KEGG   Homo sapiens (human): 1733Help
Entry
1733              CDS       T01001                                 

Gene name
DIO1, 5DI, TXDI1
Definition
(RefSeq) iodothyronine deiodinase 1
  KO
K01562  type I thyroxine 5'-deiodinase [EC:1.21.99.4]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04919  Thyroid hormone signaling pathway
Drug target
Propylthiouracil: D00562
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    1733 (DIO1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.21  Catalysing the reaction X-H + Y-H = X-Y
   1.21.99  With unknown physiological acceptors
    1.21.99.4  thyroxine 5'-deiodinase
     1733 (DIO1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: T4_deiodinase DUF2019 SCIMP SWIM
Motif
Other DBs
NCBI-GeneID: 1733
NCBI-ProteinID: NP_000783
OMIM: 147892
HGNC: 2883
Ensembl: ENSG00000211452
Vega: OTTHUMG00000008435
Pharos: P49895(Tclin)
UniProt: P49895 A8K415
Position
1p32.3
AA seq 249 aa AA seqDB search
MGLPQPGLWLKRLWVLLEVAVHVVVGKVLLILFPDRVKRNILAMGEKTGMTRNPHFSHDN
WIPTFFSTQYFWFVLKVRWQRLEDTTELGGLAPNCPVVRLSGQRCNIWEFMQGNRPLVLN
FGSCTUPSFMFKFDQFKRLIEDFSSIADFLVIYIEEAHASDGWAFKNNMDIRNHQNLQDR
LQAAHLLLARSPQCPVVVDTMQNQSSQLYAALPERLYIIQEGRILYKGKSGPWNYNPEEV
RAVLEKLHS
NT seq 750 nt NT seq  +upstreamnt  +downstreamnt
atggggctgccccagccagggctgtggctgaagaggctctgggtgctcttggaggtggct
gtgcatgtggtcgtgggtaaagtgcttctgatattgtttccagacagagtcaagcggaac
atcctggccatgggcgagaagacgggtatgaccaggaacccccatttcagccacgacaac
tggataccaacctttttcagcacccagtatttctggttcgtcttgaaggtccgttggcag
cgactagaggacacgactgagctagggggtctggccccaaactgcccggtggtccgcctc
tcaggacagaggtgcaacatttgggagtttatgcaaggtaataggccactggtgctgaat
tttggaagttgtacctgaccttcatttatgttcaaatttgaccagttcaagaggcttatt
gaagactttagttccatagcagattttcttgtcatttacattgaagaagcacatgcatca
gatggctgggcttttaagaacaacatggacatcagaaatcaccagaaccttcaggatcgc
ctgcaggcagcccatctactgctggccaggagcccccagtgccctgtggtggtggacacc
atgcagaaccagagcagccagctctacgcagcactgcctgagaggctctacataatccag
gagggcaggatcctctacaagggtaaatctggcccttggaactacaacccagaggaagtt
cgtgctgttctggaaaagctccacagttaa

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