KEGG   Homo sapiens (human): 1806
Entry
1806              CDS       T01001                                 

Gene name
DPYD, DHP, DHPDHASE, DPD
Definition
(RefSeq) dihydropyrimidine dehydrogenase
  KO
K00207  dihydropyrimidine dehydrogenase (NADP+) [EC:1.3.1.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00240  Pyrimidine metabolism
hsa00410  beta-Alanine metabolism
hsa00770  Pantothenate and CoA biosynthesis
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
Module
hsa_M00046  Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate
Disease
H00193  Dihydropyrimidine dehydrogenase deficiency
Drug target
Eniluracil: D03998
Gimeracil: D01846
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    1806 (DPYD)
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    1806 (DPYD)
  09108 Metabolism of cofactors and vitamins
   00770 Pantothenate and CoA biosynthesis
    1806 (DPYD)
  09111 Xenobiotics biodegradation and metabolism
   00983 Drug metabolism - other enzymes
    1806 (DPYD)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.2  dihydropyrimidine dehydrogenase (NADP+)
     1806 (DPYD)
SSDB
Motif
Pfam: DHO_dh Fer4_20 Fer4_21 Pyr_redox_2 Dus NAD_binding_8 Pyr_redox_3 Pyr_redox Fer4_10 Fer4_7 Fer4_2 Fer4_6 Fer4_9 Fer4 Fer4_8 HEPN_SAV2148 Fer4_17
Other DBs
NCBI-GeneID: 1806
NCBI-ProteinID: NP_000101
OMIM: 612779
HGNC: 3012
Ensembl: ENSG00000188641
Vega: OTTHUMG00000039683
Pharos: Q12882(Tclin)
UniProt: Q12882
Position
1p21.3
AA seq 1025 aa
MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNFD
DIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKMIFSDN
PLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEVFKAMSIPQIRNPSLPPPE
KMSEAYSAKIALFGAGPASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDV
VNFEIELMKDLGVKIICGKSLSVNEMTLSTLKEKGYKAAFIGIGLPEPNKDAIFQGLTQD
QGFYTSKDFLPLVAKGSKAGMCACHSPLPSIRGVVIVLGAGDTAFDCATSALRCGARRVF
IVFRKGFVNIRAVPEEMELAKEEKCEFLPFLSPRKVIVKGGRIVAMQFVRTEQDETGKWN
EDEDQMVHLKADVVISAFGSVLSDPKVKEALSPIKFNRWGLPEVDPETMQTSEAWVFAGG
DVVGLANTTVESVNDGKQASWYIHKYVQSQYGASVSAKPELPLFYTPIDLVDISVEMAGL
KFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPMY
GPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDWTELAKKSEDS
GADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSI
ARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGVSGTAIRPIALRAVTS
IARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYL
KSIEELQDWDGQSPATVSHQKGKPVPRIAELMDKKLPSFGPYLEQRKKIIAENKIRLKEQ
NVAFSPLKRNCFIPKRPIPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCY
MTCNDSGYQAIQFDPETHLPTITDTCTGCTLCLSVCPIVDCIKMVSRTTPYEPKRGVPLS
VNPVC
NT seq 3078 nt   +upstreamnt  +downstreamnt
atggcccctgtgctcagtaaggactcggcggacatcgagagtatcctggctttaaatcct
cgaacacaaactcatgcaactctgtgttccacttcggccaagaaattagacaagaaacat
tggaaaagaaatcctgataagaactgctttaattgtgagaagctggagaataattttgat
gacatcaagcacacgactcttggtgagcgaggagctctccgagaagcaatgagatgcctg
aaatgtgcagatgccccgtgtcagaagagctgtccaactaatcttgatattaaatcattc
atcacaagtattgcaaacaagaactattatggagctgctaagatgatattttctgacaac
ccacttggtctgacttgtggaatggtatgtccaacctctgatctttgtgtaggtggatgc
aatttatatgccactgaagagggacccattaatattggtggattgcagcaatttgctact
