KEGG   Homo sapiens (human): 1906
Entry
1906              CDS       T01001                                 
Symbol
EDN1, ARCND3, ET1, HDLCQ7, PPET1, QME
Name
(RefSeq) endothelin 1
  KO
K16366  endothelin-1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04024  cAMP signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04668  TNF signaling pathway
hsa04916  Melanogenesis
hsa04924  Renin secretion
hsa04926  Relaxin signaling pathway
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa05200  Pathways in cancer
hsa05410  Hypertrophic cardiomyopathy
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06325  Hormone/cytokine signaling
  Element
N01792  EDN-EDNR signaling pathway
Disease
H01884  Auriculocondylar syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    1906 (EDN1)
   04066 HIF-1 signaling pathway
    1906 (EDN1)
   04024 cAMP signaling pathway
    1906 (EDN1)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1906 (EDN1)
 09150 Organismal Systems
  09152 Endocrine system
   04926 Relaxin signaling pathway
    1906 (EDN1)
   04916 Melanogenesis
    1906 (EDN1)
   04924 Renin secretion
    1906 (EDN1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    1906 (EDN1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1906 (EDN1)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    1906 (EDN1)
   05410 Hypertrophic cardiomyopathy
    1906 (EDN1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    1906 (EDN1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    1906 (EDN1)
Cytokines and neuropeptides [BR:hsa04052]
 Neuropeptides
  GPCR binding
   1906 (EDN1)
SSDB
Motif
Pfam: Endothelin
Other DBs
NCBI-GeneID: 1906
NCBI-ProteinID: NP_001946
OMIM: 131240
HGNC: 3176
Ensembl: ENSG00000078401
CPD: C16009 C16010
UniProt: P05305 Q6FH53
Structure
Position
6:12230516..12297194
AA seq 212 aa
MDYLLMIFSLLFVACQGAPETAVLGAELSAVGENGGEKPTPSPPWRLRRSKRCSCSSLMD
KECVYFCHLDIIWVNTPEHVVPYGLGSPRSKRALENLLPTKATDRENRCQCASQKDKKCW
NFCQAGKELRAEDIMEKDWNNHKKGKDCSKLGKKCIYQQLVRGRKIRRSSEEHLRQTRSE
TMRNSVKSSFHDPKLKGKPSRERYVTHNRAHW
NT seq 639 nt   +upstreamnt  +downstreamnt
atggattatttgctcatgattttctctctgctgtttgtggcttgccaaggagctccagaa
acagcagtcttaggcgctgagctcagcgcggtgggtgagaacggcggggagaaacccact
cccagtccaccctggcggctccgccggtccaagcgctgctcctgctcgtccctgatggat
aaagagtgtgtctacttctgccacctggacatcatttgggtcaacactcccgagcacgtt
gttccgtatggacttggaagccctaggtccaagagagccttggagaatttacttcccaca
aaggcaacagaccgtgaaaatagatgccaatgtgctagccaaaaagacaagaagtgctgg
aatttttgccaagcaggaaaagaactcagggctgaagacattatggagaaagactggaat
aatcataagaaaggaaaagactgttccaagcttgggaaaaagtgtatttatcagcagtta
gtgagaggaagaaaaatcagaagaagttcagaggaacacctaagacaaaccaggtcggag
accatgagaaacagcgtcaaatcatcttttcatgatcccaagctgaaaggcaagccctcc
agagagcgttatgtgacccacaaccgagcacattggtga

  All links  
Disease (3)   
   OMIM (3)   
Gene (18)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (7)   
   OC (1)   
Protein sequence (8)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (37)   
   RefSeq(nuc) (5)   
   GenBank (16)   
   EMBL (16)   
3D Structure (17)   
   PDB (17)   
Protein domain (1)   
   Pfam (1)   
All databases (84)   

