KEGG   Homo sapiens (human): 1812
Entry
1812              CDS       T01001                                 
Symbol
DRD1, D1R, DADR, DRD1A
Name
(RefSeq) dopamine receptor D1
  KO
K04144  dopamine receptor D1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04081  Hormone signaling
hsa04082  Neuroactive ligand signaling
hsa04540  Gap junction
hsa04728  Dopaminergic synapse
hsa05012  Parkinson disease
hsa05030  Cocaine addiction
hsa05031  Amphetamine addiction
hsa05032  Morphine addiction
hsa05034  Alcoholism
Network
nt06167  Human cytomegalovirus (HCMV)
nt06544  Neuroactive ligand signaling
  Element
N00410  DRD1-GNAS-AC-PKA signaling pathway
N01897  Dopamine-DRD-GNAQ/S signaling pathway
Drug target
Acepromazine (DG00870): D02604 D07065
Acetophenazine (DG00878): D00788
Adrogolide hydrochloride: D02775
Apomorphine (DG00486): D02004<JP/US> D07460
Butaclamol hydrochloride: D02641
Carphenazine maleate: D02644
Chlorprothixene (DG00894): D00790 D02162 D07686 D07687
Ciladopa hydrochloride: D03494
Clopenthixol: D02613
Dexpramipexole (DG01331): D09886 D09887
Docarpamine: D01903<JP>
Dopamine (DG00213): D00633<JP/US> D07870
Dopexamine (DG00222): D03891 D03892
Ecopipam hydrochloride: D03937
Etilevodopa: D04097
Fenoldopam (DG00226): D00613 D07946
Flupentixol (DG00893): D01044 D02236 D07976
Foslevodopa: D11839
Ibopamine (DG00223): D04488 D08057
Levodopa: D00059<JP/US>
Mevidalen (DG03111): D11822 D11826
Oxiperomide: D02676
Pergolide (DG00861): D00502<JP> D08339
Pipotiazine (DG00884): D02680 D08385
Razpipadon: D12766
Tavapadon: D11431
Zicronapine (DG01539): D10329 D10495
Zuclopenthixol (DG00896): D03556 D08691 D08692 D08693
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    1812 (DRD1)
   04024 cAMP signaling pathway
    1812 (DRD1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1812 (DRD1)
   04082 Neuroactive ligand signaling
    1812 (DRD1)
   04081 Hormone signaling
    1812 (DRD1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    1812 (DRD1)
 09150 Organismal Systems
  09156 Nervous system
   04728 Dopaminergic synapse
    1812 (DRD1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    1812 (DRD1)
  09165 Substance dependence
   05030 Cocaine addiction
    1812 (DRD1)
   05031 Amphetamine addiction
    1812 (DRD1)
   05032 Morphine addiction
    1812 (DRD1)
   05034 Alcoholism
    1812 (DRD1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    1812 (DRD1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Biogenic amine
   Dopamine
    1812 (DRD1)
SSDB
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx DUF621
Other DBs
NCBI-GeneID: 1812
NCBI-ProteinID: NP_000785
OMIM: 126449
HGNC: 3020
Ensembl: ENSG00000184845
UniProt: P21728
Structure
Position
5:complement(175440036..175444182)
AA seq 446 aa
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLA
ETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN
CQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGS
GETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIET
VSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPAL
SVILDYDTDVSLEKIQPITQNGQHPT
NT seq 1341 nt   +upstreamnt  +downstreamnt
atgaggactctgaacacctctgccatggacgggactgggctggtggtggagagggacttc
tctgttcgtatcctcactgcctgtttcctgtcgctgctcatcctgtccacgctcctgggg
aacacgctggtctgtgctgccgttatcaggttccgacacctgcggtccaaggtgaccaac
ttctttgtcatctccttggctgtgtcagatctcttggtggccgtcctggtcatgccctgg
aaggcagtggctgagattgctggcttctggccctttgggtccttctgtaacatctgggtg
gcctttgacatcatgtgctccactgcatccatcctcaacctctgtgtgatcagcgtggac
aggtattgggctatctccagccctttccggtatgagagaaagatgacccccaaggcagcc
ttcatcctgatcagtgtggcatggaccttgtctgtactcatctccttcatcccagtgcag
ctcagctggcacaaggcaaaacccacaagcccctctgatggaaatgccacttccctggct
gagaccatagacaactgtgactccagcctcagcaggacatatgccatctcatcctctgta
ataagcttttacatccctgtggccatcatgattgtcacctacaccaggatctacaggatt
gctcagaaacaaatacggcgcattgcggccttggagagggcagcagtccacgccaagaat
tgccagaccaccacaggtaatggaaagcctgtcgaatgttctcaaccggaaagttctttt
aagatgtccttcaaaagagaaactaaagtcctgaagactctgtcggtgatcatgggtgtg
tttgtgtgctgttggctacctttcttcatcttgaactgcattttgcccttctgtgggtct
ggggagacgcagcccttctgcattgattccaacacctttgacgtgtttgtgtggtttggg
tgggctaattcatccttgaaccccatcatttatgcctttaatgctgattttcggaaggca
ttttcaaccctcttaggatgctacagactttgccctgcgacgaataatgccatagagacg
gtgagtatcaataacaatggggccgcgatgttttccagccatcatgagccacgaggctcc
atctccaaggagtgcaatctggtttacctgatcccacatgctgtgggctcctctgaggac
ctgaaaaaggaggaggcagctggcatcgccagacccttggagaagctgtccccagcccta
tcagtcatattggactatgacactgacgtctctctggagaagatccaacccatcacacaa
aacggtcagcacccaacctga

  All links  
Disease (1)   
   OMIM (1)   
Gene (12)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (17)   
   RefSeq(nuc) (1)   
   GenBank (8)   
   EMBL (8)   
3D Structure (22)   
   PDB (22)   
Protein domain (4)   
   Pfam (4)   
All databases (59)   

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