KEGG   Homo sapiens (human): 1520
Entry
1520              CDS       T01001                                 

Gene name
CTSS
Definition
(RefSeq) cathepsin S
  KO
K01368  cathepsin S [EC:3.4.22.27]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04142  Lysosome
hsa04145  Phagosome
hsa04210  Apoptosis
hsa04612  Antigen processing and presentation
hsa05152  Tuberculosis
Drug target
Petesicatib: D11376
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    1520 (CTSS)
   04142 Lysosome
    1520 (CTSS)
  09143 Cell growth and death
   04210 Apoptosis
    1520 (CTSS)
 09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    1520 (CTSS)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    1520 (CTSS)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    1520 (CTSS)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    1520 (CTSS)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.27  cathepsin S
     1520 (CTSS)
Peptidases and inhibitors [BR:hsa01002]
 Cysteine peptidases
  Family C1: papain family
   1520 (CTSS)
Chaperones and folding catalysts [BR:hsa03110]
 Intramolecular chaperones
  Papain family
   1520 (CTSS)
SSDB
Motif
Pfam: Peptidase_C1 Inhibitor_I29 Peptidase_C1_2
Other DBs
NCBI-GeneID: 1520
NCBI-ProteinID: NP_004070
OMIM: 116845
HGNC: 2545
Ensembl: ENSG00000163131
Vega: OTTHUMG00000035010
Pharos: P25774(Tchem)
UniProt: P25774
Structure
PDB: 

Position
1q21.3
AA seq 331 aa
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
NT seq 996 nt   +upstreamnt  +downstreamnt
atgaaacggctggtttgtgtgctcttggtgtgctcctctgcagtggcacagttgcataaa
gatcctaccctggatcaccactggcatctctggaagaaaacctatggcaaacaatacaag
gaaaagaatgaagaagcagtacgacgtctcatctgggaaaagaatctaaagtttgtgatg
cttcacaacctggagcattcaatgggaatgcactcatacgatctgggcatgaaccacctg
ggagacatgaccagtgaagaagtgatgtctttgatgagttccctgagagttcccagccag
tggcagagaaatatcacatataagtcaaaccctaatcggatattgcctgattctgtggac
tggagagagaaagggtgtgttactgaagtgaaatatcaaggttcttgtggtgcttgctgg
gctttcagtgctgtgggggccctggaagcacagctgaagctgaaaacaggaaagctggtg
tctctcagtgcccagaacctggtggattgctcaactgaaaaatatggaaacaaaggctgc
aatggtggcttcatgacaacggctttccagtacatcattgataacaagggcatcgactca
gacgcttcctatccctacaaagccatggatcagaaatgtcaatatgactcaaaatatcgt
gctgccacatgttcaaagtacactgaacttccttatggcagagaagatgtcctgaaagaa
gctgtggccaataaaggcccagtgtctgttggtgtagatgcgcgtcatccttctttcttc
ctctacagaagtggtgtctactatgaaccatcctgtactcagaatgtgaatcatggtgta
cttgtggttggctatggtgatcttaatgggaaagaatactggcttgtgaaaaacagctgg
ggccacaactttggtgaagaaggatatattcggatggcaagaaataaaggaaatcattgt
gggattgctagctttccctcttacccagaaatctag

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (5)   
   KEGG PATHWAY (5)   
Disease (1)   
   OMIM (1)   
Drug (1)   
   KEGG DRUG (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (22)   
   RefSeq(nuc) (2)   
   GenBank (10)   
   EMBL (10)   
Protein domain (3)   
   Pfam (3)   
All databases (63)   

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