KEGG   Homo sapiens (human): 1385
Entry
1385              CDS       T01001                                 

Symbol
CREB1, CREB, CREB-1
Name
(RefSeq) cAMP responsive element binding protein 1
  KO
K05870  cyclic AMP-responsive element-binding protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04211  Longevity regulating pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04380  Osteoclast differentiation
hsa04612  Antigen processing and presentation
hsa04668  TNF signaling pathway
hsa04710  Circadian rhythm
hsa04713  Circadian entrainment
hsa04714  Thermogenesis
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04911  Insulin secretion
hsa04915  Estrogen signaling pathway
hsa04916  Melanogenesis
hsa04918  Thyroid hormone synthesis
hsa04922  Glucagon signaling pathway
hsa04924  Renin secretion
hsa04925  Aldosterone synthesis and secretion
hsa04926  Relaxin signaling pathway
hsa04927  Cortisol synthesis and secretion
hsa04928  Parathyroid hormone synthesis, secretion and action
hsa04931  Insulin resistance
hsa04934  Cushing syndrome
hsa04935  Growth hormone synthesis, secretion and action
hsa04962  Vasopressin-regulated water reabsorption
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
hsa05152  Tuberculosis
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05203  Viral carcinogenesis
hsa05207  Chemical carcinogenesis - receptor activation
hsa05215  Prostate cancer
Network
nt06123  TNF signaling (viruses and bacteria)
nt06124  Chemokine signaling (viruses)
nt06140  Transcription (viruses)
nt06150  Cytokine-cytokine receptor interaction (viruses)
nt06161  Human immunodeficiency virus type 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06167  Human cytomegalovirus (HCMV)
nt06210  ERK signaling
nt06234  cAMP signaling
nt06263  Hepatocellular carcinoma
nt06310  CRH-ACTH-cortisol signaling
nt06316  Angiotensin-aldosterone signaling
nt06322  TRH-TSH-TH signaling
nt06324  GHRH-GH-IGF signaling
nt06360  Cushing syndrome
nt06415  PI3K signaling
nt06440  Transcription
nt06461  Huntington disease
nt06465  Prion disease
  Element
N00297  ACTH-cortisol signaling pathway
N00298  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway
N00301  Angiotensin-aldosterone signaling pathway
N00302  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway
N00303  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway
N00304  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
N00305  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway
N00320  Mutation-activated PRKACA to ACTH-cortisol signaling pathway
N00321  Mutation-activated GNAS to ACTH-cortisol signaling pathway
N00322  Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway
N00323  Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway
N00324  CRHR-PKA-ACTH signaling pathway
N00325  Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway
N00326  Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway
N00327  Mutation-inactivated PRKAR1A to CRHR-PKA-ACTH signaling pathway
N00409  HCMV UL33 to GNB/G-Rho signaling pathway
N00410  DRD1-GNAS-AC-PKA signaling pathway
N00411  HCMV UL33 to GNAS-AC-PKA signaling pathway
N00412  HCMV UL33 to GNAI-AC-PKA signaling pathway
N00444  TNF-p38 signaling pathway
N00544  HBV HBx to CREB-mediated transcription
N00782  TSH-TG signaling pathway
N00783  Mutation-inactivated TSH to TSH-TG signaling pathway
N00784  Mutation-inactivated TSHR to TSH-TG signaling pathway
N00797  Mutation-activated TSHR to TSH-TG signaling pathway
N00910  GHRHR-PKA-GH signaling pathway
N00912  Mutation-activated GNAS to GHRHR-PKA-GH signaling pathway
N00981  Mutation-caused aberrant Htt to CREB-mediated transcription
N01204  PRNP-PI3K-NOX2 signaling pathway
N01343  ACH-CHRN-RAS-ERK signaling pathway
N01351  E2-ER-RAS-ERK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    1385 (CREB1)
   04024 cAMP signaling pathway
    1385 (CREB1)
   04022 cGMP-PKG signaling pathway
    1385 (CREB1)
   04151 PI3K-Akt signaling pathway
    1385 (CREB1)
   04152 AMPK signaling pathway
    1385 (CREB1)
 09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    1385 (CREB1)
  09152 Endocrine system
   04911 Insulin secretion
    1385 (CREB1)
   04922 Glucagon signaling pathway
    1385 (CREB1)
   04915 Estrogen signaling pathway
    1385 (CREB1)
   04926 Relaxin signaling pathway
    1385 (CREB1)
   04935 Growth hormone synthesis, secretion and action
    1385 (CREB1)
   04918 Thyroid hormone synthesis
    1385 (CREB1)
   04928 Parathyroid hormone synthesis, secretion and action
    1385 (CREB1)
   04916 Melanogenesis
    1385 (CREB1)
   04924 Renin secretion
    1385 (CREB1)
   04925 Aldosterone synthesis and secretion
    1385 (CREB1)
   04927 Cortisol synthesis and secretion
    1385 (CREB1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    1385 (CREB1)
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    1385 (CREB1)
  09156 Nervous system
   04725 Cholinergic synapse
    1385 (CREB1)
   04728 Dopaminergic synapse
    1385 (CREB1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    1385 (CREB1)
  09149 Aging
   04211 Longevity regulating pathway
    1385 (CREB1)
  09159 Environmental adaptation
   04710 Circadian rhythm
    1385 (CREB1)
   04713 Circadian entrainment
    1385 (CREB1)
   04714 Thermogenesis
    1385 (CREB1)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    1385 (CREB1)
   05203 Viral carcinogenesis
    1385 (CREB1)
  09162 Cancer: specific types
   05215 Prostate cancer
    1385 (CREB1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    1385 (CREB1)
   05161 Hepatitis B
    1385 (CREB1)
   05163 Human cytomegalovirus infection
    1385 (CREB1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    1385 (CREB1)
   05165 Human papillomavirus infection
    1385 (CREB1)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    1385 (CREB1)
  09164 Neurodegenerative disease
   05016 Huntington disease
    1385 (CREB1)
   05020 Prion disease
    1385 (CREB1)
  09165 Substance dependence
   05030 Cocaine addiction
    1385 (CREB1)
   05031 Amphetamine addiction
    1385 (CREB1)
   05034 Alcoholism
    1385 (CREB1)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    1385 (CREB1)
   04934 Cushing syndrome
    1385 (CREB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    1385 (CREB1)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    1385 (CREB1)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   CREB
    1385 (CREB1)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Ubiquitas transcription factors
    1385 (CREB1)
SSDB
Motif
Pfam: pKID bZIP_1 bZIP_2 bZIP_Maf
Other DBs
NCBI-GeneID: 1385
NCBI-ProteinID: NP_004370
OMIM: 123810
HGNC: 2345
Ensembl: ENSG00000118260
Vega: OTTHUMG00000132936
Pharos: P16220(Tbio)
UniProt: P16220 Q53X93
Structure
PDB: 
5ZKO 5ZK1 2LXT

