KEGG   Homo sapiens (human): 1615
Entry
1615              CDS       T01001                                 
Symbol
DARS1, DARS, HBSL, aspRS
Name
(RefSeq) aspartyl-tRNA synthetase 1
  KO
K22503  aspartyl-tRNA synthetase [EC:6.1.1.12]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00970  Aminoacyl-tRNA biosynthesis
Disease
H02433  Hypomyelination with brainstem and spinal cord involvement and leg spasticity
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   00970 Aminoacyl-tRNA biosynthesis
    1615 (DARS1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01007 Amino acid related enzymes [BR:hsa01007]
    1615 (DARS1)
  09182 Protein families: genetic information processing
   03016 Transfer RNA biogenesis [BR:hsa03016]
    1615 (DARS1)
Enzymes [BR:hsa01000]
 6. Ligases
  6.1  Forming carbon-oxygen bonds
   6.1.1  Ligases forming aminoacyl-tRNA and related compounds
    6.1.1.12  aspartate---tRNA ligase
     1615 (DARS1)
Amino acid related enzymes [BR:hsa01007]
 Aminoacyl-tRNA synthetase
  Class II (A)
   1615 (DARS1)
Transfer RNA biogenesis [BR:hsa03016]
 Eukaryotic type
  Aminoacyl-tRNA synthetases (AARSs)
   Multi-aminoacyl-tRNA synthetase complex (MSC)
    1615 (DARS1)
SSDB
Motif
Pfam: tRNA-synt_2 tRNA_anti-codon tRNA-synt_2d S-AdoMet_synt_N HTH_NOL4_2nd
Other DBs
NCBI-GeneID: 1615
NCBI-ProteinID: NP_001340
OMIM: 603084
HGNC: 2678
Ensembl: ENSG00000115866
UniProt: P14868 A0A140VJW5
Structure
Position
2:complement(135905881..135985684)
AA seq 501 aa
MPSASASRKSQEKPREIMDAAEDYAKERYGISSMIQSQEKPDRVLVRVRDLTIQKADEVV
WVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVV
RKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRL
DNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYF
KNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYH
EVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGV
EMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFM
RGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLF
LGLHNVRQTSMFPRDPKRLTP
NT seq 1506 nt   +upstreamnt  +downstreamnt
atgcccagcgccagcgccagccgcaagagtcaggagaagccgcgggagatcatggacgcg
gcggaagattatgctaaagagagatatggaatatcttcaatgatacaatcacaagaaaaa
ccagatcgagttttggttcgggttagagacttgacaatacaaaaagctgatgaagttgtt
tgggtacgtgcaagagttcatacaagcagagctaaagggaaacagtgcttcttagtccta
cgtcagcagcagtttaatgtccaggctcttgtggcggtgggagaccatgcaagcaagcag
atggttaaatttgctgccaacatcaacaaagagagcattgtggatgtagaaggtgttgtg
agaaaagtgaatcagaaaattggaagctgtacacagcaagacgttgagttacatgttcag
aagatttatgtgatcagtttggctgaaccccgtctgcccctgcagctggatgatgctgtt
cggcctgaggcagaaggagaagaggaaggaagagctactgttaaccaggatacaagatta
gacaacagagtcattgatcttaggacatcaactagtcaggcagtcttccgtctccagtct
ggcatctgccatctcttccgagaaactttaattaacaaaggttttgtggaaatccaaact
cctaaaattatttcagctgccagtgaaggaggagccaatgtttttactgtgtcatatttt
aaaaataatgcatacctggctcagtccccacagctatataagcaaatgtgcatttgtgct
gattttgagaaggttttctctattggaccagtattcagagcggaagactctaatacccat
agacatctaactgagtttgttggtttggacattgaaatggcttttaattaccattaccac
gaagttatggaagaaattgctgacaccatggtacaaatattcaaaggacttcaagaaagg
tttcagactgaaattcaaacagtgaataaacagttcccatgtgagccattcaaatttttg
gagccaactctaagactagaatattgtgaagcattggctatgcttagggaagctggagtc
gaaatgggagatgaagacgatctgagcacaccaaatgaaaagctgttgggtcatttggta
aaggaaaagtatgatacagatttttatattcttgataaatatccattggctgtaagacct
ttctataccatgcctgacccaagaaatcccaaacagtccaactcttacgatatgttcatg
agaggagaagaaatattgtcaggagctcaaagaatacatgatcctcaactgctaacagag
agagctttacatcatggaattgatttggagaaaattaaggcttacattgattccttccgc
tttggagcccctcctcatgctggtggaggcattggattggaacgagttactatgctgttt
ctgggattgcataatgttcgtcagacctccatgttccctcgtgatcccaaacgactcact
ccttaa

  All links  
Disease (2)   
   OMIM (2)   
Gene (19)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (5)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (30)   
   RefSeq(nuc) (2)   
   GenBank (14)   
   EMBL (14)   
3D Structure (3)   
   PDB (3)   
Protein domain (5)   
   Pfam (5)   
All databases (64)   

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