KEGG T01001: 146

Homo sapiens (human): 146

Entry

146               CDS       T01001

Symbol

ADRA1D, ADRA1, ADRA1A, ADRA1R, ALPHA1, DAR, dJ779E11.2

Name

(RefSeq) adrenoceptor alpha 1D

K04137

adrenergic receptor alpha-1D

Organism

hsa Homo sapiens (human)

Pathway

hsa04020

Calcium signaling pathway

hsa04022

cGMP-PKG signaling pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04081

Hormone signaling

hsa04261

Adrenergic signaling in cardiomyocytes

hsa04270

Vascular smooth muscle contraction

hsa04970

Salivary secretion

Network

nt06528 Calcium signaling

Element

N01640

GPCR-PLCB-ITPR signaling pathway

Drug target

Adrenalone (DG00016):

D02774 D07560

Amidephrine mesylate:

D02901

Amiodarone (DG00204):

D00636<JP/US> D02910

Amosulalol (DG01302):

D01469<JP> D07451

Arotinolol (DG01303):

D01830<JP> D07465

Bevantolol:

D01369<JP>

Bunazosin (DG01316):

D01887<JP> D07550

Bunitrolol hydrochloride:

D01444

Carvedilol (DG00321):

D00255<JP/US> D03415<US>

Dapiprazole (DG01140):

D03648<US> D07775

Dibutepinephrine (DG03315):

D12934 D12935

Dihydroergocristine (DG00284):

D07833 D07834

Dipivefrine (DG01129):

D01017 D02349

Domazoline fumarate:

D03887

Doxazosin (DG00256):

D00608<JP/US> D07874

Dronedarone (DG00207):

D02537 D03914<US>

Droperidol:

D00308<JP/US>

Droxidopa:

D01277<JP/US>

Ephedrine (DG00227):

D00124 D01386<JP/US> D04018<US>

Epinephrine (DG00013):

D00095<JP/US> D00996 D02149

Epinephryl borate:

D04026

Ergoloid mesylates:

D02268

Ergometrine (DG00446):

D01163 D07905

Ergot alkaloids:

D07906

Ergotamine (DG00834):

D00679<US>

Etilefrine (DG00210):

D01573<JP> D07931

Flesinoxan:

D02568

Guanadrel:

D08029

Guanadrel sulfate:

D00607

Ifenprodil (DG00292):

D01445<JP> D08064

Indoramin (DG00254):

D04531 D04532

Labetalol (DG00320):

D00600<JP/US> D08106

Levobunolol (DG01136):

D01025<JP/US> D08115

Metaraminol (DG00218):

D01019 D08192

Methoxamine (DG00219):

D01020 D08201

Methylephedrine (DG01229):

D01952 D02109<JP> D08206 D09842

Methylergometrine (DG00445):

D00680<JP/US> D08207

Midodrine (DG00224):

D01307<JP/US> D08220

Monatepil maleate:

D01171

Moxisylyte (DG00287):

D01571 D08239

Naftopidil:

D01674<JP>

Naphazoline (DG01032):

D00743 D01021<JP> D08253

Nefazodone (DG00953):

D00819<US> D08257

Nicergoline (DG00283):

D01290<JP> D08271

Nipradilol:

D01691<JP>

Norepinephrine (DG00212):

D00076<JP> D05206<US> D08284 D09794

Norfenefrine (DG00214):

D01405 D08286

Octodrine:

D05228

Olanzapine (DG00898):

D00454<JP/US> D06623<US>

Pelanserin hydrochloride:

D05395

Periciazine:

D01485<JP>

Phenoxybenzamine (DG00285):

D00507<US> D08358

Phentolamine (DG00280):

D00509<JP/US> D08362

Phenylephrine (DG00215):

D00511<JP/US> D08365 D08366 D08966

Phenylpropanolamine (DG01041):

D01224 D05466 D08368

Prazosin (DG00253):

D00609<JP/US> D08411

Propylhexedrine (DG01919):

D05637 D08444

Pseudoephedrine (DG01042):

D00485 D05648 D05649 D08449

Racephedrine hydrochloride:

D08982

Racepinephrine (DG01444):

D05688 D05689

Tamsulosin (DG00490):

D01024<JP/US> D08560

Terazosin (DG00491):

D00610<JP/US> D08569 D11585<US>

Tetryzoline (DG01030):

