KEGG   Homo sapiens (human): 1889
Entry
1889              CDS       T01001                                 
Symbol
ECE1, ECE
Name
(RefSeq) endothelin converting enzyme 1
  KO
K01415  endothelin-converting enzyme [EC:3.4.24.71]
Organism
hsa  Homo sapiens (human)
Disease
H00910  Hirschsprung disease
H01633  High blood pressure
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    1889 (ECE1)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    1889 (ECE1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.71  endothelin-converting enzyme 1
     1889 (ECE1)
Peptidases and inhibitors [BR:hsa01002]
 Metallo peptidases
  Family M13: neprilysin family
   1889 (ECE1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   1889 (ECE1)
SSDB
Motif
Pfam: Peptidase_M13_N Peptidase_M13
Other DBs
NCBI-GeneID: 1889
NCBI-ProteinID: NP_001388
OMIM: 600423
HGNC: 3146
Ensembl: ENSG00000117298
UniProt: P42892
Structure
Position
1:complement(21217250..21345504)
AA seq 770 aa
MRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWA
ARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVD
PCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQV
YYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVY
VSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAI
RPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVE
INESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEV
MYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLS
TLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNF
SWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGG
IGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVN
GRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTP
ESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
NT seq 2313 nt   +upstreamnt  +downstreamnt
atgcggggcgtgtggccgcccccggtgtccgccctgctgtcggcgctggggatgtcgacg
tacaagcgggccacgctggacgaggaggacctggtggactcgctctccgagggcgacgca
taccccaacggcctgcaggtgaacttccacagcccccggagtggccagaggtgctgggct
gcacggacccaggtggagaagcggctggtggtgttggtggtacttctggcggcaggactg
gtggcctgcttggcagcactgggcatccagtaccagacaagatccccctctgtgtgcctg
agcgaagcttgtgtctcagtgaccagctccatcttgagctccatggaccccacagtggac
ccctgccatgacttcttcagctacgcctgtgggggctggatcaaggccaacccagtccct
gatggccactcacgctgggggaccttcagcaacctctgggaacacaaccaagcaatcatc
aagcacctcctcgaaaactccacggccagcgtgagcgaggcagagagaaaggcgcaagta
tactaccgtgcgtgcatgaacgagaccaggatcgaggagctcagggccaaacctctaatg
gagttgattgagaggctcgggggctggaacatcacaggtccctgggccaaggacaacttc
caggacaccctgcaggtggtcaccgcccactaccgcacctcacccttcttctctgtctat
gtcagtgccgattccaagaactccaacagcaacgtgatccaggtggaccagtctggcctg
ggcttgccctcgagagactattacctgaacaaaactgaaaacgagaaggtgctgaccgga
tatctgaactacatggtccagctggggaagctgctgggcggcggggacgaggaggccatc
cggccccagatgcagcagatcttggactttgagacggcactggccaacatcaccatccca
caggagaagcgccgtgatgaggagctcatctaccacaaagtgacggcagccgagctgcag
accttggcacccgccatcaactggttgccttttctcaacaccatcttctaccccgtggag
atcaatgaatccgagcctattgtggtctatgacaaggaataccttgagcagatctccact
ctcatcaacaccaccgacagatgcctgctcaacaactacatgatctggaacctggtgcgg
aaaacaagctccttccttgaccagcgctttcaggacgccgatgagaagttcatggaagtc
atgtacgggaccaagaagacctgtcttcctcgctggaagttttgcgtgagtgacacagaa
aacaacctgggctttgcgttgggccccatgtttgtcaaagcaaccttcgccgaggacagc
aagagcatagccaccgagatcatcctggagattaagaaggcatttgaggaaagcctgagc
accctgaagtggatggatgaggaaacccgaaaatcagccaaggaaaaggccgatgccatc
tacaacatgataggataccccaacttcatcatggatcccaaggagctggacaaagtgttt
aatgactacactgcagttccagacctctactttgaaaatgccatgcggtttttcaacttc
tcatggagggtcactgccgatcagctcaggaaagcccccaacagagatcagtggagcatg
accccgcccatggtgaacgcctactactcgcccaccaagaatgagattgtgtttccggcc
gggatcctgcaggcaccattctacacacgctcctcacccaaggccttaaactttggtggc
ataggtgtcgtcgtgggccatgagctgactcatgcttttgatgatcaaggacgggagtat
gacaaggacgggaacctccggccatggtggaagaactcatccgtggaggccttcaagcgt
cagaccgagtgcatggtagagcagtacagcaactacagcgtgaacggggagccggtgaac
gggcggcacaccctgggggagaacatcgccgacaacgggggtctcaaggcggcctatcgg
gcttaccagaactgggtgaagaagaacggggctgagcactcgctccccaccctgggcctc
accaataaccagctcttcttcctgggctttgcacaggtctggtgctccgtccgcacacct
gagagctcccacgaaggcctcatcaccgatccccacagcccctctcgcttccgggtcatc
ggctccctctccaattccaaggagttctcagaacacttccgctgcccacctggctcaccc
atgaacccgcctcacaagtgcgaagtctggtaa

  All links  
Disease (3)   
   OMIM (3)   
Gene (18)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (14)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (12)   
DNA sequence (70)   
   RefSeq(nuc) (12)   
   GenBank (29)   
   EMBL (29)   
3D Structure (1)   
   PDB (1)   
Protein domain (2)   
   Pfam (2)   
All databases (108)   

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