KEGG   Homo sapiens (human): 1687
Entry
1687              CDS       T01001                                 
Symbol
GSDME, DFNA5, ICERE-1
Name
(RefSeq) gasdermin E
  KO
K22146  gasdermin-E
Organism
hsa  Homo sapiens (human)
Pathway
hsa04623  Cytosolic DNA-sensing pathway
Disease
H00604  Deafness, autosomal dominant
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04623 Cytosolic DNA-sensing pathway
    1687 (GSDME)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    1687 (GSDME)
Transporters [BR:hsa02000]
 Other transporters
  Pores ion channels [TC:1]
   1687 (GSDME)
SSDB
Motif
Pfam: Gasdermin Gasdermin_C Ig-like_KY
Other DBs
NCBI-GeneID: 1687
NCBI-ProteinID: NP_001120925
OMIM: 608798
HGNC: 2810
Ensembl: ENSG00000105928
UniProt: O60443
Position
7:complement(24698355..24795539)
AA seq 496 aa
MFAKATRNFLREVDADGDLIAVSNLNDSDKLQLLSLVTKKKRFWCWQRPKYQFLSLTLGD
VLIEDQFPSPVVVESDFVKYEGKFANHVSGTLETALGKVKLNLGGSSRVESQSSFGTLRK
QEVDLQQLIRDSAERTINLRNPVLQQVLEGRNEVLCVLTQKITTMQKCVISEHMQVEEKC
GGIVGIQTKTVQVSATEDGNVTKDSNVVLEIPAATTIAYGVIELYVKLDGQFEFCLLRGK
QGGFENKKRIDSVYLDPLVFREFAFIDMPDAAHGISSQDGPLSVLKQATLLLERNFHPFA
ELPEPQQTALSDIFQAVLFDDELLMVLEPVCDDLVSGLSPTVAVLGELKPRQQQDLVAFL
QLVGCSLQGGCPGPEDAGSKQLFMTAYFLVSALAEMPDSAAALLGTCCKLQIIPTLCHLL
RALSDDGVSDLEDPTLTPLKDTERFGIVQRLFASADISLERLKSSVKAVILKDSKVFPLL
LCITLNGLCALGREHS
NT seq 1491 nt   +upstreamnt  +downstreamnt
atgtttgccaaagcaaccaggaattttcttagagaagttgatgctgatggtgacctgatt
gcagtatcaaatctgaatgactctgataagttacagcttctaagtctggtgacaaaaaag
aagagattctggtgctggcagagacccaagtaccagtttttatccctcacccttggcgat
gtactcatagaagaccaatttccgagtccagtggtcgtggagtcggactttgtgaaatac
gagggcaagtttgcaaaccacgtgagtggaaccctggagactgcactggggaaggtcaag
ctgaacctggggggcagcagccgcgtagagagccagtcttcatttggaaccctgaggaag
caggaggtggatttgcagcagctcatcagagactctgccgagagaacaataaatctgaga
aaccctgtgctccagcaggtgctggaaggaaggaatgaggtcctgtgcgttttgacacag
aagatcacgacgatgcagaagtgtgtgatctctgagcacatgcaggtcgaggagaagtgt
ggtggcatcgtgggcatccagaccaagacggtgcaggtgtcagcgacggaggatgggaat
gtcaccaaggactccaacgtggtgctggagatcccagctgccaccaccattgcctacggt
gtcattgagttatacgtgaaactggacggccagttcgagttctgccttctccgagggaag
caaggtggcttcgagaacaagaagagaattgactctgtctacctggaccccctggtcttt
cgagagtttgcattcatagacatgccagatgctgcgcatgggatatcttcccaggatgga
ccattaagtgttttaaagcaagcgaccctgctcctggagaggaatttccatccatttgcg
gagctgcctgagccacaacagacagctttgagtgacatcttccaggcggtcctatttgat
gatgaactactcatggtcctggaaccagtgtgcgatgacctggtcagcggcctctcgccc
acagtggcggtgctgggggagctgaagccccggcagcagcaggaccttgtggccttcctg
cagctggtggggtgcagcttacagggtgggtgtccgggccccgaggatgcaggcagcaag
cagctgtttatgacagcctacttcttggtcagtgccctcgcagaaatgccagatagcgca
gcagctctgctgggcacttgctgcaaactccagatcattcccacactgtgccacttgctt
cgtgctctgtctgatgatggagtatctgatcttgaagacccaaccttgactcccctgaaa
gatacagaaaggtttgggattgtgcagcgcttgtttgcctcagctgacattagtctggag
agactgaagtcatctgtgaaagctgtcattctgaaggactctaaagtcttcccactgctt
ctttgtataaccctgaatggactctgtgctttaggcagagaacattcatga

  All links  
Disease (2)   
   OMIM (2)   
Gene (16)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (8)   
   OC (1)   
Protein sequence (10)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (40)   
   RefSeq(nuc) (8)   
   GenBank (16)   
   EMBL (16)   
Protein domain (3)   
   Pfam (3)   
All databases (71)   

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