KEGG T01001: 1813

Homo sapiens (human): 1813

Entry

1813              CDS       T01001

Symbol

DRD2, D2DR, D2R

Name

(RefSeq) dopamine receptor D2

K04145

dopamine receptor D2

Organism

hsa Homo sapiens (human)

Pathway

hsa04015

Rap1 signaling pathway

hsa04024

cAMP signaling pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04540

Gap junction

hsa04728

Dopaminergic synapse

hsa05012

Parkinson disease

hsa05030

Cocaine addiction

hsa05034

Alcoholism

Disease

H01611

Alcohol dependence

Drug target

Acepromazine (DG00870):

D02604 D07065

Acetophenazine (DG00878):

D00788

Alentemol hydrobromide:

D02634

Alizapride (DG00058):

D07102 D07563

Amisulpride:

D07310<US>

Aplindore fumarate:

D03214

Apomorphine (DG00486):

D02004<JP/US> D07460

Aripiprazole (DG00906):

D01164<JP/US> D10355 D10364<US> D10516<JP/US>

Asenapine (DG03100):

D02995<JP/US> D11769<US>

Benperidol:

D02627

Bifeprunox (DG01304):

D06566 D06567

Blonanserin:

D01176<JP>

Brexpiprazole:

D10309<JP/US>

Bromocriptine (DG00452):

D00780<JP/US> D03165

Bromopride:

D07101

Bromperidol (DG00890):

D01101<JP> D02626

Buspirone (DG00913):

D00702<US> D07593

Butaclamol hydrochloride:

D02641

Cabergoline:

D00987<JP/US>

Cariprazine (DG01305):

D09876<US> D09997

Carphenazine maleate:

D02644

Carvotroline hydrochloride:

D02645

Chlorpromazine (DG00867):

D00270 D00789<JP/US> D03274 D04034<JP> D09819

Chlorprothixene (DG00894):

D00790 D02162 D07686 D07687

Ciladopa hydrochloride:

D03494

Clebopride (DG00059):

D01742 D03534

Clocapramine (DG01313):

D02371<JP> D07718

Clopenthixol:

D02613

Dexpramipexole (DG01331):

D09886 D09887

Dihydroergocryptine (DG01329):

D07835

Dihydroergocryptine mesylate:

D07836

Domperidone (DG00057):

D01745<JP> D07868

Dopamine (DG00213):

D00633<JP/US> D07870

Dopexamine (DG00222):

D03891 D03892

Droperidol:

D00308<JP/US>

Etilevodopa:

D04097

Flupentixol (DG00893):

D01044 D02236 D07976

Fluphenazine (DG00874):

D00791<US> D00792 D00793<JP/US> D02163<JP> D07977

Foslevodopa:

D11839

Haloperidol (DG00885):

D00136<JP/US> D01898<JP/US> D08035<US>

Ibopamine (DG00223):

D04488 D08057

Iloperidone:

D02666<US>

Itopride (DG01395):

D02729<JP> D08094

Lergotrile (DG01319):

D04693 D04694

Levodopa:

D00059<JP/US>

Levomepromazine (DG00868):

D00403 D01520<JP> D02248<JP>

Levosulpiride:

D07312

Lisuride (DG00453):

D01462 D08132

Loxapine (DG00897):

D00794<US> D02340<US> D08148

Lumateperone (DG02937):

D11169 D11170<US>

Lurasidone:

D04820<JP/US>

Mazapertine succinate:

D02670

Melperone (DG00887):

D07309 D08172

Mesoridazine (DG00883):

D00795 D02671

Methoxypromazine maleate:

D02605

Metoclopramide (DG00055):

D00726<JP> D02213<JP> D05008<US>

Metopimazine:

D05010

Molindone (DG00891):

D00796<US> D08226

Moperone (DG00888):

D01105 D02623

Mosapramine (DG00905):

D01548<JP> D08235

Naxagolide hydrochloride:

D05124

Nemonapride:

D01468<JP>

Ocaperidone:

D02675

Olanzapine (DG00898):

D00454<JP/US> D06623<US>

Opipramol (DG00930):

D01477 D08297

Oxiperomide:

D02676

Paliperidone (DG00907):

D05339<JP/US> D05340<JP/US>

Pardoprunox (DG01324):

D09366 D09397

Perazine (DG00881):

D01412 D01860 D02608

Pergolide (DG00861):

D00502<JP> D08339

Periciazine:

D01485<JP>

Perospirone hydrochloride hydrate:

D02372<JP>

Perphenazine (DG00875):

D00503<JP/US> D02037<JP> D04038<JP> D04965<JP> D08341 D08342

Pimozide:

D00560<US>

Pipamperone (DG00889):

D01482<JP> D02622

Pipotiazine (DG00884):

D02680 D08385

Piquindone hydrochloride:

D02681

Piribedil:

D07305

Pramipexole (DG00863):

D00559<JP/US> D05575

Pridopidine (DG01325):

D09953 D09954

Prochlorperazine (DG00876):

