KEGG   Homo sapiens (human): 1806
Entry
1806              CDS       T01001                                 
Symbol
DPYD, DHP, DHPDHASE, DPD, DYPD
Name
(RefSeq) dihydropyrimidine dehydrogenase
  KO
K00207  dihydropyrimidine dehydrogenase (NADP+) [EC:1.3.1.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00240  Pyrimidine metabolism
hsa00410  beta-Alanine metabolism
hsa00770  Pantothenate and CoA biosynthesis
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
Module
hsa_M00046  Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate
Disease
H00193  Dihydropyrimidine dehydrogenase deficiency
Drug target
Eniluracil: D03998
Gimeracil: D01846
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    1806 (DPYD)
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    1806 (DPYD)
  09108 Metabolism of cofactors and vitamins
   00770 Pantothenate and CoA biosynthesis
    1806 (DPYD)
  09111 Xenobiotics biodegradation and metabolism
   00983 Drug metabolism - other enzymes
    1806 (DPYD)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.2  dihydropyrimidine dehydrogenase (NADP+)
     1806 (DPYD)
SSDB
Motif
Pfam: DHO_dh Fer4_20 Fer4_21 Pyr_redox_2 Dus NAD_binding_8 Fer4_7 Fer4_2 Pyr_redox_3 Fer4_10 Pyr_redox Fer4_6 FAD_oxidored Fer4_9 Fer4 HEPN_SAV2148
Other DBs
NCBI-GeneID: 1806
NCBI-ProteinID: NP_000101
OMIM: 612779
HGNC: 3012
Ensembl: ENSG00000188641
UniProt: Q12882
Position
1:complement(97077743..97921059)
AA seq 1025 aa
MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNFD
DIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKMIFSDN
PLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEVFKAMSIPQIRNPSLPPPE
KMSEAYSAKIALFGAGPASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDV
VNFEIELMKDLGVKIICGKSLSVNEMTLSTLKEKGYKAAFIGIGLPEPNKDAIFQGLTQD
QGFYTSKDFLPLVAKGSKAGMCACHSPLPSIRGVVIVLGAGDTAFDCATSALRCGARRVF
IVFRKGFVNIRAVPEEMELAKEEKCEFLPFLSPRKVIVKGGRIVAMQFVRTEQDETGKWN
EDEDQMVHLKADVVISAFGSVLSDPKVKEALSPIKFNRWGLPEVDPETMQTSEAWVFAGG
DVVGLANTTVESVNDGKQASWYIHKYVQSQYGASVSAKPELPLFYTPIDLVDISVEMAGL
KFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPMY
GPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDWTELAKKSEDS
GADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSI
ARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGVSGTAIRPIALRAVTS
IARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYL
KSIEELQDWDGQSPATVSHQKGKPVPRIAELMDKKLPSFGPYLEQRKKIIAENKIRLKEQ
NVAFSPLKRNCFIPKRPIPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCY
MTCNDSGYQAIQFDPETHLPTITDTCTGCTLCLSVCPIVDCIKMVSRTTPYEPKRGVPLS
VNPVC
NT seq 3078 nt   +upstreamnt  +downstreamnt
atggcccctgtgctcagtaaggactcggcggacatcgagagtatcctggctttaaatcct
cgaacacaaactcatgcaactctgtgttccacttcggccaagaaattagacaagaaacat
tggaaaagaaatcctgataagaactgctttaattgtgagaagctggagaataattttgat
gacatcaagcacacgactcttggtgagcgaggagctctccgagaagcaatgagatgcctg
aaatgtgcagatgccccgtgtcagaagagctgtccaactaatcttgatattaaatcattc
atcacaagtattgcaaacaagaactattatggagctgctaagatgatattttctgacaac
ccacttggtctgacttgtggaatggtatgtccaacctctgatctttgtgtaggtggatgc
aatttatatgccactgaagagggacccattaatattggtggattgcagcaatttgctact