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KEGG   Homo sapiens (human): 1907
Entry
1907              CDS       T01001                                 
Symbol
EDN2, ET-2, ET2, PPET2
Name
(RefSeq) endothelin 2
  KO
K16367  endothelin-2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04924  Renin secretion
Network
nt06325  Hormone/cytokine signaling
  Element
N01792  EDN-EDNR signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    1907 (EDN2)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1907 (EDN2)
 09150 Organismal Systems
  09152 Endocrine system
   04924 Renin secretion
    1907 (EDN2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    1907 (EDN2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    1907 (EDN2)
Cytokines and neuropeptides [BR:hsa04052]
 Neuropeptides
  GPCR binding
   1907 (EDN2)
SSDB
Motif
Pfam: Endothelin
Other DBs
NCBI-GeneID: 1907
NCBI-ProteinID: NP_001947
OMIM: 131241
HGNC: 3177
Ensembl: ENSG00000127129
CPD: C16012
UniProt: P20800
Position
1:complement(41478775..41484683)
AA seq 178 aa
MVSVPTTWCSVALALLVALHEGKGQAAATLEQPASSSHAQGTHLRLRRCSCSSWLDKECV
YFCHLDIIWVNTPEQTAPYGLGNPPRRRRRSLPRRCQCSSARDPACATFCLRRPWTEAGA
VPSRKSPADVFQTGKTGATTGELLQRLRDISTVKSLFAKRQQEAMREPRSTHSRWRKR
NT seq 537 nt   +upstreamnt  +downstreamnt
atggtctccgtgcctaccacctggtgctccgttgcgctagccctgctcgtggccctgcat
gaagggaagggccaggctgctgccaccctggagcagccagcgtcctcatctcatgcccaa
ggcacccaccttcggcttcgccgttgctcctgcagctcctggctcgacaaggagtgcgtc
tacttctgccacttggacatcatctgggtgaacactcctgaacagacagctccttacggc
ctgggaaacccgccaagacgccggcgccgctccctgccaaggcgctgtcagtgctccagt
gccagggaccccgcctgtgccaccttctgccttcgaaggccctggactgaagccggggca
gtcccaagccggaagtcccctgcagacgtgttccagactggcaagacaggggccactaca
ggagagcttctccaaaggctgagggacatttccacagtcaagagcctctttgccaagcga
caacaggaggccatgcgggagcctcggtccacacattccaggtggaggaagagatag

  All links  
Disease (1)   
   OMIM (1)   
Gene (16)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (34)   
   RefSeq(nuc) (8)   
   GenBank (13)   
   EMBL (13)   
Protein domain (1)   
   Pfam (1)   
All databases (59)   

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KEGG   Homo sapiens (human): 1908
Entry
1908              CDS       T01001                                 
Symbol
EDN3, ET-3, ET3, HSCR4, PPET3, WS4B
Name
(RefSeq) endothelin 3
  KO
K05227  endothelin-3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04924  Renin secretion
Network
nt06325  Hormone/cytokine signaling
  Element
N01792  EDN-EDNR signaling pathway
Disease
H00759  Waardenburg syndrome
H00910  Hirschsprung disease
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    1908 (EDN3)
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1908 (EDN3)
 09150 Organismal Systems
  09152 Endocrine system
   04924 Renin secretion
    1908 (EDN3)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    1908 (EDN3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    1908 (EDN3)
Cytokines and neuropeptides [BR:hsa04052]
 Neuropeptides
  GPCR binding
   1908 (EDN3)
SSDB
Motif
Pfam: Endothelin
Other DBs
NCBI-GeneID: 1908
NCBI-ProteinID: NP_996917
OMIM: 131242
HGNC: 3178
Ensembl: ENSG00000124205
CPD: C16013
UniProt: P14138
Structure
Position
20:59300611..59325992
AA seq 238 aa
MEPGLWLLFGLTVTSAAGFVPCSQSGDAGRRGVSQAPTAARSEGDCEETVAGPGEETVAG
PGEGTVAPTALQGPSPGSPGQEQAAEGAPEHHRSRRCTCFTYKDKECVYYCHLDIIWINT
PEQTVPYGLSNYRGSFRGKRSAGPLPGNLQLSHRPHLRCACVGRYDKACLHFCTQTLDVS
SNSRTAEKTDKEEEGKVEVKDQQSKQALDLHHPKLMPGSGLALAPSTCPRCLFQEGAP
NT seq 717 nt   +upstreamnt  +downstreamnt
atggagccggggctgtggctccttttcgggctcacagtgacctccgccgcaggattcgtg
ccttgctcccagtctggggatgctggcaggcgcggcgtgtcccaggcccccactgcagcc
agatctgagggggactgtgaagagactgtggctggccctggcgaggagactgtggctggc
cctggcgaggggactgtggccccgacagcactgcagggtccaagccctggaagccctggg
caggagcaggcggccgagggggcccctgagcaccaccgatccaggcgctgcacgtgcttc
acctacaaggacaaggagtgtgtctactattgccacctggacatcatttggatcaacact
cccgaacagacggtgccctatggactgtccaactacagaggaagcttccggggcaagagg
tctgcggggccacttccagggaatctgcagctctcacatcggccacacttgcgctgcgct
tgtgtggggagatatgacaaggcctgcctgcacttttgcacccaaactctggacgtcagc
agtaattcaaggacggcagaaaaaacagacaaagaagaggaagggaaggttgaagtcaag
gaccaacaaagcaagcaggctttagacctccaccatccaaagctcatgcccggcagtgga
ctcgccctcgctccatctacctgcccccgctgcctctttcaggaaggagccccttag

  All links  
Disease (3)   
   OMIM (3)   
Gene (15)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
Protein sequence (12)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (10)   
DNA sequence (33)   
   RefSeq(nuc) (13)   
   GenBank (10)   
   EMBL (10)   
3D Structure (1)   
   PDB (1)   
Protein domain (1)   
   Pfam (1)   
All databases (65)   

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