D00479<JP/US> D00493<US> D02022<JP> D02609<US>

Promazine (DG00869):

D00797 D08430

Quetiapine (DG00899):

D00458<JP/US> D08456

Quinagolide (DG00454):

D07217 D08457

Quinelorane hydrochloride:

D05677

Quinpirole hydrochloride:

D05682

Raclopride C11:

D05690

Remoxipride (DG00902):

D02682 D02683

Risperidone:

D00426<JP/US>

Ropinirole (DG00862):

D00784<JP/US> D08489

Rotigotine:

D05768<JP/US>

Sarizotan hydrochloride:

D05804

Sertindole:

D00561

Sibenadet hydrochloride:

D05832

Spiperone:

D01051<JP>

Sulpiride:

D01226<JP>

Sultopride (DG00900):

D02208<JP> D08549

Talipexole (DG01326):

D01505 D08558

Terguride:

D01348

Thiethylperazine (DG01102):

D01130 D02354 D02610

Thioproperazine (DG00879):

D01447 D08585

Thioridazine (DG00882):

D00373 D00798<US>

Tiapride (DG00901):

D01522<JP> D08590

Timiperone:

D02035<JP>

Tiospirone hydrochloride:

D02688

Tiotixene (DG00895):

D00374<US> D02612

Trazpiroben:

D11982

Trifluoperazine (DG00877):

D00799<US> D01448 D08636

Trifluperidol (DG00886):

D02625 D08637

Triflupromazine (DG00871):

D00390 D00800

Zicronapine (DG01539):

D10329 D10495

Ziprasidone (DG00892):

D01939<US> D02100<US> D08687

Zotepine:

D01321<JP>

Zuclopenthixol (DG00896):

D03556 D08691 D08692 D08693

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    1813 (DRD2)
   04024 cAMP signaling pathway
    1813 (DRD2)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1813 (DRD2)
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    1813 (DRD2)
09150 Organismal Systems
  09156 Nervous system
   04728 Dopaminergic synapse
    1813 (DRD2)
09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    1813 (DRD2)
  09165 Substance dependence
   05030 Cocaine addiction
    1813 (DRD2)
   05034 Alcoholism
    1813 (DRD2)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    1813 (DRD2)
G protein-coupled receptors [BR:hsa04030]
Rhodopsin family
  Biogenic amine
   Dopamine
    1813 (DRD2)

SSDB

Motif

Pfam:

7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srv DUF2207 RIFIN Stevor

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Pharos:

P14416(Tclin)

UniProt:

P14416 A0A024R3C5

Structure

Position

11:complement(113409605..113475398)

AA seq 443 aa
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
VNPIIYTTFNIEFRKAFLKILHC

NT seq 1332 nt +upstreamnt +downstreamnt
atggatccactgaatctgtcctggtatgatgatgatctggagaggcagaactggagccgg
cccttcaacgggtcagacgggaaggcggacagaccccactacaactactatgccacactg
ctcaccctgctcatcgctgtcatcgtcttcggcaacgtgctggtgtgcatggctgtgtcc
cgcgagaaggcgctgcagaccaccaccaactacctgatcgtcagcctcgcagtggccgac
ctcctcgtcgccacactggtcatgccctgggttgtctacctggaggtggtaggtgagtgg
aaattcagcaggattcactgtgacatcttcgtcactctggacgtcatgatgtgcacggcg
agcatcctgaacttgtgtgccatcagcatcgacaggtacacagctgtggccatgcccatg
ctgtacaatacgcgctacagctccaagcgccgggtcaccgtcatgatctccatcgtctgg
gtcctgtccttcaccatctcctgcccactcctcttcggactcaataacgcagaccagaac
gagtgcatcattgccaacccggccttcgtggtctactcctccatcgtctccttctacgtg
cccttcattgtcaccctgctggtctacatcaagatctacattgtcctccgcagacgccgc
aagcgagtcaacaccaaacgcagcagccgagctttcagggcccacctgagggctccacta
aagggcaactgtactcaccccgaggacatgaaactctgcaccgttatcatgaagtctaat
gggagtttcccagtgaacaggcggagagtggaggctgcccggcgagcccaggagctggag
atggagatgctctccagcaccagcccacccgagaggacccggtacagccccatcccaccc
agccaccaccagctgactctccccgacccgtcccaccatggtctccacagcactcccgac
agccccgccaaaccagagaagaatgggcatgccaaagaccaccccaagattgccaagatc
tttgagatccagaccatgcccaatggcaaaacccggacctccctcaagaccatgagccgt
aggaagctctcccagcagaaggagaagaaagccactcagatgctcgccattgttctcggc
gtgttcatcatctgctggctgcccttcttcatcacacacatcctgaacatacactgtgac
tgcaacatcccgcctgtcctgtacagcgccttcacgtggctgggctatgtcaacagcgcc
gtgaaccccatcatctacaccaccttcaacattgagttccgcaaggccttcctgaagatc
ctccactgctga

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