KEGG   Homo sapiens (human): 1565Help
Entry
1565              CDS       T01001                                 

Gene name
CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1
Definition
(RefSeq) cytochrome P450 family 2 subfamily D member 6
  KO
K17712  cytochrome P450 family 2 subfamily D polypeptide 6 [EC:1.14.14.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa01522  Endocrine resistance
hsa04726  Serotonergic synapse
Disease
H01171  Poor drug metabolism
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    1565 (CYP2D6)
   00982 Drug metabolism - cytochrome P450
    1565 (CYP2D6)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    1565 (CYP2D6)
 09160 Human Diseases
  09176 Drug resistance: Antineoplastic
   01522 Endocrine resistance
    1565 (CYP2D6)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    1565 (CYP2D6)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     1565 (CYP2D6)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP2 family
   1565 (CYP2D6)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: p450
Motif
Other DBs
NCBI-GeneID: 1565
NCBI-ProteinID: NP_000097
OMIM: 124030
HGNC: 2625
Ensembl: ENSG00000100197
Vega: OTTHUMG00000150918
Pharos: P10635(Tclin)
UniProt: P10635 C1ID52 Q5Y7H2
Structure
PDB: 

Position
22q13.2
AA seq 497 aa AA seqDB search
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
NT seq 1494 nt NT seq  +upstreamnt  +downstreamnt
atggggctagaagcactggtgcccctggccgtgatagtggccatcttcctgctcctggtg
gacctgatgcaccggcgccaacgctgggctgcacgctacccaccaggccccctgccactg
cccgggctgggcaacctgctgcatgtggacttccagaacacaccatactgcttcgaccag
ttgcggcgccgcttcggggacgtgttcagcctgcagctggcctggacgccggtggtcgtg
ctcaatgggctggcggccgtgcgcgaggcgctggtgacccacggcgaggacaccgccgac
cgcccgcctgtgcccatcacccagatcctgggtttcgggccgcgttcccaaggggtgttc
ctggcgcgctatgggcccgcgtggcgcgagcagaggcgcttctccgtgtccaccttgcgc
aacttgggcctgggcaagaagtcgctggagcagtgggtgaccgaggaggccgcctgcctt
tgtgccgccttcgccaaccactccggacgcccctttcgccccaacggtctcttggacaaa
gccgtgagcaacgtgatcgcctccctcacctgcgggcgccgcttcgagtacgacgaccct
cgcttcctcaggctgctggacctagctcaggagggactgaaggaggagtcgggctttctg
cgcgaggtgctgaatgctgtccccgtcctcctgcatatcccagcgctggctggcaaggtc
ctacgcttccaaaaggctttcctgacccagctggatgagctgctaactgagcacaggatg
acctgggacccagcccagcccccccgagacctgactgaggccttcctggcagagatggag
aaggccaaggggaaccctgagagcagcttcaatgatgagaacctgcgcatagtggtggct
gacctgttctctgccgggatggtgaccacctcgaccacgctggcctggggcctcctgctc
atgatcctacatccggatgtgcagcgccgtgtccaacaggagatcgacgacgtgataggg
caggtgcggcgaccagagatgggtgaccaggctcacatgccctacaccactgccgtgatt
catgaggtgcagcgctttggggacatcgtccccctgggtgtgacccatatgacatcccgt
gacatcgaagtacagggcttccgcatccctaagggaacgacactcatcaccaacctgtca
tcggtgctgaaggatgaggccgtctgggagaagcccttccgcttccaccccgaacacttc
ctggatgcccagggccactttgtgaagccggaggccttcctgcctttctcagcaggccgc
cgtgcatgcctcggggagcccctggcccgcatggagctcttcctcttcttcacctccctg
ctgcagcacttcagcttctcggtgcccactggacagccccggcccagccaccatggtgtc
tttgctttcctggtgagcccatccccctatgagctttgtgctgtgccccgctag

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