KEGG T01001: 148022

Homo sapiens (human): 148022

Entry

148022 CDS T01001

Gene name

TICAM1, IIAE6, MyD88-3, PRVTIRB, TICAM-1, TRIF

Definition

(RefSeq) toll like receptor adaptor molecule 1

K05842

toll-like receptor adapter molecule 1

Organism

hsa Homo sapiens (human)

Pathway

hsa04064

NF-kappa B signaling pathway

hsa04217

Necroptosis

hsa04620

Toll-like receptor signaling pathway

hsa04621

NOD-like receptor signaling pathway

hsa05133

Pertussis

hsa05135

Yersinia infection

hsa05142

Chagas disease

hsa05160

Hepatitis C

hsa05161

Hepatitis B

hsa05164

Influenza A

hsa05165

Human papillomavirus infection

hsa05167

Kaposi sarcoma-associated herpesvirus infection

hsa05168

Herpes simplex virus 1 infection

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

hsa05417

Lipid and atherosclerosis

Network

nt06121  TLR signaling (viruses and bacteria)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06166  Human papillomavirus (HPV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06221  TLR signaling
nt06263  Hepatocellular carcinoma

Element

N00148

TLR3-IRF7 signaling pathway

N00149

TLR3-IRF3 signaling pathway

N00516

HCV NS3/4A to TLR3-IRF3 signaling pathway

N00553

TLR4-IRF3/7 signaling pathway

N00555

HBV HBe to TLR4-IRF3/7 signaling pathway

N00563

TLR3-NFKB signaling pathway

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    148022 (TICAM1)
09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    148022 (TICAM1)
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    148022 (TICAM1)
   04621 NOD-like receptor signaling pathway
    148022 (TICAM1)
09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    148022 (TICAM1)
  09172 Infectious disease: viral
   05161 Hepatitis B
    148022 (TICAM1)
   05160 Hepatitis C
    148022 (TICAM1)
   05164 Influenza A
    148022 (TICAM1)
   05168 Herpes simplex virus 1 infection
    148022 (TICAM1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    148022 (TICAM1)
   05165 Human papillomavirus infection
    148022 (TICAM1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    148022 (TICAM1)
   05133 Pertussis
    148022 (TICAM1)
  09174 Infectious disease: parasitic
   05142 Chagas disease
    148022 (TICAM1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    148022 (TICAM1)

SSDB

Motif

Pfam:

TRIF-NTD RHIM TIR_2

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

Q8IUC6(Tbio)

UniProt:

Q8IUC6

Structure

PDB:

4BSX 4C0M 2M63 2M1X

Position

19p13.3

AA seq 712 aa
MACTGPSLPSAFDILGAAGQDKLLYLKHKLKTPRPGCQGQDLLHAMVLLKLGQETEARIS
LEALKADAVARLVARQWAGVDSTEDPEEPPDVSWAVARLYHLLAEEKLCPASLRDVAYQE
AVRTLSSRDDHRLGELQDEARNRCGWDIAGDPGSIRTLQSNLGCLPPSSALPSGTRSLPR
PIDGVSDWSQGCSLRSTGSPASLASNLEISQSPTMPFLSLHRSPHGPSKLCDDPQASLVP
EPVPGGCQEPEEMSWPPSGEIASPPELPSSPPPGLPEVAPDATSTGLPDTPAAPETSTNY
PVECTEGSAGPQSLPLPILEPVKNPCSVKDQTPLQLSVEDTTSPNTKPCPPTPTTPETSP
PPPPPPPSSTPCSAHLTPSSLFPSSLESSSEQKFYNFVILHARADEHIALRVREKLEALG
VPDGATFCEDFQVPGRGELSCLQDAIDHSAFIILLLTSNFDCRLSLHQVNQAMMSNLTRQ
GSPDCVIPFLPLESSPAQLSSDTASLLSGLVRLDEHSQIFARKVANTFKPHRLQARKAMW
RKEQDTRALREQSQHLDGERMQAAALNAAYSAYLQSYLSYQAQMEQLQVAFGSHMSFGTG
APYGARMPFGGQVPLGAPPPFPTWPGCPQPPPLHAWQAGTPPPPSPQPAAFPQSLPFPQS
PAFPTASPAPPQSPGLQPLIIHHAQMVQLGLNNHMWNQRGSQAPEDKTQEAE