gaggtattcaaagcaatgagtatcccacagatcagaaatccttcgctgcctcccccagaa
aaaatgtctgaagcctattctgcaaagattgctctttttggtgctgggcctgcaagtata
agttgtgcttcctttttggctcgattggggtactctgacatcactatatttgaaaaacaa
gaatatgttggtggtttaagtacttctgaaattcctcagttccggctgccgtatgatgta
gtgaattttgagattgagctaatgaaggaccttggtgtaaagataatttgcggtaaaagc
ctttcagtgaatgaaatgactcttagcactttgaaagaaaaaggctacaaagctgctttc
attggaataggtttgccagaacccaataaagatgccatcttccaaggcctgacgcaggac
caggggttttatacatccaaagactttttgccacttgtagccaaaggcagtaaagcagga
atgtgcgcctgtcactctccattgccatcgatacggggagtcgtgattgtacttggagct
ggagacactgcctttgactgtgcaacatctgctctacgttgtggagctcgccgtgtgttc
atcgtcttcagaaaaggctttgttaatataagagctgtccctgaggagatggaacttgct
aaggaagaaaagtgtgaatttctgccattcctgtccccacggaaggttatagtaaaaggt
gggagaattgttgctatgcagtttgttcggacagagcaagatgaaactggaaaatggaat
gaagatgaagatcagatggtccatctgaaagccgatgtggtcatcagtgcctttggttca
gttctgagtgatcctaaagtaaaagaagccttgagccctataaaatttaacagatggggt
ctcccagaagtagatccagaaactatgcaaactagtgaagcatgggtatttgcaggtggt
gatgtcgttggtttggctaacactacagtggaatcggtgaatgatggaaagcaagcttct
tggtacattcacaaatacgtacagtcacaatatggagcttccgtttctgccaagcctgaa
ctacccctcttttacactcctattgatctggtggacattagtgtagaaatggccggattg
aagtttataaatccttttggtcttgctagcgcaactccagccaccagcacatcaatgatt
cgaagagcttttgaagctggatggggttttgccctcaccaaaactttctctcttgataag
gacattgtgacaaatgtttcccccagaatcatccggggaaccacctctggccccatgtat
ggccctggacaaagctcctttctgaatattgagctcatcagtgagaaaacggctgcatat
tggtgtcaaagtgtcactgaactaaaggctgactttccagacaacattgtgattgctagc
attatgtgcagttacaataaaaatgactggacggaacttgccaagaagtctgaggattct
ggagcagatgccctggagttaaatttatcatgtccacatggcatgggagaaagaggaatg
ggcctggcctgtgggcaggatccagagctggtgcggaacatctgccgctgggttaggcaa
gctgttcagattcctttttttgccaagctgaccccaaatgtcactgatattgtgagcatc
gcaagagctgcaaaggaaggtggtgccaatggcgttacagccaccaacactgtctcaggt
ctgatgggattaaaatctgatggcacaccttggccagcagtggggattgcaaagcgaact
acatatggaggagtgtctgggacagcaatcagacctattgctttgagagctgtgacctcc
attgctcgtgctctgcctggatttcccattttggctactggtggaattgactctgctgaa
agtggtcttcagtttctccatagtggtgcttccgtcctccaggtatgcagtgccattcag
aatcaggatttcactgtgatcgaagactactgcactggcctcaaagccctgctttatctg
aaaagcattgaagaactacaagactgggatggacagagtccagctactgtgagtcaccag
aaagggaaaccagttccacgtatagctgaactcatggacaagaaactgccaagttttgga
ccttatctggaacagcgcaagaaaatcatagcagaaaacaagattagactgaaagaacaa
aatgtagctttttcaccacttaagagaaactgttttatccccaaaaggcctattcctacc
atcaaggatgtaataggaaaagcactgcagtaccttggaacatttggtgaattgagcaac
gtagagcaagttgtggctatgattgatgaagaaatgtgtatcaactgtggtaaatgctac
atgacctgtaatgattctggctaccaggctatacagtttgatccagaaacccacctgccc
accataaccgacacttgtacaggctgtactctgtgtctcagtgtttgccctattgtcgac
tgcatcaaaatggtttccaggacaacaccttatgaaccaaagagaggcgtacccttatct
gtgaatccggtgtgttaa

  All links  
Disease (2)   
   OMIM (2)   
Gene (18)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (9)   
   OC (1)   
Protein sequence (13)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (11)   
DNA sequence (41)   
   RefSeq(nuc) (13)   
   GenBank (14)   
   EMBL (14)   
Protein domain (16)   
   Pfam (16)   
All databases (90)   

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