KEGG   Homo sapiens (human): 1508
Entry
1508              CDS       T01001                                 
Symbol
CTSB, APPS, CPSB, KWE, RECEUP
Name
(RefSeq) cathepsin B
  KO
K01363  cathepsin B [EC:3.4.22.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04140  Autophagy - animal
hsa04142  Lysosome
hsa04210  Apoptosis
hsa04612  Antigen processing and presentation
hsa04621  NOD-like receptor signaling pathway
hsa04924  Renin secretion
Disease
H00932  Tropical calcific pancreatitis
H02920  Keratolytic winter erythema
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    1508 (CTSB)
   04140 Autophagy - animal
    1508 (CTSB)
  09143 Cell growth and death
   04210 Apoptosis
    1508 (CTSB)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    1508 (CTSB)
   04612 Antigen processing and presentation
    1508 (CTSB)
  09152 Endocrine system
   04924 Renin secretion
    1508 (CTSB)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    1508 (CTSB)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    1508 (CTSB)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    1508 (CTSB)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    1508 (CTSB)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.1  cathepsin B
     1508 (CTSB)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C1: papain family
   1508 (CTSB)
Chaperones and folding catalysts [BR:hsa03110]
 Intramolecular chaperones
  Papain family
   1508 (CTSB)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of microglial cells
   1508 (CTSB)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Others
   1508 (CTSB)
SSDB
Motif
Pfam: Peptidase_C1 Propeptide_C1 Peptidase_C1_2
Other DBs
NCBI-GeneID: 1508
NCBI-ProteinID: NP_001899
OMIM: 116810
HGNC: 2527
Ensembl: ENSG00000164733
UniProt: P07858 A0A024R374
Structure
Position
8:complement(11842524..11868087)
AA seq 339 aa
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
NT seq 1020 nt   +upstreamnt  +downstreamnt
atgtggcagctctgggcctccctctgctgcctgctggtgttggccaatgcccggagcagg
ccctctttccatcccctgtcggatgagctggtcaactatgtcaacaaacggaataccacg
tggcaggccgggcacaacttctacaacgtggacatgagctacttgaagaggctatgtggt
accttcctgggtgggcccaagccaccccagagagttatgtttaccgaggacctgaagctg
cctgcaagcttcgatgcacgggaacaatggccacagtgtcccaccatcaaagagatcaga
gaccagggctcctgtggctcctgctgggccttcggggctgtggaagccatctctgaccgg
atctgcatccacaccaatgcgcacgtcagcgtggaggtgtcggcggaggacctgctcaca
tgctgtggcagcatgtgtggggacggctgtaatggtggctatcctgctgaagcttggaac
ttctggacaagaaaaggcctggtttctggtggcctctatgaatcccatgtagggtgcaga
ccgtactccatccctccctgtgagcaccacgtcaacggctcccggcccccatgcacgggg
gagggagatacccccaagtgtagcaagatctgtgagcctggctacagcccgacctacaaa
caggacaagcactacggatacaattcctacagcgtctccaatagcgagaaggacatcatg
gccgagatctacaaaaacggccccgtggagggagctttctctgtgtattcggacttcctg
ctctacaagtcaggagtgtaccaacacgtcaccggagagatgatgggtggccatgccatc
cgcatcctgggctggggagtggagaatggcacaccctactggctggttgccaactcctgg
aacactgactggggtgacaatggcttctttaaaatactcagaggacaggatcactgtgga
atcgaatcagaagtggtggctggaattccacgcaccgatcagtactgggaaaagatctaa

  All links  
Disease (2)   
   OMIM (2)   
Gene (89)   
   RefGene (68)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (16)   
   OC (1)   
Protein sequence (16)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (13)   
DNA sequence (65)   
   RefSeq(nuc) (13)   
   GenBank (26)   
   EMBL (26)   
3D Structure (19)   
   PDB (19)   
Protein domain (3)   
   Pfam (3)   
All databases (194)   

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