KEGG   Homo sapiens (human): 1911
Entry
1911              CDS       T01001                                 
Symbol
PHC1, EDR1, HPH1, MCPH11, RAE28
Name
(RefSeq) polyhomeotic homolog 1
  KO
K11456  polyhomeotic-like protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa03083  Polycomb repressive complex
Network
nt06523  Epigenetic regulation by Polycomb complexes
  Element
N01577  Gene silencing by methylation of H3K27 and ubiquitination of H2AK119
N01585  Deubiquitination of H2AK119
Disease
H00269  Primary microcephaly
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    1911 (PHC1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    1911 (PHC1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   Polycomb repressive complex (PRC) and associated proteins
    Canonical PRC1 (PRC1.2/1.4)
     1911 (PHC1)
SSDB
Motif
Pfam: PHC2_SAM_assoc zf-FCS_1 SAM_1 SAM_2 SAM_PNT zf-FCS zf-CGNR
Other DBs
NCBI-GeneID: 1911
NCBI-ProteinID: NP_004417
OMIM: 602978
HGNC: 3182
Ensembl: ENSG00000111752
UniProt: P78364 Q6GMQ3 Q6N083
Structure
Position
12:8913843..8941467
AA seq 1004 aa
METESEQNSNSTNGSSSSGGSSRPQIAQMSLYERQAVQALQALQRQPNAAQYFHQFMLQQ
QLSNAQLHSLAAVQQATIAASRQASSPNTSTTQQQTTTTQASINLATTSAAQLISRSQSV
SSPSATTLTQSVLLGNTTSPPLNQSQAQMYLRPQLGNLLQVNRTLGRNVPLASQLILMPN
GAVAAVQQEVPSAQSPGVHADADQVQNLAVRNQQASAQGPQMQGSTQKAIPPGASPVSSL
SQASSQALAVAQASSGATNQSLNLSQAGGGSGNSIPGSMGPGGGGQAHGGLGQLPSSGMG
GGSCPRKGTGVVQPLPAAQTVTVSQGSQTEAESAAAKKAEADGSGQQNVGMNLTRTATPA
PSQTLISSATYTQIQPHSLIQQQQQIHLQQKQVVIQQQIAIHHQQQFQHRQSQLLHTATH
LQLAQQQQQQQQQQQQQQQPQATTLTAPQPPQVPPTQQVPPSQSQQQAQTLVVQPMLQSS
PLSLPPDAAPKPPIPIQSKPPVAPIKPPQLGAAKMSAAQQPPPHIPVQVVGTRQPGTAQA
QALGLAQLAAAVPTSRGMPGTVQSGQAHLASSPPSSQAPGALQECPPTLAPGMTLAPVQG
TAHVVKGGATTSSPVVAQVPAAFYMQSVHLPGKPQTLAVKRKADSEEERDDVSTLGSMLP
AKASPVAESPKVMDEKSSLGEKAESVANVNANTPSSELVALTPAPSVPPPTLAMVSRQMG
DSKPPQAIVKPQILTHIIEGFVIQEGAEPFPVGCSQLLKESEKPLQTGLPTGLTENQSGG
PLGVDSPSAELDKKANLLKCEYCGKYAPAEQFRGSKRFCSMTCAKRYNVSCSHQFRLKRK
KMKEFQEANYARVRRRGPRRSSSDIARAKIQGKCHRGQEDSSRGSDNSSYDEALSPTSPG
PLSVRAGHGERDLGNPNTAPPTPELHGINPVFLSSNPSRWSVEEVYEFIASLQGCQEIAE
EFRSQEIDGQALLLLKEEHLMSAMNIKLGPALKICAKINVLKET
NT seq 3015 nt   +upstreamnt  +downstreamnt
atggagactgagagcgagcagaactccaattccaccaatgggagttctagctcagggggc
agctctcggccccagatagctcaaatgtcactttatgaacgacaagcagtgcaggctctg
caagcactgcagcggcagcccaatgcagctcagtatttccaccagttcatgctccagcag
cagctcagtaatgcccagctgcatagcctggctgccgtccagcaggccacaattgctgcc
agtcggcaggccagctccccaaacaccagcactacacagcagcagactaccaccacccag
gcctcgatcaatctggccaccacatcggccgcccagctcatcagccgatcccagagtgtg
agctctcccagtgctaccaccttgacccaatctgtgctactggggaacaccacctcccca
cccctcaaccagtctcaggcccagatgtatctacggccacagctgggaaacctattgcag
gtaaaccgaaccctgggtcggaatgtgcctctagcctcccaactcatcctgatgcctaat
ggggcggtggctgcagtccagcaggaggtgccatctgctcagtctcctggagttcatgca
gatgcagatcaggttcagaacttggcagtaaggaatcaacaggcctcagctcaaggacct
