KEGG   Homo sapiens (human): 146
Entry
146               CDS       T01001                                 

Gene name
ADRA1D, ADRA1, ADRA1A, ADRA1R, ALPHA1, DAR, dJ779E11.2
Definition
(RefSeq) adrenoceptor alpha 1D
  KO
K04137  adrenergic receptor alpha-1D
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion
Drug target
Adrenalone (DG00016): D02774 D07560
Amidephrine mesylate: D02901
Amiodarone (DG00204): D00636 D02910
Amosulalol (DG01302): D01469 D07451
Arotinolol (DG01303): D01830 D07465
Bevantolol: D01369
Bunazosin (DG01316): D01887 D07550
Bunitrolol hydrochloride: D01444
Carvedilol (DG00321): D00255 D03415
Dapiprazole (DG01140): D03648 D07775
Dihydroergocristine (DG00284): D07833 D07834
Dipivefrine (DG01129): D01017 D02349
Domazoline fumarate: D03887
Doxazosin (DG00256): D00608 D07874
Dronedarone (DG00207): D02537 D03914
Droperidol: D00308
Droxidopa: D01277
Ephedrine (DG00227): D00124 D01386 D04018
Epinephrine (DG00013): D00095 D00996 D02149
Epinephryl borate: D04026
Ergoloid mesylates: D02268
Ergometrine (DG00446): D01163 D07905
Ergot alkaloids: D07906
Ergotamine (DG00834): D00679
Etilefrine (DG00210): D01573 D07931
Flesinoxan: D02568
Guanadrel: D08029
Guanadrel sulfate: D00607
Ifenprodil (DG00292): D01445 D08064
Indoramin (DG00254): D04531 D04532
Labetalol (DG00320): D00600 D08106
Levobunolol (DG01136): D01025 D08115
Metaraminol (DG00218): D01019 D08192
Methoxamine (DG00219): D01020 D08201
Methylephedrine (DG01229): D01952 D02109 D08206 D09842
Methylergometrine (DG00445): D00680 D08207
Midodrine (DG00224): D01307 D08220
Monatepil maleate: D01171
Moxisylyte (DG00287): D01571 D08239
Naftopidil: D01674
Naphazoline (DG01032): D00743 D01021 D08253
Nefazodone (DG00953): D00819 D08257
Nicergoline (DG00283): D01290 D08271
Nipradilol: D01691
Norepinephrine (DG00212): D00076 D05206 D08284 D09794
Octodrine: D05228
Olanzapine (DG00898): D00454 D06623
Pelanserin hydrochloride: D05395
Periciazine: D01485
Phenoxybenzamine (DG00285): D00507 D08358
Phentolamine (DG00280): D00509 D08362
Phenylephrine (DG00215): D00511 D08365 D08366 D08966
Phenylpropanolamine (DG01041): D01224 D05466 D08368
Prazosin (DG00253): D00609 D08411
Propylhexedrine (DG01919): D05637 D08444
Pseudoephedrine (DG01042): D00485 D05648 D05649 D08449
Racephedrine Hydrochloride: D08982
Racepinephrine (DG01444): D05688 D05689
Tamsulosin (DG00490): D01024 D08560
Terazosin (DG00491): D00610 D08569 D11585
Tetryzoline (DG01030): D00756 D01023 D08578
Tolazoline (DG00281): D00997 D08614
Tramazoline (DG01033): D01347 D08624
Trimazosin (DG00255): D06234 D08212
Urapidil (DG00257): D01333 D08662
Xylometazoline (DG01031): D00757 D08684
Zolertine hydrochloride: D06380
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    146 (ADRA1D)
   04022 cGMP-PKG signaling pathway
    146 (ADRA1D)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    146 (ADRA1D)
 09150 Organismal Systems
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    146 (ADRA1D)
   04270 Vascular smooth muscle contraction
    146 (ADRA1D)
  09154 Digestive system
   04970 Salivary secretion
