KEGG   Homo sapiens (human): 1615
Entry
1615              CDS       T01001                                 
Symbol
DARS1, DARS, HBSL, aspRS
Name
(RefSeq) aspartyl-tRNA synthetase 1
  KO
K22503  aspartyl-tRNA synthetase [EC:6.1.1.12]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00970  Aminoacyl-tRNA biosynthesis
Disease
H02433  Hypomyelination with brainstem and spinal cord involvement and leg spasticity
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   00970 Aminoacyl-tRNA biosynthesis
    1615 (DARS1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01007 Amino acid related enzymes [BR:hsa01007]
    1615 (DARS1)
  09182 Protein families: genetic information processing
   03016 Transfer RNA biogenesis [BR:hsa03016]
    1615 (DARS1)
Enzymes [BR:hsa01000]
 6. Ligases
  6.1  Forming carbon-oxygen bonds
   6.1.1  Ligases forming aminoacyl-tRNA and related compounds
    6.1.1.12  aspartate---tRNA ligase
     1615 (DARS1)
Amino acid related enzymes [BR:hsa01007]
 Aminoacyl-tRNA synthetase
  Class II (A)
   1615 (DARS1)
Transfer RNA biogenesis [BR:hsa03016]
 Eukaryotic type
  Aminoacyl-tRNA synthetases (AARSs)
   Multi-aminoacyl-tRNA synthetase complex (MSC)
    1615 (DARS1)
SSDB
Motif
Pfam: tRNA-synt_2 tRNA_anti-codon tRNA-synt_2d S-AdoMet_synt_N
Other DBs
NCBI-GeneID: 1615
NCBI-ProteinID: NP_001340
OMIM: 603084
HGNC: 2678
Ensembl: ENSG00000115866
Pharos: P14868(Tbio)
UniProt: P14868 A0A140VJW5
Structure
Position
2:complement(135905881..135985684)
AA seq 501 aa
MPSASASRKSQEKPREIMDAAEDYAKERYGISSMIQSQEKPDRVLVRVRDLTIQKADEVV
WVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVV
RKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRL
DNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYF
KNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYH
EVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGV
EMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFM
RGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLF
LGLHNVRQTSMFPRDPKRLTP
NT seq 1506 nt   +upstreamnt  +downstreamnt
atgcccagcgccagcgccagccgcaagagtcaggagaagccgcgggagatcatggacgcg
gcggaagattatgctaaagagagatatggaatatcttcaatgatacaatcacaagaaaaa
ccagatcgagttttggttcgggttagagacttgacaatacaaaaagctgatgaagttgtt
tgggtacgtgcaagagttcatacaagcagagctaaagggaaacagtgcttcttagtccta
cgtcagcagcagtttaatgtccaggctcttgtggcggtgggagaccatgcaagcaagcag
atggttaaatttgctgccaacatcaacaaagagagcattgtggatgtagaaggtgttgtg
agaaaagtgaatcagaaaattggaagctgtacacagcaagacgttgagttacatgttcag
aagatttatgtgatcagtttggctgaaccccgtctgcccctgcagctggatgatgctgtt
cggcctgaggcagaaggagaagaggaaggaagagctactgttaaccaggatacaagatta
gacaacagagtcattgatcttaggacatcaactagtcaggcagtcttccgtctccagtct
ggcatctgccatctcttccgagaaactttaattaacaaaggttttgtggaaatccaaact
cctaaaattatttcagctgccagtgaaggaggagccaatgtttttactgtgtcatatttt
aaaaataatgcatacctggctcagtccccacagctatataagcaaatgtgcatttgtgct
gattttgagaaggttttctctattggaccagtattcagagcggaagactctaatacccat
agacatctaactgagtttgttggtttggacattgaaatggcttttaattaccattaccac
gaagttatggaagaaattgctgacaccatggtacaaatattcaaaggacttcaagaaagg
tttcagactgaaattcaaacagtgaataaacagttcccatgtgagccattcaaatttttg
gagccaactctaagactagaatattgtgaagcattggctatgcttagggaagctggagtc
gaaatgggagatgaagacgatctgagcacaccaaatgaaaagctgttgggtcatttggta
aaggaaaagtatgatacagatttttatattcttgataaatatccattggctgtaagacct
ttctataccatgcctgacccaagaaatcccaaacagtccaactcttacgatatgttcatg
agaggagaagaaatattgtcaggagctcaaagaatacatgatcctcaactgctaacagag
agagctttacatcatggaattgatttggagaaaattaaggcttacattgattccttccgc
tttggagcccctcctcatgctggtggaggcattggattggaacgagttactatgctgttt
ctgggattgcataatgttcgtcagacctccatgttccctcgtgatcccaaacgactcact
ccttaa

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
   PHAROS (1)   
Protein sequence (5)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (30)   
   RefSeq(nuc) (2)   
   GenBank (14)   
   EMBL (14)   
3D Structure (3)   
   PDB (3)   
Protein domain (4)   
   Pfam (4)   
All databases (80)   

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