KEGG   Homo sapiens (human): 1268
Entry
1268              CDS       T01001                                 

Gene name
CNR1, CANN6, CB-R, CB1, CB1A, CB1K5, CB1R, CNR
Definition
(RefSeq) cannabinoid receptor 1
  KO
K04277  cannabinoid receptor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04015  Rap1 signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04714  Thermogenesis
hsa04723  Retrograde endocannabinoid signaling
Drug target
Cannabidiol: D10915<US>
Dronabinol: D00306<US>
Ibipinabant: D09349
Levonantradol hydrochloride: D04717
Nabilone: D05099<US>
Nantradol hydrochloride: D05117
Nimacimab: D11435
Otenabant (DG01351): D09362 D09363
Rimonabant: D05731
Taranabant: D09009
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    1268 (CNR1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1268 (CNR1)
 09150 Organismal Systems
  09156 Nervous system
   04723 Retrograde endocannabinoid signaling
    1268 (CNR1)
  09159 Environmental adaptation
   04714 Thermogenesis
    1268 (CNR1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    1268 (CNR1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Others
   Cannabinoid
    1268 (CNR1)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srx YlaC
Other DBs
NCBI-GeneID: 1268
NCBI-ProteinID: NP_001153698
OMIM: 114610
HGNC: 2159
Ensembl: ENSG00000118432
Vega: OTTHUMG00000015184
Pharos: P21554(Tclin)
UniProt: P21554 S5TLS4
Structure
PDB: 
6N4B 2KOE

Position
6q15
AA seq 472 aa
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
NT seq 1419 nt   +upstreamnt  +downstreamnt
atgaagtcgatcctagatggccttgcagataccaccttccgcaccatcaccactgacctc
ctgtacgtgggctcaaatgacattcagtacgaagacatcaaaggtgacatggcatccaaa
ttagggtacttcccacagaaattccctttaacttcctttaggggaagtcccttccaagag
aagatgactgcgggagacaacccccagctagtcccagcagaccaggtgaacattacagaa
ttttacaacaagtctctctcgtccttcaaggagaatgaggagaacatccagtgtggggag
aacttcatggacatagagtgtttcatggtcctgaaccccagccagcagctggccattgca
gtcctgtccctcacgctgggcaccttcacggtcctggagaacctcctggtgctgtgcgtc
atcctccactcccgcagcctccgctgcaggccttcctaccacttcatcggcagcctggcg
gtggcagacctcctggggagtgtcatttttgtctacagcttcattgacttccacgtgttc
caccgcaaagatagccgcaacgtgtttctgttcaaactgggtggggtcacggcctccttc
actgcctccgtgggcagcctgttcctcacagccatcgacaggtacatatccattcacagg
cccctggcctataagaggattgtcaccaggcccaaggccgtggtggcgttttgcctgatg
tggaccatagccattgtgatcgccgtgctgcctctcctgggctggaactgcgagaaactg
caatctgtttgctcagacattttcccacacattgatgaaacctacctgatgttctggatc
ggggtcaccagcgtactgcttctgttcatcgtgtatgcgtacatgtatattctctggaag
gctcacagccacgccgtccgcatgattcagcgtggcacccagaagagcatcatcatccac
acgtctgaggatgggaaggtacaggtgacccggccagaccaagcccgcatggacattagg
ttagccaagaccctggtcctgatcctggtggtgttgatcatctgctggggccctctgctt
gcaatcatggtgtatgatgtctttgggaagatgaacaagctcattaagacggtgtttgca
ttctgcagtatgctctgcctgctgaactccaccgtgaaccccatcatctatgctctgagg
agtaaggacctgcgacacgctttccggagcatgtttccctcttgtgaaggcactgcgcag
cctctggataacagcatgggggactcggactgcctgcacaaacacgcaaacaatgcagcc
agtgttcacagggccgcagaaagctgcatcaagagcacggtcaagattgccaaggtaacc
atgtctgtgtccacagacacgtctgccgaggctctgtga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (4)   
Disease (1)   
   OMIM (1)   
Drug (11)   
   KEGG DRUG (11)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (16)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (13)   
DNA sequence (60)   
   RefSeq(nuc) (14)   
   GenBank (23)   
   EMBL (23)   
Protein domain (5)   
   Pfam (5)   
All databases (115)   

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