KEGG   Homo sapiens (human): 1832
Entry
1832              CDS       T01001                                 
Symbol
DSP, DCWHKTA, DP
Name
(RefSeq) desmoplakin
  KO
K10381  desmoplakin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04382  Cornified envelope formation
hsa04820  Cytoskeleton in muscle cells
hsa05412  Arrhythmogenic right ventricular cardiomyopathy
Network
nt06539  Cytoskeleton in muscle cells
nt06545  Cornified envelope formation
  Element
N01758  Desmosome - Vimentin filaments
N01922  Localization of envoplakin and periplakin to the plasma membrane (PM)
Disease
H00293  Arrhythmogenic right ventricular cardiomyopathy
H00717  Striate palmoplantar keratoderma
H00893  Dilated cardiomyopathy with woolly hair, keratoderma, and tooth agenesis
H01737  Epidermolysis bullosa
H02094  Carvajal syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    1832 (DSP)
 09150 Organismal Systems
  09158 Development and regeneration
   04382 Cornified envelope formation
    1832 (DSP)
 09160 Human Diseases
  09166 Cardiovascular disease
   05412 Arrhythmogenic right ventricular cardiomyopathy
    1832 (DSP)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    1832 (DSP)
   04147 Exosome [BR:hsa04147]
    1832 (DSP)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Intermediate filaments
   Intermediate filament-binding proteins
    1832 (DSP)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   1832 (DSP)
SSDB
Motif
Pfam: Plectin SR_desmoplakin_3 Spectrin_2 Spectrin_3 SH3_10 KH_YLL032C_3rd ERM_helical CCDC39 Fez1
Other DBs
NCBI-GeneID: 1832
NCBI-ProteinID: NP_004406
OMIM: 125647
HGNC: 3052
Ensembl: ENSG00000096696
UniProt: P15924 B4DKX6
Structure
Position
6:7541671..7586714
AA seq 2871 aa
MSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTG
TMSRHQNQNTIQELLQNCSDCLMRAELIVQPELKYGDGIQLTRSRELDECFAQANDQMEI
LDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQSGSGW
DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA
DLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSD
KNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSW
ILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKE
LEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGD
ECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQL
YINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMF
GDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRE
NDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIA
EVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQT
EDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHS
QTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCK
WLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKD
YELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEM
LKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLE
ELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYD
QLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYN
EEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSI
LQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTI
QDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQL
TMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEV
SQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCL
EDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQ
NSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLE
QASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHL
RNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSE
ADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQE
SKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQI
QNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDS
TRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQL
YECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLI
SPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPF
SGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYR
SLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVT
ELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKI
GLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYN
DPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEE
LSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNT
LRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLV
DRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDD
VFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERG
IVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEG
VKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRA
AQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNMS
SAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYSFSSSSIGH
NT seq 8616 nt   +upstreamnt  +downstreamnt
atgagctgcaacggaggctcccacccgcggatcaacactctgggccgcatgatccgcgcc
gagtctggcccggacctgcgctacgaggtgaccagcggcggcgggggcaccagcaggatg
tactattctcggcgcggcgtgatcaccgaccagaactcggacggctactgtcaaaccggc
acgatgtccaggcaccagaaccagaacaccatccaggagctgctgcagaactgctccgac
tgcttgatgcgagcagagctcatcgtgcagcctgaattgaagtatggagatggaatacaa
ctgactcggagtcgagaattggatgagtgttttgcccaggccaatgaccaaatggaaatc
ctcgacagcttgatcagagagatgcggcagatgggccagccctgtgatgcttaccagaaa
aggcttcttcagctccaagagcaaatgcgagccctttataaagccatcagtgtccctcga
gtccgcagggccagctccaagggtggtggaggctacacttgtcagagtggctctggctgg
gatgagttcaccaaacatgtcaccagtgaatgtttggggtggatgaggcagcaaagggcg
gagatggacatggtggcctggggtgtggacctggcctcagtggagcagcacattaacagc
caccggggcatccacaactccatcggcgactatcgctggcagctggacaaaatcaaagcc
gacctgcgcgagaaatctgcgatctaccagttggaggaggagtatgaaaacctgctgaaa
gcgtcctttgagaggatggatcacctgcgacagctgcagaacatcattcaggccacgtcc
agggagatcatgtggatcaatgactgcgaggaggaggagctgctgtacgactggagcgac
aagaacaccaacatcgctcagaaacaggaggccttctccatacgcatgagtcaactggaa
gttaaagaaaaagagctcaataagctgaaacaagaaagtgaccaacttgtcctcaatcag
catccagcttcagacaaaattgaggcctatatggacactctgcagacgcagtggagttgg
attcttcagatcaccaagtgcattgatgttcatctgaaagaaaatgctgcctactttcag
ttttttgaagaggcgcagtctactgaagcatacctgaaggggctccaggactccatcagg
aagaagtacccctgcgacaagaacatgcccctgcagcacctgctggaacagatcaaggag
ctggagaaagaacgagagaaaatccttgaatacaagcgtcaggtgcagaacttggtaaac
aagtctaagaagattgtacagctgaagcctcgtaacccagactacagaagcaataaaccc
attattctcagagctctctgtgactacaaacaagatcagaaaatcgtgcataagggggat
gagtgtatcctgaaggacaacaacgagcgcagcaagtggtacgtgacgggcccgggaggc
gttgacatgcttgttccctctgtggggctgatcatccctcctccgaacccactggccgtg
gacctctcttgcaagattgagcagtactacgaagccatcttggctctgtggaaccagctc
tacatcaacatgaagagcctggtgtcctggcactactgcatgattgacatagagaagatc
agggccatgacaatcgccaagctgaaaacaatgcggcaggaagattacatgaagacgata
gccgaccttgagttacattaccaagagttcatcagaaatagccaaggctcagagatgttt
ggagatgatgacaagcggaaaatacagtctcagttcaccgatgcccagaagcattaccag
accctggtcattcagctccctggctatccccagcaccagacagtgaccacaactgaaatc
actcatcatggaacctgccaagatgtcaaccataataaagtaattgaaaccaacagagaa
aatgacaagcaagaaacatggatgctgatggagctgcagaagattcgcaggcagatagag
cactgcgagggcaggatgactctcaaaaacctccctctagcagaccagggatcttctcac
cacatcacagtgaaaattaacgagcttaagagtgtgcagaatgattcacaagcaattgct
gaggttctcaaccagcttaaagatatgcttgccaacttcagaggttctgaaaagtactgc
tatttacagaatgaagtatttggactatttcagaaactggaaaatatcaatggtgttaca
