KEGG   Homo sapiens (human): 146956Help
Entry
146956            CDS       T01001                                 

Gene name
EME1, MMS4L, SLX2A
Definition
(RefSeq) essential meiotic structure-specific endonuclease 1
  KO
K10882  crossover junction endonuclease EME1 [EC:3.1.22.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03440  Homologous recombination
hsa03460  Fanconi anemia pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03440 Homologous recombination
    146956 (EME1)
   03460 Fanconi anemia pathway
    146956 (EME1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    146956 (EME1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.22  Endodeoxyribonucleases producing 3'-phosphomonoesters
    3.1.22.-  
     146956 (EME1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic Type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    Other HR factors
     146956 (EME1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: ERCC4
Motif
Other DBs
NCBI-GeneID: 146956
NCBI-ProteinID: NP_689676
OMIM: 610885
HGNC: 24965
Ensembl: ENSG00000154920
Vega: OTTHUMG00000164974
Pharos: Q96AY2(Tbio)
UniProt: Q96AY2
Structure
PDB: 

Position
17q21.33
AA seq 570 aa AA seqDB search
MALKKSSPSLDSGDSDSEELPTFAFLKKEPSSTKRRQPEREEKIVVVDISDCEASCPPAP
ELFSPPVPEIAETVTQTQPVRLLSSESEDEEEFIPLAQRLTCKFLTHKQLSPEDSSSPVK
SVLDHQNNEGASCDWKKPFPKIPEVPLHDTPERSAADNKDLILDPCCQLPAYLSTCPGQS
SSLAVTKTNSDILPPQKKTKPSQKVQGRGSHGCRQQRQARQKESTLRRQERKNAALVTRM
KAQRPEECLKHIIVVLDPVLLQMEGGGQLLGALQTMECRCVIEAQAVPCSVTWRRRAGPS
EDREDWVEEPTVLVLLRAEAFVSMIDNGKQGSLDSTMKGKETLQGFVTDITAKTAGKALS
LVIVDQEKCFSAQNPPRRGKQGANKQTKKQQQRQPEASIGSMVSRVDAEEALVDLQLHTE
AQAQIVQSWKELADFTCAFTKAVAEAPFKKLRDETTFSFCLESDWAGGVKVDLAGRGLAL
VWRRQIQQLNRVSLEMASAVVNAYPSPQLLVQAYQQCFSDKERQNLLADIQVRRGEGVTS
TSRRIGPELSRRIYLQMTTLQPHLSLDSAD
NT seq 1713 nt NT seq  +upstreamnt  +downstreamnt
atggctctaaagaagtcatcaccctcactggattctggtgatagtgactctgaggagttg
ccaacatttgcctttctgaagaaggaaccatcttcaacaaagaggagacagcctgaaagg
gaagagaagattgtagtggttgacatctcagattgtgaagcctcctgtcctccagcacca
gagttattttcaccacctgtcccagaaatagctgaaactgtcacacaaacacagccagtc
aggttgctaagcagtgaaagtgaagatgaagaagaatttattcctctggctcaaaggctt
acatgtaagtttctgacccacaagcaactgagccctgaggactctagctccccagttaaa
agtgttttggatcatcaaaataatgaaggtgcatcatgtgactggaaaaagccctttcca
aagatccctgaagttcccctccatgataccccagagaggagtgcagcagataacaaggac
ctgatcttagatccatgctgtcagcttccagcctacctgtctacctgccctggccagagc
agcagcttggcagtaaccaaaacaaattctgacatccttccaccccagaagaaaaccaag
ccgagtcagaaggtccagggaagaggctcacacggatgccggcagcagagacaagcaagg
cagaaggaaagcaccctgagaagacaggaaagaaagaatgcagcactggttaccaggatg
aaagcccagaggccagaggaatgcttaaaacacatcattgtagtgctggatccagtgctc
ttacagatggaaggtgggggccagctcctaggagcactgcagaccatggagtgccgctgt
gtgattgaggcgcaggctgtgccttgcagtgtcacttggaggagaagggctgggccgtct
gaggacagagaggactgggtggaggagccaacagtactggtgttgctccgggcagaggca
tttgtgtccatgatcgacaatggaaagcagggaagcctggacagcactatgaaagggaag
gaaacgcttcagggctttgtaactgacatcacagcaaagacagcagggaaagctctgtca
ctggtgattgtggatcaggagaaatgcttcagtgctcagaatcctccaagaagagggaaa
cagggagcaaataaacagaccaagaagcagcagcagagacaaccagaggccagcataggg
tccatggtatccagggtagacgctgaagaggcattggtggatctgcagctacacacagaa
gcccaggctcaaattgtgcagagctggaaagagctggccgacttcacatgcgcattcaca
aaggctgtggctgaggcgcccttcaagaagctccgagatgaaactaccttctccttctgt
ctggagagtgactgggctggaggggtgaaggtggaccttgctggcaggggactcgcacta
gtctggaggagacagattcagcagctgaaccgagtcagcctggaaatggccagtgcagtt
gtgaatgcctatccctccccacagctcctggtacaggcttatcagcagtgtttttcggat
aaagaacgccagaatttgctcgcagacatacaggtgcgccgtggggaaggtgtgacatcc
acttctcgccgcattggaccagaactatccaggcgtatctaccttcagatgaccacttta
cagccacatctctctttagatagtgctgactga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   UniGene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (21)   
   RefSeq(nuc) (7)   
   GenBank (7)   
   EMBL (7)   
Protein domain (1)   
   Pfam (1)   
All databases (58)   

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