KEGG   Homo sapiens (human): 1773
Entry
1773              CDS       T01001                                 
Symbol
DNASE1, DNL1, DRNI
Name
(RefSeq) deoxyribonuclease 1
  KO
K11994  deoxyribonuclease-1 [EC:3.1.21.1]
Organism
hsa  Homo sapiens (human)
Network
nt06520  CGAS-STING signaling
  Element
N01571  DNA degradation by extracellular/endolysosomal DNAse
Disease
H00080  Systemic lupus erythematosus
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09190 Not Included in Pathway or Brite
  09191 Unclassified: metabolism
   99980 Enzymes with EC numbers
    1773 (DNASE1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.21  Endodeoxyribonucleases producing 5'-phosphomonoesters
    3.1.21.1  deoxyribonuclease I
     1773 (DNASE1)
SSDB
Motif
Pfam: Exo_endo_phos
Other DBs
NCBI-GeneID: 1773
NCBI-ProteinID: NP_005214
OMIM: 125505
HGNC: 2956
Ensembl: ENSG00000213918
UniProt: P24855
Structure
Position
16:3611760..3665461
AA seq 282 aa
MRGMKLLGALLALAALLQGAVSLKIAAFNIQTFGETKMSNATLVSYIVQILSRYDIALVQ
EVRDSHLTAVGKLLDNLNQDAPDTYHYVVSEPLGRNSYKERYLFVYRPDQVSAVDSYYYD
DGCEPCGNDTFNREPAIVRFFSRFTEVREFAIVPLHAAPGDAVAEIDALYDVYLDVQEKW
GLEDVMLMGDFNAGCSYVRPSQWSSIRLWTSPTFQWLIPDSADTTATPTHCAYDRIVVAG
MLLRGAVVPDSALPFNFQAAYGLSDQLAQAISDHYPVEVMLK
NT seq 849 nt   +upstreamnt  +downstreamnt
atgaggggcatgaagctgctgggggcgctgctggcactggcggccctactgcagggggcc
gtgtccctgaagatcgcagccttcaacatccagacatttggggagaccaagatgtccaat
gccaccctcgtcagctacattgtgcagatcctgagccgctatgacatcgccctggtccag
gaggtcagagacagccacctgactgccgtggggaagctgctggacaacctcaatcaggat
gcaccagacacctatcactacgtggtcagtgagccactgggacggaacagctataaggag
cgctacctgttcgtgtacaggcctgaccaggtgtctgcggtggacagctactactacgat
gatggctgcgagccctgcgggaacgacaccttcaaccgagagccagccattgtcaggttc
ttctcccggttcacagaggtcagggagtttgccattgttcccctgcatgcggccccgggg
gacgcagtagccgagatcgacgctctctatgacgtctacctggatgtccaagagaaatgg
ggcttggaggacgtcatgttgatgggcgacttcaatgcgggctgcagctatgtgagaccc
tcccagtggtcatccatccgcctgtggacaagccccaccttccagtggctgatccccgac
agcgctgacaccacagctacacccacgcactgtgcctatgacaggatcgtggttgcaggg
atgctgctccgaggcgccgttgttcccgactcggctcttccctttaacttccaggctgcc
tatggcctgagtgaccaactggcccaagccatcagtgaccactatccagtggaggtgatg
ctgaagtga

  All links  
Disease (2)   
   OMIM (2)   
Gene (27)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (19)   
   OC (1)   
Protein sequence (26)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (24)   
DNA sequence (58)   
   RefSeq(nuc) (26)   
   GenBank (16)   
   EMBL (16)   
3D Structure (1)   
   PDB (1)   
Protein domain (1)   
   Pfam (1)   
All databases (115)   

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