KEGG T01001: 185

Homo sapiens (human): 185

Entry

185               CDS       T01001

Symbol

AGTR1, AG2S, AGTR1B, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, ATR1, HAT1R

Name

(RefSeq) angiotensin II receptor type 1

K04166

angiotensin II receptor type 1

Organism

hsa Homo sapiens (human)

Pathway

hsa04020

Calcium signaling pathway

hsa04022

cGMP-PKG signaling pathway

hsa04072

Phospholipase D signaling pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04261

Adrenergic signaling in cardiomyocytes

hsa04270

Vascular smooth muscle contraction

hsa04371

Apelin signaling pathway

hsa04614

Renin-angiotensin system

hsa04924

Renin secretion

hsa04925

Aldosterone synthesis and secretion

hsa04927

Cortisol synthesis and secretion

hsa04933

AGE-RAGE signaling pathway in diabetic complications

hsa04934

Cushing syndrome

hsa05171

Coronavirus disease - COVID-19

hsa05200

Pathways in cancer

hsa05415

Diabetic cardiomyopathy

Network

nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06316  Renin-angiotensin-aldosterone signaling
nt06528  Calcium signaling

Element

N00301

Angiotensin-aldosterone signaling pathway

N01306

AngII-AT1R-NOX2 signaling pathway

N01307

SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway

N01640

GPCR-PLCB-ITPR signaling pathway

N01743

Renin-angiotensin signaling pathway

Disease

H00575

Renal tubular dysgenesis

H01633

High blood pressure

Drug target

Angiotensin II:

D00150 D02014 D11142<US>

Angiotensinamide:

D02939

Azilsartan (DG00351):

D08864<JP>

Azilsartan medoxomil (DG00351):

D08067 D08865<US>

Candesartan (DG00350):

D00522 D00626<JP/US>

Eprosartan (DG00349):

D02082 D04040

Fimasartan:

D10556

Forasartan:

D04243

Irbesartan:

D00523<JP/US>

Losartan (DG00348):

D00357<JP/US> D08146

Olmesartan (DG01544):

D05246

Olmesartan medoxomil:

D01204<JP/US>

Pratosartan:

D01922

Saprisartan potassium:

D05801

Saralasin acetate:

D04126

Sparsentan:

D11776<US>

Talfirastide:

D12942

Tasosartan:

D06010

Telmisartan:

D00627<JP/US>

Valsartan:

D00400<JP/US>

Valsartan and sacubitril:

D10226<JP/US>

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    185 (AGTR1)
   04020 Calcium signaling pathway
    185 (AGTR1)
   04072 Phospholipase D signaling pathway
    185 (AGTR1)
   04022 cGMP-PKG signaling pathway
    185 (AGTR1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    185 (AGTR1)
09150 Organismal Systems
  09152 Endocrine system
   04924 Renin secretion
    185 (AGTR1)
   04614 Renin-angiotensin system
    185 (AGTR1)
   04925 Aldosterone synthesis and secretion
    185 (AGTR1)
   04927 Cortisol synthesis and secretion
    185 (AGTR1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    185 (AGTR1)
   04270 Vascular smooth muscle contraction
    185 (AGTR1)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    185 (AGTR1)
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    185 (AGTR1)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    185 (AGTR1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    185 (AGTR1)
   04934 Cushing syndrome
    185 (AGTR1)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    185 (AGTR1)
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    185 (AGTR1)
Membrane trafficking [BR:hsa04131]
Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    185 (AGTR1)
G protein-coupled receptors [BR:hsa04030]
Rhodopsin family
  Peptide
   Angiotensin
    185 (AGTR1)

SSDB

Motif

Pfam:

7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx DUF6814

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

Position

3:148697903..148743003

AA seq 359 aa
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE

NT seq 1080 nt +upstreamnt +downstreamnt
atgattctcaactcttctactgaagatggtattaaaagaatccaagatgattgtcccaaa
gctggaaggcataattacatatttgtcatgattcctactttatacagtatcatctttgtg
gtgggaatatttggaaacagcttggtggtgatagtcatttacttttatatgaagctgaag
actgtggccagtgtttttcttttgaatttagcactggctgacttatgctttttactgact
ttgccactatgggctgtctacacagctatggaataccgctggccctttggcaattaccta
tgtaagattgcttcagccagcgtcagtttcaacctgtacgctagtgtgtttctactcacg
tgtctcagcattgatcgatacctggctattgttcacccaatgaagtcccgccttcgacgc
acaatgcttgtagccaaagtcacctgcatcatcatttggctgctggcaggcttggccagt
ttgccagctataatccatcgaaatgtatttttcattgagaacaccaatattacagtttgt
gctttccattatgagtcccaaaattcaaccctcccgatagggctgggcctgaccaaaaat
atactgggtttcctgtttccttttctgatcattcttacaagttatactcttatttggaag
gccctaaagaaggcttatgaaattcagaagaacaaaccaagaaatgatgatatttttaag
ataattatggcaattgtgcttttctttttcttttcctggattccccaccaaatattcact
tttctggatgtattgattcaactaggcatcatacgtgactgtagaattgcagatattgtg
gacacggccatgcctatcaccatttgtatagcttattttaacaattgcctgaatcctctt
ttttatggctttctggggaaaaaatttaaaagatattttctccagcttctaaaatatatt
cccccaaaagccaaatcccactcaaacctttcaacaaaaatgagcacgctttcctaccgc
ccctcagataatgtaagctcatccaccaagaagcctgcaccatgttttgaggttgagtga

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