KEGG   Homo sapiens (human): 1555
Entry
1555              CDS       T01001                                 

Symbol
CYP2B6, CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450
Name
(RefSeq) cytochrome P450 family 2 subfamily B member 6
  KO
K17709  cytochrome P450 family 2 subfamily B6 [EC:1.14.14.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00590  Arachidonic acid metabolism
hsa00830  Retinol metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa01100  Metabolic pathways
hsa05207  Chemical carcinogenesis - receptor activation
hsa05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    1555 (CYP2B6)
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    1555 (CYP2B6)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    1555 (CYP2B6)
   00982 Drug metabolism - cytochrome P450
    1555 (CYP2B6)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    1555 (CYP2B6)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    1555 (CYP2B6)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    1555 (CYP2B6)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.-  
     1555 (CYP2B6)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP2 family
   1555 (CYP2B6)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 1555
NCBI-ProteinID: NP_000758
OMIM: 123930
HGNC: 2615
Ensembl: ENSG00000197408
Vega: OTTHUMG00000182714
Pharos: P20813(Tbio)
UniProt: P20813
Structure
PDB: 

Position
19q13.2
AA seq 491 aa
MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE
KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR
WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIIC
SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE
INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT
ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS
DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL
KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI
PPTYQIRFLPR
NT seq 1476 nt   +upstreamnt  +downstreamnt
atggaactcagcgtcctcctcttccttgcactcctcacaggactcttgctactcctggtt
cagcgccaccctaacacccatgaccgcctcccaccagggccccgccctctgccccttttg
ggaaaccttctgcagatggatagaagaggcctactcaaatcctttctgaggttccgagag
aaatatggggacgtcttcacggtacacctgggaccgaggcccgtggtcatgctgtgtgga
gtagaggccatacgggaggcccttgtggacaaggctgaggccttctctggccggggaaaa
atcgccatggtcgacccattcttccggggatatggtgtgatctttgccaatggaaaccgc
tggaaggtgcttcggcgattctctgtgaccactatgagggacttcgggatgggaaagcgg
agtgtggaggagcggattcaggaggaggctcagtgtctgatagaggagcttcggaaatcc
aagggggccctcatggaccccaccttcctcttccagtccattaccgccaacatcatctgc
tccatcgtctttggaaaacgattccactaccaagatcaagagttcctgaagatgctgaac
ttgttctaccagactttttcactcatcagctctgtattcggccagctgtttgagctcttc
tctggcttcttgaaatactttcctggggcacacaggcaagtttacaaaaacctgcaggaa
atcaatgcttacattggccacagtgtggagaagcaccgtgaaaccctggaccccagcgcc
cccaaggacctcatcgacacctacctgctccacatggaaaaagagaaatccaacgcacac
agtgaattcagccaccagaacctcaacctcaacacgctctcgctcttctttgctggcact
gagaccaccagcaccactctccgctacggcttcctgctcatgctcaaataccctcatgtt
gcagagagagtctacagggagattgaacaggtgattggcccacatcgccctccagagctt
catgaccgagccaaaatgccatacacagaggcagtcatctatgagattcagagattttcc
gaccttctccccatgggtgtgccccacattgtcacccaacacaccagcttccgagggtac
atcatccccaaggacacagaagtatttctcatcctgagcactgctctccatgacccacac
tactttgaaaaaccagacgccttcaatcctgaccactttctggatgccaatggggcactg
aaaaagactgaagcttttatccccttctccttagggaagcggatttgtcttggtgaaggc
atcgcccgtgcggaattgttcctcttcttcaccaccatcctccagaacttctccatggcc
agccccgtggccccagaagacatcgatctgacaccccaggagtgtggtgtgggcaaaata
cccccaacataccagatccgcttcctgccccgctga

