KEGG T01001: 134

Homo sapiens (human): 134

Entry

134               CDS       T01001

Symbol

ADORA1, RDC7

Name

(RefSeq) adenosine A1 receptor

K04265

adenosine receptor A1

Organism

hsa Homo sapiens (human)

Pathway

hsa04022

cGMP-PKG signaling pathway

hsa04024

cAMP signaling pathway

hsa04071

Sphingolipid signaling pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04923

Regulation of lipolysis in adipocytes

hsa04924

Renin secretion

hsa05032

Morphine addiction

Drug target

Adenosine (DG00243):

D00045<JP/US> D02300<JP> D02769 D08646 D08647

Aminophylline (DG01062):

D00227 D05429<JP> D11630<US>

Apaxifylline:

D02964

Bamifylline (DG01064):

D03051 D07491

Caffeine (DG00974):

D00528<JP> D01453<JP> D07603<US>

Choline theophyllinate:

D02017

Diprophylline:

D00691<JP>

Enprofylline:

D04006

Naxifylline:

D05125

Proxyphylline:

D01771<JP>

Rolofylline:

D08989

Selodenoson:

D05818

Tecadenoson:

D06019

Theophylline (DG01061):

D00371<JP/US> D01712 D06103 D06104

Tonapofylline:

D09684

Trabodenoson:

D10493

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04071 Sphingolipid signaling pathway
    134 (ADORA1)
   04024 cAMP signaling pathway
    134 (ADORA1)
   04022 cGMP-PKG signaling pathway
    134 (ADORA1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    134 (ADORA1)
09150 Organismal Systems
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    134 (ADORA1)
   04924 Renin secretion
    134 (ADORA1)
09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    134 (ADORA1)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    134 (ADORA1)
G protein-coupled receptors [BR:hsa04030]
Rhodopsin family
  Base and nucleoside
   Adenosine
    134 (ADORA1)

SSDB

Motif

Pfam:

7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srx

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Pharos:

P30542(Tclin)

UniProt:

P30542

Structure

Position

1:203127726..203167405

AA seq 326 aa
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVT
PRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPAPPIDEDLPEERPDD

NT seq 981 nt +upstreamnt +downstreamnt
atgccgccctccatctcagctttccaggccgcctacatcggcatcgaggtgctcatcgcc
ctggtctctgtgcccgggaacgtgctggtgatctgggcggtgaaggtgaaccaggcgctg
cgggatgccaccttctgcttcatcgtgtcgctggcggtggctgatgtggccgtgggtgcc
ctggtcatccccctcgccatcctcatcaacattgggccacagacctacttccacacctgc
ctcatggttgcctgtccggtcctcatcctcacccagagctccatcctggccctgctggca
attgctgtggaccgctacctccgggtcaagatccctctccggtacaagatggtggtgacc
ccccggagggcggcggtggccatagccggctgctggatcctctccttcgtggtgggactg
acccctatgtttggctggaacaatctgagtgcggtggagcgggcctgggcagccaacggc
agcatgggggagcccgtgatcaagtgcgagttcgagaaggtcatcagcatggagtacatg
gtctacttcaacttctttgtgtgggtgctgcccccgcttctcctcatggtcctcatctac
ctggaggtcttctacctaatccgcaagcagctcaacaagaaggtgtcggcctcctccggc
gacccgcagaagtactatgggaaggagctgaagatcgccaagtcgctggccctcatcctc
ttcctctttgccctcagctggctgcctttgcacatcctcaactgcatcaccctcttctgc
ccgtcctgccacaagcccagcatccttacctacattgccatcttcctcacgcacggcaac
tcggccatgaaccccattgtctatgccttccgcatccagaagttccgcgtcaccttcctt
aagatttggaatgaccatttccgctgccagcctgcacctcccattgacgaggatctccca
gaagagaggcctgatgactag

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