KEGG   Homo sapiens (human): 1557
Entry
1557              CDS       T01001                                 

Symbol
CYP2C19, CPCJ, CYP2C, CYPIIC17, CYPIIC19, P450C2C, P450IIC19
Name
(RefSeq) cytochrome P450 family 2 subfamily C member 19
  KO
K17721  cytochrome P450 family 2 subfamily C19 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.75 1.14.14.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00590  Arachidonic acid metabolism
hsa00591  Linoleic acid metabolism
hsa00982  Drug metabolism - cytochrome P450
hsa01100  Metabolic pathways
hsa04726  Serotonergic synapse
hsa05204  Chemical carcinogenesis - DNA adducts
Disease
H01171  Poor drug metabolism
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    1557 (CYP2C19)
   00591 Linoleic acid metabolism
    1557 (CYP2C19)
  09111 Xenobiotics biodegradation and metabolism
   00982 Drug metabolism - cytochrome P450
    1557 (CYP2C19)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    1557 (CYP2C19)
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    1557 (CYP2C19)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    1557 (CYP2C19)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.51  (S)-limonene 6-monooxygenase
     1557 (CYP2C19)
    1.14.14.52  (S)-limonene 7-monooxygenase
     1557 (CYP2C19)
    1.14.14.53  (R)-limonene 6-monooxygenase
     1557 (CYP2C19)
    1.14.14.75  fenbendazole monooxygenase (4'-hydroxylating)
     1557 (CYP2C19)
    1.14.14.-  
     1557 (CYP2C19)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP2 family
   1557 (CYP2C19)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 1557
NCBI-ProteinID: NP_000760
OMIM: 124020
HGNC: 2621
Ensembl: ENSG00000165841
Vega: OTTHUMG00000018799
Pharos: P33261(Tchem)
UniProt: P33261
Structure
PDB: 
4GQS

Position
10q23.33
AA seq 490 aa
MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI
YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM
ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYID
LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK
KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP
PFYQLCFIPV
NT seq 1473 nt   +upstreamnt  +downstreamnt
atggatccttttgtggtccttgtgctctgtctctcatgtttgcttctcctttcaatctgg
agacagagctctgggagaggaaaactccctcctggccccactcctctcccagtgattgga
aatatcctacagatagatattaaggatgtcagcaaatccttaaccaatctctcaaaaatc
tatggccctgtgttcactctgtattttggcctggaacgcatggtggtgctgcatggatat
gaagtggtgaaggaagccctgattgatcttggagaggagttttctggaagaggccatttc
ccactggctgaaagagctaacagaggatttggaatcgttttcagcaatggaaagagatgg
aaggagatccggcgtttctccctcatgacgctgcggaattttgggatggggaagaggagc
attgaggaccgtgttcaagaggaagcccgctgccttgtggaggagttgagaaaaaccaag
gcttcaccctgtgatcccactttcatcctgggctgtgctccctgcaatgtgatctgctcc
attattttccagaaacgtttcgattataaagatcagcaatttcttaacttgatggaaaaa
ttgaatgaaaacatcaggattgtaagcaccccctggatccagatatgcaataattttccc
actatcattgattatttcccgggaacccataacaaattacttaaaaaccttgcttttatg
gaaagtgatattttggagaaagtaaaagaacaccaagaatcgatggacatcaacaaccct
cgggactttattgattgcttcctgatcaaaatggagaaggaaaagcaaaaccaacagtct
gaattcactattgaaaacttggtaatcactgcagctgacttacttggagctgggacagag
acaacaagcacaaccctgagatatgctctccttctcctgctgaagcacccagaggtcaca
gctaaagtccaggaagagattgaacgtgtcattggcagaaaccggagcccctgcatgcag
gacaggggccacatgccctacacagatgctgtggtgcacgaggtccagagatacatcgac
ctcatccccaccagcctgccccatgcagtgacctgtgacgttaaattcagaaactacctc
attcccaagggcacaaccatattaacttccctcacttctgtgctacatgacaacaaagaa
tttcccaacccagagatgtttgaccctcgtcactttctggatgaaggtggaaattttaag
aaaagtaactacttcatgcctttctcagcaggaaaacggatttgtgtgggagagggcctg
gcccgcatggagctgtttttattcctgaccttcattttacagaactttaacctgaaatct
ctgattgacccaaaggaccttgacacaactcctgttgtcaatggatttgcttctgtcccg
cccttctatcagctgtgcttcattcctgtctga

