KEGG   Homo sapiens (human): 1508
Entry
1508              CDS       T01001                                 

Gene name
CTSB, APPS, CPSB, RECEUP
Definition
(RefSeq) cathepsin B
  KO
K01363  cathepsin B [EC:3.4.22.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04140  Autophagy - animal
hsa04142  Lysosome
hsa04210  Apoptosis
hsa04612  Antigen processing and presentation
hsa04621  NOD-like receptor signaling pathway
hsa04924  Renin secretion
Disease
H00932  Tropical calcific pancreatitis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    1508 (CTSB)
   04140 Autophagy - animal
    1508 (CTSB)
  09143 Cell growth and death
   04210 Apoptosis
    1508 (CTSB)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    1508 (CTSB)
   04612 Antigen processing and presentation
    1508 (CTSB)
  09152 Endocrine system
   04924 Renin secretion
    1508 (CTSB)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    1508 (CTSB)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    1508 (CTSB)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    1508 (CTSB)
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    1508 (CTSB)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.1  cathepsin B
     1508 (CTSB)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C1: papain family
   1508 (CTSB)
Chaperones and folding catalysts [BR:hsa03110]
 Intramolecular chaperones
  Papain family
   1508 (CTSB)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of microglial cells
   1508 (CTSB)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Others
   1508 (CTSB)
SSDB
Motif
Pfam: Peptidase_C1 Propeptide_C1 Peptidase_C1_2
Other DBs
NCBI-GeneID: 1508
NCBI-ProteinID: NP_001899
OMIM: 116810
HGNC: 2527
Ensembl: ENSG00000164733
Vega: OTTHUMG00000090799
Pharos: P07858(Tchem)
UniProt: P07858 A0A024R374
Structure
PDB: 

Position
8p23.1
AA seq 339 aa
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
NT seq 1020 nt   +upstreamnt  +downstreamnt
atgtggcagctctgggcctccctctgctgcctgctggtgttggccaatgcccggagcagg
ccctctttccatcccctgtcggatgagctggtcaactatgtcaacaaacggaataccacg
tggcaggccgggcacaacttctacaacgtggacatgagctacttgaagaggctatgtggt
accttcctgggtgggcccaagccaccccagagagttatgtttaccgaggacctgaagctg
cctgcaagcttcgatgcacgggaacaatggccacagtgtcccaccatcaaagagatcaga
gaccagggctcctgtggctcctgctgggccttcggggctgtggaagccatctctgaccgg
atctgcatccacaccaatgcgcacgtcagcgtggaggtgtcggcggaggacctgctcaca
tgctgtggcagcatgtgtggggacggctgtaatggtggctatcctgctgaagcttggaac
ttctggacaagaaaaggcctggtttctggtggcctctatgaatcccatgtagggtgcaga
ccgtactccatccctccctgtgagcaccacgtcaacggctcccggcccccatgcacgggg
gagggagatacccccaagtgtagcaagatctgtgagcctggctacagcccgacctacaaa
caggacaagcactacggatacaattcctacagcgtctccaatagcgagaaggacatcatg
gccgagatctacaaaaacggccccgtggagggagctttctctgtgtattcggacttcctg
ctctacaagtcaggagtgtaccaacacgtcaccggagagatgatgggtggccatgccatc
cgcatcctgggctggggagtggagaatggcacaccctactggctggttgccaactcctgg
aacactgactggggtgacaatggcttctttaaaatactcagaggacaggatcactgtgga
atcgaatcagaagtggtggctggaattccacgcaccgatcagtactgggaaaagatctaa

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Ontology (6)   
   KEGG BRITE (6)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (92)   
   KEGG ORTHOLOGY (1)   
   RefGene (68)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (16)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (17)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (14)   
DNA sequence (66)   
   RefSeq(nuc) (14)   
   GenBank (26)   
   EMBL (26)   
Protein domain (3)   
   Pfam (3)   
All databases (195)   

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