KEGG   Homo sapiens (human): 152
Entry
152               CDS       T01001                                 

Gene name
ADRA2C, ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR
Definition
(RefSeq) adrenoceptor alpha 2C
  KO
K04140  adrenergic receptor alpha-2C
Organism
hsa  Homo sapiens (human)
Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Drug target
Apraclonidine (DG01130): D01008<JP/US> D07461
Aptazapine maleate: D02972
Atipamezole: D03002
Betanidine: D01603
Brimonidine (DG00442): D02076<JP/US> D07540
Chlorpromazine (DG00867): D00270 D00789<JP/US> D03274 D04034<JP> D09819
Clonidine (DG00249): D00281<US> D00604<JP/US>
Clozapine: D00283<JP/US>
Delequamine hydrochloride: D03672
Detomidine (DG01318): D03702 D07795
Dexmedetomidine (DG00926): D00514 D01205<JP/US>
Dihydroergocristine (DG00284): D07833 D07834
Dipivefrine (DG01129): D01017<JP> D02349
Domazoline fumarate: D03887
Droxidopa: D01277<JP/US>
Ephedrine (DG00227): D00124 D01386<JP> D04018<US>
Epinephrine (DG00013): D00095<JP/US> D00996 D02149
Epinephryl borate: D04026
Ergoloid mesylates: D02268
Ergometrine (DG00446): D01163<JP> D07905
Etilefrine (DG00210): D01573<JP> D07931
Fadolmidine hydrochloride: D04124
Fluparoxan hydrochloride: D04223
Guanabenz (DG01230): D00605<JP> D04375
Guanadrel: D08029
Guanadrel sulfate: D00607
Levonordefrin: D02388
Lidamidine (DG02870): D02407 D08126
Lofexidine (DG01001): D04765<US> D08141
Medetomidine (DG01320): D04883 D08165
Metaraminol (DG00218): D01019 D08192
Methyldopa (levorotatory) (DG00248): D00405<JP/US> D08205
Methylephedrine (DG01229): D01952 D02109<JP> D08206 D09842
Methylergometrine (DG00445): D00680<JP/US> D08207
Mianserin (DG00951): D01358<JP> D08216
Mirtazapine (DG02838): D00563<JP/US> D11056
Moxonidine: D05087
Napamezole hydrochloride: D05119
Norepinephrine (DG00212): D00076<JP> D05206<US> D08284 D09794
Octodrine: D05228
Phenoxybenzamine (DG00285): D00507<US> D08358
Phentolamine (DG00280): D00509<JP/US> D08362
Phenylpropanolamine (DG01041): D01224 D05466 D08368
Propylhexedrine (DG01919): D05637 D08444
Pseudoephedrine (DG01042): D00485 D05648 D05649 D08449
Racephedrine Hydrochloride: D08982
Racepinephrine (DG01444): D05688 D05689
Rilmenidine: D08482
Romifidine: D08487
Setiptiline (DG01231): D02034<JP> D08511
Sunepitron hydrochloride: D02569
Tizanidine (DG00773): D00776<JP/US> D08611
Tolazoline (DG00281): D00997 D08614
Tramazoline (DG01033): D01347<JP> D08624
Vatinoxan (DG02987): D11320 D11321
Xylazine (DG01321): D06344 D08683
Xylometazoline (DG01031): D00757 D08684
Yohimbin (DG00485): D06671 D08685
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04022 cGMP-PKG signaling pathway
    152 (ADRA2C)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    152 (ADRA2C)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    152 (ADRA2C)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Adrenaline
    152 (ADRA2C)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7tm_4
Other DBs
NCBI-GeneID: 152
NCBI-ProteinID: NP_000674
OMIM: 104250
HGNC: 283
Ensembl: ENSG00000184160
Vega: OTTHUMG00000159830
Pharos: P18825(Tclin)
UniProt: P18825 Q4W594
Position
4p16.3
AA seq 462 aa
MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGF
LIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFG
QVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISA
VISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLR
TRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGA
LRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRR
RRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFK
FFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
NT seq 1389 nt   +upstreamnt  +downstreamnt
atggcgtccccggcgctggcggcggcgctggcggtggcggcagcggcgggccccaatgcg
agcggcgcgggcgagaggggcagcggcggggttgccaatgcctcgggggcttcctggggg
ccgccgcgcggccagtactcggcgggcgcggtggcagggctggctgccgtggtgggcttc
ctcatcgtcttcaccgtggtgggcaacgtgctggtggtgatcgccgtgctgaccagccgg
gcgctgcgcgcgccacagaacctcttcctggtgtcgctggcctcggccgacatcctggtg
gccacgctggtcatgcccttctcgttggccaacgagctcatggcctactggtacttcggg
caggtgtggtgcggcgtgtacctggcgctcgatgtgctgttttgcacctcgtcgatcgtg
catctgtgtgccatcagcctggaccgctactggtcggtgacgcaggccgtcgagtacaac
ctgaagcgcacaccacgccgcgtcaaggccaccatcgtggccgtgtggctcatctcggcc
gtcatctccttcccgccgctggtctcgctctaccgccagcccgacggcgccgcctacccg
cagtgcggcctcaacgacgagacctggtacatcctgtcctcctgcatcggctccttcttc
gcgccctgcctcatcatgggcctggtctacgcgcgcatctaccgagtggccaagctgcgc
acgcgcacgctcagcgagaagcgcgcccccgtgggccccgacggtgcgtccccgactacc
gaaaacgggctgggcgcggcggcaggcgcaggcgagaacgggcactgcgcgcccccgccc
gccgacgtggagccggacgagagcagcgcagcggccgagaggcggcggcgccggggcgcg
ttgcggcggggcgggcggcggcgagcgggcgcggaggggggcgcgggcggtgcggacggg
cagggggcggggccgggggcggctgagtcgggggcgctgaccgcctccaggtccccgggg
cccggtggccgcctgtcgcgcgccagctcgcgctccgtcgagttcttcctgtcgcgccgg
cgccgggcgcgcagcagcgtgtgccgccgcaaggtggcccaggcgcgcgagaagcgcttc
acctttgtgctggctgtggtcatgggcgtgttcgtgctctgctggttccccttcttcttc
agctacagcctgtacggcatctgccgcgaggcctgccaggtgcccggcccgctcttcaag
ttcttcttctggatcggctactgcaacagctcgctcaacccggtcatctacacggtcttc
aaccaggatttccggcgatcctttaagcacatcctcttccgacggaggagaaggggcttc
aggcagtga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Drug (107)   
   KEGG DRUG (107)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG ORTHOLOGY (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (5)   
   RefSeq(nuc) (1)   
   GenBank (2)   
   EMBL (2)   
Protein domain (3)   
   Pfam (3)   
All databases (145)   

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