KEGG   Homo sapiens (human): 1558
Entry
1558              CDS       T01001                                 

Symbol
CYP2C8, CPC8, CYP2C8DM, CYPIIC8, MP-12/MP-20
Name
(RefSeq) cytochrome P450 family 2 subfamily C member 8
  KO
K17718  cytochrome P450 family 2 subfamily C8 [EC:1.14.14.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00590  Arachidonic acid metabolism
hsa00591  Linoleic acid metabolism
hsa00830  Retinol metabolism
hsa00982  Drug metabolism - cytochrome P450
hsa01100  Metabolic pathways
hsa04726  Serotonergic synapse
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    1558 (CYP2C8)
   00591 Linoleic acid metabolism
    1558 (CYP2C8)
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    1558 (CYP2C8)
  09111 Xenobiotics biodegradation and metabolism
   00982 Drug metabolism - cytochrome P450
    1558 (CYP2C8)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    1558 (CYP2C8)
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    1558 (CYP2C8)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    1558 (CYP2C8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    1558 (CYP2C8)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     1558 (CYP2C8)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP2 family
   1558 (CYP2C8)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 1558
NCBI-ProteinID: NP_000761
OMIM: 601129
HGNC: 2622
Ensembl: ENSG00000138115
Vega: OTTHUMG00000018804
Pharos: P10632(Tbio)
UniProt: P10632
Structure
PDB: 
2NNJ 2NNH 2VN0 1PQ2 2NNI

Position
10q23.33
AA seq 490 aa
MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV
YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW
KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS
VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT
RSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTE
TTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSD
LVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFK
KSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLP
PSYQICFIPV
NT seq 1473 nt   +upstreamnt  +downstreamnt
atggaaccttttgtggtcctggtgctgtgtctctcttttatgcttctcttttcactctgg
agacagagctgtaggagaaggaagctccctcctggccccactcctcttcctattattgga
aatatgctacagatagatgttaaggacatctgcaaatctttcaccaatttctcaaaagtc
tatggtcctgtgttcaccgtgtattttggcatgaatcccatagtggtgtttcatggatat
gaggcagtgaaggaagccctgattgataatggagaggagttttctggaagaggcaattcc
ccaatatctcaaagaattactaaaggacttggaatcatttccagcaatggaaagagatgg
aaggagatccggcgtttctccctcacaaccttgcggaattttgggatggggaagaggagc
attgaggaccgtgttcaagaggaagctcactgccttgtggaggagttgagaaaaaccaag
gcttcaccctgtgatcccactttcatcctgggctgtgctccctgcaatgtgatctgctcc
gttgttttccagaaacgatttgattataaagatcagaattttctcaccctgatgaaaaga
ttcaatgaaaacttcaggattctgaactccccatggatccaggtctgcaataatttccct
ctactcattgattgtttcccaggaactcacaacaaagtgcttaaaaatgttgctcttaca
cgaagttacattagggagaaagtaaaagaacaccaagcatcactggatgttaacaatcct
cgggactttatcgattgcttcctgatcaaaatggagcaggaaaaggacaaccaaaagtca
gaattcaatattgaaaacttggttggcactgtagctgatctatttgttgctggaacagag
acaacaagcaccactctgagatatggactcctgctcctgctgaagcacccagaggtcaca
gctaaagtccaggaagagattgatcatgtaattggcagacacaggagcccctgcatgcag
gataggagccacatgccttacactgatgctgtagtgcacgagatccagagatacagtgac
cttgtccccaccggtgtgccccatgcagtgaccactgatactaagttcagaaactacctc
atccccaagggcacaaccataatggcattactgacttccgtgctacatgatgacaaagaa
tttcctaatccaaatatctttgaccctggccactttctagataagaatggcaactttaag
aaaagtgactacttcatgcctttctcagcaggaaaacgaatttgtgcaggagaaggactt
gcccgcatggagctatttttatttctaaccacaattttacagaactttaacctgaaatct
gttgatgatttaaagaacctcaatactactgcagttaccaaagggattgtttctctgcca
ccctcataccagatctgcttcatccctgtctga

