KEGG   Homo sapiens (human): 1901Help
Entry
1901              CDS       T01001                                 

Gene name
S1PR1, CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1
Definition
(RefSeq) sphingosine-1-phosphate receptor 1
  KO
K04288  sphingosine 1-phosphate receptor 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04068  FoxO signaling pathway
hsa04071  Sphingolipid signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Drug target
Amiselimod (DG02399): D10904 D10905
Cenerimod: D11283
Etrasimod (DG02444): D10930
Fingolimod (DG00741): D04187 D10001
Ozanimod (DG02827): D10967 D10968
Ponesimod: D11215
Siponimod (DG03018): D11072 D11460
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    1901 (S1PR1)
   04071 Sphingolipid signaling pathway
    1901 (S1PR1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1901 (S1PR1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    1901 (S1PR1)
   04090 CD molecules [BR:hsa04090]
    1901 (S1PR1)
G protein-coupled receptors [BR:hsa04030]
 Rhodopsin family
  Lipid
   Sphingolipid
    1901 (S1PR1)
CD molecules [BR:hsa04090]
 Proteins
  1901 (S1PR1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 7tm_1 7TM_GPCR_Srsx 7tm_4 JTB
Motif
Other DBs
NCBI-GeneID: 1901
NCBI-ProteinID: NP_001307659
OMIM: 601974
HGNC: 3165
Ensembl: ENSG00000170989
Vega: OTTHUMG00000010835
Pharos: P21453(Tclin)
UniProt: P21453
Position
1p21.2
AA seq 382 aa AA seqDB search
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS
NT seq 1149 nt NT seq  +upstreamnt  +downstreamnt
atggggcccaccagcgtcccgctggtcaaggcccaccgcagctcggtctctgactacgtc
aactatgatatcatcgtccggcattacaactacacgggaaagctgaatatcagcgcggac
aaggagaacagcattaaactgacctcggtggtgttcattctcatctgctgctttatcatc
ctggagaacatctttgtcttgctgaccatttggaaaaccaagaaattccaccgacccatg
tactattttattggcaatctggccctctcagacctgttggcaggagtagcctacacagct
aacctgctcttgtctggggccaccacctacaagctcactcccgcccagtggtttctgcgg
gaagggagtatgtttgtggccctgtcagcctccgtgttcagtctcctcgccatcgccatt
gagcgctatatcacaatgctgaaaatgaaactccacaacgggagcaataacttccgcctc
ttcctgctaatcagcgcctgctgggtcatctccctcatcctgggtggcctgcctatcatg
ggctggaactgcatcagtgcgctgtccagctgctccaccgtgctgccgctctaccacaag
cactatatcctcttctgcaccacggtcttcactctgcttctgctctccatcgtcattctg
tactgcagaatctactccttggtcaggactcggagccgccgcctgacgttccgcaagaac
atttccaaggccagccgcagctctgagaagtcgctggcgctgctcaagaccgtaattatc
gtcctgagcgtcttcatcgcctgctgggcaccgctcttcatcctgctcctgctggatgtg
ggctgcaaggtgaagacctgtgacatcctcttcagagcggagtacttcctggtgttagct
gtgctcaactccggcaccaaccccatcatttacactctgaccaacaaggagatgcgtcgg
gccttcatccggatcatgtcctgctgcaagtgcccgagcggagactctgctggcaaattc
aagcgacccatcatcgccggcatggaattcagccgcagcaaatcggacaattcctcccac
ccccagaaagacgaaggggacaacccagagaccattatgtcttctggaaacgtcaactct
tcttcctag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (1)   
   OMIM (1)   
Drug (11)   
   KEGG DRUG (11)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
   PHAROS (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (32)   
   RefSeq(nuc) (2)   
   GenBank (15)   
   EMBL (15)   
Protein domain (4)   
   Pfam (4)   
All databases (81)   

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