KEGG   Homo sapiens (human): 1859
Entry
1859              CDS       T01001                                 
Symbol
DYRK1A, DYRK, DYRK1, HP86, MNB, MNBH, MRD7
Name
(RefSeq) dual specificity tyrosine phosphorylation regulated kinase 1A
  KO
K08825  dual specificity tyrosine-phosphorylation-regulated kinase 1 [EC:2.7.12.1]
Organism
hsa  Homo sapiens (human)
Disease
H00773  Autosomal dominant intellectual developmental disorder
Drug target
Lorecivivint: D11588
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    1859 (DYRK1A)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    1859 (DYRK1A)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.1  dual-specificity kinase
     1859 (DYRK1A)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CMGC group
  DYRK family [OT]
   1859 (DYRK1A)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Kinases
    1859 (DYRK1A)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Filament_head
Other DBs
NCBI-GeneID: 1859
NCBI-ProteinID: NP_001387
OMIM: 600855
HGNC: 3091
Ensembl: ENSG00000157540
UniProt: Q13627
Structure
Position
21:37365573..37526358
AA seq 763 aa
MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD
QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ
QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV
EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM
LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR
SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL
FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT
RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK
KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG
HFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHH
HHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSS
STTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTY
QFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS
NT seq 2292 nt   +upstreamnt  +downstreamnt
atgcatacaggaggagagacttcagcatgcaaaccttcatctgttcggcttgcaccgtca
ttttcattccatgctgctggccttcagatggctggacagatgccccattcacatcagtac
agtgaccgtcgccagccaaacataagtgaccaacaggtttctgccttatcatattctgac
cagattcagcaacctctaactaaccaggtgatgcctgatattgtcatgttacagaggcgg
atgccccaaaccttccgtgacccagcaactgctcccctgagaaaactttctgttgacttg
atcaaaacatacaagcatattaatgaggtttactatgcaaaaaagaagcgaagacaccaa
cagggccagggagacgattctagtcataagaaggaacggaaggtttacaatgatggttat
gatgatgataactatgattatattgtaaaaaacggagaaaagtggatggatcgttacgaa
attgactccttgataggcaaaggttcctttggacaggttgtaaaggcatatgatcgtgtg
gagcaagaatgggttgccattaaaataataaagaacaagaaggcttttctgaatcaagca
cagatagaagtgcgacttcttgagctcatgaacaaacatgacactgaaatgaaatactac
atagtgcatttgaaacgccactttatgtttcgaaaccatctctgtttagtttttgaaatg
ctgtcctacaacctctatgacttgctgagaaacaccaatttccgaggggtctctttgaac
ctaacacgaaagtttgcgcaacagatgtgcactgcactgcttttccttgcgactccagaa
cttagtatcattcactgtgatctaaaacctgaaaatatccttctttgtaaccccaaacgc
agtgcaatcaagatagttgactttggcagttcttgtcagttggggcagaggatataccag
tatattcagagtcgcttttatcggtctccagaggtgctactgggaatgccttatgacctt
gccattgatatgtggtccctcgggtgtattttggttgaaatgcacactggagaacctctg
ttcagtggtgccaatgaggtagatcagatgaataaaatagtggaagttctgggtattcca
cctgctcatattcttgaccaagcaccaaaagcaagaaagttctttgagaagttgccagat
ggcacttggaacttaaagaagaccaaagatggaaaacgggagtacaaaccaccaggaacc
cgtaaacttcataacattcttggagtggaaacaggaggacctggtgggcgacgtgctggg
gagtcaggtcatacggtcgctgactacttgaagttcaaagacctcattttaaggatgctt
gattatgaccccaaaactcgaattcaaccttattatgctctgcagcacagtttcttcaag
aaaacagctgatgaaggtacaaatacaagtaatagtgtatctacaagccccgccatggag
cagtctcagtcttcgggcaccacctccagtacatcgtcaagctcaggtggctcatcgggg
acaagcaacagtgggagagcccggtcggatccgacgcaccagcatcggcacagtggtggg
cacttcacagctgccgtgcaggccatggactgcgagacacacagtccccaggtgcgtcag
caatttcctgctcctcttggttggtcaggcactgaagctcctacacaggtcactgttgaa
actcatcctgttcaagaaacaacctttcatgtagcccctcaacagaatgcattgcatcat
caccatggtaacagttcccatcaccatcaccaccaccaccaccatcaccaccaccatgga
caacaagccttgggtaaccggaccaggccaagggtctacaattctccaacgaatagctcc
tctacccaagattctatggaggttggccacagtcaccactccatgacatccctgtcttcc
tcaacgacttcttcctcgacatcttcctcctctactggtaaccaaggcaatcaggcctac
cagaatcgcccagtggctgctaataccttggactttggacagaatggagctatggacgtt
aatttgaccgtctactccaatccccgccaagagactggcatagctggacatccaacatac
caattttctgctaatacaggtcctgcacattacatgactgaaggacatctgacaatgagg
caaggggctgatagagaagagtcccccatgacaggagtttgtgtgcaacagagtcctgta
gctagctcgtga

  All links  
Disease (2)   
   OMIM (2)   
Gene (13)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (42)   
   RefSeq(nuc) (8)   
   GenBank (17)   
   EMBL (17)   
3D Structure (84)   
   PDB (84)   
Protein domain (3)   
   Pfam (3)   
All databases (153)   

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