KEGG   Homo sapiens (human): 1573
Entry
1573              CDS       T01001                                 

Symbol
CYP2J2, CPJ2, CYPIIJ2
Name
(RefSeq) cytochrome P450 family 2 subfamily J member 2
  KO
K07418  cytochrome P450 family 2 subfamily J [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00590  Arachidonic acid metabolism
hsa00591  Linoleic acid metabolism
hsa01100  Metabolic pathways
hsa04726  Serotonergic synapse
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04913  Ovarian steroidogenesis
hsa05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    1573 (CYP2J2)
   00591 Linoleic acid metabolism
    1573 (CYP2J2)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    1573 (CYP2J2)
  09156 Nervous system
   04726 Serotonergic synapse
    1573 (CYP2J2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    1573 (CYP2J2)
 09160 Human Diseases
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    1573 (CYP2J2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    1573 (CYP2J2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     1573 (CYP2J2)
    1.14.14.73  albendazole monooxygenase (sulfoxide-forming)
     1573 (CYP2J2)
    1.14.14.74  albendazole monooxygenase (hydroxylating)
     1573 (CYP2J2)
    1.14.14.75  fenbendazole monooxygenase (4'-hydroxylating)
     1573 (CYP2J2)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP2 family
   1573 (CYP2J2)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 1573
NCBI-ProteinID: NP_000766
OMIM: 601258
HGNC: 2634
Ensembl: ENSG00000134716
Vega: OTTHUMG00000008991
Pharos: P51589(Tchem)
UniProt: P51589
Position
1p32.1
AA seq 502 aa
MLAAMGSLAAALWAVVHPRTLLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVD
FEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHI
FKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDP
HFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFL
PGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEEN
LICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMP
YTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDT
FNPDHFLENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLS
LKFRMGITISPVSHRLCAVPQV
NT seq 1509 nt   +upstreamnt  +downstreamnt
atgctcgcggcgatgggctctctggcggctgccctctgggcagtggtccatcctcggact
ctcctactgggcactgtcgcctttctgctcgctgctgactttctcaaaagacggcgccca
aagaactacccgccggggccctggcgcctgcccttccttggcaacttcttccttgtggac
ttcgagcagtcgcacctggaggttcagctgtttgtgaagaaatatgggaacctttttagc
ttggagcttggtgacatatctgcagttcttattactggcttgcccttaatcaaagaagcc
cttatccacatggaccaaaactttgggaaccgccccgtgacccctatgcgagaacatatc
tttaagaaaaatggattgattatgtcaagtggccaggcatggaaggagcaaagaaggttc
actctgacagcactaaggaactttggtttaggaaagaagagcttagaggaacgcattcag
gaggaggcccaacacctcactgaagcaataaaagaggagaacggacagccttttgaccct
catttcaagatcaacaatgcagtttccaatatcatttgctccatcaccttcggagaacgc
tttgagtaccaggatagttggtttcagcagctgctgaagttactagatgaagtcacatac
ttggaggcttcaaagacatgccagctctacaatgtctttccatggataatgaaattcctg
cctggaccccaccaaactctcttcagcaactggaaaaaactgaaattgtttgtttctcat
atgattgacaaacacagaaaggattggaatcctgcagaaacaagagactttattgatgct
taccttaaagaaatgtcaaagcacacaggcaatcctacttcaagtttccatgaagaaaac
ctcatctgcagcaccctggacctcttctttgccggaaccgagacaacttccacaactctg
cgatgggctctgctttatatggccctctacccagaaatccaagaaaaagtacaagctgag
attgacagagtgattggccaggggcagcagccgagcacagccgcccgggagtccatgccc
tacaccaatgctgtcatccatgaggtgcagagaatgggcaacatcatccccctgaacgtt
cccagggaagtgacagttgataccactttggctgggtaccacctgcccaagggtaccatg
atcctgaccaatttgacggcgctgcacagggaccccacagagtgggccacccctgacaca
ttcaatccggaccattttctggagaatggacagtttaagaaaagggaagcctttatgcct
ttctcaataggaaagcgggcatgcctcggagaacagttggccaggactgagctgtttatt
ttcttcacttcccttatgcaaaaatttaccttcaggcccccaaacaatgagaagctgagc
ctgaagtttagaatgggtatcaccatttccccagtcagtcaccgcctctgcgctgttcct
caggtgtaa

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