513 (COX2)
   05012 Parkinson disease
    4513 (COX2)
   05016 Huntington disease
    4513 (COX2)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease (NAFLD)
    4513 (COX2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis [BR:hsa03029]
    4513 (COX2)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial DNA-encoded proteins
   Cytochrome c oxidase
    4513 (COX2)
SSDB
Motif
Pfam: COX2 COX2_TM DUF3100 DPM3 NPCC
Other DBs
NCBI-GeneID: 4513
NCBI-ProteinID: YP_003024029
OMIM: 516040
HGNC: 7421
Pharos: P00403(Tchem)
UniProt: P00403 A0A1X7RBF7 U5Z487
Structure
PDB: 
5Z62

Position
MT
AA seq 227 aa
MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFLTLTTKLTNTNISDAQE
METVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGHQWYWTYEYTDYGGLIFNS
YMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQDVLHSWAVPTLGLKTDAIPGRLN
QTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKIFEMGPVFTL
NT seq 684 nt   +upstreamnt  +downstreamnt
atggcacatgcagcgcaagtaggtctacaagacgctacttcccctatcatagaagagctt
atcacctttcatgatcacgccctcataatcattttccttatctgcttcctagtcctgtat
gcccttttcctaacactcacaacaaaactaactaatactaacatctcagacgctcaggaa
atagaaaccgtctgaactatcctgcccgccatcatcctagtcctcatcgccctcccatcc
ctacgcatcctttacataacagacgaggtcaacgatccctcccttaccatcaaatcaatt
ggccaccaatggtactgaacctacgagtacaccgactacggcggactaatcttcaactcc
tacatacttcccccattattcctagaaccaggcgacctgcgactccttgacgttgacaat
cgagtagtactcccgattgaagcccccattcgtataataattacatcacaagacgtcttg
cactcatgagctgtccccacattaggcttaaaaacagatgcaattcccggacgtctaaac
caaaccactttcaccgctacacgaccgggggtatactacggtcaatgctctgaaatctgt
ggagcaaaccacagtttcatgcccatcgtcctagaattaattcccctaaaaatctttgaa
atagggcccgtatttaccctatag

KEGG   Homo sapiens (human): 4514
Entry
4514              CDS       T01001                                 

Gene name
COX3, COIII, MTCO3, MT-CO3
Definition
(RefSeq) cytochrome c oxidase III
  KO
K02262  cytochrome c oxidase subunit 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04260  Cardiac muscle contraction
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease (NAFLD)
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05016  Huntington disease
Module
hsa_M00154  Cytochrome c oxidase
Network
nt06418  Oxidative phosphorylation
nt06460  Alzheimer disease
  Element
N00998  Electron transfer in Complex IV
N00999  Mutation-caused aberrant Abeta to electron transfer in Complex IV
Disease
H00068  Leber hereditary optic atrophy
H01355  Kearns-Sayre syndrome
H01368  Cytochrome c oxidase (COX) deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    4514 (COX3)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    4514 (COX3)
  09159 Environmental adaptation
   04714 Thermogenesis
    4514 (COX3)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    4514 (COX3)
   05012 Parkinson disease
    4514 (COX3)
   05016 Huntington disease
    4514 (COX3)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease (NAFLD)
    4514 (COX3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis [BR:hsa03029]
    4514 (COX3)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial DNA-encoded proteins
   Cytochrome c oxidase
    4514 (COX3)
SSDB
Motif
Pfam: COX3
Other DBs
NCBI-GeneID: 4514
NCBI-ProteinID: YP_003024032
OMIM: 516050
HGNC: 7422
Pharos: P00414(Tbio)
UniProt: P00414 A0A1X7RBF0 Q7GIM7
Structure
PDB: 
5Z62