cagatgcaaggctccactcagaaggccattcctccaggagcctcccctgtctctagcctc
tcccaggcctctagccaggccctagcggtggcacaggcttcctctggggccacaaaccag
tccctcaaccttagtcaagctggtggaggcagtgggaatagcatcccagggtccatgggt
ccaggtggaggtgggcaggcacatggtggtttgggtcagttgccttcctcaggaatgggt
ggtgggagctgtcccagaaagggtacaggagtggtgcagcccttgcctgcagcccaaaca
gtgactgtgagccagggcagccagacagaggcagaaagtgcagcagccaagaaggcagaa
gcagatgggagtggccagcagaatgtgggcatgaacctgacacggacagccacacctgcg
cccagccagacacttattagctcagccacctacacacagatccagccccattcactgatt
cagcaacagcaacagatccacctccagcagaaacaggtggtgatccagcagcagattgcc
atccaccaccagcagcagttccagcaccggcagtcccagctccttcacacagctacacac
ctccagttggcgcagcagcagcagcagcaacaacagcaacagcagcaacagcagcagccg
caagccaccaccctcactgcccctcagccaccacaggtcccacctactcagcaggtccca
ccttcccagtcccagcagcaagcccaaaccctggtcgttcagcccatgcttcagtcttca
cccttgtctcttccacctgatgcagcccctaagccaccaattcccatccaatccaaacca
cctgtagcacctatcaagccgcctcagttaggggccgctaagatgtcagctgcccagcaa
ccaccaccccatatccctgtgcaagttgtaggcactcgacagccaggtacagcccaggca
caggctttggggttggcacagctggcagctgctgtacctacttcccgggggatgccaggt
acagtgcagtctggtcaggcccatttggcctcctcgccaccttcatcccaggctcctggt
gcactgcaggagtgccctcccacattggcccctgggatgacccttgctcctgtgcagggg
acagcacatgtggtaaagggtggggctaccacctcctcacctgttgtagcccaggtccct
gctgccttctatatgcagtctgtgcacttgccgggtaaaccccagacattggctgtcaaa
cgcaaggctgactctgaggaggagagagatgatgtctccacattgggttcaatgcttcct
gccaaggcatctccagtagcagaaagcccaaaagtcatggacgagaagagcagtcttgga
gaaaaagctgaatcagtggctaatgtgaatgctaatactccaagcagtgaactagtagcc
ttgacccccgccccttcagtaccgcctcctacactagccatggtgtctagacaaatgggt
gactcaaaacccccacaggccatcgtgaagccccagattctcacccacatcattgaaggc
tttgttatccaggaaggagcagaacctttcccggtgggttgttctcagttactgaaggag
tctgagaagccactacagactggccttccgacagggctgactgagaatcagtcaggtggc
cctttgggagtggacagcccatctgctgagttagataagaaggcgaatctcctgaagtgc
gagtactgtgggaagtacgcccccgcagagcagtttcgtggctctaagaggttctgctcc
atgacttgcgctaagaggtacaatgtgagctgtagccatcagttccggctgaagaggaaa
aaaatgaaagagtttcaagaagccaactatgctcgcgttcgcaggcgtggaccccgccgc
agctcctctgacattgcccgtgccaagattcagggcaagtgccaccggggtcaagaagac
tctagccggggttcagataattccagttatgatgaagcactctctccaacatctcctggg
cctttatcagtaagagctgggcatggagaacgtgacctggggaatcccaatacagctcca
cctacaccggaattacatggcatcaaccctgtgttcctgtccagtaatcccagccgttgg
agtgtagaggaggtgtacgagtttattgcttctctccaaggctgccaagagattgcagag
gaatttcgctcacaggagattgatggacaggcccttttattacttaaagaagaacatctt
atgagtgccatgaacatcaagctgggccctgccctcaagatctgcgccaagataaatgtc
ctcaaggagacctaa

  All links  
Disease (2)   
   OMIM (2)   
Gene (19)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (38)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (34)   
DNA sequence (59)   
   RefSeq(nuc) (35)   
   GenBank (12)   
   EMBL (12)   
3D Structure (1)   
   PDB (1)   
Protein domain (7)   
   Pfam (7)   
All databases (126)   

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