KEGG   Homo sapiens (human): 19Help
Entry
19                CDS       T01001                                 

Gene name
ABCA1, ABC-1, ABC1, CERP, HDLDT1, TGD
Definition
(RefSeq) ATP binding cassette subfamily A member 1
  KO
K05641  ATP-binding cassette, subfamily A (ABC1), member 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa02010  ABC transporters
hsa04975  Fat digestion and absorption
hsa04979  Cholesterol metabolism
Disease
H00159  Tangier disease
H00930  Hypoalphalipoproteinemia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09131 Membrane transport
   02010 ABC transporters
    19 (ABCA1)
 09150 Organismal Systems
  09154 Digestive system
   04975 Fat digestion and absorption
    19 (ABCA1)
   04979 Cholesterol metabolism
    19 (ABCA1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:hsa02000]
    19 (ABCA1)
Transporters [BR:hsa02000]
 ABC Transporters, Eukaryotic Type
  ABCA (ABC1) subfamily
   ABCA1, 2, 3, 4, 7, 12, 13 subgroups
    19 (ABCA1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: ABC2_membrane_3 ABC_tran AAA_21 DUF4162 AAA_23 Mst1_SARAH
Motif
Other DBs
NCBI-GeneID: 19
NCBI-ProteinID: NP_005493
OMIM: 600046
HGNC: 29
Ensembl: ENSG00000165029
Vega: OTTHUMG00000020417
Pharos: O95477(Tclin)
UniProt: O95477 B7XCW9 B2RUU2
Structure
PDB: 

Position
9q31.1
AA seq 2261 aa AA seqDB search
MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKA
MPSAGTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVARLFSDARRLLLYSQKDT
SMKDMRKVLRTLQQIKKSSSNLKLQDFLVDNETFSGFLYHNLSLPKSTVDKMLRADVILH
KVFLQGYQLHLTSLCNGSKSEEMIQLGDQEVSELCGLPREKLAAAERVLRSNMDILKPIL
RTLNSTSPFPSKELAEATKTLLHSLGTLAQELFSMRSWSDMRQEVMFLTNVNSSSSSTQI
YQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALFGGNGTEEDAETFYDNSTTPYCNDLMK
NLESSPLSRIIWKALKPLLVGKILYTPDTPATRQVMAEVNKTFQELAVFHDLEGMWEELS
PKIWTFMENSQEMDLVRMLLDSRDNDHFWEQQLDGLDWTAQDIVAFLAKHPEDVQSSNGS
VYTWREAFNETNQAIRTISRFMECVNLNKLEPIATEVWLINKSMELLDERKFWAGIVFTG
ITPGSIELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVV
EQAIIRVLTGTEKKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKGIV
YEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFV
FLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQDYVGFTLKIFAS
LLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSVSMMLFDTFLYGVMTW
YIEAVFPGQYGIPRPWYFPCTKSYWFGEESDEKSHPGSNQKRISEICMEEEPTHLKLGVS
IQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYIL
GKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVG
LPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQ
GRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLS
SCRNSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDI
GHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAE
TSDGTLPARRNRRAFGDKQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVK
GWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQ
PWMYNEQYTFVSNDAPEDTGTLELLNALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTTAP
VPQTIMDLFQNGNWTMQNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQDL
TGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQEVNDAIKQMKK
HLKLAKDSSADRFLNSLGRFMTGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQK
GENPSHYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQER
VSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLAL
LLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTDNKLNNIN
DILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEG
VVFFLITVLIQYRFFIRPRPVNAKLSPLNDEDEDVRRERQRILDGGGQNDILEIKELTKI
YRRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSN
IHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEK
YAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLT
SHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFG
LAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNF
AKDQSDDDHLKDLSLHKNQTVVDVAVLTSFLQDEKVKESYV
NT seq 6786 nt NT seq  +upstreamnt  +downstreamnt
atggcttgttggcctcagctgaggttgctgctgtggaagaacctcactttcagaagaaga
caaacatgtcagctgctgctggaagtggcctggcctctatttatcttcctgatcctgatc
tctgttcggctgagctacccaccctatgaacaacatgaatgccattttccaaataaagcc
atgccctctgcaggaacacttccttgggttcaggggattatctgtaatgccaacaacccc
tgtttccgttacccgactcctggggaggctcccggagttgttggaaactttaacaaatcc
attgtggctcgcctgttctcagatgctcggaggcttcttttatacagccagaaagacacc
agcatgaaggacatgcgcaaagttctgagaacattacagcagatcaagaaatccagctca
aacttgaagcttcaagatttcctggtggacaatgaaaccttctctgggttcctgtatcac
aacctctctctcccaaagtctactgtggacaagatgctgagggctgatgtcattctccac
aaggtatttttgcaaggctaccagttacatttgacaagtctgtgcaatggatcaaaatca
gaagagatgattcaacttggtgaccaagaagtttctgagctttgtggcctaccaagggag
aaactggctgcagcagagcgagtacttcgttccaacatggacatcctgaagccaatcctg
agaacactaaactctacatctcccttcccgagcaaggagctggctgaagccacaaaaaca
ttgctgcatagtcttgggactctggcccaggagctgttcagcatgagaagctggagtgac
atgcgacaggaggtgatgtttctgaccaatgtgaacagctccagctcctccacccaaatc
taccaggctgtgtctcgtattgtctgcgggcatcccgagggaggggggctgaagatcaag
tctctcaactggtatgaggacaacaactacaaagccctctttggaggcaatggcactgag
gaagatgctgaaaccttctatgacaactctacaactccttactgcaatgatttgatgaag
aatttggagtctagtcctctttcccgcattatctggaaagctctgaagccgctgctcgtt
gggaagatcctgtatacacctgacactccagccacaaggcaggtcatggctgaggtgaac
aagaccttccaggaactggctgtgttccatgatctggaaggcatgtgggaggaactcagc
cccaagatctggaccttcatggagaacagccaagaaatggaccttgtccggatgctgttg
gacagcagggacaatgaccacttttgggaacagcagttggatggcttagattggacagcc
caagacatcgtggcgtttttggccaagcacccagaggatgtccagtccagtaatggttct
gtgtacacctggagagaagctttcaacgagactaaccaggcaatccggaccatatctcgc
ttcatggagtgtgtcaacctgaacaagctagaacccatagcaacagaagtctggctcatc
aacaagtccatggagctgctggatgagaggaagttctgggctggtattgtgttcactgga
attactccaggcagcattgagctgccccatcatgtcaagtacaagatccgaatggacatt
gacaatgtggagaggacaaataaaatcaaggatgggtactgggaccctggtcctcgagct
gacccctttgaggacatgcggtacgtctgggggggcttcgcctacttgcaggatgtggtg
gagcaggcaatcatcagggtgctgacgggcaccgagaagaaaactggtgtctatatgcaa
cagatgccctatccctgttacgttgatgacatctttctgcgggtgatgagccggtcaatg
cccctcttcatgacgctggcctggatttactcagtggctgtgatcatcaagggcatcgtg
tatgagaaggaggcacggctgaaagagaccatgcggatcatgggcctggacaacagcatc
ctctggtttagctggttcattagtagcctcattcctcttcttgtgagcgctggcctgcta
gtggtcatcctgaagttaggaaacctgctgccctacagtgatcccagcgtggtgtttgtc
ttcctgtccgtgtttgctgtggtgacaatcctgcagtgcttcctgattagcacactcttc
tccagagccaacctggcagcagcctgtgggggcatcatctacttcacgctgtacctgccc
tacgtcctgtgtgtggcatggcaggactacgtgggcttcacactcaagatcttcgctagc
ctgctgtctcctgtggcttttgggtttggctgtgagtactttgccctttttgaggagcag
ggcattggagtgcagtgggacaacctgtttgagagtcctgtggaggaagatggcttcaat
ctcaccacttcggtctccatgatgctgtttgacaccttcctctatggggtgatgacctgg
tacattgaggctgtctttccaggccagtacggaattcccaggccctggtattttccttgc
accaagtcctactggtttggcgaggaaagtgatgagaagagccaccctggttccaaccag
aagagaatatcagaaatctgcatggaggaggaacccacccacttgaagctgggcgtgtcc
attcagaacctggtaaaagtctaccgagatgggatgaaggtggctgtcgatggcctggca
ctgaatttttatgagggccagatcacctccttcctgggccacaatggagcggggaagacg
accaccatgtcaatcctgaccgggttgttccccccgacctcgggcaccgcctacatcctg
ggaaaagacattcgctctgagatgagcaccatccggcagaacctgggggtctgtccccag
cataacgtgctgtttgacatgctgactgtcgaagaacacatctggttctatgcccgcttg
aaagggctctctgagaagcacgtgaaggcggagatggagcagatggccctggatgttggt
ttgccatcaagcaagctgaaaagcaaaacaagccagctgtcaggtggaatgcagagaaag
ctatctgtggccttggcctttgtcgggggatctaaggttgtcattctggatgaacccaca
gctggtgtggacccttactcccgcaggggaatatgggagctgctgctgaaataccgacaa
ggccgcaccattattctctctacacaccacatggatgaagcggacgtcctgggggacagg
