KEGG   Homo sapiens (human): 126Help
Entry
126               CDS       T01001                                 

Gene name
ADH1C, ADH3
Definition
(RefSeq) alcohol dehydrogenase 1C (class I), gamma polypeptide
  KO
K13951  alcohol dehydrogenase 1/7 [EC:1.1.1.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00010  Glycolysis / Gluconeogenesis
hsa00071  Fatty acid degradation
hsa00350  Tyrosine metabolism
hsa00830  Retinol metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa01100  Metabolic pathways
hsa05204  Chemical carcinogenesis
Disease
H01611  Alcohol dependence
Drug target
Fomepizole: D00707
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    126 (ADH1C)
  09103 Lipid metabolism
   00071 Fatty acid degradation
    126 (ADH1C)
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    126 (ADH1C)
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    126 (ADH1C)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    126 (ADH1C)
   00982 Drug metabolism - cytochrome P450
    126 (ADH1C)
 09160 Human Diseases
  09161 Cancers: Overview
   05204 Chemical carcinogenesis
    126 (ADH1C)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.1  alcohol dehydrogenase
     126 (ADH1C)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: ADH_N ADH_zinc_N Glu_dehyd_C UDPG_MGDP_dh_N ADH_zinc_N_2 2-Hacid_dh_C TrkA_N
Motif
Other DBs
NCBI-GeneID: 126
NCBI-ProteinID: NP_000660
OMIM: 103730
HGNC: 251
Ensembl: ENSG00000248144
Vega: OTTHUMG00000161422
Pharos: P00326(Tclin)
UniProt: P00326
Structure
PDB: 

Position
4q23
AA seq 375 aa AA seqDB search
MSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAAGICRSDEHVVSGNLVT
PLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRICKNPESNYCLKNDLGNP
RGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTG
YGSAVKVAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATE
CINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQ
NLSINPMLLLTGRTWKGAIFGGFKSKESVPKLVADFMAKKFSLDALITNILPFEKINEGF
DLLRSGKSIRTVLTF
NT seq 1128 nt NT seq  +upstreamnt  +downstreamnt
atgagcacagcaggaaaagtaatcaaatgcaaagcagctgtgctatgggagttaaagaaa
cccttttccattgaggaggtagaggttgcacctcctaaggctcatgaagttcgcattaag
atggtggctgcaggaatctgtcgttcagatgagcatgtggttagtggcaacctggtgacc
ccccttcctgtgattttaggccatgaggcagccggcatcgtggaaagtgttggagaaggg
gtgactacagtcaaaccaggtgataaagtcatcccgctctttactcctcagtgtggaaaa
tgcagaatttgtaaaaacccagaaagcaactactgcttgaaaaatgatctaggcaatcct
cgggggaccctgcaggatggcaccaggaggttcacctgcagcgggaagcccatccaccac
ttcgtcggcgtcagcaccttctcccagtacacagtggtggatgagaatgcagtggccaaa
attgatgcagcctcgcccctggagaaagtctgcctcattggctgtggattttcgactggt
tatgggtctgcagtcaaagttgccaaggtcaccccagggtctacctgtgctgtgtttggc
ctgggaggggtcggcctatctgttgttatgggctgtaaagcagctggagcagccagaatc
attgctgtggacatcaacaaggacaaatttgcaaaggctaaagagttgggtgccactgaa
tgcatcaaccctcaagactacaagaaacccattcaggaagtgctaaaggaaatgactgat
ggaggtgtggatttttcgtttgaagtcatcggtcggcttgacaccatgatggcttccctg
ttatgttgtcatgaggcatgtggcacaagtgtcattgtaggggtacctcctgattcccag
aacctctcaataaaccctatgctgctactgactggacgcacgtggaaaggagctattttt
ggaggctttaagagtaaagaatctgtccccaaacttgtggctgactttatggctaagaag
ttttcactggatgcattaataacaaatattttaccttttgaaaaaataaatgaaggattt
gacctgcttcgctctggaaagagtatccgtaccgtcctgacgttttga

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