gatggctacttaaatagcttatgcacagtaagggcactgctccaggctattctccaaaca
gaagacatgttaaaggtttatgaagccaggctcactgaggaggaaactgtctgcctggac
ctggataaagtggaagcttaccgctgtggactgaagaaaataaaaaatgacttgaacttg
aagaagtcgttgttggccactatgaagacagaactacagaaagcccagcagatccactct
cagacttcacagcagtatccactttatgatctggacttgggcaagttcggtgaaaaagtc
acacagctgacagaccgctggcaaaggatagataaacagatcgactttaggttatgggac
ctggagaaacaaatcaagcaattgaggaattatcgtgataactatcaggctttctgcaag
tggctctatgatgctaaacgccgccaggattccttagaatccatgaaatttggagattcc
aacacagtcatgcggtttttgaatgagcagaagaacttgcacagtgaaatatctggcaaa
cgagacaaatcagaggaagtacaaaaaattgctgaactttgcgccaattcaattaaggat
tatgagctccagctggcctcatacacctcaggactggaaactctgctgaacatacctatc
aagaggaccatgattcagtccccttctggggtgattctgcaagaggctgcagatgttcat
gctcggtacattgaactacttacaagatctggagactattacaggttcttaagtgagatg
ctgaagagtttggaagatctgaagctgaaaaataccaagatcgaagttttggaagaggag
ctcagactggcccgagatgccaactcggaaaactgtaataagaacaaattcctggatcag
aacctgcagaaataccaggcagagtgttcccagttcaaagcgaagcttgcgagcctggag
gagctgaagagacaggctgagctggatgggaagtcggctaagcaaaatctagacaagtgc
tacggccaaataaaagaactcaatgagaagatcacccgactgacttatgagattgaagat
gaaaagagaagaagaaaatctgtggaagacagatttgaccaacagaagaatgactatgac
caactgcagaaagcaaggcaatgtgaaaaggagaaccttggttggcagaaattagagtct
gagaaagccatcaaggagaaggagtacgagattgaaaggttgagggttctactgcaggaa
gaaggcacccggaagagagaatatgaaaatgagctggcaaaggtaagaaaccactataat
gaggagatgagtaatttaaggaacaagtatgaaacagagattaacattacgaagaccacc
atcaaggagatatccatgcaaaaagaggatgattccaaaaatcttagaaaccagcttgat
agactttcaagggaaaatcgagatctgaaggatgaaattgtcaggctcaatgacagcatc
ttgcaggccactgagcagcgaaggcgagctgaagaaaacgcccttcagcaaaaggcctgt
ggctctgagataatgcagaagaagcagcatctggagatagaactgaagcaggtcatgcag
cagcgctctgaggacaatgcccggcacaagcagtccctggaggaggctgccaagaccatt
caggacaaaaataaggagatcgagagactcaaagctgagtttcaggaggaggccaagcgc
cgctgggaatatgaaaatgaactgagtaaggtaagaaacaattatgatgaggagatcatt
agcttaaaaaatcagtttgagaccgagatcaacatcaccaagaccaccatccaccagctc
accatgcagaaggaagaggataccagtggctaccgggctcagatagacaatctcacccga
gaaaacaggagcttatctgaagaaataaagaggctgaagaacactctaacccagaccaca
gagaatctcaggagggtggaagaagacatccaacagcaaaaggccactggctctgaggtg
tctcagaggaaacagcagctggaggttgagctgagacaagtcactcagatgcgaacagag
gagagcgtaagatataagcaatctcttgatgatgctgccaaaaccatccaggataaaaac
aaggagatagaaaggttaaaacaactgatcgacaaagaaacaaatgaccggaaatgcctg
gaagatgaaaacgcgagattacaaagggtccagtatgacctgcagaaagcaaacagtagt
gcgacggagacaataaacaaactgaaggttcaggagcaagaactgacacgcctgaggatc
gactatgaaagggtttcccaggagaggactgtgaaggaccaggatatcacgcggttccag
aactctctgaaagagctgcagctgcagaagcagaaggtggaagaggagctgaatcggctg
aagaggaccgcgtcagaagactcctgcaagaggaagaagctggaggaagagctggaaggc
atgaggaggtcgctgaaggagcaagccatcaaaatcaccaacctgacccagcagctggag
caggcatccattgttaagaagaggagtgaggatgacctccggcagcagagggacgtgctg
gatggccacctgagggaaaagcagaggacccaggaagagctgaggaggctctcttctgag
gtcgaggccctgaggcggcagttactccaggaacaggaaagtgtcaaacaagctcacttg
aggaatgagcatttccagaaggcgatagaagataaaagcagaagcttaaatgaaagcaaa
atagaaattgagaggctgcagtctctcacagagaacctgaccaaggagcacttgatgtta
gaagaagaactgcggaacctgaggctggagtacgatgacctgaggagaggacgaagcgaa
gcggacagtgataaaaatgcaaccatcttggaactaaggagccagctgcagatcagcaac
aaccggaccctggaactgcaggggctgattaatgatttacagagagagagggaaaatttg
agacaggaaattgagaaattccaaaagcaggctttagaggcatctaataggattcaggaa
tcaaagaatcagtgtactcaggtggtacaggaaagagagagccttctggtgaaaatcaaa
gtcctggagcaagacaaggcaaggctgcagaggctggaggatgagctgaatcgtgcaaaa
tcaactctagaggcagaaaccagggtgaaacagcgcctggagtgtgagaaacagcaaatt
cagaatgacctgaatcagtggaagactcaatattcccgcaaggaggaggctattaggaag
