KEGG   Homo sapiens (human): 148
Entry
148               CDS       T01001                                 

Gene name
ADRA1A, ADRA1C, ADRA1L1, ALPHA1AAR
Definition
(RefSeq) adrenoceptor alpha 1A
  KO
K04135  adrenergic receptor alpha-1A
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04152  AMPK signaling pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion
Drug target
Adrenalone (DG00016): D02774 D07560
Alfuzosin (DG00489): D01692<US> D07124
Amidephrine mesylate: D02901
Amiodarone (DG00204): D00636<JP/US> D02910
Amosulalol (DG01302): D01469<JP> D07451
Arotinolol (DG01303): D01830<JP> D07465
Bevantolol: D01369<JP>
Bunazosin (DG01316): D01887<JP> D07550
Bunitrolol hydrochloride: D01444
Carvedilol (DG00321): D00255<JP/US> D03415<US>
Dabuzalgron hydrochloride: D06394
Dapiprazole (DG01140): D03648<US> D07775
Dihydroergocristine (DG00284): D07833 D07834
Dipivefrine (DG01129): D01017<JP> D02349
Domazoline fumarate: D03887
Doxazosin (DG00256): D00608<JP/US> D07874
Dronedarone (DG00207): D02537 D03914<US>
Droperidol: D00308<JP/US>
Droxidopa: D01277<JP/US>
Ephedrine (DG00227): D00124 D01386<JP> D04018<US>
Epinephrine (DG00013): D00095<JP/US> D00996 D02149
Epinephryl borate: D04026
Ergoloid mesylates: D02268
Ergometrine (DG00446): D01163<JP> D07905
Ergot alkaloids: D07906
Ergotamine (DG00834): D00679<US>
Etilefrine (DG00210): D01573<JP> D07931
Fiduxosin hydrochloride: D04184
Flesinoxan: D02568
Garomefrine hydrochloride: D09784
Guanadrel: D08029
Guanadrel sulfate: D00607
Ifenprodil (DG00292): D01445<JP> D08064
Indoramin (DG00254): D04531 D04532
Isometheptene: D07097
Labetalol (DG00320): D00600<JP/US> D08106<US>
Levobunolol (DG01136): D01025<JP/US> D08115
Metaraminol (DG00218): D01019 D08192
Methoxamine (DG00219): D01020 D08201
Methylephedrine (DG01229): D01952 D02109<JP> D08206 D09842
Methylergometrine (DG00445): D00680<JP/US> D08207
Midodrine (DG00224): D01307<JP/US> D08220
Monatepil maleate: D01171
Moxisylyte (DG00287): D01571 D08239
Naftopidil: D01674<JP>
Naphazoline (DG01032): D00743 D01021<JP> D08253
Nefazodone (DG00953): D00819<US> D08257
Nicergoline (DG00283): D01290<JP> D08271
Nipradilol: D01691<JP>
Norepinephrine (DG00212): D00076<JP> D05206<US> D08284 D09794
Octodrine: D05228
Olanzapine (DG00898): D00454<JP/US> D06623<US>
Oxymetazoline (DG01029): D01022<JP/US> D08322
Pelanserin hydrochloride: D05395
Periciazine: D01485<JP>
Phenoxybenzamine (DG00285): D00507<US> D08358
Phentolamine (DG00280): D00509<JP/US> D08362
Phenylephrine (DG00215): D00511<JP/US> D08365 D08366 D08966
Phenylpropanolamine (DG01041): D01224 D05466 D08368
Prazosin (DG00253): D00609<JP/US> D08411
Propylhexedrine (DG01919): D05637 D08444
Pseudoephedrine (DG01042): D00485 D05648 D05649 D08449
Racephedrine Hydrochloride: D08982
Racepinephrine (DG01444): D05688 D05689
Silodosin: D01965<JP/US>
Tamsulosin (DG00490): D01024<JP/US> D08560
Terazosin (DG00491): D00610<JP/US> D08569 D11585<US>
Tetryzoline (DG01030): D00756 D01023 D08578
Tolazoline (DG00281): D00997 D08614
Tramazoline (DG01033): D01347<JP> D08624