KEGG   Homo sapiens (human): 1559
Entry
1559              CDS       T01001                                 

Symbol
CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9
Name
(RefSeq) cytochrome P450 family 2 subfamily C member 9
  KO
K17719  cytochrome P450 family 2 subfamily C9 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00590  Arachidonic acid metabolism
hsa00591  Linoleic acid metabolism
hsa00830  Retinol metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa01100  Metabolic pathways
hsa04726  Serotonergic synapse
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05417  Lipid and atherosclerosis
Disease
H01205  Coumarin resistance
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    1559 (CYP2C9)
   00591 Linoleic acid metabolism
    1559 (CYP2C9)
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    1559 (CYP2C9)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    1559 (CYP2C9)
   00982 Drug metabolism - cytochrome P450
    1559 (CYP2C9)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    1559 (CYP2C9)
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    1559 (CYP2C9)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    1559 (CYP2C9)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    1559 (CYP2C9)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.51  (S)-limonene 6-monooxygenase
     1559 (CYP2C9)
    1.14.14.52  (S)-limonene 7-monooxygenase
     1559 (CYP2C9)
    1.14.14.53  (R)-limonene 6-monooxygenase
     1559 (CYP2C9)
    1.14.14.-  
     1559 (CYP2C9)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP2 family
   1559 (CYP2C9)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 1559
NCBI-ProteinID: NP_000762
OMIM: 601130
HGNC: 2623
Ensembl: ENSG00000138109
Vega: OTTHUMG00000018805
Pharos: P11712(Tchem)
UniProt: P11712 S5RV20
Structure
PDB: 

Position
10q23.33
AA seq 490 aa
MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV
YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM
KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID
LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK
KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP
PFYQLCFIPV
NT seq 1473 nt   +upstreamnt  +downstreamnt
atggattctcttgtggtccttgtgctctgtctctcatgtttgcttctcctttcactctgg
agacagagctctgggagaggaaaactccctcctggccccactcctctcccagtgattgga
aatatcctacagataggtattaaggacatcagcaaatccttaaccaatctctcaaaggtc
tatggccctgtgttcactctgtattttggcctgaaacccatagtggtgctgcatggatat
gaagcagtgaaggaagccctgattgatcttggagaggagttttctggaagaggcattttc
ccactggctgaaagagctaacagaggatttggaattgttttcagcaatggaaagaaatgg
aaggagatccggcgtttctccctcatgacgctgcggaattttgggatggggaagaggagc
attgaggaccgtgttcaagaggaagcccgctgccttgtggaggagttgagaaaaaccaag
gcctcaccctgtgatcccactttcatcctgggctgtgctccctgcaatgtgatctgctcc
attattttccataaacgttttgattataaagatcagcaatttcttaacttaatggaaaag
ttgaatgaaaacatcaagattttgagcagcccctggatccagatctgcaataatttttct
cctatcattgattacttcccgggaactcacaacaaattacttaaaaacgttgcttttatg
aaaagttatattttggaaaaagtaaaagaacaccaagaatcaatggacatgaacaaccct
caggactttattgattgcttcctgatgaaaatggagaaggaaaagcacaaccaaccatct
gaatttactattgaaagcttggaaaacactgcagttgacttgtttggagctgggacagag
acgacaagcacaaccctgagatatgctctccttctcctgctgaagcacccagaggtcaca
gctaaagtccaggaagagattgaacgtgtgattggcagaaaccggagcccctgcatgcaa
gacaggagccacatgccctacacagatgctgtggtgcacgaggtccagagatacattgac
cttctccccaccagcctgccccatgcagtgacctgtgacattaaattcagaaactatctc
attcccaagggcacaaccatattaatttccctgacttctgtgctacatgacaacaaagaa
tttcccaacccagagatgtttgaccctcatcactttctggatgaaggtggcaattttaag
aaaagtaaatacttcatgcctttctcagcaggaaaacggatttgtgtgggagaagccctg
gccggcatggagctgtttttattcctgacctccattttacagaactttaacctgaaatct
ctggttgacccaaagaaccttgacaccactccagttgtcaatggatttgcctctgtgccg
cccttctaccagctgtgcttcattcctgtctga

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