KEGG   Homo sapiens (human): 1559
Entry
1559              CDS       T01001                                 
Symbol
CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450-2C9, P450IIC9
Name
(RefSeq) cytochrome P450 family 2 subfamily C member 9
  KO
K17719  cytochrome P450 family 2 subfamily C9 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00590  Arachidonic acid metabolism
hsa00591  Linoleic acid metabolism
hsa00830  Retinol metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa01100  Metabolic pathways
hsa04726  Serotonergic synapse
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05417  Lipid and atherosclerosis
Disease
H01205  Coumarin resistance
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    1559 (CYP2C9)
   00591 Linoleic acid metabolism
    1559 (CYP2C9)
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    1559 (CYP2C9)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    1559 (CYP2C9)
   00982 Drug metabolism - cytochrome P450
    1559 (CYP2C9)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    1559 (CYP2C9)
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    1559 (CYP2C9)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    1559 (CYP2C9)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    1559 (CYP2C9)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.51  (S)-limonene 6-monooxygenase
     1559 (CYP2C9)
    1.14.14.52  (S)-limonene 7-monooxygenase
     1559 (CYP2C9)
    1.14.14.53  (R)-limonene 6-monooxygenase
     1559 (CYP2C9)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP2 family
   1559 (CYP2C9)
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 1559
NCBI-ProteinID: NP_000762
OMIM: 601130
HGNC: 2623
Ensembl: ENSG00000138109
Pharos: P11712(Tchem)
UniProt: P11712 S5RV20
Structure
Position
10:94938658..94990091
AA seq 490 aa
MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV
YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM
KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID
LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK
KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP
PFYQLCFIPV
NT seq 1473 nt   +upstreamnt  +downstreamnt
atggattctcttgtggtccttgtgctctgtctctcatgtttgcttctcctttcactctgg
agacagagctctgggagaggaaaactccctcctggccccactcctctcccagtgattgga
aatatcctacagataggtattaaggacatcagcaaatccttaaccaatctctcaaaggtc
tatggccctgtgttcactctgtattttggcctgaaacccatagtggtgctgcatggatat
gaagcagtgaaggaagccctgattgatcttggagaggagttttctggaagaggcattttc
ccactggctgaaagagctaacagaggatttggaattgttttcagcaatggaaagaaatgg
aaggagatccggcgtttctccctcatgacgctgcggaattttgggatggggaagaggagc
attgaggaccgtgttcaagaggaagcccgctgccttgtggaggagttgagaaaaaccaag
gcctcaccctgtgatcccactttcatcctgggctgtgctccctgcaatgtgatctgctcc
attattttccataaacgttttgattataaagatcagcaatttcttaacttaatggaaaag
ttgaatgaaaacatcaagattttgagcagcccctggatccagatctgcaataatttttct
cctatcattgattacttcccgggaactcacaacaaattacttaaaaacgttgcttttatg
aaaagttatattttggaaaaagtaaaagaacaccaagaatcaatggacatgaacaaccct
caggactttattgattgcttcctgatgaaaatggagaaggaaaagcacaaccaaccatct
gaatttactattgaaagcttggaaaacactgcagttgacttgtttggagctgggacagag
acgacaagcacaaccctgagatatgctctccttctcctgctgaagcacccagaggtcaca
gctaaagtccaggaagagattgaacgtgtgattggcagaaaccggagcccctgcatgcaa
gacaggagccacatgccctacacagatgctgtggtgcacgaggtccagagatacattgac
cttctccccaccagcctgccccatgcagtgacctgtgacattaaattcagaaactatctc
attcccaagggcacaaccatattaatttccctgacttctgtgctacatgacaacaaagaa
tttcccaacccagagatgtttgaccctcatcactttctggatgaaggtggcaattttaag
aaaagtaaatacttcatgcctttctcagcaggaaaacggatttgtgtgggagaagccctg
gccggcatggagctgtttttattcctgacctccattttacagaactttaacctgaaatct
ctggttgacccaaagaaccttgacaccactccagttgtcaatggatttgcctctgtgccg
cccttctaccagctgtgcttcattcctgtctga

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