KEGG   Homo sapiens (human): 1351
Entry
1351              CDS       T01001                                 
Symbol
COX8A, COX, COX8, COX8-2, COX8L, MC4DN15, VIII, VIII-L
Name
(RefSeq) cytochrome c oxidase subunit 8A
  KO
K02273  cytochrome c oxidase subunit 8
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04260  Cardiac muscle contraction
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05415  Diabetic cardiomyopathy
Module
hsa_M00154  Cytochrome c oxidase
Network
nt06252  Mitochondrial ROS formation (cancer)
nt06460  Alzheimer disease
nt06466  Pathways of neurodegeneration
nt06529  Thermogenesis
  Element
N00998  Electron transfer in Complex IV
N00999  Mutation-caused aberrant Abeta to electron transfer in Complex IV
N01394  Arsenic to electron transfer in complex IV
N01691  mitochondrial complex - UCP1 in Thermogenesis
Disease
H01368  Cytochrome c oxidase (COX) deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    1351 (COX8A)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    1351 (COX8A)
  09159 Environmental adaptation
   04714 Thermogenesis
    1351 (COX8A)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    1351 (COX8A)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    1351 (COX8A)
   05012 Parkinson disease
    1351 (COX8A)
   05014 Amyotrophic lateral sclerosis
    1351 (COX8A)
   05016 Huntington disease
    1351 (COX8A)
   05020 Prion disease
    1351 (COX8A)
   05022 Pathways of neurodegeneration - multiple diseases
    1351 (COX8A)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    1351 (COX8A)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    1351 (COX8A)
SSDB
Motif
Pfam: COX8
Other DBs
NCBI-GeneID: 1351
NCBI-ProteinID: NP_004065
OMIM: 123870
HGNC: 2294
Ensembl: ENSG00000176340
UniProt: P10176 Q53XN1
Structure
Position
11:63974620..63976543
AA seq 69 aa
MSVLTPLLLRGLTGSARRLPVPRAKIHSLPPEGKLGIMELAVGLTSCFVTFLLPAGWILS
HLETYRRPE
NT seq 210 nt   +upstreamnt  +downstreamnt
atgtccgtcctgacgccgctgctgctgcggggcttgacaggctcggcccggcggctccca
gtgccgcgcgccaagatccattcgttgccgccggaggggaagcttgggatcatggaattg
gccgttgggcttacctcctgcttcgtgaccttcctcctgccagcgggctggatcctgtca
cacctggagacctacaggaggccagagtga

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (14)   
   KEGG PATHWAY (13)   
   KEGG MODULE (1)   
Network (8)   
   KEGG NETWORK (8)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (38)   
   KEGG ORTHOLOGY (1)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (31)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (9)   
   RefSeq(nuc) (1)   
   GenBank (4)   
   EMBL (4)   
3D Structure (2)   
   PDB (2)   
Protein domain (1)   
   Pfam (1)   
All databases (81)   

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