KEGG   Homo sapiens (human): 1514
Entry
1514              CDS       T01001                                 
Symbol
CTSL, CATL, CTSL1, MEP
Name
(RefSeq) cathepsin L
  KO
K01365  cathepsin L [EC:3.4.22.15]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04140  Autophagy - animal
hsa04142  Lysosome
hsa04145  Phagosome
hsa04210  Apoptosis
hsa04612  Antigen processing and presentation
hsa05205  Proteoglycans in cancer
hsa05323  Rheumatoid arthritis
hsa05418  Fluid shear stress and atherosclerosis
Drug target
Olgotrelvir (DG03293): D12777 D12778
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    1514 (CTSL)
   04142 Lysosome
    1514 (CTSL)
   04140 Autophagy - animal
    1514 (CTSL)
  09143 Cell growth and death
   04210 Apoptosis
    1514 (CTSL)
 09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    1514 (CTSL)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    1514 (CTSL)
  09163 Immune disease
   05323 Rheumatoid arthritis
    1514 (CTSL)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    1514 (CTSL)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    1514 (CTSL)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    1514 (CTSL)
  09183 Protein families: signaling and cellular processes
   00537 Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:hsa00537]
    1514 (CTSL)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.15  cathepsin L
     1514 (CTSL)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C1: papain family
   1514 (CTSL)
Chaperones and folding catalysts [BR:hsa03110]
 Intramolecular chaperones
  Papain family
   1514 (CTSL)
Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:hsa00537]
 Others
  1514 (CTSL)
SSDB
Motif
Pfam: Peptidase_C1 Inhibitor_I29 Peptidase_C1_2 Styelin
Other DBs
NCBI-GeneID: 1514
NCBI-ProteinID: NP_001244900
OMIM: 116880
HGNC: 2537
Ensembl: ENSG00000135047
UniProt: P07711
Structure
Position
9:87726119..87731469
AA seq 333 aa
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
NT seq 1002 nt   +upstreamnt  +downstreamnt
atgaatcctacactcatccttgctgccttttgcctgggaattgcctcagctactctaaca
tttgatcacagtttagaggcacagtggaccaagtggaaggcgatgcacaacagattatac
ggcatgaatgaagaaggatggaggagagcagtgtgggagaagaacatgaagatgattgaa
ctgcacaatcaggaatacagggaagggaaacacagcttcacaatggccatgaacgccttt
ggagacatgaccagtgaagaattcaggcaggtgatgaatggctttcaaaaccgtaagccc
aggaaggggaaagtgttccaggaacctctgttttatgaggcccccagatctgtggattgg
agagagaaaggctacgtgactcctgtgaagaatcagggtcagtgtggttcttgttgggct
tttagtgctactggtgctcttgaaggacagatgttccggaaaactgggaggcttatctca
ctgagtgagcagaatctggtagactgctctgggcctcaaggcaatgaaggctgcaatggt
ggcctaatggattatgctttccagtatgttcaggataatggaggcctggactctgaggaa
tcctatccatatgaggcaacagaagaatcctgtaagtacaatcccaagtattctgttgct
aatgacaccggctttgtggacatccctaagcaggagaaggccctgatgaaggcagttgca
actgtggggcccatttctgttgctattgatgcaggtcatgagtccttcctgttctataaa
gaaggcatttattttgagccagactgtagcagtgaagacatggatcatggtgtgctggtg
gttggctacggatttgaaagcacagaatcagataacaataaatattggctggtgaagaac
agctggggtgaagaatggggcatgggtggctacgtaaagatggccaaagaccggagaaac
cattgtggaattgcctcagcagccagctaccccactgtgtga

  All links  
Disease (1)   
   OMIM (1)   
Gene (18)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (12)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (10)   
DNA sequence (64)   
   RefSeq(nuc) (10)   
   GenBank (27)   
   EMBL (27)   
3D Structure (64)   
   PDB (64)   
Protein domain (4)   
   Pfam (4)   
All databases (163)   

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