NT seq 2139 nt +upstreamnt +downstreamnt
atggcctgcacaggcccatcacttcctagcgccttcgacattctaggtgcagcaggccag
gacaagctcttgtatctgaagcacaaactgaagaccccacgcccaggctgccaggggcag
gacctcctgcatgccatggttctcctgaagctgggccaggaaactgaggccaggatctct
ctagaggcattgaaggccgatgcggtggcccggctggtggcccgccagtgggctggcgtg
gacagcaccgaggacccagaggagcccccagatgtgtcctgggctgtggcccgcttgtac
cacctgctggctgaggagaagctgtgccccgcctcgctgcgggacgtggcctaccaggaa
gccgtccgcaccctcagctccagggacgaccaccggctgggggaacttcaggatgaggcc
cgaaaccggtgtgggtgggacattgctggggatccagggagcatccggacgctccagtcc
aatctgggctgcctcccaccatcctcggctttgccctctgggaccaggagcctcccacgc
cccattgacggtgtttcggactggagccaagggtgctccctgcgatccactggcagccct
gcctccctggccagcaacttggaaatcagccagtcccctaccatgcccttcctcagcctg
caccgcagcccacatgggcccagcaagctctgtgacgacccccaggccagcttggtgccc
gagcctgtccccggtggctgccaggagcctgaggagatgagctggccgccatcgggggag
attgccagcccaccagagctgccaagcagcccacctcctgggcttcccgaagtggcccca
gatgcaacctccactggcctccctgatacccccgcagctccagaaaccagcaccaactac
ccagtggagtgcaccgaggggtctgcaggcccccagtctctccccttgcctattctggag
ccggtcaaaaacccctgctctgtcaaagaccagacgccactccaactttctgtagaagat
accacctctccaaataccaagccgtgcccacctactcccaccaccccagaaacatcccct
cctcctcctcctcctcctccttcatctactccttgttcagctcacctgaccccctcctcc
ctgttcccttcctccctggaatcatcatcggaacagaaattctataactttgtgatcctc
cacgccagggcagacgaacacatcgccctgcgggttcgggagaagctggaggcccttggc
gtgcccgacggggccaccttctgcgaggatttccaggtgccggggcgcggggagctgagc
tgcctgcaggacgccatagaccactcagctttcatcatcctacttctcacctccaacttc
gactgtcgcctgagcctgcaccaggtgaaccaagccatgatgagcaacctcacgcgacag
gggtcgccagactgtgtcatccccttcctgcccctggagagctccccggcccagctcagc
tccgacacggccagcctgctctccgggctggtgcggctggacgaacactcccagatcttc
gccaggaaggtggccaacaccttcaagccccacaggcttcaggcccgaaaggccatgtgg
aggaaggaacaggacacccgagccctgcgggaacagagccaacacctggacggtgagcgg
atgcaggcggcggcactgaacgcagcctactcagcctacctccagagctacttgtcctac
caggcacagatggagcagctccaggtggcttttgggagccacatgtcatttgggactggg
gcgccctatggggctcgaatgccctttgggggccaggtgcccctgggagccccgccaccc
tttcccacttggccggggtgcccgcagccgccacccctgcacgcatggcaggctggcacc
cccccaccgccctccccacagccagcagcctttccacagtcactgcccttcccgcagtcc
ccagccttccctacggcctcacccgcaccccctcagagcccagggctgcaacccctcatt
atccaccacgcacagatggtacagctggggctgaacaaccacatgtggaaccagagaggg
tcccaggcgcccgaggacaagacgcaggaggcagaatga

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