KEGG   Homo sapiens (human): 1728
Entry
1728              CDS       T01001                                 
Symbol
NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1
Name
(RefSeq) NAD(P)H quinone dehydrogenase 1
  KO
K00355  NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00130  Ubiquinone and other terpenoid-quinone biosynthesis
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
hsa05200  Pathways in cancer
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01413  Metals to KEAP1-NRF2 signalig pathway
Drug target
Acenocoumarol: D07064
Warfarin (DG00149): D00564<US> D01280<JP> D08682
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00130 Ubiquinone and other terpenoid-quinone biosynthesis
    1728 (NQO1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1728 (NQO1)
   05208 Chemical carcinogenesis - reactive oxygen species
    1728 (NQO1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    1728 (NQO1)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    1728 (NQO1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.6  Acting on NADH or NADPH
   1.6.5  With a quinone or similar compound as acceptor
    1.6.5.2  NAD(P)H dehydrogenase (quinone)
     1728 (NQO1)
SSDB
Motif
Pfam: Flavodoxin_2 FMN_red Flavodoxin_4
Other DBs
NCBI-GeneID: 1728
NCBI-ProteinID: NP_000894
OMIM: 125860
HGNC: 2874
Ensembl: ENSG00000181019
UniProt: P15559
Structure
Position
16:complement(69709401..69726560)
AA seq 274 aa
MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKL
KDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERV
FIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFC
GFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMK
KEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK
NT seq 825 nt   +upstreamnt  +downstreamnt
atggtcggcagaagagcactgatcgtactggctcactcagagaggacgtccttcaactat
gccatgaaggaggctgctgcagcggctttgaagaagaaaggatgggaggtggtggagtcg
gacctctatgccatgaacttcaatcccatcatttccagaaaggacatcacaggtaaactg
aaggaccctgcgaactttcagtatcctgccgagtctgttctggcttataaagaaggccat
ctgagcccagatattgtggctgaacaaaagaagctggaagccgcagaccttgtgatattc
cagttccccctgcagtggtttggagtccctgccattctgaaaggctggtttgagcgagtg
ttcataggagagtttgcttacacttacgctgccatgtatgacaaaggacccttccggagt
aagaaggcagtgctttccatcaccactggtggcagtggctccatgtactctctgcaaggg
atccacggggacatgaatgtcattctctggccaattcagagtggcattctgcatttctgt
ggcttccaagtcttagaacctcaactgacatatagcattgggcacactccagcagacgcc
cgaattcaaatcctggaaggatggaagaaacgcctggagaatatttgggatgagacacca
ctgtattttgctccaagcagcctctttgacctaaacttccaggcaggattcttaatgaaa
aaagaggtacaggatgaggagaaaaacaagaaatttggcctttctgtgggccatcacttg
ggcaagtccatcccaactgacaaccagatcaaagctagaaaatga

  All links  
Disease (1)   
   OMIM (1)   
Gene (21)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (9)   
   NAGAHAMA-H (6)   
   OC (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (46)   
   RefSeq(nuc) (4)   
   GenBank (21)   
   EMBL (21)   
3D Structure (23)   
   PDB (23)   
Protein domain (3)   
   Pfam (3)   
All databases (100)   

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