Trimazosin (DG00255): D06234 D08212
Urapidil (DG00257): D01333<JP> D08662
Xylometazoline (DG01031): D00757 D08684
Zolertine hydrochloride: D06380
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    148 (ADRA1A)
   04022 cGMP-PKG signaling pathway
    148 (ADRA1A)
   04152 AMPK signaling pathway
    148 (ADRA1A)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    148 (ADRA1A)
 09150 Organismal Systems
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    148 (ADRA1A)
   04270 Vascular smooth muscle contraction
    148 (ADRA1A)
  09154 Digestive system
   04970 Salivary secretion
    148 (ADRA1A)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    148 (ADRA1A)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Adrenaline
    148 (ADRA1A)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7tm_4
Other DBs
NCBI-GeneID: 148
NCBI-ProteinID: NP_000671
OMIM: 104221
HGNC: 277
Ensembl: ENSG00000120907
Vega: OTTHUMG00000099459
Pharos: P35348(Tclin)
UniProt: P35348
Position
8p21.2
AA seq 466 aa
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
TARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
NT seq 1401 nt   +upstreamnt  +downstreamnt
atggtgtttctctcgggaaatgcttccgacagctccaactgcacccaaccgccggcaccg
gtgaacatttccaaggccattctgctcggggtgatcttggggggcctcattcttttcggg
gtgctgggtaacatcctagtgatcctctccgtagcctgtcaccgacacctgcactcagtc
acgcactactacatcgtcaacctggcggtggccgacctcctgctcacctccacggtgctg
cccttctccgccatcttcgaggtcctaggctactgggccttcggcagggtcttctgcaac
atctgggcggcagtggatgtgctgtgctgcaccgcgtccatcatgggcctctgcatcatc
tccatcgaccgctacatcggcgtgagctacccgctgcgctacccaaccatcgtcacccag
aggaggggtctcatggctctgctctgcgtctgggcactctccctggtcatatccattgga
cccctgttcggctggaggcagccggcccccgaggacgagaccatctgccagatcaacgag
gagccgggctacgtgctcttctcagcgctgggctccttctacctgcctctggccatcatc
ctggtcatgtactgccgcgtctacgtggtggccaagagggagagccggggcctcaagtct
ggcctcaagaccgacaagtcggactcggagcaagtgacgctccgcatccatcggaaaaac
gccccggcaggaggcagcgggatggccagcgccaagaccaagacgcacttctcagtgagg
ctcctcaagttctcccgggagaagaaagcggccaaaacgctgggcatcgtggtcggctgc
ttcgtcctctgctggctgccttttttcttagtcatgcccattgggtctttcttccctgat
ttcaagccctctgaaacagtttttaaaatagtattttggctcggatatctaaacagctgc
atcaaccccatcatatacccatgctccagccaagagttcaaaaaggcctttcagaatgtc
ttgagaatccagtgtctctgcagaaagcagtcttccaaacatgccctgggctacaccctg
cacccgcccagccaggccgtggaagggcaacacaaggacatggtgcgcatccccgtggga
tcaagagagaccttctacaggatctccaagacggatggcgtttgtgaatggaaatttttc
tcttccatgccccgtggatctgccaggattacagtgtccaaagaccaatcctcctgtacc
acagcccgggtgagaagtaaaagctttttgcaggtctgctgctgtgtagggccctcaacc
cccagccttgacaagaaccatcaagttccaaccattaaggtccacaccatctccctcagt
gagaacggggaggaagtctag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (7)   
   KEGG PATHWAY (7)   
Disease (1)   
   OMIM (1)   
Drug (136)   
   KEGG DRUG (136)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (16)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (14)   
DNA sequence (61)   
   RefSeq(nuc) (17)   
   GenBank (22)   
   EMBL (22)   
Protein domain (4)   
   Pfam (4)   
All databases (241)   

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