KEGG   Homo sapiens (human): 18
Entry
18                CDS       T01001                                 
Symbol
ABAT, GABA-AT, GABAT, NPD009
Name
(RefSeq) 4-aminobutyrate aminotransferase
  KO
K13524  4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase [EC:2.6.1.19 2.6.1.22]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00250  Alanine, aspartate and glutamate metabolism
hsa00280  Valine, leucine and isoleucine degradation
hsa00410  beta-Alanine metabolism
hsa00640  Propanoate metabolism
hsa00650  Butanoate metabolism
hsa01100  Metabolic pathways
hsa04727  GABAergic synapse
Module
hsa_M00027  GABA (gamma-Aminobutyrate) shunt
Network
nt06544  Neuroactive ligand signaling
  Element
N01892  GABA metabolism and transport in glia
Disease
H01257  GABA-transaminase deficiency
Drug target
Valproic acid (DG00849): D00304<US> D00399<US> D00710<JP/US> D08667
Vigabatrin: D00535<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00640 Propanoate metabolism
    18 (ABAT)
   00650 Butanoate metabolism
    18 (ABAT)
  09105 Amino acid metabolism
   00250 Alanine, aspartate and glutamate metabolism
    18 (ABAT)
   00280 Valine, leucine and isoleucine degradation
    18 (ABAT)
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    18 (ABAT)
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    18 (ABAT)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01007 Amino acid related enzymes [BR:hsa01007]
    18 (ABAT)
Enzymes [BR:hsa01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.19  4-aminobutyrate---2-oxoglutarate transaminase
     18 (ABAT)
    2.6.1.22  (S)-3-amino-2-methylpropionate transaminase
     18 (ABAT)
Amino acid related enzymes [BR:hsa01007]
 Aminotransferase (transaminase)
  Class III
   18 (ABAT)
SSDB
Motif
Pfam: Aminotran_3 Lenti_VIF_2 WH_RGF3
Other DBs
NCBI-GeneID: 18
NCBI-ProteinID: NP_000654
OMIM: 137150
HGNC: 23
Ensembl: ENSG00000183044
UniProt: P80404 X5D8S1
Position
16:8674617..8784570
AA seq 500 aa
MASMLLAQRLACSFQHSYRLLVPGSRHISQAAAKVDVEFDYDGPLMKTEVPGPRSQELMK
QLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYSHPALLKLIQQPQ
NASMFVNRPALGILPPENFVEKLRQSLLSVAPKGMSQLITMACGSCSNENALKTIFMWYR
SKERGQRGFSQEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPS
FDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGG
DNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWAHEHWGLDDPADVMTFSKKMM
TGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNAAHAGKALLTGLL
DLQARYPQFISRVRGRGTFCSFDTPDDSIRNKLILIARNKGVVLGGCGDKSIRFRPTLVF
RDHHAHLFLNIFSDILADFK
NT seq 1503 nt   +upstreamnt  +downstreamnt
atggcctccatgttgctcgcccagcgcctggcctgcagcttccagcacagctaccgcctg
ctggtgcctggatccagacacattagtcaagctgcagccaaagtcgacgttgaatttgat
tatgatgggcctctgatgaagacggaagtcccagggcctagatctcaggagttaatgaaa
cagctgaatataattcagaatgcagaggctgtgcattttttctgcaattacgaagagagc
cgaggcaattacctggttgatgtggacggcaaccgaatgctggatctttattcccagatc
tcctctgtccccataggttacagccaccccgccctgctgaaactcatccaacagcctcaa
aatgcgagcatgtttgtcaacagacccgccctcggaatcctgcctccggagaactttgtg
gagaagctccggcagtccttgctctcggtggctcccaaagggatgtcccagctcatcacc
atggcctgcggctcctgctccaatgaaaacgccttaaagaccatcttcatgtggtaccgg
agcaaggaaagagggcagaggggcttctcccaggaggagctggagacgtgcatgattaac
caggcccctggctgccccgactacagcatcctctccttcatgggcgcgttccatgggagg
accatgggttgcttagcgaccacgcactctaaagccattcacaagatcgacatcccttcc
tttgactggcccatcgcaccgttcccacggctgaaataccctctggaagagtttgtgaaa
gagaaccaacaggaggaggcccgctgtctggaagaggtggaggatctgattgtgaaatat
cggaaaaagaagaagacggtggccgggatcatcgtggagcccatccagtccgagggtgga
gacaaccacgcatccgatgacttctttcggaagctgagagacatcgccaggaagcatggc
tgcgccttcttggtggacgaggtccagaccggaggaggctgcacgggcaagttctgggcc
catgagcactggggcctggatgacccagcagacgtgatgaccttcagcaagaagatgatg
actgggggcttcttccacaaggaggagttcaggcctaatgctccctaccggatcttcaac
acctggctgggggacccgtccaagaacctgttgctggctgaggtcatcaacatcatcaag
cgggaggacctgctaaataatgcagcccatgccgggaaggccctgctcacaggactgctg
gacctccaggcccggtacccccagttcatcagcagggtgagaggacgaggcaccttttgc
tccttcgatactcccgatgattccatacggaataagctcattttaattgccagaaacaaa
ggtgtggtgttgggtggctgtggtgacaaatccattcgtttccgtcccacgctggtcttc
agggatcaccacgctcacctgttcctcaatattttcagtgacatcttagcagacttcaag
taa

  All links  
Disease (2)   
   OMIM (2)   
Gene (10)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (31)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (28)   
DNA sequence (86)   
   RefSeq(nuc) (28)   
   GenBank (29)   
   EMBL (29)   
Protein domain (3)   
   Pfam (3)   
All databases (132)   

Download RDF
DBGET integrated database retrieval system