KEGG   Homo sapiens (human): 148022
Entry
148022            CDS       T01001                                 
Symbol
TICAM1, IIAE6, MyD88-3, PRVTIRB, TICAM-1, TRIF
Name
(RefSeq) TIR domain containing adaptor molecule 1
  KO
K05842  toll-like receptor adapter molecule 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04064  NF-kappa B signaling pathway
hsa04217  Necroptosis
hsa04620  Toll-like receptor signaling pathway
hsa04621  NOD-like receptor signaling pathway
hsa04936  Alcoholic liver disease
hsa05133  Pertussis
hsa05135  Yersinia infection
hsa05142  Chagas disease
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05417  Lipid and atherosclerosis
Network
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06166  Human papillomavirus (HPV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06221  TLR signaling
nt06263  Hepatocellular carcinoma
nt06517  TLR signaling
  Element
N00148  TLR3-IRF7 signaling pathway
N00149  TLR3-IRF3 signaling pathway
N00516  HCV NS3/4A to TLR3-IRF3 signaling pathway
N00553  TLR4-IRF3/7 signaling pathway
N00555  HBV HBe to TLR4-IRF3/7 signaling pathway
N00563  TLR3-NFKB signaling pathway
Disease
H02536  Infection-induced acute encephalopathy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    148022 (TICAM1)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    148022 (TICAM1)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    148022 (TICAM1)
   04621 NOD-like receptor signaling pathway
    148022 (TICAM1)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    148022 (TICAM1)
  09172 Infectious disease: viral
   05161 Hepatitis B
    148022 (TICAM1)
   05160 Hepatitis C
    148022 (TICAM1)
   05164 Influenza A
    148022 (TICAM1)
   05168 Herpes simplex virus 1 infection
    148022 (TICAM1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    148022 (TICAM1)
   05165 Human papillomavirus infection
    148022 (TICAM1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    148022 (TICAM1)
   05133 Pertussis
    148022 (TICAM1)
  09174 Infectious disease: parasitic
   05142 Chagas disease
    148022 (TICAM1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    148022 (TICAM1)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    148022 (TICAM1)
SSDB
Motif
Pfam: TRIF-NTD RHIM TIR_2
Other DBs
NCBI-GeneID: 148022
NCBI-ProteinID: NP_891549
OMIM: 607601
HGNC: 18348
Ensembl: ENSG00000127666
Pharos: Q8IUC6(Tbio)
UniProt: Q8IUC6
Structure
Position
19:complement(4815932..4831712)
AA seq 712 aa
MACTGPSLPSAFDILGAAGQDKLLYLKHKLKTPRPGCQGQDLLHAMVLLKLGQETEARIS
LEALKADAVARLVARQWAGVDSTEDPEEPPDVSWAVARLYHLLAEEKLCPASLRDVAYQE
AVRTLSSRDDHRLGELQDEARNRCGWDIAGDPGSIRTLQSNLGCLPPSSALPSGTRSLPR
PIDGVSDWSQGCSLRSTGSPASLASNLEISQSPTMPFLSLHRSPHGPSKLCDDPQASLVP
EPVPGGCQEPEEMSWPPSGEIASPPELPSSPPPGLPEVAPDATSTGLPDTPAAPETSTNY
PVECTEGSAGPQSLPLPILEPVKNPCSVKDQTPLQLSVEDTTSPNTKPCPPTPTTPETSP
PPPPPPPSSTPCSAHLTPSSLFPSSLESSSEQKFYNFVILHARADEHIALRVREKLEALG
VPDGATFCEDFQVPGRGELSCLQDAIDHSAFIILLLTSNFDCRLSLHQVNQAMMSNLTRQ
