KEGG   Homo sapiens (human): 191
Entry
191               CDS       T01001                                 
Symbol
AHCY, SAHH, adoHcyase
Name
(RefSeq) adenosylhomocysteinase
  KO
K01251  adenosylhomocysteinase [EC:3.13.2.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00270  Cysteine and methionine metabolism
hsa00670  One carbon pool by folate
hsa01100  Metabolic pathways
Module
hsa_M00035  Methionine degradation
Network
nt06030  Methionine metabolism
  Element
N01607  Methionine degradation
Disease
H00184  Hypermethioninemia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    191 (AHCY)
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    191 (AHCY)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    191 (AHCY)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    191 (AHCY)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.13  Acting on carbon-sulfur bonds
   3.13.2  Thioether and trialkylsulfonium hydrolases
    3.13.2.1  adenosylhomocysteinase
     191 (AHCY)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     191 (AHCY)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   191 (AHCY)
SSDB
Motif
Pfam: AdoHcyase AdoHcyase_NAD 2-Hacid_dh_C KARI_N TrkA_N ELFV_dehydrog 3HCDH_N
Other DBs
NCBI-GeneID: 191
NCBI-ProteinID: NP_000678
OMIM: 180960
HGNC: 343
Ensembl: ENSG00000101444
UniProt: P23526 A0A384MTQ3
Structure
Position
20:complement(34231981..34311836)
AA seq 432 aa
MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVET
AVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYF
KDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINV
NDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVI
ITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIG
HFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSN
SFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMS
CDGPFKPDHYRY
NT seq 1299 nt   +upstreamnt  +downstreamnt
atgtctgacaaactgccctacaaagtcgccgacatcggcctggctgcctggggacgcaag
gccctggacattgctgagaacgagatgccgggcctgatgcgtatgcgggagcggtactcg
gcctccaagccactgaagggcgcccgcatcgctggctgcctgcacatgaccgtggagacg
gccgtcctcattgagaccctcgtcaccctgggtgctgaggtgcagtggtccagctgcaac
atcttctccacccaggaccatgcggcggctgccattgccaaggctggcattccggtgtat
gcctggaagggcgaaacggacgaggagtacctgtggtgcattgagcagaccctgtacttc
aaggacgggcccctcaacatgattctggacgacgggggcgacctcaccaacctcatccac
accaagtacccgcagcttctgccaggcatccgaggcatctctgaggagaccacgactggg
gtccacaacctctacaagatgatggccaatgggatcctcaaggtgcctgccatcaatgtc
aatgactccgtcaccaagagcaagtttgacaacctctatggctgccgggagtccctcata
gatggcatcaagcgggccacagatgtgatgattgccggcaaggtagcggtggtagcaggc
tatggtgatgtgggcaagggctgtgcccaggccctgcggggtttcggagcccgcgtcatc
atcaccgagattgaccccatcaacgcactgcaggctgccatggagggctatgaggtgacc
accatggatgaggcctgtcaggagggcaacatctttgtcaccaccacaggctgtattgac
atcatccttggccggcactttgagcagatgaaggatgatgccattgtgtgtaacattgga
cactttgacgtggagatcgatgtcaagtggctcaacgagaacgccgtggagaaggtgaac
atcaagccgcaggtggaccggtatcggttgaagaatgggcgccgcatcatcctgctggcc
gagggtcggctggtcaacctgggttgtgccatgggccaccccagcttcgtgatgagtaac
tccttcaccaaccaggtgatggcgcagatcgagctgtggacccatccagacaagtacccc
gttggggttcatttcctgcccaagaagctggatgaggcagtggctgaagcccacctgggc
aagctgaatgtgaagttgaccaagctaactgagaagcaagcccagtacctgggcatgtcc
tgtgatggccccttcaagccggatcactaccgctactga

  All links  
Disease (2)   
   OMIM (2)   
Gene (57)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (27)   
   OC (1)   
   PROTHERM (10)   
Protein sequence (15)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (12)   
DNA sequence (50)   
   RefSeq(nuc) (12)   
   GenBank (19)   
   EMBL (19)   
3D Structure (8)   
   PDB (8)   
Protein domain (7)   
   Pfam (7)   
All databases (139)   

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