    146 (ADRA1D)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    146 (ADRA1D)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Adrenaline
    146 (ADRA1D)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7tm_4 7TM_GPCR_Srv
Other DBs
NCBI-GeneID: 146
NCBI-ProteinID: NP_000669
OMIM: 104219
HGNC: 280
Ensembl: ENSG00000171873
Vega: OTTHUMG00000031779
Pharos: P25100(Tclin)
UniProt: P25100 B0ZBE0
Position
20p13
AA seq 572 aa
MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAG
SGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILS
VACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCC
TASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVP
PDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKAS
EVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLC
WFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQ
CRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEM
QAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVE
AVSLGVPHEVAEGATCQAYELADYSNLRETDI
NT seq 1719 nt   +upstreamnt  +downstreamnt
atgactttccgcgatctcctgagcgtcagtttcgagggaccccgcccggacagcagcgca
gggggctccagcgcgggcggcggcgggggcagcgcgggcggcgcggccccctcggagggc
ccggcggtgggcggcgtgccggggggcgcgggcggcggcggcggcgtggtgggcgcaggc
agcggcgaggacaaccggagctccgcgggggagccggggagcgcgggcgcgggcggcgac
gtgaatggcacggcggccgtcgggggactggtggtgagcgcgcagggcgtgggcgtgggc
gtcttcctggcagccttcatccttatggccgtggcaggtaacctgcttgtcatcctctca
gtggcctgcaaccgccacctgcagaccgtcaccaactatttcatcgtgaacctggccgtg
gccgacctgctgctgagcgccaccgtactgcccttctcggccaccatggaggttctgggc
ttctgggcctttggccgcgccttctgcgacgtatgggccgccgtggacgtgctgtgctgc
acggcctccatcctcagcctctgcaccatctccgtggaccggtacgtgggcgtgcgccac
tcactcaagtacccagccatcatgaccgagcgcaaggcggccgccatcctggccctgctc
tgggtcgtagccctggtggtgtccgtagggcccctgctgggctggaaggagcccgtgccc
cctgacgagcgcttctgcggtatcaccgaggaggcgggctacgctgtcttctcctccgtg
tgctccttctacctgcccatggcggtcatcgtggtcatgtactgccgcgtgtacgtggtc
gcgcgcagcaccacgcgcagcctcgaggcgggcgtcaagcgcgagcgaggcaaggcctcc
gaggtggtgctgcgcatccactgtcgcggcgcggccacgggcgccgacggggcgcacggc
atgcgcagcgccaagggccacaccttccgcagctcgctctccgtgcgcctgctcaagttc
tcccgtgagaagaaagcggccaagactctggccatcgtcgtgggtgtcttcgtgctctgc
tggttccctttcttctttgtcctgccgctcggctccttgttcccgcagctgaagccatcg
gagggcgtcttcaaggtcatcttctggctcggctacttcaacagctgcgtgaacccgctc
atctacccctgttccagccgcgagttcaagcgcgccttcctccgtctcctgcgctgccag
tgccgtcgtcgccggcgccgccgccctctctggcgtgtctacggccaccactggcgggcc
tccaccagcggcctgcgccaggactgcgccccgagttcgggcgacgcgccccccggagcg
ccgctggccctcaccgcgctccccgaccccgaccccgaacccccaggcacgcccgagatg
caggctccggtcgccagccgtcgaaagccacccagcgccttccgcgagtggaggctgctg
gggccgttccggagacccacgacccagctgcgcgccaaagtctccagcctgtcgcacaag
atccgcgccgggggcgcgcagcgcgcagaggcagcgtgcgcccagcgctcagaggtggag
gctgtgtccctaggcgtcccacacgaggtggccgagggcgccacctgccaggcctacgaa
ttggccgactacagcaacctacgggagaccgatatttaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (1)   
   OMIM (1)   
Drug (127)   
   KEGG DRUG (127)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   RefGene (14)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (7)   
   RefSeq(nuc) (1)   
   GenBank (3)   
   EMBL (3)   
Protein domain (5)   
   Pfam (5)   
All databases (175)   

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