attgccatcatctcccatgggaagctgtgctgtgtgggctcctccctgtttctgaagaac
cagctgggaacaggctactacctgaccttggtcaagaaagatgtggaatcctccctcagt
tcctgcagaaacagtagtagcactgtgtcatacctgaaaaaggaggacagtgtttctcag
agcagttctgatgctggcctgggcagcgaccatgagagtgacacgctgaccatcgatgtc
tctgctatctccaacctcatcaggaagcatgtgtctgaagcccggctggtggaagacata
gggcatgagctgacctatgtgctgccatatgaagctgctaaggagggagcctttgtggaa
ctctttcatgagattgatgaccggctctcagacctgggcatttctagttatggcatctca
gagacgaccctggaagaaatattcctcaaggtggccgaagagagtggggtggatgctgag
acctcagatggtaccttgccagcaagacgaaacaggcgggccttcggggacaagcagagc
tgtcttcgcccgttcactgaagatgatgctgctgatccaaatgattctgacatagaccca
gaatccagagagacagacttgctcagtgggatggatggcaaagggtcctaccaggtgaaa
ggctggaaacttacacagcaacagtttgtggcccttttgtggaagagactgctaattgcc
agacggagtcggaaaggattttttgctcagattgtcttgccagctgtgtttgtctgcatt
gcccttgtgttcagcctgatcgtgccaccctttggcaagtaccccagcctggaacttcag
ccctggatgtacaacgaacagtacacatttgtcagcaatgatgctcctgaggacacggga
accctggaactcttaaacgccctcaccaaagaccctggcttcgggacccgctgtatggaa
ggaaacccaatcccagacacgccctgccaggcaggggaggaagagtggaccactgcccca
gttccccagaccatcatggacctcttccagaatgggaactggacaatgcagaacccttca
cctgcatgccagtgtagcagcgacaaaatcaagaagatgctgcctgtgtgtcccccaggg
gcaggggggctgcctcctccacaaagaaaacaaaacactgcagatatccttcaggacctg
acaggaagaaacatttcggattatctggtgaagacgtatgtgcagatcatagccaaaagc
ttaaagaacaagatctgggtgaatgagtttaggtatggcggcttttccctgggtgtcagt
aatactcaagcacttcctccgagtcaagaagttaatgatgccatcaaacaaatgaagaaa
cacctaaagctggccaaggacagttctgcagatcgatttctcaacagcttgggaagattt
atgacaggactggacaccaaaaataatgtcaaggtgtggttcaataacaagggctggcat
gcaatcagctctttcctgaatgtcatcaacaatgccattctccgggccaacctgcaaaag
ggagagaaccctagccattatggaattactgctttcaatcatcccctgaatctcaccaag
cagcagctctcagaggtggctctgatgaccacatcagtggatgtccttgtgtccatctgt
gtcatctttgcaatgtccttcgtcccagccagctttgtcgtattcctgatccaggagcgg
gtcagcaaagcaaaacacctgcagttcatcagtggagtgaagcctgtcatctactggctc
tctaattttgtctgggatatgtgcaattacgttgtccctgccacactggtcattatcatc
ttcatctgcttccagcagaagtcctatgtgtcctccaccaatctgcctgtgctagccctt
ctacttttgctgtatgggtggtcaatcacacctctcatgtacccagcctcctttgtgttc
aagatccccagcacagcctatgtggtgctcaccagcgtgaacctcttcattggcattaat
ggcagcgtggccacctttgtgctggagctgttcaccgacaataagctgaataatatcaat
gatatcctgaagtccgtgttcttgatcttcccacatttttgcctgggacgagggctcatc
gacatggtgaaaaaccaggcaatggctgatgccctggaaaggtttggggagaatcgcttt
gtgtcaccattatcttgggacttggtgggacgaaacctcttcgccatggccgtggaaggg
gtggtgttcttcctcattactgttctgatccagtacagattcttcatcaggcccagacct
gtaaatgcaaagctatctcctctgaatgatgaagatgaagatgtgaggcgggaaagacag
agaattcttgatggtggaggccagaatgacatcttagaaatcaaggagttgacgaagata
tatagaaggaagcggaagcctgctgttgacaggatttgcgtgggcattcctcctggtgag
tgctttgggctcctgggagttaatggggctggaaaatcatcaactttcaagatgttaaca
ggagataccactgttaccagaggagatgctttccttaacaaaaatagtatcttatcaaac
atccatgaagtacatcagaacatgggctactgccctcagtttgatgccatcacagagctg
ttgactgggagagaacacgtggagttctttgcccttttgagaggagtcccagagaaagaa
gttggcaaggttggtgagtgggcgattcggaaactgggcctcgtgaagtatggagaaaaa
tatgctggtaactatagtggaggcaacaaacgcaagctctctacagccatggctttgatc
ggcgggcctcctgtggtgtttctggatgaacccaccacaggcatggatcccaaagcccgg
cggttcttgtggaattgtgccctaagtgttgtcaaggaggggagatcagtagtgcttaca
tctcatagtatggaagaatgtgaagctctttgcactaggatggcaatcatggtcaatgga
aggttcaggtgccttggcagtgtccagcatctaaaaaataggtttggagatggttataca
atagttgtacgaatagcagggtccaacccggacctgaagcctgtccaggatttctttgga
cttgcatttcctggaagtgttctaaaagagaaacaccggaacatgctacaataccagctt
ccatcttcattatcttctctggccaggatattcagcatcctctcccagagcaaaaagcga
ctccacatagaagactactctgtttctcagacaacacttgaccaagtatttgtgaacttt
gccaaggaccaaagtgatgatgaccacttaaaagacctctcattacacaaaaaccagaca
gtagtggacgttgcagttctcacatcttttctacaggatgagaaagtgaaagaaagctat
gtatga

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