KEGG   Homo sapiens (human): 1493
Entry
1493              CDS       T01001                                 
Symbol
CTLA4, ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12
Name
(RefSeq) cytotoxic T-lymphocyte associated protein 4
  KO
K06538  cytotoxic T-lymphocyte-associated protein 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa04514  Cell adhesion molecules
hsa04660  T cell receptor signaling pathway
hsa05320  Autoimmune thyroid disease
hsa05323  Rheumatoid arthritis
Network
nt06537  TCR/BCR signaling
  Element
N01579  CD80/CD86-CTLA4-PP2A signaling pathway
Disease
H00080  Systemic lupus erythematosus
H00081  Hashimoto thyroiditis
H00083  Allograft rejection
H00108  Autoimmune lymphoproliferative syndromes
H00408  Type 1 diabetes mellitus
H01812  Rasmussen encephalitis
H02123  Celiac disease
Drug target
Bavunalimab: D12317
Botensilimab: D12448
Cadonilimab: D12190
Gotistobart: D13064
Ipilimumab: D04603<JP/US>
Quavonlimab: D12233
Tremelimumab: D06657<JP/US>
Vilastobart: D13005
Volrustomig: D12347
Vudalimab: D12186
Zalifrelimab: D11823
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    1493 (CTLA4)
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    1493 (CTLA4)
 09160 Human Diseases
  09163 Immune disease
   05323 Rheumatoid arthritis
    1493 (CTLA4)
   05320 Autoimmune thyroid disease
    1493 (CTLA4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    1493 (CTLA4)
CD molecules [BR:hsa04090]
 Proteins
  1493 (CTLA4)
SSDB
Motif
Pfam: V-set V-set_2 Ig_3 I-set
Other DBs
NCBI-GeneID: 1493
NCBI-ProteinID: NP_005205
OMIM: 123890
HGNC: 2505
Ensembl: ENSG00000163599
UniProt: P16410
Structure
Position
2:203867771..203873965
AA seq 223 aa
MACLGFQRHKAQLNLATRTWPCTLLFFLLFIPVFCKAMHVAQPAVVLASSRGIASFVCEY
ASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLR
AMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDPEPCPDSDFLLWILAAVSSGLFFYSFL
LTAVSLSKMLKKRSPLTTGVYVKMPPTEPECEKQFQPYFIPIN
NT seq 672 nt   +upstreamnt  +downstreamnt
atggcttgccttggatttcagcggcacaaggctcagctgaacctggctaccaggacctgg
ccctgcactctcctgttttttcttctcttcatccctgtcttctgcaaagcaatgcacgtg
gcccagcctgctgtggtactggccagcagccgaggcatcgccagctttgtgtgtgagtat
gcatctccaggcaaagccactgaggtccgggtgacagtgcttcggcaggctgacagccag
gtgactgaagtctgtgcggcaacctacatgatggggaatgagttgaccttcctagatgat
tccatctgcacgggcacctccagtggaaatcaagtgaacctcactatccaaggactgagg
gccatggacacgggactctacatctgcaaggtggagctcatgtacccaccgccatactac
ctgggcataggcaacggaacccagatttatgtaattgatccagaaccgtgcccagattct
gacttcctcctctggatccttgcagcagttagttcggggttgtttttttatagctttctc
ctcacagctgtttctttgagcaaaatgctaaagaaaagaagccctcttacaacaggggtc
tatgtgaaaatgcccccaacagagccagaatgtgaaaagcaatttcagccttattttatt
cccatcaattga

  All links  
Disease (6)   
   OMIM (6)   
Gene (17)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (8)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (34)   
   RefSeq(nuc) (2)   
   GenBank (16)   
   EMBL (16)   
3D Structure (22)   
   PDB (22)   
Protein domain (4)   
   Pfam (4)   
All databases (87)   

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