| Entry |
|
|---|
| Gene name |
CYP11B1, CPN1, CYP11B, FHI, P450C11
|
|---|
| Definition |
(RefSeq) cytochrome P450 family 11 subfamily B member 1
|
|---|
| KO |
|
|---|
| Organism |
|
|---|
| Pathway |
| hsa04927 | Cortisol synthesis and secretion |
|
|---|
| Module |
| hsa_M00108 | C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone |
| hsa_M00109 | C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone |
|
|---|
| Network |
|
|---|
| Element |
| N00297 | ACTH-cortisol signaling pathway |
| N00306 | SF-1-mediated transcription |
| N00307 | Mutation-inactivated DAX1 to SF-1-mediated transcription |
| N00308 | Mutation-inactivated SF-1 to transcription |
| N00320 | Mutation-activated PRKACA to ACTH-cortisol signaling pathway |
| N00321 | Mutation-activated GNAS to ACTH-cortisol signaling pathway |
| N00322 | Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway |
| N00323 | Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway |
| N00338 | Steroid hormone biosynthesis, progesterone to cortisol/cortisone |
| N00339 | Steroid hormone biosynthesis, progesterone to aldosterone |
| N00760 | CYP11B1 deficiency in steroid hormone biosynthesis |
| N00761 | CYP21A2 deficiency in steroid hormone biosynthesis |
| N00762 | CYP17A1 deficiency in steroid hormone biosynthesis |
| N00773 | HSD11B2 deficiency in steroid hormone biosynthesis |
| N00774 | CYP11B2 deficiency in steroid hormone biosynthesis |
|
|---|
| Disease |
| H00216 | Congenital adrenal hyperplasia |
| H00602 | Glucocorticoid-remediable aldosteronism (GRA) |
|
|---|
| Drug target |
|
|---|
| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
1584 (CYP11B1)
09150 Organismal Systems
09152 Endocrine system
04927 Cortisol synthesis and secretion
1584 (CYP11B1)
09160 Human Diseases
09167 Endocrine and metabolic disease
04934 Cushing syndrome
1584 (CYP11B1)
09180 Brite Hierarchies
09181 Protein families: metabolism
00199 Cytochrome P450 [BR:hsa00199]
1584 (CYP11B1)
Enzymes [BR:hsa01000]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
1.14.15.4 steroid 11beta-monooxygenase
1584 (CYP11B1)
Cytochrome P450 [BR:hsa00199]
Cytochrome P450, animal type
CYP11 family
1584 (CYP11B1)
|
|---|
| SSDB |
|
|---|
| Motif |
|
|---|
| Other DBs |
|
|---|
| Structure |
PDB: |
|---|
| Position |
8q24.3
|
|---|
| AA seq |
503 aa
MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED
IKMVYSFILRPSMFPLLTFRAIN |
|---|
| NT seq |
1512 nt +upstreamnt +downstreamnt
atggcactcagggcaaaggcagaggtgtgcatggcagtgccctggctgtccctgcaaagg
gcacaggcactgggcacgagagccgcccgggtccccaggacagtgctgccctttgaagcc
atgccccggcgtccaggcaacaggtggctgaggctgctgcagatctggagggagcagggt
tatgaggacctgcacctggaagtacaccagaccttccaggaactagggcccattttcagg
tacgacttgggaggagcaggcatggtgtgtgtgatgctgccggaggacgtggagaagctg
caacaggtggacagcctgcatccccacaggatgagcctggagccctgggtggcctacaga
caacatcgtgggcacaaatgtggcgtgttcttgctgaatgggcctgaatggcgcttcaac
cgattgcggctgaatccagaagtgctgtcgcccaacgctgtgcagaggttcctcccgatg
gtggatgcagtggccagggacttctcccaggccctgaagaagaaggtgctgcagaacgcc
cgggggagcctgaccctggacgtccagcccagcatcttccactacaccatagaagccagc
aacttggctctttttggagagcggctgggcctggttggccacagccccagttctgccagc
ctgaacttcctccatgccctggaggtcatgttcaaatccaccgtccagctcatgttcatg
cccaggagcctgtctcgctggaccagccccaaggtgtggaaggagcactttgaggcctgg
gactgcatcttccagtacggcgacaactgtatccagaaaatctatcaggaactggccttc
agccgccctcaacagtacaccagcatcgtggcggagctcctgttgaatgcggaactgtcg
ccagatgccatcaaggccaactctatggaactcactgcagggagcgtggacacgacggtg
tttcccttgctgatgacgctctttgagctggctcggaaccccaacgtgcagcaggccctg
cgccaggagagcctggccgccgcagccagcatcagtgaacatccccagaaggcaaccacc
gagctgcccttgctgcgtgcggccctcaaggagaccttgcggctctaccctgtgggtctg
tttctggagcgagtggcgagctcagacttggtgcttcagaactaccacatcccagctggg
acattggtgcgcgtgttcctctactctctgggtcgcaaccccgccttgttcccgaggcct
gagcgctataacccccagcgctggctagacatcaggggctccggcaggaacttctaccac
gtgccctttggctttggcatgcgccagtgccttgggcggcgcctggcagaggcagagatg
ctgctgctgctgcaccatgtgctgaaacacctccaggtggagacactaacccaagaggac
ataaagatggtctacagcttcatattgaggcccagcatgttccccctcctcaccttcaga
gccatcaactaa |
|---|
