KEGG   Homo sapiens (human): 155Help
Entry
155               CDS       T01001                                 

Gene name
ADRB3, BETA3AR
Definition
(RefSeq) adrenoceptor beta 3
  KO
K04143  adrenergic receptor beta-3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04714  Thermogenesis
hsa04923  Regulation of lipolysis in adipocytes
hsa04924  Renin secretion
hsa04970  Salivary secretion
Disease
H02106  Genetic obesity
Drug target
Adaprolol maleate: D02765
Alprenolol (DG00303): D01182 D07156
Alprenoxime hydrochloride: D02834
Amibegron (DG01237): D08850 D08851
Befunolol (DG01138): D01512 D07496
Beradilol monoethyl maleate: D09843
Bopindolol (DG00310): D01794 D07537
Bucindolol hydrochloride: D03170
Bufetolol hydrochloride: D01504
Bunitrolol hydrochloride: D01444
Bunolol hydrochloride: D03177
Bupranolol (DG00311): D01454 D07590
Carteolol (DG00308): D00599 D07624
Cetamolol hydrochloride: D03449
Cicloprolol hydrochloride: D03490
Cimaterol: D03502
Cloranolol: D07183
Deterenol hydrochloride: D03700
Dexpropranolol hydrochloride: D03729
Diacetolol hydrochloride: D03759
Dilevalol hydrochloride: D01906
Dipivefrine (DG01129): D01017 D02349
Droxidopa: D01277
Ephedrine (DG00227): D00124 D01386 D04018
Epinephrine (DG00013): D00095 D00996 D02149
Epinephryl borate: D04026
Etilefrine (DG00210): D01573 D07931
Fasobegron: D09344
Flestolol sulfate: D04190
Isoprenaline (DG00211): D01390 D02066 D02150 D08090
Levobunolol (DG01136): D01025 D08115
Medroxalol (DG01317): D04888 D04889
Mepindolol: D07181
Methylephedrine (DG01229): D01952 D02109 D08206 D09842
Metipranolol (DG01137): D02081 D02374
Mirabegron: D09535
Nipradilol: D01691
Norepinephrine (DG00212): D00076 D05206 D08284 D09794
Octodrine: D05228
Oxprenolol (DG00304): D01806 D08318
Pamatolol sulfate: D05345
Penbutolol (DG00312): D00602 D08074
Phenylpropanolamine (DG01041): D01224 D05466 D08368
Pindolol: D00513
Primidolol: D02389
Propranolol (DG00305): D00483 D08443
Pseudoephedrine (DG01042): D00485 D05648 D05649 D08449
Racephedrine Hydrochloride: D08982
Ritobegron ethyl hydrochloride: D09732
Solabegron hydrochloride: D05879
Talibegron hydrochloride: D02702
Talinolol: D07184
Tazolol hydrochloride: D06014
Tertatolol (DG00309): D07182 D08572
Tilisolol (DG01322): D01795 D08598
Tiprenolol hydrochloride: D06162
Tolamolol: D06176
Vibegron: D10433
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04020 Calcium signaling pathway
    155 (ADRB3)
   04022 cGMP - PKG signaling pathway
    155 (ADRB3)
  Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    155 (ADRB3)
 Organismal Systems
  Endocrine system
   04923 Regulation of lipolysis in adipocyte
    155 (ADRB3)
   04924 Renin secretion
    155 (ADRB3)
  Digestive system
   04970 Salivary secretion
    155 (ADRB3)
  Environmental adaptation
   04714 Thermogenesis
    155 (ADRB3)
G protein-coupled receptors [BR:hsa04030]
 Class A. Rhodopsin family
  Biogenic amine [Fig]
   Adrenaline [OT]
    155 (ADRB3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srx 7TM_GPCR_Srv
Motif
Other DBs
NCBI-GeneID: 155
NCBI-ProteinID: NP_000016
OMIM: 109691
HGNC: 288
Ensembl: ENSG00000188778
Vega: OTTHUMG00000164028
Pharos: P13945(Tclin)
UniProt: P13945 A8KAG8
Position
8p11.23
AA seq 408 aa AA seqDB search
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV
AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC
VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV
GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG
ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT
FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL
CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
NT seq 1227 nt NT seq  +upstreamnt  +downstreamnt
atggctccgtggcctcacgagaacagctctcttgccccatggccggacctccccaccctg
gcgcccaataccgccaacaccagtgggctgccaggggttccgtgggaggcggccctagcc
ggggccctgctggcgctggcggtgctggccaccgtgggaggcaacctgctggtcatcgtg
gccatcgcctggactccgagactccagaccatgaccaacgtgttcgtgacttcgctggcc
gcagccgacctggtgatgggactcctggtggtgccgccggcggccaccttggcgctgact
ggccactggccgttgggcgccactggctgcgagctgtggacctcggtggacgtgctgtgt
gtgaccgccagcatcgaaaccctgtgcgccctggccgtggaccgctacctggctgtgacc
aacccgctgcgttacggcgcactggtcaccaagcgctgcgcccggacagctgtggtcctg
gtgtgggtcgtgtcggccgcggtgtcgtttgcgcccatcatgagccagtggtggcgcgta
ggggccgacgccgaggcgcagcgctgccactccaacccgcgctgctgtgccttcgcctcc
aacatgccctacgtgctgctgtcctcctccgtctccttctaccttcctcttctcgtgatg
ctcttcgtctacgcgcgggttttcgtggtggctacgcgccagctgcgcttgctgcgcggg
gagctgggccgctttccgcccgaggagtctccgccggcgccgtcgcgctctctggccccg
gccccggtggggacgtgcgctccgcccgaaggggtgcccgcctgcggccggcggcccgcg
cgcctcctgcctctccgggaacaccgggccctgtgcaccttgggtctcatcatgggcacc
ttcactctctgctggttgcccttctttctggccaacgtgctgcgcgccctggggggcccc
tctctagtcccgggcccggctttccttgccctgaactggctaggttatgccaattctgcc
ttcaacccgctcatctactgccgcagcccggactttcgcagcgccttccgccgtcttctg
tgccgctgcggccgtcgcctgcctccggagccctgcgccgccgcccgcccggccctcttc
ccctcgggcgttcctgcggcccggagcagcccagcgcagcccaggctttgccaacggctc
gacggggcttcttggggagtttcttag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (7)   
   KEGG PATHWAY (7)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (92)   
   KEGG DRUG (92)   
Genome (1)   
   KEGG GENOME (1)   
Gene (28)   
   KEGG ORTHOLOGY (1)   
   RefGene (19)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   UniGene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (23)   
   RefSeq(nuc) (1)   
   GenBank (11)   
   EMBL (11)   
Protein domain (5)   
   Pfam (5)   
All databases (166)   

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