KEGG T01001: 150

Homo sapiens (human): 150

Entry

150               CDS       T01001

Symbol

ADRA2A, ADRA2, ADRA2R, ADRAR, ALPHA2AAR, FPLD8, ZNF32

Name

(RefSeq) adrenoceptor alpha 2A

K04138

adrenergic receptor alpha-2A

Organism

hsa Homo sapiens (human)

Pathway

hsa04022

cGMP-PKG signaling pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04081

Hormone signaling

hsa04082

Neuroactive ligand signaling

Network

nt06544 Neuroactive ligand signaling

Element

N01903

Norepinephrine-ADRA2-GNAI/O signaling pathway

Disease

H00420

Familial partial lipodystrophy

Drug target

Apraclonidine (DG01130):

D01008<JP/US> D07461

Aptazapine maleate:

D02972

Atipamezole:

D03002

Betanidine:

D01603

Brimonidine (DG00442):

D02076<JP/US> D07540

Chlorpromazine (DG00867):

D00270 D00789<JP/US> D03274 D04034<JP> D09819

Clonidine (DG00249):

D00281<US> D00604<JP/US>

Clozapine:

D00283<JP/US>

Delequamine hydrochloride:

D03672

Detomidine (DG01318):

D03702 D07795

Dexmedetomidine (DG00926):

D00514 D01205<JP/US>

Dibutepinephrine (DG03315):

D12934 D12935

Dihydroergocristine (DG00284):

D07833 D07834

Dipivefrine (DG01129):

D01017 D02349

Domazoline fumarate:

D03887

Droxidopa:

D01277<JP/US>

Ephedrine (DG00227):

D00124 D01386<JP/US> D04018<US>

Epinephrine (DG00013):

D00095<JP/US> D00996 D02149<US>

Epinephryl borate:

D04026

Ergoloid mesylates:

D02268

Ergometrine (DG00446):

D01163 D07905

Etilefrine (DG00210):

D01573<JP> D07931

Fadolmidine hydrochloride:

D04124

Fluparoxan hydrochloride:

D04223

Guanabenz (DG01230):

D00605<JP> D04375

Guanadrel:

D08029

Guanadrel sulfate:

D00607

Guanfacine (DG00250):

D00606<JP/US> D08031

Levonordefrin:

D02388

Lidamidine (DG02870):

D02407 D08126

Lofexidine (DG01001):

D04765<US> D08141

Medetomidine (DG01320):

D04883 D08165

Metaraminol (DG00218):

D01019 D08192

Methyldopa (levorotatory) (DG00248):

D00405<JP/US> D08205

Methylephedrine (DG01229):

D01952 D02109<JP> D08206 D09842

Methylergometrine (DG00445):

D00680<JP/US> D08207

Mianserin (DG00951):

D01358<JP> D08216

Mirtazapine (DG02838):

D00563<JP/US> D11056

Moxonidine:

D05087

Napamezole hydrochloride:

D05119

Norepinephrine (DG00212):

D00076<JP> D05206<US> D08284 D09794

Octodrine:

D05228

Phenoxybenzamine (DG00285):

D00507<US> D08358

Phentolamine (DG00280):

D00509<JP/US> D08362

Phenylpropanolamine (DG01041):

D01224 D05466 D08368

Pimozide:

D00560<US>

Propylhexedrine (DG01919):

D05637 D08444

Pseudoephedrine (DG01042):

D00485 D05648 D05649 D08449

Racephedrine hydrochloride:

D08982

Racepinephrine (DG01444):

D05688 D05689

Rilmenidine:

D08482

Romifidine:

D08487

Setiptiline (DG01231):

D02034<JP> D08511

Sunepitron hydrochloride:

D02569

Tizanidine (DG00773):

D00776<JP/US> D08611

Tolazoline (DG00281):

D00997 D08614

Tramazoline (DG01033):

D01347<JP> D08624

Vatinoxan (DG02987):

D11320 D11321

Xylazine (DG01321):

D06344 D08683

Xylometazoline (DG01031):

D00757 D08684

Yohimbine (DG00485):

D06671 D08685

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04022 cGMP-PKG signaling pathway
    150 (ADRA2A)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    150 (ADRA2A)
   04082 Neuroactive ligand signaling
    150 (ADRA2A)
   04081 Hormone signaling
    150 (ADRA2A)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    150 (ADRA2A)
G protein-coupled receptors [BR:hsa04030]
Rhodopsin family
  Biogenic amine
   Adrenaline
    150 (ADRA2A)

SSDB

Motif

Pfam:

7tm_1 7tm_4 7TM_GPCR_Srsx T2SSM

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

Position

10:111077029..111080907

AA seq 465 aa
MFRQEQPLAEGSFAPMGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLML
LTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAW
CEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVIS
FPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKR
RTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGP
RDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTP
AAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPR
TLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV

NT seq 1398 nt +upstreamnt +downstreamnt
atgttccgccaggagcagccgttggccgagggcagctttgcgcccatgggctccctgcag
ccggacgcgggcaacgcgagctggaacgggaccgaggcgccggggggcggcgcccgggcc
accccttactccctgcaggtgacgctgacgctggtgtgcctggccggcctgctcatgctg
ctcaccgtgttcggcaacgtgctcgtcatcatcgccgtgttcacgagccgcgcgctcaag
gcgccccaaaacctcttcctggtgtctctggcctcggccgacatcctggtggccacgctc
gtcatccctttctcgctggccaacgaggtcatgggctactggtacttcggcaaggcttgg
tgcgagatctacctggcgctcgacgtgctcttctgcacgtcgtccatcgtgcacctgtgc
gccatcagcctggaccgctactggtccatcacacaggccatcgagtacaacctgaagcgc
acgccgcgccgcatcaaggccatcatcatcaccgtgtgggtcatctcggccgtcatctcc
ttcccgccgctcatctccatcgagaagaagggcggcggcggcggcccgcagccggccgag
ccgcgctgcgagatcaacgaccagaagtggtacgtcatctcgtcgtgcatcggctccttc
ttcgctccctgcctcatcatgatcctggtctacgtgcgcatctaccagatcgccaagcgt
cgcacccgcgtgccacccagccgccggggtccggacgccgtcgccgcgccgccggggggc
accgagcgcaggcccaacggtctgggccccgagcgcagcgcgggcccggggggcgcagag
gccgaaccgctgcccacccagctcaacggcgcccctggcgagcccgcgccggccgggccg
cgcgacaccgacgcgctggacctggaggagagctcgtcttccgaccacgccgagcggcct
ccagggccccgcagacccgagcgcggtccccggggcaaaggcaaggcccgagcgagccag
gtgaagccgggcgacagcctgccgcggcgcgggccgggggcgacggggatcgggacgccg
gctgcagggccgggggaggagcgcgtcggggctgccaaggcgtcgcgctggcgcgggcgg
cagaaccgcgagaagcgcttcacgttcgtgctggccgtggtcatcggagtgttcgtggtg
tgctggttccccttcttcttcacctacacgctcacggccgtcgggtgctccgtgccacgc
acgctcttcaaattcttcttctggttcggctactgcaacagctcgttgaacccggtcatc
tacaccatcttcaaccacgatttccgccgcgccttcaagaagatcctctgtcggggggac
aggaagcggatcgtgtga

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