gaggtattcaaagcaatgagtatcccacagatcagaaatccttcgctgcctcccccagaa
aaaatgtctgaagcctattctgcaaagattgctctttttggtgctgggcctgcaagtata
agttgtgcttcctttttggctcgattggggtactctgacatcactatatttgaaaaacaa
gaatatgttggtggtttaagtacttctgaaattcctcagttccggctgccgtatgatgta
gtgaattttgagattgagctaatgaaggaccttggtgtaaagataatttgcggtaaaagc
ctttcagtgaatgaaatgactcttagcactttgaaagaaaaaggctacaaagctgctttc
attggaataggtttgccagaacccaataaagatgccatcttccaaggcctgacgcaggac
caggggttttatacatccaaagactttttgccacttgtagccaaaggcagtaaagcagga
atgtgcgcctgtcactctccattgccatcgatacggggagtcgtgattgtacttggagct
ggagacactgcctttgactgtgcaacatctgctctacgttgtggagctcgccgtgtgttc
atcgtcttcagaaaaggctttgttaatataagagctgtccctgaggagatggaacttgct
aaggaagaaaagtgtgaatttctgccattcctgtccccacggaaggttatagtaaaaggt
gggagaattgttgctatgcagtttgttcggacagagcaagatgaaactggaaaatggaat
gaagatgaagatcagatggtccatctgaaagccgatgtggtcatcagtgcctttggttca
gttctgagtgatcctaaagtaaaagaagccttgagccctataaaatttaacagatggggt
ctcccagaagtagatccagaaactatgcaaactagtgaagcatgggtatttgcaggtggt
gatgtcgttggtttggctaacactacagtggaatcggtgaatgatggaaagcaagcttct
tggtacattcacaaatacgtacagtcacaatatggagcttccgtttctgccaagcctgaa
ctacccctcttttacactcctattgatctggtggacattagtgtagaaatggccggattg
aagtttataaatccttttggtcttgctagcgcaactccagccaccagcacatcaatgatt
cgaagagcttttgaagctggatggggttttgccctcaccaaaactttctctcttgataag
gacattgtgacaaatgtttcccccagaatcatccggggaaccacctctggccccatgtat
ggccctggacaaagctcctttctgaatattgagctcatcagtgagaaaacggctgcatat
tggtgtcaaagtgtcactgaactaaaggctgactttccagacaacattgtgattgctagc
attatgtgcagttacaataaaaatgactggacggaacttgccaagaagtctgaggattct
ggagcagatgccctggagttaaatttatcatgtccacatggcatgggagaaagaggaatg
ggcctggcctgtgggcaggatccagagctggtgcggaacatctgccgctgggttaggcaa
gctgttcagattcctttttttgccaagctgaccccaaatgtcactgatattgtgagcatc
gcaagagctgcaaaggaaggtggtgccaatggcgttacagccaccaacactgtctcaggt
ctgatgggattaaaatctgatggcacaccttggccagcagtggggattgcaaagcgaact
acatatggaggagtgtctgggacagcaatcagacctattgctttgagagctgtgacctcc
attgctcgtgctctgcctggatttcccattttggctactggtggaattgactctgctgaa
agtggtcttcagtttctccatagtggtgcttccgtcctccaggtatgcagtgccattcag
aatcaggatttcactgtgatcgaagactactgcactggcctcaaagccctgctttatctg
aaaagcattgaagaactacaagactgggatggacagagtccagctactgtgagtcaccag
aaagggaaaccagttccacgtatagctgaactcatggacaagaaactgccaagttttgga
ccttatctggaacagcgcaagaaaatcatagcagaaaacaagattagactgaaagaacaa
aatgtagctttttcaccacttaagagaaactgttttatccccaaaaggcctattcctacc
atcaaggatgtaataggaaaagcactgcagtaccttggaacatttggtgaattgagcaac
gtagagcaagttgtggctatgattgatgaagaaatgtgtatcaactgtggtaaatgctac
atgacctgtaatgattctggctaccaggctatacagtttgatccagaaacccacctgccc
accataaccgacacttgtacaggctgtactctgtgtctcagtgtttgccctattgtcgac
tgcatcaaaatggtttccaggacaacaccttatgaaccaaagagaggcgtacccttatct
gtgaatccggtgtgttaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (5)   
   KEGG MODULE (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (2)   
   KEGG DRUG (2)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (9)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (10)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (35)   
   RefSeq(nuc) (9)   
   GenBank (13)   
   EMBL (13)   
Protein domain (17)   
   Pfam (17)   
All databases (110)   

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