D00756 D01023 D08578

Tolazoline (DG00281):

D00997 D08614

Tramazoline (DG01033):

D01347<JP> D08624

Trimazosin (DG00255):

D06234 D08212

Urapidil (DG00257):

D01333<JP> D08662

Xylometazoline (DG01031):

D00757 D08684

Zolertine hydrochloride:

D06380

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04022 cGMP-PKG signaling pathway
    146 (ADRA1D)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    146 (ADRA1D)
   04081 Hormone signaling
    146 (ADRA1D)
09150 Organismal Systems
  09154 Digestive system
   04970 Salivary secretion
    146 (ADRA1D)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    146 (ADRA1D)
G protein-coupled receptors [BR:hsa04030]
Rhodopsin family
  Biogenic amine
   Adrenaline
    146 (ADRA1D)

SSDB

Motif

Pfam:

7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7tm_4 7TM_GPCR_Srv

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Position

20:complement(4220630..4249287)

AA seq 572 aa
MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAG
SGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILS
VACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCC
TASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVP
PDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKAS
EVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLC
WFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQ
CRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEM
QAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVE
AVSLGVPHEVAEGATCQAYELADYSNLRETDI

NT seq 1719 nt +upstreamnt +downstreamnt
atgactttccgcgatctcctgagcgtcagtttcgagggaccccgcccggacagcagcgca
gggggctccagcgcgggcggcggcgggggcagcgcgggcggcgcggccccctcggagggc
ccggcggtgggcggcgtgccggggggcgcgggcggcggcggcggcgtggtgggcgcaggc
agcggcgaggacaaccggagctccgcgggggagccggggagcgcgggcgcgggcggcgac
gtgaatggcacggcggccgtcgggggactggtggtgagcgcgcagggcgtgggcgtgggc
gtcttcctggcagccttcatccttatggccgtggcaggtaacctgcttgtcatcctctca
gtggcctgcaaccgccacctgcagaccgtcaccaactatttcatcgtgaacctggccgtg
gccgacctgctgctgagcgccaccgtactgcccttctcggccaccatggaggttctgggc
ttctgggcctttggccgcgccttctgcgacgtatgggccgccgtggacgtgctgtgctgc
acggcctccatcctcagcctctgcaccatctccgtggaccggtacgtgggcgtgcgccac
tcactcaagtacccagccatcatgaccgagcgcaaggcggccgccatcctggccctgctc
tgggtcgtagccctggtggtgtccgtagggcccctgctgggctggaaggagcccgtgccc
cctgacgagcgcttctgcggtatcaccgaggaggcgggctacgctgtcttctcctccgtg
tgctccttctacctgcccatggcggtcatcgtggtcatgtactgccgcgtgtacgtggtc
gcgcgcagcaccacgcgcagcctcgaggcgggcgtcaagcgcgagcgaggcaaggcctcc
gaggtggtgctgcgcatccactgtcgcggcgcggccacgggcgccgacggggcgcacggc
atgcgcagcgccaagggccacaccttccgcagctcgctctccgtgcgcctgctcaagttc
tcccgtgagaagaaagcggccaagactctggccatcgtcgtgggtgtcttcgtgctctgc
tggttccctttcttctttgtcctgccgctcggctccttgttcccgcagctgaagccatcg
gagggcgtcttcaaggtcatcttctggctcggctacttcaacagctgcgtgaacccgctc
atctacccctgttccagccgcgagttcaagcgcgccttcctccgtctcctgcgctgccag
tgccgtcgtcgccggcgccgccgccctctctggcgtgtctacggccaccactggcgggcc
tccaccagcggcctgcgccaggactgcgccccgagttcgggcgacgcgccccccggagcg
ccgctggccctcaccgcgctccccgaccccgaccccgaacccccaggcacgcccgagatg
caggctccggtcgccagccgtcgaaagccacccagcgccttccgcgagtggaggctgctg
gggccgttccggagacccacgacccagctgcgcgccaaagtctccagcctgtcgcacaag
atccgcgccgggggcgcgcagcgcgcagaggcagcgtgcgcccagcgctcagaggtggag
gctgtgtccctaggcgtcccacacgaggtggccgagggcgccacctgccaggcctacgaa
ttggccgactacagcaacctacgggagaccgatatttaa

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