Position
MT
AA seq 261 aa
MTHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLMLGLLTNTLTMYQWWRD
VTRESTYQGHHTPPVQKGLRYGMILFITSEVFFFAGFFWAFYHSSLAPTPQLGGHWPPTG
ITPLNPLEVPLLNTSVLLASGVSITWAHHSLMENNRNQMIQALLITILLGLYFTLLQASE
YFESPFTISDGIYGSTFFVATGFHGLHVIIGSTFLTICFIRQLMFHFTSKHHFGFEAAAW
YWHFVDVVWLFLYVSIYWWGS
NT seq 784 nt   +upstreamnt  +downstreamnt
atgacccaccaatcacatgcctatcatatagtaaaacccagcccatgacccctaacaggg
gccctctcagccctcctaatgacctccggcctagccatgtgatttcacttccactccata
acgctcctcatactaggcctactaaccaacacactaaccatataccaatgatggcgcgat
gtaacacgagaaagcacataccaaggccaccacacaccacctgtccaaaaaggccttcga
tacgggataatcctatttattacctcagaagtttttttcttcgcaggatttttctgagcc
ttttaccactccagcctagcccctaccccccaattaggagggcactggcccccaacaggc
atcaccccgctaaatcccctagaagtcccactcctaaacacatccgtattactcgcatca
ggagtatcaatcacctgagctcaccatagtctaatagaaaacaaccgaaaccaaataatt
caagcactgcttattacaattttactgggtctctattttaccctcctacaagcctcagag
tacttcgagtctcccttcaccatttccgacggcatctacggctcaacattttttgtagcc
acaggcttccacggacttcacgtcattattggctcaactttcctcactatctgcttcatc
cgccaactaatatttcactttacatccaaacatcactttggcttcgaagccgccgcctga
tactggcattttgtagatgtggtttgactatttctgtatgtctccatctattgatgaggg
tctt

KEGG   Homo sapiens (human): 84701
Entry
84701             CDS       T01001                                 

Gene name
COX4I2, COX4, COX4-2, COX4B, COX4L2, COXIV-2, dJ857M17.2
Definition
(RefSeq) cytochrome c oxidase subunit 4I2
  KO
K02263  cytochrome c oxidase subunit 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04260  Cardiac muscle contraction
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease (NAFLD)
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05016  Huntington disease
Module
hsa_M00154  Cytochrome c oxidase
Network
nt06418  Oxidative phosphorylation
nt06460  Alzheimer disease
  Element
N00998  Electron transfer in Complex IV
N00999  Mutation-caused aberrant Abeta to electron transfer in Complex IV
Disease
H00920  Exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    84701 (COX4I2)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    84701 (COX4I2)
  09159 Environmental adaptation
   04714 Thermogenesis
    84701 (COX4I2)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    84701 (COX4I2)
   05012 Parkinson disease
    84701 (COX4I2)
   05016 Huntington disease
    84701 (COX4I2)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease (NAFLD)
    84701 (COX4I2)
SSDB
Motif
Pfam: COX4
Other DBs
NCBI-GeneID: 84701
NCBI-ProteinID: NP_115998
OMIM: 607976
HGNC: 16232
Ensembl: ENSG00000131055
Vega: OTTHUMG00000032180
Pharos: Q96KJ9(Tbio)
UniProt: Q96KJ9 H6SG14
Position
20q11.21
AA seq 171 aa
MLPRAAWSLVLRKGGGGRRGMHSSEGTTRGGGKMSPYTNCYAQRYYPMPEEPFCTELNAE
EQALKEKEKGSWTQLTHAEKVALYRLQFNETFAEMNRRSNEWKTVMGCVFFFIGFAALVI
WWQRVYVFPPKPITLTDERKAQQLQRMLDMKVNPVQGLASRWDYEKKQWKK
NT seq 516 nt   +upstreamnt  +downstreamnt
atgctccccagagctgcctggagcttggtgctgaggaaaggtggaggtggaagacgaggg
atgcacagctcagaaggcaccacccgtggtggggggaagatgtccccctacaccaactgc
tatgcccagcgctactaccccatgccagaagagcccttctgcacagaactcaacgctgag
gagcaggccctgaaggagaaggagaagggaagctggacccagctgacccacgccgaaaag
gtggccttgtaccggctccagttcaatgagacctttgcggagatgaaccgtcgctccaat
gagtggaagacagtgatgggttgtgtcttcttcttcattggattcgcagctctggtgatt
tggtggcagcgggtctacgtatttcctccaaagccgatcaccttgacggacgagcggaaa
gcccagcagctgcagcgcatgctggacatgaaggtgaatcctgtgcagggcctggcctcc
cgctgggactatgagaagaagcagtggaagaagtga