GSPDCVIPFLPLESSPAQLSSDTASLLSGLVRLDEHSQIFARKVANTFKPHRLQARKAMW
RKEQDTRALREQSQHLDGERMQAAALNAAYSAYLQSYLSYQAQMEQLQVAFGSHMSFGTG
APYGARMPFGGQVPLGAPPPFPTWPGCPQPPPLHAWQAGTPPPPSPQPAAFPQSLPFPQS
PAFPTASPAPPQSPGLQPLIIHHAQMVQLGLNNHMWNQRGSQAPEDKTQEAE
NT seq 2139 nt   +upstreamnt  +downstreamnt
atggcctgcacaggcccatcacttcctagcgccttcgacattctaggtgcagcaggccag
gacaagctcttgtatctgaagcacaaactgaagaccccacgcccaggctgccaggggcag
gacctcctgcatgccatggttctcctgaagctgggccaggaaactgaggccaggatctct
ctagaggcattgaaggccgatgcggtggcccggctggtggcccgccagtgggctggcgtg
gacagcaccgaggacccagaggagcccccagatgtgtcctgggctgtggcccgcttgtac
cacctgctggctgaggagaagctgtgccccgcctcgctgcgggacgtggcctaccaggaa
gccgtccgcaccctcagctccagggacgaccaccggctgggggaacttcaggatgaggcc
cgaaaccggtgtgggtgggacattgctggggatccagggagcatccggacgctccagtcc
aatctgggctgcctcccaccatcctcggctttgccctctgggaccaggagcctcccacgc
cccattgacggtgtttcggactggagccaagggtgctccctgcgatccactggcagccct
gcctccctggccagcaacttggaaatcagccagtcccctaccatgcccttcctcagcctg
caccgcagcccacatgggcccagcaagctctgtgacgacccccaggccagcttggtgccc
gagcctgtccccggtggctgccaggagcctgaggagatgagctggccgccatcgggggag
attgccagcccaccagagctgccaagcagcccacctcctgggcttcccgaagtggcccca
gatgcaacctccactggcctccctgatacccccgcagctccagaaaccagcaccaactac
ccagtggagtgcaccgaggggtctgcaggcccccagtctctccccttgcctattctggag
ccggtcaaaaacccctgctctgtcaaagaccagacgccactccaactttctgtagaagat
accacctctccaaataccaagccgtgcccacctactcccaccaccccagaaacatcccct
cctcctcctcctcctcctccttcatctactccttgttcagctcacctgaccccctcctcc
ctgttcccttcctccctggaatcatcatcggaacagaaattctataactttgtgatcctc
cacgccagggcagacgaacacatcgccctgcgggttcgggagaagctggaggcccttggc
gtgcccgacggggccaccttctgcgaggatttccaggtgccggggcgcggggagctgagc
tgcctgcaggacgccatagaccactcagctttcatcatcctacttctcacctccaacttc
gactgtcgcctgagcctgcaccaggtgaaccaagccatgatgagcaacctcacgcgacag
gggtcgccagactgtgtcatccccttcctgcccctggagagctccccggcccagctcagc
tccgacacggccagcctgctctccgggctggtgcggctggacgaacactcccagatcttc
gccaggaaggtggccaacaccttcaagccccacaggcttcaggcccgaaaggccatgtgg
aggaaggaacaggacacccgagccctgcgggaacagagccaacacctggacggtgagcgg
atgcaggcggcggcactgaacgcagcctactcagcctacctccagagctacttgtcctac
caggcacagatggagcagctccaggtggcttttgggagccacatgtcatttgggactggg
gcgccctatggggctcgaatgccctttgggggccaggtgcccctgggagccccgccaccc
tttcccacttggccggggtgcccgcagccgccacccctgcacgcatggcaggctggcacc
cccccaccgccctccccacagccagcagcctttccacagtcactgcccttcccgcagtcc
ccagccttccctacggcctcacccgcaccccctcagagcccagggctgcaacccctcatt
atccaccacgcacagatggtacagctggggctgaacaaccacatgtggaaccagagaggg
tcccaggcgcccgaggacaagacgcaggaggcagaatga

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (16)   
   KEGG PATHWAY (16)   
Network (6)   
   KEGG NETWORK (6)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (43)   
   KEGG ORTHOLOGY (1)   
   RefGene (34)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
   PHAROS (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (31)   
   RefSeq(nuc) (5)   
   GenBank (13)   
   EMBL (13)   
3D Structure (6)   
   PDB (6)   
Protein domain (3)   
   Pfam (3)   
All databases (116)   

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