KEGG   Homo sapiens (human): 1508Help
Entry
1508              CDS       T01001                                 

Gene name
CTSB, APPS, CPSB
Definition
(RefSeq) cathepsin B
  KO
K01363  cathepsin B [EC:3.4.22.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04140  Autophagy - animal
hsa04142  Lysosome
hsa04210  Apoptosis
hsa04612  Antigen processing and presentation
hsa04621  NOD-like receptor signaling pathway
hsa04924  Renin secretion
Disease
H00932  Tropical calcific pancreatitis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Cellular Processes
  Transport and catabolism
   04142 Lysosome
    1508 (CTSB)
   04140 Autophagy - animal
    1508 (CTSB)
  Cell growth and death
   04210 Apoptosis
    1508 (CTSB)
 Organismal Systems
  Immune system
   04621 NOD-like receptor signaling pathway
    1508 (CTSB)
   04612 Antigen processing and presentation
    1508 (CTSB)
  Endocrine system
   04924 Renin secretion
    1508 (CTSB)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.1  cathepsin B
     1508 (CTSB)
Peptidases [BR:hsa01002]
 Cysteine Peptidases
  Family C1: papain family
   1508 (CTSB)
Chaperones and folding catalysts [BR:hsa03110]
 Intramolecular chaperones
  Papain family
   1508 (CTSB)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of microglial cells
   1508 (CTSB)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate/Haparin
  Others
   1508 (CTSB)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Peptidase_C1 Propeptide_C1 Peptidase_C1_2
Motif
Other DBs
NCBI-GeneID: 1508
NCBI-ProteinID: NP_001899
OMIM: 116810
HGNC: 2527
Ensembl: ENSG00000164733
Vega: OTTHUMG00000090799
Pharos: P07858(Tchem)
UniProt: P07858 A0A024R374
Structure
PDB: 

Position
8p23.1
AA seq 339 aa AA seqDB search
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
NT seq 1020 nt NT seq  +upstreamnt  +downstreamnt
atgtggcagctctgggcctccctctgctgcctgctggtgttggccaatgcccggagcagg
ccctctttccatcccctgtcggatgagctggtcaactatgtcaacaaacggaataccacg
tggcaggccgggcacaacttctacaacgtggacatgagctacttgaagaggctatgtggt
accttcctgggtgggcccaagccaccccagagagttatgtttaccgaggacctgaagctg
cctgcaagcttcgatgcacgggaacaatggccacagtgtcccaccatcaaagagatcaga
gaccagggctcctgtggctcctgctgggccttcggggctgtggaagccatctctgaccgg
atctgcatccacaccaatgcgcacgtcagcgtggaggtgtcggcggaggacctgctcaca
tgctgtggcagcatgtgtggggacggctgtaatggtggctatcctgctgaagcttggaac
ttctggacaagaaaaggcctggtttctggtggcctctatgaatcccatgtagggtgcaga
ccgtactccatccctccctgtgagcaccacgtcaacggctcccggcccccatgcacgggg
gagggagatacccccaagtgtagcaagatctgtgagcctggctacagcccgacctacaaa
caggacaagcactacggatacaattcctacagcgtctccaatagcgagaaggacatcatg
gccgagatctacaaaaacggccccgtggagggagctttctctgtgtattcggacttcctg
ctctacaagtcaggagtgtaccaacacgtcaccggagagatgatgggtggccatgccatc
cgcatcctgggctggggagtggagaatggcacaccctactggctggttgccaactcctgg
aacactgactggggtgacaatggcttctttaaaatactcagaggacaggatcactgtgga
atcgaatcagaagtggtggctggaattccacgcaccgatcagtactgggaaaagatctaa

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