KEGG   Homo sapiens (human): 9167
Entry
9167              CDS       T01001                                 

Gene name
COX7A2L, COX7AR, COX7RP, EB1, SIG81
Definition
(RefSeq) cytochrome c oxidase subunit 7A2 like
  KO
K02270  cytochrome c oxidase subunit 7a
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04260  Cardiac muscle contraction
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease (NAFLD)
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05016  Huntington disease
Module
hsa_M00154  Cytochrome c oxidase
Network
nt06418  Oxidative phosphorylation
nt06460  Alzheimer disease
  Element
N00998  Electron transfer in Complex IV
N00999  Mutation-caused aberrant Abeta to electron transfer in Complex IV
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    9167 (COX7A2L)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    9167 (COX7A2L)
  09159 Environmental adaptation
   04714 Thermogenesis
    9167 (COX7A2L)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    9167 (COX7A2L)
   05012 Parkinson disease
    9167 (COX7A2L)
   05016 Huntington disease
    9167 (COX7A2L)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease (NAFLD)
    9167 (COX7A2L)
SSDB
Motif
Pfam: COX7a
Other DBs
NCBI-GeneID: 9167
NCBI-ProteinID: NP_001305965
OMIM: 605771
HGNC: 2289
Ensembl: ENSG00000115944
Vega: OTTHUMG00000128605
Pharos: O14548(Tdark)
UniProt: O14548 Q6FGA0
Position
2p21
AA seq 114 aa
MYYKFSGFTQKLAGAWASEAYSPQGLKPVVSTEAPPIIFATPTKLTSDSTVYDYAGKNKV
PELQKFFQKADGVPVYLKRGLPDQMLYRTTMALTVGGTIYCLIALYMASQPKNK
NT seq 345 nt   +upstreamnt  +downstreamnt
atgtactacaagtttagtggcttcacgcagaagttggcaggagcatgggcttcggaggcc
tatagcccgcagggattaaagcctgtggtttccacagaagcaccacctatcatatttgcc
acaccaactaaactgacctccgattccacagtgtatgattatgctgggaaaaacaaagtt
ccagagctacaaaagtttttccagaaagctgatggtgtgcccgtctacctgaaacgaggc
ctgcctgaccaaatgctttaccggaccaccatggcgctgactgtgggagggaccatctac
tgcctgatcgccctctacatggcttcgcagcccaaaaacaaatga

KEGG   Homo sapiens (human): 9377
Entry
9377              CDS       T01001                                 

Gene name
COX5A, COX, COX-VA, VA
Definition
(RefSeq) cytochrome c oxidase subunit 5A
  KO
K02264  cytochrome c oxidase subunit 5a
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04260  Cardiac muscle contraction
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease (NAFLD)
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05016  Huntington disease
Module
hsa_M00154  Cytochrome c oxidase
Network
nt06418  Oxidative phosphorylation
nt06460  Alzheimer disease
  Element
N00998  Electron transfer in Complex IV
N00999  Mutation-caused aberrant Abeta to electron transfer in Complex IV
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    9377 (COX5A)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    9377 (COX5A)
  09159 Environmental adaptation
   04714 Thermogenesis
    9377 (COX5A)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    9377 (COX5A)
   05012 Parkinson disease
    9377 (COX5A)
   05016 Huntington disease
    9377 (COX5A)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease (NAFLD)
    9377 (COX5A)
SSDB
Motif
Pfam: COX5A
Other DBs
NCBI-GeneID: 9377
NCBI-ProteinID: NP_004246
OMIM: 603773
HGNC: 2267
Ensembl: ENSG00000178741
Vega: OTTHUMG00000142825
Pharos: P20674(Tbio)
UniProt: P20674
Structure
PDB: 
5Z62

Position
15q24.2
AA seq 150 aa
MLGAALRRCAVAATTRADPRGLLHSARTPGPAVAIQSVRCYSHGSQETDEEFDARWVTYF
NKPDIDAWELRKGINTLVTYDMVPEPKIIDAALRACRRLNDFASTVRILEVVKDKAGPHK
EIYPYVIQELRPTLNELGISTPEELGLDKV
NT seq 453 nt   +upstreamnt  +downstreamnt
atgctgggcgccgctctccgccgctgcgctgtggccgcaaccacccgggccgaccctcga
ggcctcctgcactccgcccggacccccggccccgccgtggctatccagtcagttcgctgc
tattcccatgggtcacaggagacagatgaggagtttgatgctcgctgggtaacatacttc
aacaagccagatatagatgcctgggaattgcgtaaagggataaacacacttgttacctat
gatatggttccagagcccaaaatcattgatgctgctttgcgggcatgcagacggttaaat
gattttgctagtacagttcgtatcctagaggttgttaaggacaaagcaggacctcataag
gaaatctacccctatgtcatccaggaacttagaccaactttaaatgaactgggaatctcc
actccggaggaactgggccttgacaaagtgtaa

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