atagaatcggaaagagaaaagagtgagagagagaagaacagtcttaggagtgagatcgaa
agactccaagcagagatcaagagaattgaagagaggtgcaggcgtaagctggaggattct
accagggagacacagtcacagttagaaacagaacgctcccgatatcagagggagattgat
aaactcagacagcgcccatatgggtcccatcgagagacccagactgagtgtgagtggacc
gttgacacctccaagctggtgtttgatgggctgaggaagaaggtgacagcaatgcagctc
tatgagtgtcagctgatcgacaaaacaaccttggacaaactattgaaggggaagaagtca
gtggaagaagttgcttctgaaatccagccattccttcggggtgcaggatctatcgctgga
gcatctgcttctcctaaggaaaaatactctttggtagaggccaagagaaagaaattaatc
agcccagaatccacagtcatgcttctggaggcccaggcagctacaggtggtataattgat
ccccatcggaatgagaagctgactgtcgacagtgccatagctcgggacctcattgacttc
gatgaccgtcagcagatatatgcagcagaaaaagctatcactggttttgatgatccattt
tcaggcaagacagtatctgtttcagaagccatcaagaaaaatttgattgatagagaaacc
ggaatgcgcctgctggaagcccagattgcttcagggggtgtagtagaccctgtgaacagt
gtctttttgccaaaagatgtcgccttggcccgggggctgattgatagagatttgtatcga
tccctgaatgatccccgagatagtcagaaaaactttgtggatccagtcaccaaaaagaag
gtcagttacgtgcagctgaaggaacggtgcagaatcgaaccacatactggtctgctcttg
ctttcagtacagaagagaagcatgtccttccaaggaatcagacaacctgtgaccgtcact
gagctagtagattctggtatattgagaccgtccactgtcaatgaactggaatctggtcag
atttcttatgacgaggttggtgagagaattaaggacttcctccagggttcaagctgcata
gcaggcatatacaatgagaccacaaaacagaagcttggcatttatgaggccatgaaaatt
ggcttagtccgacctggtactgctctggagttgctggaagcccaagcagctactggcttt
atagtggatcctgttagcaacttgaggttaccagtggaggaagcctacaagagaggtctg
gtgggcattgagttcaaagagaagctcctgtctgcagaacgagctgtcactgggtataat
gatcctgaaacaggaaacatcatctctttgttccaagccatgaataaggaactcatcgaa
aagggccacggtattcgcttattagaagcacagatcgcaaccggggggatcattgaccca
aaggagagccatcgtttaccagttgacatagcatataagaggggctatttcaatgaggaa
ctcagtgagattctctcagatccaagtgatgataccaaaggattttttgaccccaacact
gaagaaaatcttacctatctgcaactaaaagaaagatgcattaaggatgaggaaacaggg
ctctgtcttctgcctctgaaagaaaagaagaaacaggtgcagacatcacaaaagaatacc
ctcaggaagcgtagagtggtcatagttgacccagaaaccaataaagaaatgtctgttcag
gaggcctacaagaagggcctaattgattatgaaaccttcaaagaactgtgtgagcaggaa
tgtgaatgggaagaaataaccatcacgggatcagatggctccaccagggtggtcctggta
gatagaaagacaggcagtcagtatgatattcaagatgctattgacaagggccttgttgac
aggaagttctttgatcagtaccgatccggcagcctcagcctcactcaatttgctgacatg
atctccttgaaaaatggtgtcggcaccagcagcagcatgggcagtggtgtcagcgatgat
gtttttagcagctcccgacatgaatcagtaagtaagatttccaccatatccagcgtcagg
aatttaaccataaggagcagctctttttcagacaccctggaagaatcgagccccattgca
gccatctttgacacagaaaacctggagaaaatctccattacagaaggtatagagcggggc
atcgttgacagcatcacgggtcagaggcttctggaggctcaggcctgcacaggtggcatc
atccacccaaccacgggccagaagctgtcacttcaggacgcagtctcccagggtgtgatt
gaccaagacatggccaccaggctgaagcctgctcagaaagccttcataggcttcgagggt
gtgaagggaaagaagaagatgtcagcagcagaggcagtgaaagaaaaatggctcccgtat
gaggctggccagcgcttcctggagttccagtacctcacgggaggtcttgttgacccggaa
gtgcatgggaggataagcaccgaagaagccatccggaaggggttcatagatggccgcgcc
gcacagaggctgcaagacaccagcagctatgccaaaatcctgacctgccccaaaaccaaa
ttaaaaatatcctataaggatgccataaatcgctccatggtagaagatatcactgggctg
cgccttctggaagccgcctccgtgtcgtccaagggcttacccagcccttacaacatgtct
tcggctccggggtcccgctccggctcccgctcgggatctcgctccggatctcgctccggg
tcccgcagtgggtcccggagaggaagctttgacgccacagggaattcttcctactcttat
tcctactcatttagcagtagttctattgggcactag

  All links  
Disease (6)   
   OMIM (6)   
Gene (42)   
   RefGene (36)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (7)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (42)   
   RefSeq(nuc) (4)   
   GenBank (19)   
   EMBL (19)   
3D Structure (4)   
   PDB (4)   
Protein domain (9)   
   Pfam (9)   
All databases (110)   

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