Position
2q33.3
AA seq 327 aa
MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPN
GQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSY
RKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLA
NNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQI
RTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENR
VAVLENQNKTLIEELKALKDLYCHKSD
NT seq 984 nt   +upstreamnt  +downstreamnt
atgaccatggaatctggagccgagaaccagcagagtggagatgcagctgtaacagaagct
gaaaaccaacaaatgacagttcaagcccagccacagattgccacattagcccaggtatct
atgccagcagctcatgcaacatcatctgctcccaccgtaactctagtacagctgcccaat
gggcagacagttcaagtccatggagtcattcaggcggcccagccatcagttattcagtct
ccacaagtccaaacagttcagatttcaactattgcagaaagtgaagattcacaggagtca
gtggatagtgtaactgattcccaaaagcgaagggaaattctttcaaggaggccttcctac
aggaaaattttgaatgacttatcttctgatgcaccaggagtgccaaggattgaagaagag
aagtctgaagaggagacttcagcacctgccatcaccactgtaacggtgccaactccaatt
taccaaactagcagtggacagtatattgccattacccagggaggagcaatacagctggct
aacaatggtaccgatggggtacagggcctgcaaacattaaccatgaccaatgcagcagcc
actcagccgggtactaccattctacagtatgcacagaccactgatggacagcagatctta
gtgcccagcaaccaagttgttgttcaagctgcctctggagacgtacaaacataccagatt
cgcacagcacccactagcactattgcccctggagttgttatggcatcctccccagcactt
cctacacagcctgctgaagaagcagcacgaaagagagaggtccgtctaatgaagaacagg
gaagcagctcgagagtgtcgtagaaagaagaaagaatatgtgaaatgtttagaaaacaga
gtggcagtgcttgaaaatcaaaacaagacattgattgaggagctaaaagcacttaaggac
ctttactgccacaaatcagattaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (42)   
   KEGG PATHWAY (42)   
Network (31)   
   KEGG NETWORK (31)   
Disease (2)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG ORTHOLOGY (1)   
   RefGene (14)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (14)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (11)   
DNA sequence (64)   
   RefSeq(nuc) (18)   
   GenBank (23)   
   EMBL (23)   
Protein domain (4)   
   Pfam (4)   
All databases (188)   

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