KEGG   Homo sapiens (human): 1312
Entry
1312              CDS       T01001                                 
Symbol
COMT, HEL-S-98n
Name
(RefSeq) catechol-O-methyltransferase
  KO
K00545  catechol O-methyltransferase [EC:2.1.1.6]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00140  Steroid hormone biosynthesis
hsa00350  Tyrosine metabolism
hsa01100  Metabolic pathways
hsa04728  Dopaminergic synapse
Network
nt06544  Neuroactive ligand signaling
  Element
N01918  Dopamine metabolism in astrocyte
N01919  Dopamine/Adrenaline metabolism in presynaptic neuron
Disease
H01649  Schizophrenia
Drug target
Entacapone: D00781<JP/US>
Flopropione: D01259<JP>
Nitecapone: D03241
Opicapone: D10825<JP/US>
Phloroglucinol (DG00050): D00152 D08369
Tolcapone: D00786<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    1312 (COMT)
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    1312 (COMT)
 09150 Organismal Systems
  09156 Nervous system
   04728 Dopaminergic synapse
    1312 (COMT)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   03037 Cilium and associated proteins [BR:hsa03037]
    1312 (COMT)
   04147 Exosome [BR:hsa04147]
    1312 (COMT)
Enzymes [BR:hsa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.6  catechol O-methyltransferase
     1312 (COMT)
Cilium and associated proteins [BR:hsa03037]
 Other cilia and associated proteins
  Stereociliary proteins
   1312 (COMT)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of breast cancer cells
   1312 (COMT)
SSDB
Motif
Pfam: Methyltransf_3 Methyltransf_24 Methyltransf_15 RMNT_CmcI PCMT Methyltransf_31
Other DBs
NCBI-GeneID: 1312
NCBI-ProteinID: NP_000745
OMIM: 116790
HGNC: 2228
Ensembl: ENSG00000093010
UniProt: P21964 A0A140VJG8
Structure
Position
22:19941772..19969975
AA seq 271 aa
MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRIL
NHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCG
YSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKY
DVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFE
CTHYQSFLEYREVVDGLEKAIYKGPGSEAGP
NT seq 816 nt   +upstreamnt  +downstreamnt
atgccggaggccccgcctctgctgttggcagctgtgttgctgggcctggtgctgctggtg
gtgctgctgctgcttctgaggcactggggctggggcctgtgccttatcggctggaacgag
ttcatcctgcagcccatccacaacctgctcatgggtgacaccaaggagcagcgcatcctg
aaccacgtgctgcagcatgcggagcccgggaacgcacagagcgtgctggaggccattgac
acctactgcgagcagaaggagtgggccatgaacgtgggcgacaagaaaggcaagatcgtg
gacgccgtgattcaggagcaccagccctccgtgctgctggagctgggggcctactgtggc
tactcagctgtgcgcatggcccgcctgctgtcaccaggggcgaggctcatcaccatcgag
atcaaccccgactgtgccgccatcacccagcggatggtggatttcgctggcgtgaaggac
aaggtcacccttgtggttggagcgtcccaggacatcatcccccagctgaagaagaagtat
gatgtggacacactggacatggtcttcctcgaccactggaaggaccggtacctgccggac
acgcttctcttggaggaatgtggcctgctgcggaaggggacagtgctactggctgacaac
gtgatctgcccaggtgcgccagacttcctagcacacgtgcgcgggagcagctgctttgag
tgcacacactaccaatcgttcctggaatacagggaggtggtggacggcctggagaaggcc
atctacaagggcccaggcagcgaagcagggccctga

  All links  
Disease (3)   
   OMIM (3)   
Gene (41)   
   RefGene (20)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (16)   
   OC (1)   
Protein sequence (8)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (63)   
   RefSeq(nuc) (5)   
   GenBank (29)   
   EMBL (29)   
3D Structure (12)   
   PDB (12)   
Protein domain (6)   
   Pfam (6)   
All databases (133)   

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