KEGG   Homo sapiens (human): 1493Help
Entry
1493              CDS       T01001                                 

Gene name
CTLA4, ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12
Definition
(RefSeq) cytotoxic T-lymphocyte associated protein 4
  KO
K06538  cytotoxic T-lymphocyte-associated protein 4
Organism
hsa  Homo sapiens (human)
Pathway
hsa04514  Cell adhesion molecules (CAMs)
hsa04660  T cell receptor signaling pathway
hsa05320  Autoimmune thyroid disease
hsa05323  Rheumatoid arthritis
Disease
H00081  Hashimoto's thyroiditis
H00082  Graves' disease
H00083  Allograft rejection
H00108  Autoimmune lymphoproliferative syndromes (ALPS)
H00408  Type I diabetes mellitus
H01812  Rasmussen encephalitis
H02123  Celiac disease
Drug target
Ipilimumab: D04603
Tremelimumab: D06657
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signaling molecules and interaction
   04514 Cell adhesion molecules (CAMs)
    1493 (CTLA4)
 Organismal Systems
  Immune system
   04660 T cell receptor signaling pathway
    1493 (CTLA4)
 Human Diseases
  Immune diseases
   05323 Rheumatoid arthritis
    1493 (CTLA4)
   05320 Autoimmune thyroid disease
    1493 (CTLA4)
CD molecules [BR:hsa04090]
 Proteins
  1493 (CTLA4)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: V-set V-set_2 Ig_3 I-set
Motif
Other DBs
NCBI-GeneID: 1493
NCBI-ProteinID: NP_005205
OMIM: 123890
HGNC: 2505
Ensembl: ENSG00000163599
Vega: OTTHUMG00000132877
Pharos: P16410(Tclin)
UniProt: P16410
Structure
PDB: 

Position
2q33.2
AA seq 223 aa AA seqDB search
MACLGFQRHKAQLNLATRTWPCTLLFFLLFIPVFCKAMHVAQPAVVLASSRGIASFVCEY
ASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLR
AMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDPEPCPDSDFLLWILAAVSSGLFFYSFL
LTAVSLSKMLKKRSPLTTGVYVKMPPTEPECEKQFQPYFIPIN
NT seq 672 nt NT seq  +upstreamnt  +downstreamnt
atggcttgccttggatttcagcggcacaaggctcagctgaacctggctaccaggacctgg
ccctgcactctcctgttttttcttctcttcatccctgtcttctgcaaagcaatgcacgtg
gcccagcctgctgtggtactggccagcagccgaggcatcgccagctttgtgtgtgagtat
gcatctccaggcaaagccactgaggtccgggtgacagtgcttcggcaggctgacagccag
gtgactgaagtctgtgcggcaacctacatgatggggaatgagttgaccttcctagatgat
tccatctgcacgggcacctccagtggaaatcaagtgaacctcactatccaaggactgagg
gccatggacacgggactctacatctgcaaggtggagctcatgtacccaccgccatactac
ctgggcataggcaacggaacccagatttatgtaattgatccagaaccgtgcccagattct
gacttcctcctctggatccttgcagcagttagttcggggttgtttttttatagctttctc
ctcacagctgtttctttgagcaaaatgctaaagaaaagaagccctcttacaacaggggtc
tatgtgaaaatgcccccaacagagccagaatgtgaaaagcaatttcagccttattttatt
cccatcaattga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (4)   
Disease (13)   
   KEGG DISEASE (7)   
   OMIM (6)   
Drug (2)   
   KEGG DRUG (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   UniGene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (8)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (34)   
   RefSeq(nuc) (2)   
   GenBank (16)   
   EMBL (16)   
Protein domain (4)   
   Pfam (4)   
All databases (86)   

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